Eph receptors and ephrins in cancer progression

Pasquale, E. B. Eph receptor signalling casts a wide net on cell behaviour. Nat. Rev. Mol. Cell Biol. 6, 462–475 (2005).

Article  CAS  PubMed  Google Scholar 

Pasquale, E. B. Eph receptors and ephrins in cancer: bidirectional signalling and beyond. Nat. Rev. Cancer 10, 165–180 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boyd, A. W., Bartlett, P. F. & Lackmann, M. Therapeutic targeting of EPH receptors and their ligands. Nat. Rev. Drug Discov. 13, 39–62 (2014).

Article  CAS  PubMed  Google Scholar 

Wimmer-Kleikamp, S. H., Janes, P. W., Squire, A., Bastiaens, P. I. & Lackmann, M. Recruitment of Eph receptors into signaling clusters does not require ephrin contact. J. Cell Biol. 164, 661–666 (2004).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Seiradake, E., Harlos, K., Sutton, G., Aricescu, A. R. & Jones, E. Y. An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly. Nat. Struct. Mol. Biol. 17, 398–402 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Seiradake, E. et al. Structurally encoded intraclass differences in EphA clusters drive distinct cell responses. Nat. Struct. Mol. Biol. 20, 958–964 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Himanen, J. P. et al. Architecture of Eph receptor clusters. Proc. Natl Acad. Sci. USA 107, 10860–10865 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang, L. Y., Patel, O., Janes, P. W., Murphy, J. M. & Lucet, I. S. Eph receptor signalling: from catalytic to non-catalytic functions. Oncogene 38, 6567–6584 (2019).

Article  CAS  PubMed  Google Scholar 

Hattori, M., Osterfield, M. & Flanagan, J. G. Regulated cleavage of a contact-mediated axon repellent. Science 289, 1360–1365 (2000).

Article  CAS  PubMed  Google Scholar 

Janes, P. W. et al. Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans. Cell 123, 291–304 (2005).

Article  CAS  PubMed  Google Scholar 

Janes, P. W. et al. Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10. PLoS Biol. 7, e1000215 (2009).

Article  PubMed  PubMed Central  Google Scholar 

Solanas, G., Cortina, C., Sevillano, M. & Batlle, E. Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling. Nat. Cell Biol. 13, 1100–1107 (2011).

Article  CAS  PubMed  Google Scholar 

Batlle, E. & Wilkinson, D. G. Molecular mechanisms of cell segregation and boundary formation in development and tumorigenesis. Cold Spring Harb. Perspect. Biol. 4, a008227 (2012).

Article  PubMed  PubMed Central  Google Scholar 

Janes, P. W., Nievergall, E. & Lackmann, M. Concepts and consequences of Eph receptor clustering. Semin. Cell Dev. Biol. 23, 43–50 (2012).

Article  CAS  PubMed  Google Scholar 

Cai, C. et al. ADAM10-cleaved ephrin-A5 contributes to prostate cancer metastasis. Cell Death Dis. 13, 453 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schaupp, A. et al. The composition of EphB2 clusters determines the strength in the cellular repulsion response. J. Cell Biol. 204, 409–422 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, Z., Oh, D., Biswas, K. H., Zaidel-Bar, R. & Groves, J. T. Probing the effect of clustering on EphA2 receptor signaling efficiency by subcellular control of ligand-receptor mobility. eLife 10, e67379 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zapata-Mercado, E. et al. The efficacy of receptor tyrosine kinase EphA2 autophosphorylation increases with EphA2 oligomer size. J. Biol. Chem. 298, 102370 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ojosnegros, S. et al. Eph-ephrin signaling modulated by polymerization and condensation of receptors. Proc. Natl Acad. Sci. USA 114, 13188–13193 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stein, E. et al. Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses. Genes Dev. 12, 667–678 (1998).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Salaita, K. et al. Restriction of receptor movement alters cellular response: physical force sensing by EphA2. Science 327, 1380–1385 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Conway, A. et al. Multivalent ligands control stem cell behaviour in vitro and in vivo. Nat. Nanotechnol. 8, 831–838 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong, M. et al. Spatiomechanical modulation of EphB4-ephrin-B2 signaling in neural stem cell differentiation. Biophys. J. 115, 865–873 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Verheyen, T. et al. Spatial organization-dependent EphA2 transcriptional responses revealed by ligand nanocalipers. Nucleic Acids Res. 48, 5777–5787 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cortina, C. et al. EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells. Nat. Genet. 39, 1376–1383 (2007).

Article  CAS  PubMed  Google Scholar 

Miura, K., Nam, J. M., Kojima, C., Mochizuki, N. & Sabe, H. EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts. Mol. Biol. Cell 20, 1949–1959 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nievergall, E. et al. PTP1B regulates Eph receptor function and trafficking. J. Cell Biol. 191, 1189–1203 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wakayama, Y., Miura, K., Sabe, H. & Mochizuki, N. EphrinA1-EphA2 signal induces compaction and polarization of Madin-Darby canine kidney cells by inactivating ezrin through negative regulation of RhoA. J. Biol. Chem. 286, 44243–44253 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stahl, S. et al. Phosphoproteomic profiling of NSCLC cells reveals that ephrin B3 regulates pro-survival signaling through Akt1-mediated phosphorylation of the EphA2 receptor. J. Proteome Res. 10, 2566–2578 (2011).

Article  CAS  PubMed  Google Scholar 

Falivelli, G. et al. Attenuation of eph receptor kinase activation in cancer cells by coexpressed ephrin ligands. PLoS ONE 8, e81445 (2013).

Article  PubMed  PubMed Central  Google Scholar 

Lisabeth, E. M., Falivelli, G. & Pasquale, E. B. Eph receptor signaling and ephrins. Cold Spring Harb. Perspect. Biol. 5, a009159 (2013).

Article  PubMed  PubMed Central  Google Scholar 

Efazat, G. et al. Ephrin B3 interacts with multiple EphA receptors and drives migration and invasion in non-small cell lung cancer. Oncotarget 7, 60332–60347 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Xu, K. et al. Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5. Proc. Natl Acad. Sci. USA 110, 14634–14639 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu, Y. et al. The Ephb2 receptor uses homotypic, head-to-tail interactions within its ectodomain as an autoinhibitory control mechanism. Int. J. Mol. Sci. 22, 10473 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miao, H. et al. EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt. Cancer Cell 16, 9–20 (2009).

Article  CAS  PubMed  PubMed Central 

留言 (0)

沒有登入
gif