Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity

Letai, A. Cell death and cancer therapy: don’t forget to kill the cancer cell! Clin. Cancer Res. 21, 5015–5020 (2015).

Article  CAS  PubMed  Google Scholar 

Roberts, A. W. et al. Targeting BCL2 with venetoclax in relapsed chronic lymphocytic leukemia. N. Engl. J. Med. 374, 311–322 (2016).

Article  CAS  PubMed  Google Scholar 

Marin-Acevedo, J. A., Soyano, A. E., Dholaria, B., Knutson, K. L. & Lou, Y. Cancer immunotherapy beyond immune checkpoint inhibitors. J. Hematol. Oncol. 11, 8 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Vasan, N., Baselga, J. & Hyman, D. M. A view on drug resistance in cancer. Nature 575, 299–309 (2019).

Article  CAS  ADS  PubMed  PubMed Central  Google Scholar 

Hangauer, M. J. et al. Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. Nature 551, 247–250 (2017).

Article  CAS  ADS  PubMed  PubMed Central  Google Scholar 

Cabanos, H. F. & Hata, A. N. Emerging insights into targeted therapy-tolerant persister cells in cancer. Cancers 13, 2666 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pfeffer, C. M. & Singh, A. T. K. Apoptosis: a target for anticancer therapy. Int. J. Mol. Sci. 19, 448 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Legrand, A. J., Konstantinou, M., Goode, E. F. & Meier, P. The diversification of cell death and immunity: memento mori. Mol. Cell 76, 232–242 (2019).

Article  CAS  PubMed  Google Scholar 

Fadok, V. A. et al. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J. Clin. Invest. 101, 890–898 (1998).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Voll, R. E. et al. Immunosuppressive effects of apoptotic cells. Nature 390, 350–351 (1997).

Article  CAS  ADS  PubMed  Google Scholar 

Vitale, I. et al. Apoptotic cell death in disease — current understanding of the NCCD 2023. Cell Death Differ. 30, 1097–1154 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Segawa, K. & Nagata, S. An apoptotic ‘eat me’ signal: phosphatidylserine exposure. Trends Cell Biol. 25, 639–650 (2015).

Article  CAS  PubMed  Google Scholar 

Scaffidi, C., Schmitz, I., Krammer, P. H. & Peter, M. E. The role of c-FLIP in modulation of CD95-induced apoptosis. J. Biol. Chem. 274, 1541 (1999).

Article  CAS  PubMed  Google Scholar 

Pasparakis, M. & Vandenabeele, P. Necroptosis and its role in inflammation. Nature 517, 311–320 (2015).

Article  CAS  ADS  PubMed  Google Scholar 

Fulda, S. Therapeutic exploitation of necroptosis for cancer therapy. Semin. Cell Dev. Biol. 35, 51–56 (2014).

Article  CAS  PubMed  Google Scholar 

Su, Z., Yang, Z., Xu, Y., Chen, Y. & Yu, Q. Apoptosis, autophagy, necroptosis, and cancer metastasis. Mol. Cancer 14, 48 (2015).

Article  PubMed  PubMed Central  Google Scholar 

Nicolai, S., Pieraccioli, M., Peschiaroli, A., Melino, G. & Raschella, G. Neuroblastoma: oncogenic mechanisms and therapeutic exploitation of necroptosis. Cell Death Dis. 6, e2010 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moriwaki, K. & Chan, F. K. Regulation of RIPK3- and RHIM-dependent necroptosis by the proteasome. J. Biol. Chem. 291, 5948–5959 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaczmarek, A., Vandenabeele, P. & Krysko, D. V. Necroptosis: the release of damage-associated molecular patterns and its physiological relevance. Immunity 38, 209–223 (2013).

Article  CAS  PubMed  Google Scholar 

Brault, M., Olsen, T. M., Martinez, J., Stetson, D. B. & Oberst, A. Intracellular nucleic acid sensing triggers necroptosis through synergistic type I IFN and TNF signaling. J. Immunol. 200, 2748–2756 (2018).

Article  CAS  PubMed  Google Scholar 

Hildebrand, J. M. et al. Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death. Proc. Natl Acad. Sci. USA 111, 15072–15077 (2014).

Article  CAS  ADS  PubMed  PubMed Central  Google Scholar 

Chen, X. et al. Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death. Cell Res. 24, 105–121 (2014).

Article  CAS  PubMed  Google Scholar 

Cai, Z. et al. Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis. Nat. Cell Biol. 16, 55–65 (2014).

Article  CAS  PubMed  Google Scholar 

Murphy, J. M. et al. The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity 39, 443–453 (2013).

Article  CAS  PubMed  Google Scholar 

Meng, Y. et al. Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling. Cell Death Dis. 13, 565 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vanden Berghe, T., Hassannia, B. & Vandenabeele, P. An outline of necrosome triggers. Cell. Mol. Life Sci. 73, 2137–2152 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vercammen, D. et al. Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways. J. Exp. Med. 188, 919–930 (1998).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vercammen, D. et al. Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. J. Exp. Med. 187, 1477–1485 (1998).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Holler, N. et al. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat. Immunol. 1, 489–495 (2000). In this seminal paper, the first identification of RIPK1 as an essential mediator of necroptosis is provided.

Article  CAS  PubMed  Google Scholar 

Ermolaeva, M. A. et al. Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses. Nat. Immunol. 9, 1037–1046 (2008).

Article  CAS  PubMed  Google Scholar 

Pobezinskaya, Y. L. et al. The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors. Nat. Immunol. 9, 1047–1054 (2008).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Micheau, O. & Tschopp, J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114, 181–190 (2003). The groundbreaking first description of the TNFR1 complex I and complex II.

Article  CAS  PubMed  Google Scholar 

Hsu, H., Xiong, J. & Goeddel, D. V. The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation. Cell 81, 495–504 (1995).

Article  CAS  PubMed  Google Scholar 

Rothe, M. et al. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 83, 1243–1252 (1995).

Article  CAS  PubMed  Google Scholar 

Shu, H. B., Takeuchi, M. & Goeddel, D. V. The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex. Proc. Natl Acad. Sci. USA 93, 13973–13978 (1996).

Article  CAS  ADS  PubMed  PubMed Central  Google Scholar 

Varfolomeev, E. et al. c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor α (TNFα)-induced NF-κB activation. J. Biol. Chem. 283, 24295–24299 (2008).

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