Bai H, Zhang Q (2021) Activation of NLRP3 inflammasome and onset of Alzheimer’s disease. Front Immunol 12:701282

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cai Q, Tammineni P (2016) Alterations in mitochondrial quality control in Alzheimer’s disease. Front Cell Neurosci 10:24

Article  PubMed  PubMed Central  Google Scholar 

Cai Y, Chai Y, Fu Y, Wang Y, Zhang Y, Zhang X, Zhu L, Miao M, Yan T (2021) Salidroside ameliorates Alzheimer’s disease by targeting NLRP3 inflammasome-mediated pyroptosis. Front Aging Neurosci 13:809433

Article  CAS  PubMed  Google Scholar 

Cecarini V, Bonfili L, Cuccioloni M, Keller JN, Bruce-Keller AJ, Eleuteri AM (2016) Effects of ghrelin on the proteolytic pathways of Alzheimer’s disease neuronal cells. Mol Neurobiol 53:3168–3178

Article  CAS  PubMed  Google Scholar 

Cheng X, Wei Y, Qian Z, Han L (2023) Autophagy balances neuroinflammation in Alzheimer’s disease. Cell Mol Neurobiol 43:1537–1549

Article  PubMed  Google Scholar 

Eslami M, Sadeghi B, Goshadrou F (2018) Chronic ghrelin administration restores hippocampal long-term potentiation and ameliorates memory impairment in rat model of Alzheimer’s disease. Hippocampus 28:724–734

Article  CAS  PubMed  Google Scholar 

Ezquerro S, Fruhbeck G, Rodriguez A (2017) Ghrelin and autophagy. Curr Opin Clin Nutr Metab Care 20:402–408

Article  PubMed  Google Scholar 

Fu L, Liu C, Chen L, Lv Y, Meng G, Hu M, Long Y, Hong H, Tang S (2019) Protective effects of 1-methylnicotinamide on abeta(1–42)-induced cognitive deficits, neuroinflammation and apoptosis in mice. J Neuroimmune Pharmacol 14:401–412

Article  PubMed  Google Scholar 

Gao Y, Yan Y, Fang Q, Zhang N, Kumar G, Zhang J, Song LJ, Yu J, Zhao L, Zhang HT, Ma CG (2019) The Rho kinase inhibitor fasudil attenuates Aβ(1–42)-induced apoptosis via the ASK1/JNK signal pathway in primary cultures of hippocampal neurons. Metab Brain Dis 34:1787–1801

Article  CAS  PubMed  Google Scholar 

He X, Yuan W, Yang CQ, Zhu L, Liu F, Feng J, Xue YX (2022) Ghrelin alleviates 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. Neural Regen Res 17:170–177

Article  CAS  PubMed  Google Scholar 

Jeon SG, Hong SB, Nam Y, Tae J, Yoo A, Song EJ, Kim KI, Lee D, Park J, Lee SM, Kim JI, Moon M (2019) Ghrelin in Alzheimer’s disease: pathologic roles and therapeutic implications. Ageing Res Rev 55:100945

Article  CAS  PubMed  Google Scholar 

Jiao ZT, Luo Q (2022) Molecular mechanisms and health benefits of ghrelin: a narrative review. Nutrients 14:4191

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khan S, Barve KH, Kumar MS (2020) Recent advancements in pathogenesis, diagnostics and treatment of Alzheimer’s disease. Curr Neuropharmacol 18:1106–1125

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim S, Nam Y, Shin SJ, Park YH, Jeon SG, Kim JI, Kim MJ, Moon M (2020) The potential roles of ghrelin in metabolic syndrome and secondary symptoms of Alzheimer’s disease. Front Neurosci 14:583097

Article  PubMed  PubMed Central  Google Scholar 

Li N, Shu J, Yang X, Wei W, Yan A (2022) Exosomes derived from M2 microglia cells attenuates neuronal impairment and mitochondrial dysfunction in Alzheimer’s disease through the PINK1/Parkin pathway. Front Cell Neurosci 16:874102

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu R, Zhang L, Yang X (2022) Interaction between autophagy and the NLRP3 inflammasome in Alzheimer’s and Parkinson’s disease. Front Aging Neurosci 14:1018848

Article  CAS  PubMed  PubMed Central  Google Scholar 

Naseri NN, Wang H, Guo J, Sharma M, Luo W (2019) The complexity of tau in Alzheimer’s disease. Neurosci Lett 705:183–194

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park MH, Park KH, Choi BJ, Han WH, Yoon HJ, Jung HY, Lee J, Song IS, Lim DY, Choi MK, Lee YH, Park CM, Wang M, Jo J, Kim HJ, Kim SH, Schuchman EH, Jin HK, Bae JS (2022) Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer’s disease mice. Proc Natl Acad Sci U S A 119:e2115082119

Article  CAS  PubMed  PubMed Central  Google Scholar 

Passeri E, Elkhoury K, Morsink M, Broersen K, Linder M, Tamayol A, Malaplate C, Yen FT, Arab-Tehrany E (2022) Alzheimer’s disease: treatment strategies and their limitations. Int J Mol Sci 23:12

Article  Google Scholar 

Pellegrini C, Fornai M, Antonioli L, Blandizzi C, Calderone V (2019) Phytochemicals as novel therapeutic strategies for NLRP3 inflammasome-related neurological, metabolic, and inflammatory diseases. Int J Mol Sci 20:2876

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reddy PH, Oliver DM (2019) Amyloid beta and phosphorylated Tau-induced defective autophagy and mitophagy in Alzheimer’s disease. Cells 8:488

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reiss AB, Arain HA, Stecker MM, Siegart NM, Kasselman LJ (2018) Amyloid toxicity in Alzheimer’s disease. Rev Neurosci 29:613–627

Article  CAS  PubMed  Google Scholar 

Sarlaki F, Shahsavari Z, Goshadrou F, Naseri F, Keimasi M, Sirati-Sabet M (2022) The effect of ghrelin on antioxidant status in the rat’s model of Alzheimer’s disease induced by amyloid-beta. Biomedicine (taipei) 12:44–54

Article  PubMed  Google Scholar 

Seminara RS, Jeet C, Biswas S, Kanwal B, Iftikhar W, Sakibuzzaman M, Rutkofsky IH (2018) The neurocognitive effects of ghrelin-induced signaling on the hippocampus: a promising approach to Alzheimer’s disease. Cureus 10:e3285

PubMed  PubMed Central  Google Scholar 

Wang H, Dou S, Zhu J, Shao Z, Wang C, Cheng B (2020) Ghrelin protects dopaminergic neurons against MPTP neurotoxicity through promoting autophagy and inhibiting endoplasmic reticulum mediated apoptosis. Brain Res 1746:147023

Article  CAS  PubMed  Google Scholar 

Yuan MJ, Wang T (2020) The new mechanism of ghrelin/GHSR-1a on autophagy regulation. Peptides 126:170264

Article  CAS  PubMed  Google Scholar 

Yu L, Chen Y, Tooze SA (2018) Autophagy pathway: cellular and molecular mechanisms. Autophagy 14:207–215

Article  CAS  PubMed  Google Scholar