Decitabine combined with low-dose cytarabine, aclarubicin and rhG-CSF regimen may be a potential alternative for relapsed/refractory acute myeloid leukemia: A single-center study

Döhner H, Estey E, Grimwade D, et al. Diagnosis and management of AML in adults:2017 ELN recommendations from an international expert panel. Blood. 2017;129(4):424–47.

Article  PubMed  PubMed Central  Google Scholar 

Walter RB, Othus M, Brunett AK, et al. Resistance prediction in AML: analysis of 4601 patients from MRC/NCRI,HOVON/SAKK,SWOG and MD Anderson Cancer Center. Leukemia. 2015;29(2):312–20.

Article  CAS  PubMed  Google Scholar 

Cui L, Liu Y, Pang Y, et al. Emerging agents and regimens for treatment of relapsed and refractory acute myeloid leukemia. Cancer Gene Ther. 2020;27(1-2):1–14.

Article  Google Scholar 

Ganzel C, Sun Z, Cripe LD, et al. Very poor long-term survival in past and more recent studies for relapsed AML patients: The ECOG-ACRIN experience. Am J Hematol. 2018;93(8):1074–81.

Article  PubMed  PubMed Central  Google Scholar 

Kim TK, Gore SD, Zeidan AM. Epigenetic therapy in acute myeloid leukemia: current and future directions. Semin Hematol. 2015;52(3):172–83.

Article  PubMed  PubMed Central  Google Scholar 

Negrotto S, Ng KP, Jankowska AM, et al. CpG methylation patterns and decitabine treatment response in acute myeloid leukemia cells and normal hematopoietic precursors. Leukemia. 2012;26(2):244–54.

Article  CAS  PubMed  Google Scholar 

Jiang X, Wang Z, Ding B, et al. The hypomethylating agent decitabine prior to chemotherapy improves the therapy efficacy in refractory/relapsed acute myeloid leukemia patients. Oncotarget. 2015;6(32):33612–22.

Article  PubMed  PubMed Central  Google Scholar 

Song LX, Xu L, Li X, et al. Clinical outcome of treatment with a combined regimen of decitabine and aclacinomycin/cytarabine for patients with refractory acute myeloid leukemia. Ann Hematol. 2012;91(12):1879–86.

Article  CAS  PubMed  Google Scholar 

Megías-Vericat JE, Martínez-Cuadrón D, Sanz MÁ, et al. Salvage regimens using conventional chemotherapy agents for relapsed/refractory adult AML patients: a systematic literature review. Ann Hematol. 2018;97(7):1115–53.

Article  PubMed  Google Scholar 

Tiong IS, Wei AH. New drugs creating challenges in acute myeloid leukemia. Genes Chromosomes. Cancer. 2019;58(12):903–14.

CAS  Google Scholar 

Thol F. What to use to treat AML: the role of emerging therapies. Hematology Am Soc Hematol Educ Program. 2021;2021(1):16–23.

Article  PubMed  PubMed Central  Google Scholar 

Tawfik B, Sliesoraitis S, Lyerly S, et al. Efficacy of the hypomethylating agents as frontline, salvage, or consolidation therapy in adults with acute myeloid leukemia (AML). Ann Hematol. 2014;93(1):47–55.

Article  CAS  PubMed  Google Scholar 

Stahl M, DeVeaux M, Montesinos P, et al. Hypomethylating agents in relapsed and refractory AML:outcomes and their predictors in a large international patient cohort. Blood Adv. 2018;2(8):923–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ritchie EK, Feldman EJ, Christos PJ, et al. Decitabine in patients with newly diagnosed and relapsed acute myeloid leukemia. Leuk Lymphoma. 2013;54(9):2003–7.

Article  CAS  PubMed  Google Scholar 

Lee SR, Yang DH, Ahn JS, et al. The clinical outcome of FLAG chemotherapy without idarubicin in patients with relapsed or refractory acute myeloid leukemia. J Korean Med Sci.2009;24(3):498–503.

Wang LJ, Ding J, Zhu CY, et al. Clinic outcome of FLAG regimen treating patients with refractory and relapse acute myeloid leukemia. J Exp Hematol. 2016;24(1):19–24.

Google Scholar 

Martin MG, Welch JS, Augustin K, et al. Cladribine in the treatment of acute myeloid leukemia: a single-institution experience. Clin Lymphoma Myeloma. 2009;9(4):298–301.

Article  CAS  PubMed  Google Scholar 

Price SL, Lancet JE, George TJ, et al. Salvage chemotherapy regimens for acute myeloid leukemia: is one better efficacy comparison between CLAG and MEC regimens. Leuk Res. 2011;35(3):301–4.

Article  CAS  PubMed  Google Scholar 

Trifilio SM, Rademaker AW, Newman D, et al. Mitoxantrone and etoposide with or without intermediate dose cytarabine for the treatment of primary induction failure or relapsed acute myeloid leukemia. Leuk Res. 2012;36(4):394–6.

Article  CAS  PubMed  Google Scholar 

Kohrt HE, Patel S, Ho M, et al. Second-line mitoxantrone, etoposide, and cytarabine for acute myeloid leukemia: a single-center experience. Am J Hematol. 2010;85(11):877–81.

Article  CAS  PubMed  Google Scholar 

Fan CH, Yu MJ, Mai MY, et al. Efficacy of HAA regimen in the treatment of 64 patients with refractory/relapsed acute myeloid leukemia. Chin J Hematol. 2016;37(2):100–4.

Google Scholar 

Li L, Zhang X, Yu H, et al. Low-dose hypomethylating agent decitabine in combination with aclacinomycin and cytarabine achieves a better outcome than standard FLAG chemotherapy in refractory/relapsed acute myeloid leukemia patients with poor-risk cytogenetics and mutations. Onco Targets Ther. 2018;11:6863–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, Dai M, Liu Q. Efficacy and safety of DAC combined with CAG regimen (decitabine in combined with aclacinomycin, cytarabine and G‑CSF) as a second induction regimen compared with Non-DAC regimen for acute myeloid leukemia who failed the first course of standard induction IA chemotherapy. Blood. 2019;134((sup1):5104–5104.

Article  Google Scholar 

Wang L, Luo J, Chen G, et al. Chidamide, decitabine, cytarabine, aclarubicin, and granulocyte colony-stimulating factor (CDCAG) in patients with relapsed/refractory acute myeloid leukemia: a single-arm, phase 1/2 study. Clin Epigenetics. 2020;12(1):132.

Article  Google Scholar 

Kadia TM, Jain P, Ravandi F, et al. TP53 mutations in newly diagnosed acute myeloid leukemia: Clinicomolecular characteristics, response to therapy, and outcomes. Cancer. 2016;122(22):3484–91.

Article  CAS  PubMed  Google Scholar 

Hunter AM, Sallman DA. Current status and new treatment approaches in TP53 mutated AML. Best Pract Res Clin Haematol. 2019;32(2):134–44.

Article  PubMed  Google Scholar 

Rücker FG, Schlenk RF, Bullinger L, et al. TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome. Blood. 2012;119(9):2114–21.

Article  PubMed  Google Scholar 

Hou HA, Chou WC, Kuo YY, et al. TP53 mutations in de novo acute myeloid leukemia patients: longitudinal follow-ups show the mutation is stable during disease evolution. Blood Cancer J. 2015;5(7):e331.

Article  PubMed  PubMed Central  Google Scholar 

Welch JS, Petti AA, Miller CA, et al. TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes. N Engl J Med. 2016;375(21):2023–36.

Article  CAS  PubMed  Google Scholar 

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