Hunter DJ, Bierma-Zeinstra S. Osteoarthritis Lancet. 2019;393(10182):1745–59. https://doi.org/10.1016/S0140-6736(19)30417-9.

Article  CAS  PubMed  Google Scholar 

Compston JE, McClung MR, Leslie WD. Osteoporosis. Lancet. 2019;393(10169):364–76. https://doi.org/10.1016/S0140-6736(18)32112-3.

Article  CAS  PubMed  Google Scholar 

Tatangelo G, Watts J, Lim K, Connaughton C, Abimanyi-Ochom J, Borgstrom F, et al. The cost of osteoporosis, osteopenia, and associated fractures in Australia in 2017. J Bone Miner Res. 2019;34(4):616–25. https://doi.org/10.1002/jbmr.3640.

Article  PubMed  Google Scholar 

Makitie O, Zillikens MC. Early-onset osteoporosis. Calcif Tissue Int. 2022;110(5):546–61. https://doi.org/10.1007/s00223-021-00885-6.

Article  CAS  PubMed  Google Scholar 

Sakka SD. Osteoporosis in children and young adults. Best Pract Res Clin Rheumatol. 2022;36(3):101776. https://doi.org/10.1016/j.berh.2022.101776.

Article  PubMed  Google Scholar 

Ciancia S, Hogler W, Sakkers RJB, Appelman-Dijkstra NM, Boot AM, Sas TCJ, Renes JS. Osteoporosis in children and adolescents: how to treat and monitor? Eur J Pediatr. 2023;182(2):501–11. https://doi.org/10.1007/s00431-022-04743-x.

Article  PubMed  Google Scholar 

Di Marcello F, Di Donato G, d’Angelo DM, Breda L, Chiarelli F. Bone health in children with rheumatic disorders: focus on molecular mechanisms, diagnosis, and management. Int J Mol Sci. 2022;23(10):5725. https://doi.org/10.3390/ijms23105725.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Costantini A, Makitie RE, Hartmann MA, Fratzl-Zelman N, Zillikens MC, Kornak U, et al. Early-onset osteoporosis: rare monogenic forms elucidate the complexity of disease pathogenesis beyond type I collagen. J Bone Miner Res. 2022;37(9):1623–41. https://doi.org/10.1002/jbmr.4668.

Article  CAS  PubMed  Google Scholar 

Bakkaloglu SA, Bacchetta J, Lalayiannis AD, Leifheit-Nestler M, Stabouli S, Haarhaus M, et al. Bone evaluation in paediatric chronic kidney disease: clinical practice points from the European Society for Paediatric Nephrology CKD-MBD and Dialysis working groups and CKD-MBD working group of the ERA-EDTA. Nephrol Dial Transplant. 2021;36(3):413–25. https://doi.org/10.1093/ndt/gfaa210.

Article  CAS  PubMed  Google Scholar 

Zheng Y, Rostami Haji Abadi M, Ghafouri Z, Meira Goes S, Johnston JJD, Nour M, Kontulainen S. Bone deficits in children and youth with type 1 diabetes: a systematic review and meta-analysis. Bone. 2022;163:116509. https://doi.org/10.1016/j.bone.2022.116509.

Article  PubMed  Google Scholar 

Marini JC, Forlino A, Bachinger HP, Bishop NJ, Byers PH, Paepe A, et al. Osteogenesis imperfecta. Nat Rev Dis Primers. 2017;3:17052. https://doi.org/10.1038/nrdp.2017.52.

Article  PubMed  Google Scholar 

Bishop N. Bone material properties in osteogenesis imperfecta. J Bone Miner Res. 2016;31(4):699–708. https://doi.org/10.1002/jbmr.2835.

Article  CAS  PubMed  Google Scholar 

•• Collins MT, Marcucci G, Anders HJ, Beltrami G, Cauley JA, Ebeling PR, et al. Skeletal and extraskeletal disorders of biomineralization. Nat Rev Endocrinol. 2022;18(8):473–89. https://doi.org/10.1038/s41574-022-00682-7. (This review summarizes current knowledge about principal regulators of mineralization and crystallization and the role of their alteration in disorders of bone mineralization and ectopic mineralization.)

Fratzl P, Weinkamer R. Nature’s hierarchical materials. Prog Mater Sci. 2007;52:1263–334.

Article  CAS  Google Scholar 

Burr DB. Bone quality: understanding what matters. J Musculoskelet Neuronal Interact. 2004;4(2):184–6.

CAS  PubMed  Google Scholar 

Seeman E, Delmas PD. Bone quality–the material and structural basis of bone strength and fragility. N Engl J Med. 2006;354(21):2250–61. https://doi.org/10.1056/NEJMra053077.

Article  CAS  PubMed  Google Scholar 

Bala Y, Farlay D, Boivin G. Bone mineralization: from tissue to crystal in normal and pathological contexts. Osteoporos Int. 2013;24(8):2153–66. https://doi.org/10.1007/s00198-012-2228-y.

Article  CAS  PubMed  Google Scholar 

Fratzl P, Gupta H, Paschalis E, Roschger P. Structure and mechanical quality of the collagen-mineral nano-composite in bone. J Mater Chem. 2004;14:2115–23.

Article  CAS  Google Scholar 

Reznikov N, Shahar R, Weiner S. Bone hierarchical structure in three dimensions. Acta Biomater. 2014;10(9):3815–26. https://doi.org/10.1016/j.actbio.2014.05.024.

Article  PubMed  Google Scholar 

Wagermaier W, Klaushofer K, Fratzl P. Fragility of bone material controlled by internal interfaces. Calcif Tissue Int. 2015;97(3):201–12. https://doi.org/10.1007/s00223-015-9978-4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bala Y, Seeman E. Bone’s material constituents and their contribution to bone strength in health, disease, and treatment. Calcif Tissue Int. 2015;97(3):308–26. https://doi.org/10.1007/s00223-015-9971-y.

Article  CAS  PubMed  Google Scholar 

Burr DB. Repair mechanisms for microdamage in bone. J Bone Miner Res. 2014;29(12):2534–6. https://doi.org/10.1002/jbmr.2366.

Article  PubMed  Google Scholar 

Manolagas SC. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev. 2000;21(2):115–37. https://doi.org/10.1210/edrv.21.2.0395.

Article  CAS  PubMed  Google Scholar 

Dallas SL, Prideaux M, Bonewald LF. The osteocyte: an endocrine cell … and more. Endocr Rev. 2013;34(5):658–90. https://doi.org/10.1210/er.2012-1026.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Robling AG, Bonewald LF. The osteocyte: new insights. Annu Rev Physiol. 2020;82:485–506. https://doi.org/10.1146/annurev-physiol-021119-034332.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brockstedt H, Kassem M, Eriksen EF, Mosekilde L, Melsen F. Age- and sex-related changes in iliac cortical bone mass and remodeling. Bone. 1993;14(4):681–91. https://doi.org/10.1016/8756-3282(93)90092-o.

Article  CAS  PubMed  Google Scholar 

Gamsjaeger S, Hofstetter B, Fratzl-Zelman N, Roschger P, Roschger A, Fratzl P, et al. Pediatric reference Raman data for material characteristics of iliac trabecular bone. Bone. 2014;69:89–97. https://doi.org/10.1016/j.bone.2014.09.012.

Article  CAS  PubMed  Google Scholar 

Gamsjaeger S, Rauch F, Glorieux FH, Paschalis EP. Cortical bone material / compositional properties in growing children and young adults aged 1.5–23 years, as a function of gender, age, metabolic activity, and growth spurt. Bone. 2022;165:116548. https://doi.org/10.1016/j.bone.2022.116548.

Article  CAS  PubMed  Google Scholar 

Burr DB. Changes in bone matrix properties with aging. Bone. 2019;120:85–93. https://doi.org/10.1016/j.bone.2018.10.010.

Article  CAS  PubMed  Google Scholar 

Fratzl P, Groschner M, Vogl G, Plenk H Jr, Eschberger J, Fratzl-Zelman N, et al. Mineral crystals in calcified tissues: a comparative study by SAXS. J Bone Miner Res. 1992;7(3):329–34. https://doi.org/10.1002/jbmr.5650070313.

Article  CAS  PubMed  Google Scholar 

Fratzl P, Fratzl-Zelman N, Klaushofer K, Vogl G, Koller K. Nucleation and growth of mineral crystals in bone studied by small-angle X-ray scattering. Calcif Tissue Int. 1991;48(6):407–13. https://doi.org/10.1007/BF02556454.

Article  CAS  PubMed  Google Scholar 

Roschger P, Grabner BM, Rinnerthaler S, Tesch W, Kneissel M, Berzlanovich A, et al. Structural development of the mineralized tissue in the human L4 vertebral body. J Struct Biol. 2001;136(2):126–36. https://doi.org/10.1006/jsbi.2001.4427.

Article  CAS  PubMed  Google Scholar 

Ruffoni D, Fratzl P, Roschger P, Klaushofer K, Weinkamer R. The bone mineralization density distribution as a fingerprint of the mineralization process. Bone. 2007;40(5):1308–19. https://doi.org/10.1016/j.bone.2007.01.012.

Article  CAS  PubMed  Google Scholar 

Akkus O, Polyakova-Akkus A, Adar F, Schaffler MB. Aging of microstructural compartments in human compact bone. J Bone Miner Res. 2003;18(6):1012–9. https://doi.org/10.1359/jbmr.2003.18.6.1012.

Article  CAS  PubMed  Google Scholar 

Misof BM, Roschger P, Zhou H, Nieves JW, Bostrom M, Cosman F, et al. No evidence for alteration in early secondary mineralization by either alendronate, teriparatide or combination of both in transiliac bone biopsy samples from postmenopausal osteoporotic patients. Bone Rep. 2020;12:100253. https://doi.org/10.1016/j.bonr.2020.100253.

Article  PubMed  PubMed Central  Google Scholar