Aebi H (1984) [13] Catalase in vitro. Methods Enzymol 105:121–126

Article  CAS  PubMed  Google Scholar 

Ahmed Mustafa Z, Hamed Ali R, Rostum Ali D, Abdulkarimi R, Abdulkareem NK, Akbari A (2021) The combination of ginger powder and zinc supplement improves the fructose-induced metabolic syndrome in rats by modulating the hepatic expression of NF-κB, mTORC1, PPAR-α SREBP-1c, and Nrf2. J Food Biochem 45:e13546

Article  CAS  PubMed  Google Scholar 

Akbari A, Jelodar G (2013) The effect of oxidative stress and antioxidants on men fertility. Zahedan J Res Med Sci 15:1–7

CAS  Google Scholar 

Akbari A, Jelodar G, Nazifi S (2016) The proposed mechanisms of radio frequency waves (RFWs) on nervous system functions impairment. Comp Clin Pathol 25:1289–1301

Article  Google Scholar 

Akbari A, Nasiri K, Heydari M, Mosavat SH, Iraji A (2017) The protective effect of hydroalcoholic extract of Zingiber officinale roscoe (Ginger) on ethanol-induced reproductive toxicity in male rats. J Evid Based Complementary Altern Med 22:609–617

Article  CAS  PubMed  PubMed Central  Google Scholar 

Al Hroob AM, Abukhalil MH, Alghonmeen RD, Mahmoud AM (2018) Ginger alleviates hyperglycemia-induced oxidative stress, inflammation and apoptosis and protects rats against diabetic nephropathy. Biomed Pharmacother 106:381–389

Article  CAS  PubMed  Google Scholar 

Al-Amin ZM, Thomson M, Al-Qattan KK, Peltonen-Shalaby R, Ali M (2006) Anti-diabetic and hypolipidaemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats. Br J Nutr 96:660–666

Article  CAS  PubMed  Google Scholar 

Alirezei M, Jelodar G, Niknam P, Al E (2011) Betaine prevents ethanol-induced oxidative stress and reduces total homocysteine in the rat cerebellum. J Physiol Biochem 67:605–612

Article  Google Scholar 

Atta A, Elkoly T, Mouneir S, Kamel G, Alwabel N, Zaher S (2010) Hepatoprotective effect of methanol extracts of Zingiber officinale and Cichoriumintybus. Indian J Pharm Sci 72:564–570

Article  CAS  PubMed  PubMed Central  Google Scholar 

Azam F, Amer AM, Abulifa AR, Elzwawi MM (2014) Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer’s drugs: a computational investigation. Drug Des Dev Ther 8:2045–2059

Article  Google Scholar 

Cao J, Hou J, Ping J, Cai D (2018) Advances in developing novel therapeutic strategies for Alzheimer’s disease. Mol Neurodegener 13:64–64

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chandrasekar R (2013) Alcohol and NMDA receptor: current research and future direction. Front Mol Neurosci 6:14–21

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cushman JD, Moore MD, Jacobs NS, Olsen RW, Fanselow MS (2011) Behavioral pharmacogenetic analysis on the role of the α4 GABAA receptor subunit in the ethanol-mediated impairment of hippocampus-dependent contextual learning. Alcoholism: Clin Exp Res 35:1948–1959

Article  CAS  Google Scholar 

Davies M (2003) The role of GABAA receptors in mediating the effects of alcohol in the central nervous system. J Psychiatry Neurosci: JPN 28:263–274

PubMed  PubMed Central  Google Scholar 

Dröge W (2002) Free radicals in the physiological control of cell function. Physiol Rev 82:47–95

Article  PubMed  Google Scholar 

El-Akabawy G, El-Kholy W (2014) Neuroprotective effect of ginger in the brain of streptozotocin-induced diabetic rats. Ann Anat - Anatomischer Anzeiger 196:119–128

Article  PubMed  Google Scholar 

Farooqui T, Farooqui AA (2017) Neuroprotective effects of phytochemicals in neurological disorders. The Ohio State University, Columbus, OH, USA

Book  Google Scholar 

Fathi R, Akbari A, Nasiri K, Chardahcherik M (2021) Ginger (Zingiber officinale roscoe) extract could upregulate the renal expression of NRF2 and TNFα and prevents ethanol-induced toxicity in rat kidney. Avicenna J Phytomed 11:134–139

CAS  PubMed  PubMed Central  Google Scholar 

Fukushima W, Miyake Y, Tanaka K, Sasaki S, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M, Kinki F (2010) Alcohol drinking and risk of Parkinson’s disease: a case-control study in Japan. BMC Neurol 10:111–119

Article  PubMed  PubMed Central  Google Scholar 

Gawel K, Kukula KW, Banono NS, Nieoczym D, Targowska-Duda KM, Czernicka L, Parada-Turska J, Esguerra CV (2021) 6-Gingerol, a major constituent of Zingiber officinale Rhizoma, exerts anticonvulsant activity in the pentylenetetrazole-induced seizure model in Larval Zebrafish. Int J Mol Sci 22:7745–7751

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghasemzadeh A, Jaafar HZ, Rahmat A (2010) Antioxidant activities, total phenolics and flavonoids content in two varieties of Malaysia young ginger (Zingiber officinale Roscoe). Molecules 15:4324–4333

Article  CAS  PubMed  PubMed Central  Google Scholar 

Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH (2010) Mechanisms underlying inflammation in neurodegeneration. Cell 140:918–934

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gohlke J, Griffith W, Faustman E (2008) Computational models of ethanol-induced neurodevelopmental toxicity across species: Implications for risk assessment. Birth Defects Res B Dev Reprod Toxicol 83:1–11

Article  CAS  PubMed  Google Scholar 

Gomar A, Hosseini A, Mirazi N, Gomar M (2015) Effect of Zingiber Officinale (ginger rhizomes) hydroethanolic extract on hyoscine-induced memory impairment in adult male rats. Int Clin Neurosci J 2:105–110

Google Scholar 

Haorah J, Ramirez SH, Floreani N, Gorantla S, Morsey B, Persidsky Y (2008) Mechanism of alcohol-induced oxidative stress and neuronal injury. Free Radic Biol Med 45:1542–1550

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harrison NL, Skelly MJ, Grosserode EK, Lowes DC, Zeric T, Phister S, Salling MC (2017) Effects of acute alcohol on excitability in the CNS. Neuropharmacology 122:36–45

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hokenson RE, Short AK, Chen Y, Pham AL, Adams ET, Bolton JL, Swarup V, Gall CM, Baram TZ (2021) Unexpected role of physiological estrogen in acute stress-induced memory deficits. J Neurosci 41:648–662

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hussein UK, Hassan NEHY, Elhalwagy MEA, Zaki AR, Abubakr HO, Nagulapalli Venkata KC, Jang KY, Bishayee A (2017) Ginger and propolis exert neuroprotective effects against monosodium glutamate-induced neurotoxicity in rats. Molecules (Basel, Switzerland) 22:1928–1934

Article  PubMed  Google Scholar 

Jafarpour M, Yousefi G, Hamedi A, Shariat A, Salehi A, Heydari M (2016) Effect of a traditional syrup from Citrus medica L. fruit juice on migraine headache: A randomized double blind placebo controlled clinical trial. J Ethnopharmacol 179:170–176

Article  PubMed  Google Scholar 

Jin Z, Bhandage AK, Bazov I, Kononenko O, Bakalkin G, Korpi ER, Birnir B (2014) Selective increases of AMPA, NMDA, and kainate receptor subunit mRNAs in the hippocampus and orbitofrontal cortex but not in prefrontal cortex of human alcoholics. Front Cell Neurosci 8:11–21

Article  PubMed  PubMed Central  Google Scholar 

Kim CY, Seo Y, Lee C, Park GH, Jang JH (2018) Neuroprotective effect and molecular mechanism of [6]-gingerol against scopolamine-induced amnesia in C57BL/6 Mice. Evid Based Complement Altern Med 2018:8941564–8941571

Google Scholar 

Kumar S, Fleming RL, Morrow AL (2004) Ethanol regulation of gamma-aminobutyric acid A receptors: genomic and nongenomic mechanisms. Pharmacol Ther 101:211–226

Article  CAS  PubMed  Google Scholar 

Kumar S, Porcu P, Werner DF, Matthews DB, Diaz-Granados JL, Helfand RS, Morrow AL (2009) The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress. Psychopharmacology 205:529–564

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lantz RC, Chen G, Sarihan M, Solyom A, Jolad S, Timmermann B (2007) The effect of extracts from ginger rhizome on inflammatory mediator production. Phytomedicine 14:123–128

Article  CAS  PubMed  Google Scholar 

Lim S, Moon M, Oh H, Kim HG, Kim SY, Oh MS (2014) Ginger improves cognitive function via NGF-induced ERK/CREB activation in the hippocampus of the mouse. J Nutr Biochem 25:1058–1065

Article  CAS  PubMed  Google Scholar 

Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2− ΔΔCT method. Methods 25:402–408

Article  CAS  PubMed  Google Scholar 

Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–275

Article  CAS  PubMed  Google Scholar 

Ma H, Li J (2022) The ginger extract could improve diabetic retinopathy by inhibiting the expression of e/iNOS and G6PDH, apoptosis, inflammation, and angiogenesis. J Food Biochem 46:e14084

Article