Efficacy and safety of Huachansu combined with adjuvant chemotherapy in resected colorectal cancer patients: a prospective, open-label, randomized phase II study

Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2020;71(3):209–49.

Article  Google Scholar 

Cao W, Chen HD, Yu YW, et al. Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics. Chin Med J (Engl). 2021;134(7):783–91.

Article  PubMed  Google Scholar 

Bonjer HJ, Deijen CL, Abis GA, et al. A randomized trial of laparoscopic versus open surgery for rectal cancer. N Engl J Med. 2015;372(14):1324–32.

Article  CAS  PubMed  Google Scholar 

Jayne DG, Guillou PJ, Thorpe H, et al. Randomized trial of laparoscopic-assisted resection of colorectal carcinoma: 3-year results of the UK MRC CLASICC trial group. J Clin Oncol. 2007;25(21):3061–8.

Article  PubMed  Google Scholar 

Tiselius C, Gunnarsson U, Smedh K, et al. Patients with rectal cancer receiving adjuvant chemotherapy have an increased survival: a population-based longitudinal study. Ann Oncol. 2013;24(1):160–5.

Article  CAS  PubMed  Google Scholar 

Schmoll HJ, Twelves C, Sun W, et al. Effect of adjuvant capecitabine or fluorouracil, with or without oxaliplatin, on survival outcomes in stage III colon cancer and the effect of oxaliplatin on post-relapse survival: a pooled analysis of individual patient data from four randomised controlled trials. Lancet Oncol. 2014;15(13):1481–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu G, Franssen E, Fitch MI, et al. Patient preferences for oral versus intravenous palliative chemotherapy. J Clin Oncol. 1997;15(1):110–5.

Article  CAS  PubMed  Google Scholar 

Dhakal P, Wichman CS, Pozehl B, et al. Preferences of adults with cancer for systemic cancer treatment: do preferences differ based on age? Future Oncol. 2022;18(3):311–21.

Article  CAS  PubMed  Google Scholar 

Chionh F, Lau D, Yeung Y, et al. Oral versus intravenous fluoropyrimidines for colorectal cancer. Cochrane Database Syst Rev. 2017;7(7):D8398.

Google Scholar 

Zhan X, Wu H, Wu H, et al. Metabolites from Bufo gargarizans (Cantor, 1842): a review of traditional uses, pharmacological activity, toxicity and quality control. J Ethnopharmacol. 2020;246:112178.

Article  CAS  PubMed  Google Scholar 

Li R, Wu H, Wang M, et al. An integrated strategy to delineate the chemical and dynamic metabolic profile of Huachansu tablets in rat plasma based on UPLC-ESI-QTOF/MS(E). J Pharm Biomed Anal. 2022;218: 114866.

Article  CAS  PubMed  Google Scholar 

Peng C, Chen J, Cui W, et al. Comparative efficacy of various CHIs combined with western medicine for non-small cell lung cancer: a Bayesian network meta-analysis of randomized controlled trials. Front Pharmacol. 2022;13:1037620.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu J, Zhang D, Ni M, et al. Effectiveness of Huachansu injection combined with chemotherapy for treatment of gastric cancer in China: a systematic review and meta-analysis. J Tradit Chin Med. 2020;40(5):749–57.

PubMed  Google Scholar 

Zhang D, Ni M, Wu J, et al. The optimal Chinese herbal injections for use with radiotherapy to treat esophageal cancer: a systematic review and bayesian network meta-analysis. Front Pharmacol. 2018;9:1470.

Article  CAS  PubMed  Google Scholar 

Tang M, He B, Zhai J, et al. Oral Chinese patent medicine combined with oxaliplatin-based chemotherapy regimen for the treatment of colorectal cancer: a network meta-analysis. Integr Cancer Ther. 2021;20:1543373305. https://doi.org/10.1177/15347354211058169.

Article  CAS  Google Scholar 

Miller AB, Hoogstraten B, Staquet M, Winkler A. Reporting results of cancer treatment. Cancer. 1981;47(1):207–14. https://doi.org/10.1002/1097-0142(19810101)47:1<207::aid-cncr2820470134>3.0.co;2-6

Article  CAS  PubMed  Google Scholar 

Lu XM, Zheng J, Zhu YJ. [Effect of Chinese materia medica combined chemotherapy on the survivals of stage II and III colorectal cancer]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012;32(9):1166–70.

PubMed  Google Scholar 

Sun J, Jiang T, Qiu Z, et al. Short-term and medium-term clinical outcomes of laparoscopic-assisted and open surgery for colorectal cancer: a single center retrospective case-control study. BMC Gastroenterol. 2011;11:85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tao F. Effect of Huachasu on prevention and treatment of postoperative recurrence and metastasis of colorectal cancer. Guangdong Med J. 2013;34(24):3808–9.

CAS  Google Scholar 

Sun Q, He M, Zhang M, et al. Traditional Chinese medicine and colorectal cancer: implications for drug discovery. Front Pharmacol. 2021;12: 685002.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qi F, Li A, Inagaki Y, et al. Antitumor activity of extracts and compounds from the skin of the toad Bufo bufo gargarizans Cantor. Int Immunopharmacol. 2011;11(3):342–9.

Article  CAS  PubMed  Google Scholar 

Wei WL, Hou JJ, Wang X, et al. Venenum bufonis: an overview of its traditional use, natural product chemistry, pharmacology, pharmacokinetics and toxicology. J Ethnopharmacol. 2019;237:215–35.

Article  CAS  PubMed  Google Scholar 

Shi XK, Cheng C, Guo LS, et al. Clinical observation of Huachansu in preventing postoperative recurrence and metastasis of colorectal cancer. Shenzhen J Integr Tradit Chin West Med. 2016;26(11):72–3.

Google Scholar 

Meng Z, Garrett CR, Shen Y, et al. Prospective randomised evaluation of traditional Chinese medicine combined with chemotherapy: a randomised phase II study of wild toad extract plus gemcitabine in patients with advanced pancreatic adenocarcinomas. Br J Cancer. 2012;107(3):411–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meng Z, Yang P, Shen Y, et al. Pilot study of huachansu in patients with hepatocellular carcinoma, nonsmall-cell lung cancer, or pancreatic cancer. Cancer. 2009;115(22):5309–18.

Article  PubMed  Google Scholar 

Tan X, Liang X, Xi J, et al. Clinical efficacy and safety of Huachansu injection combination with platinum-based chemotherapy for advanced non-small cell lung cancer:a systematic review and meta-analysis of randomized controlled trials. Medicine. 2021;100(36): e27161.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McQuade RM, Stojanovska V, Abalo R, et al. Chemotherapy-induced constipation and diarrhea: pathophysiology, current and emerging treatments. Front Pharmacol. 2016;7:414.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qu L, Tan W, Yang J, et al. Combination compositions composed of l-glutamine and Si-Jun-Zi-tang might be a preferable choice for 5-fluorouracil-induced intestinal mucositis: an exploration in a mouse model. Front Pharmacol. 2020;11:918.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tarricone R, Abu KD, Nyanzi-Wakholi B, et al. A systematic literature review of the economic implications of chemotherapy-induced diarrhea and its impact on quality of life. Crit Rev Oncol Hematol. 2016;99:37–48.

Article  PubMed  Google Scholar 

Maroun JA, Anthony LB, Blais N, et al. Prevention and management of chemotherapy-induced diarrhea in patients with colorectal cancer: a consensus statement by the Canadian working group on chemotherapy-induced diarrhea. Curr Oncol. 2007;14(1):13–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bai Y, Wang S, Xu W, et al. Cinobufacini ameliorates experimental colitis via modulating the composition of gut microbiota. PLoS ONE. 2019;14(9): e223231.

Article  Google Scholar 

Burzykowski T, Buyse M, Yothers G, et al. Exploring and validating surrogate endpoints in colorectal cancer. Lifetime Data Anal. 2008;14(1):54–64.

Article  PubMed  Google Scholar 

Iveson TJ, Kerr RS, Saunders MP, et al. 3 versus 6 months of adjuvant oxaliplatin-fluoropyrimidine combination therapy for colorectal cancer (SCOT): an international, randomised, phase 3, non-inferiority trial. Lancet Oncol. 2018;19(4):562–78.

Article  PubMed  PubMed Central  Google Scholar 

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