CRP inhibits the osteoblastic differentiation of OPCs via the up-regulation of primary cilia and repression of the Hedgehog signaling pathway

Alman BA. The role of hedgehog signalling in skeletal health and disease. Nat Rev Rheumatol. 2015;11:552–60.

Article  CAS  PubMed  Google Scholar 

Basten SG, Giles RH. Functional aspects of primary cilia in signaling, cell cycle and tumorigenesis. Cilia. 2013;2:6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berbari NF, O’Connor AK, Haycraft CJ, Yoder BK. The primary cilium as a complex signaling center. Curr Biol. 2009;19:R526-535.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Black S, Kushner I, Samols D. C-reactive protein. J Biol Chem. 2004;279:48487–90.

Article  CAS  PubMed  Google Scholar 

Chang CF, Ramaswamy G, Serra R. Depletion of primary cilia in articular chondrocytes results in reduced Gli3 repressor to activator ratio, increased Hedgehog signaling, and symptoms of early osteoarthritis. Osteoarthr Cartil. 2012;20:152–61.

Article  Google Scholar 

Cho IJ, Choi KH, Oh CH, Hwang YC, Jeong IK, Ahn KJ, Chung HY. Effects of C-reactive protein on bone cells. Life Sci. 2016;145:1–8.

Article  CAS  PubMed  Google Scholar 

Christensen ST, Clement CA, Satir P, Pedersen LB. Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling. J Pathol. 2012;226:172–84.

Article  CAS  PubMed  Google Scholar 

Christopher RW. The cilium secretes bioactive ectosomes. Curr Biol. 2013;10:906–11.

Google Scholar 

Corbit KC, Aanstad P, Singla V, Norman AR, Stainier DY, Reiter JF. Vertebrate smoothened functions at the primary cilium. Nature. 2005;437:1018–21.

Article  CAS  PubMed  ADS  Google Scholar 

de Pablo P, Cooper MS, Buckley CD. Association between bone mineral density and C-reactive protein in a large population-based sample. Arthritis Rheum. 2012;64:2624–31.

Article  PubMed  Google Scholar 

Ding C, Parameswaran V, Udayan R, Burgess J, Jones G. Circulating levels of inflammatory markers predict change in bone mineral density and resorption in older adults: a longitudinal study. J Clin Endocrinol Metab. 2008;93:1952–8.

Article  CAS  PubMed  Google Scholar 

Eguether T, Hahne M. Mixed signals from the cells antennae: primary cilia in cancer. EMBO Rep. 2018. https://doi.org/10.15252/embr.201846589.

Article  PubMed  PubMed Central  Google Scholar 

Ezratty EJ, Stokes N, Chai S, Shah AS, Williams SE, Fuchs E. A role for the primary cilium in Notch signaling and epidermal differentiation during skin development. Cell. 2011;145:1129–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fang Z, Lv J, Wang J, Qin Q, Wang Q. C-reactive protein promotes the activation of fibroblast-like synoviocytes from patients with rheumatoid arthritis. Front Immunol. 2020;11:958.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Regi G. The zinc-finger transcription factor GLI2 antagonizes contact inhibition and differentiation of human epidermal cells. Oncogene. 2004;6:1263–74.

Google Scholar 

Ganesan K, Teklehaimanot S, Tran T, Asuncion M, Norris K. Relationship of C-reactive protein and bone mineral density in community-dwelling elderly females. J Natl Med Assoc. 2005;97:329–33.

PubMed  PubMed Central  Google Scholar 

Haycraft CJ, Serra R. Cilia involvement in patterning and maintenance of the skeleton. Curr Top Dev Biol. 2008;85:303–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haycraft CJ, Zhang Q, Song B, Jackson WS, Detloff PJ, Serra R, Yoder BK. Intraflagellar transport is essential for endochondral bone formation. Development. 2007;134:307–16.

Article  CAS  PubMed  Google Scholar 

Heydeck W, Fievet L, Davis E, Katsanis N. The complexity of the cilium: spatiotemporal diversity of an ancient organelle. Curr Opin Cell Biol. 2018;55:139–49.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ho L, Ali SA, Al-Jazrawe M, Kandel R, Wunder JS, Alman BA. Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes. Oncogene. 2013;32:5388–96.

Article  CAS  PubMed  Google Scholar 

Hojo H, Ohba S, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Takato T, Kawaguchi H, Chung UI. Gli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossification. J Biol Chem. 2012;287:17860–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hui C-C, Angers S. Gli proteins in development and disease. Annu Rev Cell Dev Biol. 2010;27:513–37.

Article  Google Scholar 

Jia Z, Li H, Liang Y, Potempa L, Ji S, Wu Y. Monomeric C-reactive protein binds and neutralizes receptor activator of NF-κB ligand-induced osteoclast differentiation. Front Immunol. 2018;9:234.

Article  PubMed  PubMed Central  Google Scholar 

Jiang J, Hui CC. Hedgehog signaling in development and cancer. Dev Cell. 2008;15:801–12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jimenez RV, Wright TT, Jones NR, Jianming W, Gibson AW, Szalai AJ. C-reactive protein impairs dendritic cell development, maturation, and function: implications for peripheral tolerance. Front Immunol. 2018;9:372.

Article  PubMed  PubMed Central  Google Scholar 

Kalogeropoulos M, Varanasi SS, Olstad OK, Sanderson P, Gautvik VT, Reppe S, Francis RM, Gautvik KM, Birch MA, Datta HK. Zic1 transcription factor in bone: neural developmental protein regulates mechanotransduction in osteocytes. FASEB J. 2010;24:2893–903.

Article  CAS  PubMed  Google Scholar 

Kanke K, Masaki H, Saito T, Komiyama Y, Hojo H, Nakauchi H, Lichtler AC, Takato T, Chung UI, Ohba S. Stepwise differentiation of pluripotent stem cells into osteoblasts using four small molecules under serum-free and feeder-free conditions. Stem Cell Rep. 2014;2:751–60.

Article  CAS  Google Scholar 

Kimura H, Ng JM, Curran T. Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure. Cancer Cell. 2008;13:249–60.

Article  CAS  PubMed  Google Scholar 

Koh JM, Khang YH, Jung CH, Bae S, Kim DJ, Chung YE, Kim GS. Higher circulating hsCRP levels are associated with lower bone mineral density in healthy pre- and postmenopausal women: evidence for a link between systemic inflammation and osteoporosis. Osteoporos Int. 2005;16:1263–71.

Article  CAS  PubMed  Google Scholar 

Kushner I. The phenomenon of the acute phase response. Ann NY Acad Sci. 1982;389:39–48.

Article  CAS  PubMed  ADS  Google Scholar 

Lancaster MA, Schroth J, Gleeson JG. Subcellular spatial regulation of canonical Wnt signalling at the primary cilium. Nat Cell Biol. 2011;13:700–7.

Article  PubMed  PubMed Central  Google Scholar 

Li JJ, Fang CH. C-reactive protein is not only an inflammatory marker but also a direct cause of cardiovascular diseases. Med Hypotheses. 2004;62:499–506.

Article  CAS  PubMed  Google Scholar 

Loi F, Córdova LA, Pajarinen J, Lin TH, Yao Z, Goodman SB. Inflammation, fracture and bone repair. Bone. 2016;86:119–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marigo V, Johnson RL, Vortkamp A, Tabin CJ. Sonic Hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev Biol. 1996;180:273–83.

Article  CAS  PubMed  Google Scholar 

Martín-Guerrero E, Tirado-Cabrera I, Buendía I, Alonso V, Gortázar A, Ardura J. Primary cilia mediate parathyroid hormone receptor type 1 osteogenic actions in osteocytes and osteoblasts via Gli activation. J Cell Physiol. 2020;235:7356–69.

Article  PubMed  Google Scholar 

Martins AA, Paiva A, Morgado JM, Gomes A, Pais ML. Quantification and immunophenotypic characterization of bone marrow and umbilical cord blood mesenchymal stem cells by multicolor flow cytometry. Transplant Proc. 2009;41:943–6.

Article  CAS  PubMed  Google Scholar 

McMahon AP, Ingham PW, Tabin CJ. Developmental roles and clinical significance of Hedgehog signaling. Curr Top Dev Biol. 2003;53:1–114.

Article  CAS  PubMed  Google Scholar 

留言 (0)

沒有登入
gif