Algaidi SA, Faddladdeen KA, Alrefaei GI, Qahl SH, Albadawi EA, A. L. HM and N. N., Ayuob (2022) Thymoquinone protects the testes of hypothyroid rats by suppressing pro-inflammatory cytokines and oxidative stress and promoting SIRT1 testicular expression. Front Pharmacol 13: 1040857

Ambrogini P, Cuppini R, Ferri P, Mancini C, Ciaroni S, Voci A, Gerdoni E, Gallo G (2005) Thyroid hormones affect neurogenesis in the dentate gyrus of adult rat. Neuroendocrinology 81(4):244–253

Article  CAS  PubMed  Google Scholar 

Amirahmadi S, Hosseini M, Ahmadabady S, Akbarian M, Abrari K, Vafaee F, Rajabian A (2021) Folic acid attenuated learning and memory impairment via inhibition of oxidative damage and acetylcholinesterase activity in hypothyroid rats. Metab Brain Dis 36:2393–2403

Article  CAS  PubMed  Google Scholar 

Baghcheghi Y, Beheshti F, Shafei MN, Salmani H, Sadeghnia HR, Soukhtanloo M, Anaeigoudari A, Hosseini M (2018) The effects of vitamin E on brain derived neurotrophic factor, tissues oxidative damage and learning and memory of juvenile hypothyroid rats. Metab Brain Dis 33(3):713–724

Article  CAS  PubMed  Google Scholar 

Bonatti HJR, Gona SR, Feaga C, George AE (2023) Hypothyroidism Complicated by Vitamin C and Thiamin Deficiency in Surgical Patients. Am Surg: 31348231175098

Calderón-Ospina CA, Nava-Mesa MO (2020) B vitamins in the nervous system: current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin. CNS Neurosci Ther 26(1):5–13

Article  PubMed  Google Scholar 

Capalbo D, Alfano S, Polizzi M, Di Mase R, Improda N, Esposito A, Bravaccio C, Salerno M (2020) Cognitive function in children with idiopathic subclinical hypothyroidism: effects of 2 years of Levothyroxine Therapy. J Clin Endocrinol Metab 105(3)

Chaalal A, Poirier R, Blum D, Laroche S, Enderlin V (2019) Thyroid hormone supplementation restores spatial memory, hippocampal markers of Neuroinflammation, plasticity-related signaling molecules, and β-Amyloid peptide load in hypothyroid rats. Mol Neurobiol 56(1):722–735

Article  CAS  PubMed  Google Scholar 

Dos A, Cordeiro JM, Santos LC, de Oliveira LS, Santos BR, Santos EO, Barbosa EM, de Macêdo IO, de Freitas GJC, Santos DA, de Lavor MSL, Silva JF (2022) Maternal hypothyroidism causes oxidative stress and endoplasmic reticulum stress in the maternal-fetal interface of rats. Free Radic Biol Med 191:24–39

Article  Google Scholar 

Ergin Ertağ H (2022) The acute effect of thiamine on serum insulin levels and some biochemical parameters in excessive alcohol-consuming rats. MAE Vet Fak Derg 7(2):120–125

Google Scholar 

Fan Y, Qin Y, Chen M, Li X, Wang R, Huang Z, Xu Q, Yu M, Zhang Y, Han X, Du G, Xia Y, Wang X, Lu C (2019) Prenatal low-dose DEHP exposure induces metabolic adaptation and obesity: Role of hepatic thiamine metabolism. J Hazard Mater 2020;385:121534. https://doi.org/10.1016/j.jhazmat.2019.121534

Garcia-Serrano AM, Mohr AA, Philippe J, Skoug C, Spégel P, Duarte JMN (2022) Cognitive impairment and Metabolite Profile alterations in the Hippocampus and Cortex of male and female mice exposed to a Fat and Sugar-Rich Diet are normalized by Diet reversal. Aging Dis 13(1):267–283

Article  PubMed  PubMed Central  Google Scholar 

Giacobini E, Cuello AC, Fisher A (2022) Reimagining cholinergic therapy for Alzheimer’s Disease. Brain 145(7):2250–2275

Article  PubMed  Google Scholar 

Gibson GE, Hirsch JA, Fonzetti P, Jordan BD, Cirio RT, Elder J (2016) Vitamin B1 (thiamine) and Dementia. Ann N Y Acad Sci 1367(1):21–30

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gibson GE, Feldman HH, Zhang S, Flowers SA, Luchsinger JA (2022) Pharmacological thiamine levels as a therapeutic approach in Alzheimer’s Disease. Front Med (Lausanne) 9:1033272

Article  PubMed  Google Scholar 

Hassan I, El-Masri H, Kosian PA, Ford J, Degitz SJ, Gilbert ME (2017) Neurodevelopment and thyroid hormone synthesis inhibition in the rat: quantitative understanding within the adverse outcome pathway Framework. Toxicol Sci 160(1):57–73

Article  CAS  PubMed  Google Scholar 

Hazell AS, Wang D, Oanea R, Sun S, Aghourian M, Yong JJ (2014) Pyrithiamine-induced thiamine deficiency alters proliferation and neurogenesis in both neurogenic and vulnerable areas of the rat brain. Metab Brain Dis 29(1):145–152

Article  CAS  PubMed  Google Scholar 

Hosseinzadeh A, Dehdashtian E, Jafari-Sabet M, Mehrzadi S (2022) The effects of vitamin D3 and melatonin combination on Pentylenetetrazole- induced seizures in mice. Cent Nerv Syst Agents Med Chem 22(2):118–124

Article  CAS  PubMed  Google Scholar 

Khaleghzadeh-Ahangar H, Talebi A, Mohseni-Moghaddam P (2022) Thyroid disorders and Development of Cognitive Impairment: a review study. Neuroendocrinology 112(9):835–844

Article  CAS  PubMed  Google Scholar 

Kim JO, Lee SJ, Pyo JS (2020) Effect of acetylcholinesterase inhibitors on post-stroke cognitive impairment and vascular Dementia: a meta-analysis. PLoS ONE 15(2):e0227820

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kouba BR, Camargo A, Rodrigues ALS (2023) Neuroinflammation in Alzheimer’s Disease: potential beneficial effects of vitamin D. Metab Brain Dis 38(3):819–829

Article  CAS  PubMed  Google Scholar 

Lukienko PI, Mel’nichenko NG, Zverinskii IV, Zabrodskaya SV (2000) Antioxidant properties of thiamine. Bull Exp Biol Med 130(9):874–876

Article  CAS  PubMed  Google Scholar 

Mesdaghinia A, Alinejad M, Abed A, Heydari A, Banafshe HR (2017) Anticonvulsant effects of thiamine on pentylenetetrazole-induced seizure in mice. Nutr Neurosci 22(3):165–173

Article  PubMed  Google Scholar 

Nantachai G, Vasupanrajit A, Tunvirachaisakul C, Solmi M, Maes M (2022) Oxidative stress and antioxidant defenses in mild cognitive impairment: a systematic review and meta-analysis. Ageing Res Rev 79:101639

Article  CAS  PubMed  Google Scholar 

Ortí JER, Cuerda-Ballester M, Drehmer E, Carrera-Juliá S, Motos-Muñoz M, Cunha-Pérez C, Benlloch M, López-Rodríguez MM (2020) Vitamin B1 intake in multiple sclerosis patients and its impact on Depression Presence: a pilot study. Nutrients 12(9).

Perri K, De Mori L, Tortora D, Calevo MG, Allegri AEM, Napoli F, Patti G, Fava D, Crocco M, Schiavone M, Casalini E, Severino M, Rossi A, Di Iorgi N, Gastaldi R, Maghnie M (2021) Cognitive and white Matter Microstructure Development in congenital hypothyroidism and familial thyroid disorders. J Clin Endocrinol Metab 106(10):e3990–e4006

Article  PubMed  Google Scholar 

Polegato BF, Pereira AG, Azevedo PS, Costa NA, Zornoff LAM, Paiva SAR, Minicucci MF (2019) Role of Thiamin in Health and Disease. Nutr Clin Pract 34(4):558–564

Article  PubMed  Google Scholar 

Rastegar-Moghaddam SH, Hosseini M, Alipour F, Rajabian A, Ebrahimzadeh Bideskan A (2022) The effects of vitamin D on learning and memory of hypothyroid juvenile rats and brain tissue acetylcholinesterase activity and oxidative stress indicators. Naunyn Schmiedebergs Arch Pharmacol 395(3):337–351

Article  CAS  PubMed  Google Scholar 

Salami M, Bandegi AR, Sameni HR, Vafaei AA, Pakdel A (2019) Hippocampal Up-Regulation of apolipoprotein D in a rat model of maternal hypo- and hyperthyroidism: implication of oxidative stress. Neurochem Res 44(9):2190–2201

Article  CAS  PubMed  Google Scholar 

Salazar P, Cisternas P, Martinez M, Inestrosa NC (2019) Hypothyroidism and Cognitive disorders during Development and Adulthood: implications in the Central Nervous System. Mol Neurobiol 56(4):2952–2963

Article  CAS  PubMed  Google Scholar 

Sambon M, Napp A, Demelenne A, Vignisse J, Wins P, Fillet M, Bettendorff L (2019) Thiamine and benfotiamine protect neuroblastoma cells against paraquat and β-amyloid toxicity by a coenzyme-independent mechanism. Heliyon 5(5):e01710

Article  PubMed  PubMed Central  Google Scholar 

Sechi GP, Bardanzellu F, Pintus MC, Sechi MM, Marcialis MA, Fanos V (2021) Thiamine as a Possible Neuroprotective Strategy in Neonatal Hypoxic-Ischemic Encephalopathy. Antioxidants (Basel) 11(1)

Talarowska M, Bobińska K, Zajączkowska M, Su KP, Maes M, Gałecki P (2014) Impact of oxidative/nitrosative stress and inflammation on cognitive functions in patients with recurrent depressive disorders. Med Sci Monit 20:110–115

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tapias V, Jainuddin S, Ahuja M, Stack C, Elipenahli C, Vignisse J, Gerges M, Starkova N, Xu H, Starkov AA, Bettendorff L, Hushpulian DM, Smirnova NA, Gazaryan IG, Kaidery NA, Wakade S, Calingasan NY, Thomas B, Gibson GE, Dumont M, Beal MF (2018) Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy. Hum Mol Genet 27(16):2874–2892

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vignisse J, Sambon M, Gorlova A, Pavlov D, Caron N, Malgrange B, Shevtsova E, Svistunov A, Anthony DC, Markova N, Bazhenova N, Coumans B, Lakaye B, Wins P, Strekalova T, Bettendorff L (2017) Thiamine and benfotiamine prevent stress-induced suppression of hippocampal neurogenesis in mice exposed to predation without affecting brain thiamine diphosphate levels. Mol Cell Neurosci 82:126–136

Article  CAS  PubMed  Google Scholar 

Villanueva I, Alva-Sánchez C, Pacheco-Rosado J (2013) The role of thyroid hormones as inductors of oxidative stress and neurodegeneration.Oxid Med Cell Longev 2013: 218145

Wang N, Sun Y, Yang H, Xu Y, Cai Y, Liu T, Xia Q, Zhu D, Wang F (2021) Hashimoto’s Thyroiditis induces Hippocampus-dependent cognitive alterations by impairing astrocytes in Euthyroid Mice. Thyroid 31(3):482–493

Article  CAS  PubMed  Google Scholar 

Xu H, Liu D, Chen J, Li H, Xu M, Wen W, Frank JA, Grahame NJ, Zhu H, Luo J (2019) Effects of Chronic Voluntary Alcohol drinking on thiamine concentrations, endoplasmic reticulum stress, and oxidative stress in the brain of crossed high Alcohol Preferring mice. Neurotox Res 36(4):777–787

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yassine HN, Self W, Kerman BE, Santoni G, Navalpur Shanmugam N, Abdullah L, Golden LR, Fonteh AN, Harrington MG, Gräff J, Gibson GE, Kalaria R, Luchsinger JA, Feldman HH, Swerdlow RH, Johnson LA, Albensi BC, Zlokovic BV, Tanzi R, Cunnane S, Samieri C, Scarmeas N, Bowman GL (2022) Nutritional metabolism and cerebral bioenergetics in Alzheimer’s disease and related dementias. Alzheimers Dement

Zhang F, Chen J, Lin X, Peng S, Yu X, Shan Z, Teng W (2018) Subclinical hypothyroidism in pregnant rats impaired learning and memory of their offspring by promoting the p75(NTR) signal pathway. Endocr Connect 7(5):688–697

Article  CAS  PubMed  PubMed Central  Google Scholar