Abeysinghe A, Deshapriya R, Udawatte C (2020) Alzheimer’s disease; a review of the pathophysiological basis and therapeutic interventions. Life Sci [j] 256:117996

Article  CAS  PubMed  Google Scholar 

Ashrafian H, Zadeh EH, Khan RH (2021) Review on Alzheimer’s disease: inhibition of amyloid beta and tau tangle formation. Int J of Biol Macromol [j] 167:382–394

Article  CAS  PubMed  Google Scholar 

Bernd, Schröder, Paul et al (2010) Molecular insights into mechanisms of intramembrane proteolysis through signal peptide peptidase (SPP): Figure 1. Biochem J [J]

Blumenthal, Nils R et al (2014) Stochastic nanoroughness modulates neuron-astrocyte interactions and function via mechanosensing cation channels. Proc Natl Acad Sci USA [J]

Bourdenx M, Martín-segura A, Scrivo A et al (2021) Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell [j] 184:2696-2714.e2625

Article  CAS  PubMed  Google Scholar 

Butterfield DA, Halliwell B (2019) Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease. Nat Rev Neurosci [j] 20:148–160

Article  CAS  PubMed  Google Scholar 

Calsolaro V, Edison P (2016) Neuroinflammation in Alzheimer's disease: current evidence and future directions. Alzheimer's & Dementia [J] 12

Cattaneo A, Cattane N, Galluzzi S et al (2017) Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. Neurobiol Aging [j] 49:60–68

Article  CAS  PubMed  Google Scholar 

Chan LC, Li CW, Xia W et al (2019) IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion. J Clin Invest [j] 129:3324–3338

Article  PubMed  Google Scholar 

Darweesh SKL, Wolters FJ, Ikram MA et al (2018) Inflammatory markers and the risk of dementia and Alzheimer’s disease: a meta-analysis. Alzheimers Dement [j] 14:1450–1459

Article  PubMed  Google Scholar 

de Lorenzo BH, Godoy LC, Novaes E Brito RR et al (2010) Macrophage suppression following phagocytosis of apoptotic neutrophils is mediated by the S100A9 calcium-binding protein. Immunobiology [j] 215:341–347

Article  PubMed  Google Scholar 

Donato R, Cannon BR, Sorci G et al (2013) Functions of S100 proteins. Curr Mol Med [j] 13:24–57

Article  CAS  PubMed  Google Scholar 

dos Santos RS, Veras FP, Ferreira DW et al (2020) Involvement of the Hsp70/TLR4/IL-6 and TNF-α pathways in delayed-onset muscle soreness. J Neurochem [j] 155:29–44

Article  PubMed  Google Scholar 

Ehrchen JM, Sunderkötter C, Foell D et al (2009) The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer. J Leukoc Biol [j] 86:557–566

Article  CAS  PubMed  Google Scholar 

Foell D, Roth J (2004) Proinflammatory S100 proteins in arthritis and autoimmune disease. Arthritis Rheum [j] 50:3762–3771

Article  CAS  PubMed  Google Scholar 

Foell D, Wittkowski H, Vogl T et al (2007) S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules. J Leukoc Biol [j] 81:28–37

Article  CAS  PubMed  Google Scholar 

Forrester JV, McMenamin PG, Dando SJ (2018) CNS infection and immune privilege. Nat Rev Neurosci [j] 19:655–671

Article  CAS  PubMed  Google Scholar 

Fuhrmann M, Bittner T, Jung CK et al (2010) Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer’s disease. Nat Neurosci [j] 13:411–413

Article  CAS  PubMed  Google Scholar 

Gate D, Saligrama N, Levanthal O et al (2020) Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease: molecular and cell biology: inflammatory and microglia-mediated mechanisms in AD. Alzheimer's and Dementia [J] 16

Giacomini E, Severa M, Rizzo F et al (2013) IFN-β therapy modulates B-cell and monocyte crosstalk via TLR7 in multiple sclerosis patients. Eur J Immunol [j] 43:1963–1972

Article  CAS  PubMed  Google Scholar 

Gimsa U, Peter SV, Lehmann K et al (2000) Axonal damage induced by invading T cells in organotypic central nervous system tissue in vitro: involvement of microglial cells. Brain Pathol [j] 10:365–377

Article  CAS  PubMed  Google Scholar 

Ginhoux F, Lim S, Hoeffel G et al (2013) Origin and differentiation of microglia. Front Cell Neurosci [j] 7:45

PubMed  Google Scholar 

Grada A, Otero-Vinas M, Prieto-Castrillo F et al (2017) Research techniques made simple: analysis of collective cell migration using the wound healing assay. J Invest Dermatol [j] 137:e11–e16

Article  CAS  PubMed  Google Scholar 

Ha TY, Chang KA, Kim J et al (2010) S100a9 knockdown decreases the memory impairment and the neuropathology in Tg2576 mice, AD animal model. PLoS One [j] 5:e8840

Article  PubMed  Google Scholar 

Habib R, Noureen N, Nadeem N (2018) Decoding common features of neurodegenerative disorders: from differentially expressed genes to pathways. Curr Genomics [j] 19:300–312

Article  CAS  PubMed  Google Scholar 

Hashioka S, Wu Z, Klegeris A (2021) Glia-driven neuroinflammation and systemic inflammation in Alzheimer’s disease. Current Neuropharmacol 19:908–924

Article  CAS  Google Scholar 

Heizmann CW, Ackermann GE, Galichet A (2007) Pathologies involving the S100 proteins and RAGE. Subcell Biochem [j] 45:93–138

Article  CAS  PubMed  Google Scholar 

Hou Y, Wei Y, Lautrup S et al (2021) NAD(+) supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING. Proc Natl Acad Sci USA [J], 118

Iqbal K, Alonso AdeL C, Chen S et al (2005) Tau pathology in Alzheimer disease and other tauopathies. Biochim Biophys Acta [j] 1739:198–210

Article  CAS  PubMed  Google Scholar 

Jiao D, Wong CK, Qiu HN et al (2016) NOD2 and TLR2 ligands trigger the activation of basophils and eosinophils by interacting with dermal fibroblasts in atopic dermatitis-like skin inflammation. Cell Mol Immunol [j] 13:535–550

Article  CAS  PubMed  Google Scholar 

Katarzyna C, Ewa T, Magdalena SG et al (2019) The potential role of dysfunctions in neuron - microglia communication in the pathogenesis of brain disorders. Current neuropharmacology [J], Curr Neuropharmacol 408–430

Kolaczkowska E, Kubes P (2013) Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol [j] 13:159–175

Article  CAS  PubMed  Google Scholar 

Lashley T, Schott J M, Weston P et al (2018) Molecular biomarkers of Alzheimer's disease: progress and prospects. Dis Model Mech [J] 11

Lauer A, Grimm H, Apel B et al (2022) Mechanistic link between vitamin B12 and Alzheimer's disease. Biomolecules [J] 12

le Douce J, Maugard M, Veran J et al (2020) Impairment of glycolysis-derived l-serine production in astrocytes contributes to cognitive deficits in Alzheimer’s disease. Cell Metab [j] 31:503-517.e508

Article  PubMed  Google Scholar 

Leclerc E, Fritz G, Vetter SW et al (2009) Binding of S100 proteins to RAGE: an update. Biochim Biophys Acta [j] 1793:993–1007

Article  CAS  PubMed  Google Scholar 

Lei Q, Gu H, Li L et al (2020) TNIP1-mediated TNF-α/NF-κB signalling cascade sustains glioma cell proliferation. J Cell Mol Med [j] 24:530–538

Article  CAS  PubMed  Google Scholar 

Li G, Chen H, Cheng L et al (2014) Amyloid precursor-like protein 2 C-terminal fragments upregulate S100A9 gene and protein expression in BV2 cells. Neural Regen Res [j] 9:1923–1928

Article  PubMed  Google Scholar 

Ma L, Sun P, Zhang JC et al (2017) Proinflammatory effects of S100A8/A9 via TLR4 and RAGE signaling pathways in BV-2 microglial cells. Int J Mol Med [j] 40:31–38

Article  CAS  PubMed  Google Scholar 

Mathieu E, Paul CD, Stahl R et al (2016) Time-lapse lens-free imaging of cell migration in diverse physical microenvironments. Lab Chip [j] 16:3304–3316

Article  CAS  PubMed  Google Scholar 

Mufson EJ, Counts SE, Perez SE et al (2008) Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications. Expert Rev Neurother [j] 8:1703–1718

Article  CAS  PubMed  Google Scholar 

Nakatsuji Y, Miller RH (1998) Homotypic cell contact-dependent inhibition of astrocyte proliferation. Glia [j] 22:379–389

Article  CAS  PubMed  Google Scholar 

Recasens M, Almolda B, Pérez-clausell J et al (2021) Chronic exposure to IL-6 induces a desensitized phenotype of the microglia. J Neuroinflammation [j] 18:31

Article  CAS  PubMed  Google Scholar 

Russo MV, Mcgavern DB (2016) Inflammatory neuroprotection following traumatic brain injury. Science [j] 353:783–785

Article  CAS  PubMed  Google Scholar 

Saito ER, Miller JB, Harari O et al (2021) Alzheimer’s disease alters oligodendrocytic glycolytic and ketolytic gene expression. Alzheimers Dement [j] 17:1474–1486

Article  CAS  PubMed  Google Scholar 

Selkoe DJ, Hardy J (2016) The amyloid hypothesis of Alzheimer’s disease at 25 years. EMBO Mol Med [j] 8:595–608

Article