Acosta CM, Cortes C, MacPhee H, Namaka MP (2013) Exploring the role of nerve growth factor in multiple sclerosis: implications in myelin repair. CNS Neurol Disord: Drug Targets 12(8):1242–1256. https://doi.org/10.2174/18715273113129990087

Article  CAS  PubMed  Google Scholar 

Aharoni R, Eilam R, Domev H, Labunskay G, Sela M, Arnon R (2005) The immunomodulator glatiramer acetate augments the expression of neurotrophic factors in brains of experimental autoimmune encephalomyelitis mice. Proc Natl Acad Sci USA 102(52):19045–19050. https://doi.org/10.1073/pnas.0509438102

Article  CAS  PubMed Central  Google Scholar 

Aid T, Kazantseva A, Piirsoo M, Palm K, Timmusk T (2007) Mouse and rat BDNF gene structure and expression revisited. J Neurosci Res 85(3):525–535. https://doi.org/10.1002/jnr.21139

Article  CAS  PubMed  Google Scholar 

Althaus HH, Klöppner S, Klopfleisch S, Schmitz M (2008) Oligodendroglial cells and neurotrophins: a polyphonic cantata in major and minor. J Mol Neurosci 35(1):65–79. https://doi.org/10.1007/s12031-008-9053-y

Article  CAS  Google Scholar 

Ankeny DP, McTigue DM, Guan Z, Yan Q, Kinstler O, Stokes BT, Jakeman LB (2001) Pegylated brain-derived neurotrophic factor shows improved distribution into the spinal cord and stimulates locomotor activity and morphological changes after injury. Exp Neurol 170(1):85–100. https://doi.org/10.1006/exnr.2001.7699

Article  CAS  Google Scholar 

Arnold AC (2005) Evolving management of optic neuritis and multiple sclerosis. Am J Ophthalmol 139(6):1101–1108. https://doi.org/10.1016/j.ajo.2005.01.031

Article  Google Scholar 

Ashtari F, Safaei A, Shaygannejad V, Najafi MA, Vesal S (2017) Neuromyelitis optica spectrum disease characteristics in Isfahan, Iran: a cross-sectional study. J Res Med Sci 22:41. https://doi.org/10.4103/1735-1995.202142

Article  PubMed Central  Google Scholar 

Ausió J, Martínez de Paz A, Esteller M (2014) MeCP2: the long trip from a chromatin protein to neurological disorders. Trends Mol Med 20(9):487–498. https://doi.org/10.1016/j.molmed.2014.03.004

Article  CAS  PubMed  Google Scholar 

Autry AE, Monteggia LM (2012) Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharmacol Rev 64(2):238–258. https://doi.org/10.1124/pr.111.005108

Article  CAS  PubMed Central  Google Scholar 

Azoulay D, Vachapova V, Shihman B, Miler A, Karni A (2005) Lower brain-derived neurotrophic factor in serum of relapsing remitting MS: reversal by glatiramer acetate. J Neuroimmunol 167(1–2):215–218. https://doi.org/10.1016/j.jneuroim.2005.07.001

Article  CAS  PubMed  Google Scholar 

Azoulay D, Urshansky N, Karni A (2008) Low and dysregulated BDNF secretion from immune cells of MS patients is related to reduced neuroprotection. J Neuroimmunol 195(1–2):186–193. https://doi.org/10.1016/j.jneuroim.2008.01.010

Article  CAS  Google Scholar 

Bach S, Ryan NM, Guasoni P, Corvin AP, El-Nemr RA, Khan D, Sanfeliu A, Tropea D (2020) Methyl-CpG-binding protein 2 mediates overlapping mechanisms across brain disorders. Sci Rep 10(1):22255. https://doi.org/10.1038/s41598-020-79268-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baker D, Pryce G, Croxford JL, Brown P, Pertwee RG, Makriyannis A, Khanolkar A, Layward L, Fezza F, Bisogno T, Di Marzo V (2001) Endocannabinoids control spasticity in a multiple sclerosis model. FASEB J 15(2):300–302. https://doi.org/10.1096/fj.00-0399fje

Article  CAS  PubMed  Google Scholar 

Bakondi B, Lv W, Lu B, Jones MK, Tsai Y, Kim KJ, Levy R, Akhtar AA, Breunig JJ, Svendsen CN, Wang S (2016) In Vivo CRISPR/Cas9 gene editing corrects retinal dystrophy in the S334ter-3 rat model of autosomal dominant retinitis pigmentosa. Mol Ther 24(3):556–563. https://doi.org/10.1038/mt.2015.220

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barber BA, Rastegar M (2010) Epigenetic control of Hox genes during neurogenesis, development, and disease. Ann Anat 192(5):261–274. https://doi.org/10.1016/j.aanat.2010.07.009

Article  CAS  PubMed  Google Scholar 

Bashinskaya VV, Kulakova OG, Boyko AN, Favorov AV, Favorova OO (2015) A review of genome-wide association studies for multiple sclerosis: classical and hypothesis-driven approaches. Hum Genet 134(11–12):1143–1162. https://doi.org/10.1007/s00439-015-1601-2

Article  CAS  PubMed  Google Scholar 

Beattie MS, Harrington AW, Lee R, Kim JY, Boyce SL, Longo FM, Bresnahan JC, Hempstead BL, Yoon SO (2002) ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury. Neuron 36(3):375–386. https://doi.org/10.1016/s0896-6273(02)01005-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Begum F, Zhu W, Cortes C, MacNeil B, Namaka M (2013) Elevation of tumor necrosis factor α in dorsal root ganglia and spinal cord is associated with neuroimmune modulation of pain in an animal model of multiple sclerosis. J Neuroimmune Pharmacol 8(3):677–690. https://doi.org/10.1007/s11481-013-9449-5

Article  CAS  PubMed  Google Scholar 

Bennett JL, Lam C, Kalluri SR, Saikali P, Bautista K, Dupree C, Glogowska M, Case D, Antel JP, Owens GP, Gilden D, Nessler S, Stadelmann C, Hemmer B (2009) Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica. Ann Neurol 66(5):617–629. https://doi.org/10.1002/ana.21802

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ben-Zeev B, Aharoni R, Nissenkorn A, Arnon R (2011) Glatiramer acetate (GA, Copolymer-1) an hypothetical treatment option for Rett syndrome. Med Hypotheses 76(2):190–193. https://doi.org/10.1016/j.mehy.2010.09.015

Article  CAS  Google Scholar 

Bieber AJ, Kerr S, Rodriguez M (2003) Efficient central nervous system remyelination requires T cells. Ann Neurol 53(5):680–684. https://doi.org/10.1002/ana.10578

Article  PubMed  Google Scholar 

Binder DK, Scharfman HE (2004) Brain-derived neurotrophic factor. Growth Factors (Chur, Switzerland) 22(3):123–131. https://doi.org/10.1080/08977190410001723308

Article  CAS  PubMed  Google Scholar 

Brück W, Wegner C (2011) Insight into the mechanism of laquinimod action. J Neurol Sci 306(1–2):173–179. https://doi.org/10.1016/j.jns.2011.02.019

Article  CAS  Google Scholar 

Bruijstens AL, Wong YYM, van Pelt DE, van der Linden PJE, Haasnoot GW, Hintzen RQ, Claas FHJ, Neuteboom RF, Wokke BHA (2020) HLA association in MOG-IgG- and AQP4-IgG-related disorders of the CNS in the Dutch population. Neurol Neuroimmunol Neuroinflammation. https://doi.org/10.1212/nxi.0000000000000702

Article  Google Scholar 

Brum DG, Barreira AA, dos Santos AC, Kaimen-Maciel DR, Matiello M, Costa RM, Deghaide NH, Costa LS, Louzada-Junior P, Diniz PR, Comini-Frota ER, Mendes-Junior CT, Donadi EA (2010) HLA-DRB association in neuromyelitis optica is different from that observed in multiple sclerosis. Mult Scler 16(1):21–29. https://doi.org/10.1177/1352458509350741

Article  CAS  PubMed  Google Scholar 

Caggiula M, Batocchi AP, Frisullo G, Angelucci F, Patanella AK, Sancricca C, Nociti V, Tonali PA, Mirabella M (2006) Neurotrophic factors in relapsing remitting and secondary progressive multiple sclerosis patients during interferon beta therapy. Clin Immunol 118(1):77–82. https://doi.org/10.1016/j.clim.2005.09.005

Article  CAS  PubMed  Google Scholar 

Camelo S, Iglesias AH, Hwang D, Due B, Ryu H, Smith K, Gray SG, Imitola J, Duran G, Assaf B, Langley B, Khoury SJ, Stephanopoulos G, De Girolami U, Ratan RR, Ferrante RJ, Dangond F (2005) Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis. J Neuroimmunol 164(1–2):10–21. https://doi.org/10.1016/j.jneuroim.2005.02.022

Article  CAS  PubMed  Google Scholar 

Cao Q, Xu XM, Devries WH, Enzmann GU, Ping P, Tsoulfas P, Wood PM, Bunge MB, Whittemore SR (2005) Functional recovery in traumatic spinal cord injury after transplantation of multineurotrophin-expressing glial-restricted precursor cells. J Neurosci: Off J Soc Neurosci 25(30):6947–6957. https://doi.org/10.1523/jneurosci.1065-05.2005

Article  CAS  Google Scholar 

Chahrour M, Zoghbi HY (2007) The story of Rett syndrome: from clinic to neurobiology. Neuron 56(3):422–437. https://doi.org/10.1016/j.neuron.2007.10.001

Article  CAS  PubMed  Google Scholar 

Chahrour M, Jung SY, Shaw C, Zhou X, Wong ST, Qin J, Zoghbi HY (2008) MeCP2, a key contributor to neurological disease, activates and represses transcription. Science (New York, NY) 320(5880):1224–1229. https://doi.org/10.1126/science.1153252

Article  CAS  Google Scholar 

Chang Q, Khare G, Dani V, Nelson S, Jaenisch R (2006) The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. Neuron 49(3):341–348. https://doi.org/10.1016/j.neuron.2005.12.027

Article  CAS  Google Scholar 

Chen L, Gordon LK (2005) Ocular manifestations of multiple sclerosis. Curr Opin Ophthalmol 16(5):315–320. https://doi.org/10.1097/01.icu.0000179804.49842.e2

Article  PubMed  Google Scholar 

Chen M, Valenzuela RM, Dhib-Jalbut S (2003a) Glatiramer acetate-reactive T cells produce brain-derived neurotrophic factor. J Neurol Sci 215(1–2):37–44. https://doi.org/10.1016/s0022-510x(03)00177-1

Article  CAS  PubMed  Google Scholar 

Chen WG, Chang Q, Lin Y, Meissner A, West AE, Griffith EC, Jaenisch R, Greenberg ME (2003b) Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science (New York, NY) 302(5646