53BP1

Tumor Protein P53 Binding Protein 1

AGS

Aicardi-goutières syndrome

ALT

Alternative lengthening of telomeres

alt-EJ

Alternative end-joining

ATM

Ataxia telangiectasia mutate

ATR

Ataxia telangiectasia and Rad3-related protein

BFB

Breakage-fusion-bridge

BITS

Break-induced telomere synthesis

BRCA1

Breast cancer type 1 susceptibility protein

BRCA2

Breast cancer type 2 susceptibility protein

BTR complex

RecQ helicase BLM, topoisomerase IIIα, and RMI

c-NHEJ

Canonical non-homologous end-joining

CARD

Caspase recruitment domain

CARDIF

CARD adapter inducing interferon beta

CASP

Crisis-associated secretory phenotype

CCFs

Cytoplasmic chromatin fragments

cGAMP

Cyclic guanosine monophosphate–adenosine monophosphate

cGAS

Cyclic GMP-AMP synthase

CTC1

Conserved telomere maintenance component 1

CtIP

CtBP-interacting protein

DAI

DNA-dependent activator of IFN-regulatory factors

DAMPs

Damage-associated molecular patterns

DKC

Dyskeratosis congenita

DLM-1

Tumor stroma and activated macrophage protein

DNA-PKcs

DNA-dependent protein kinase catalytic subunit

DNA2

DNA replication ATP-dependent helicase/nuclease DNA2

DNMT1

DNA (cytosine-5)-methyltransferase 1

ECTR

Extrachromosomal telomere repeat

ERE

Endogenous retroviral elements

ERGIC

ER-Golgi intermediate compartment

HDR

Homology-directed repair

IFNAR1

Interferon alpha/beta receptor 1

IFNAR2

Interferon alpha/beta receptor 2

IKK-β

Inhibitor of nuclear factor kappa-B kinase ε

IPS-1

Interferon beta promoter stimulator protein 1

IRF3

Interferon regulatory factor 3

IRF7

Interferon regulatory factor 7

ISG

Interferon-stimulated gene

IκB

Inhibitor of nuclear factor kappa B

LINE-1

Long interspersed nuclear elements 1

MAM

Mitochondria-associated endoplasmic reticulum membrane

MAPK

Mitogen-activated protein kinase

MAVS

Mitochondrial antiviral signaling protein

MCMV

Murine cytomegalovirus

MDA5

Melanoma differentiation-associated protein 5

MDC1

Mediator of DNA damage checkpoint 1

MLKL

Mixed lineage kinase domain like pseudokinase

MRN

MRE11, RAD50, and NBS1

NAF1

Nuclear assembly factor 1 ribonucleoprotein

NBS1

Nijmegen breakage syndrome 1

NF-κB

Nuclear factor kappa B

NHP2

Nucleolar protein family A, member 2

NOP10

Nucleolar protein 10

OMM

Outer mitochondrial membrane

ORC2

Origin recognition complex subunit 2

PALB2

Partner and localizer of BRCA2

PAMPs

Pathogen-associated molecular pattern molecules

PARN

Poly(A)-specific ribonuclease

PARP1

Poly(ADP-Ribose) polymerase 1

PCNA

Proliferating Cell Nuclear Antigen

PNPase

Polyribonucleotide Nucleotidyltransferase 1, Mitochondrial

POT1

Protection of telomeres 1

pRb

RB transcriptional corepressor 1

PRRs

Pattern recognition receptors

RFC1

Replication Factor C Subunit 1

RHIM

RIP homotypic interaction motif

RIG-I

Retinoic Acid-Inducible Gene 1 Protein

RIPK1

Receptor Interacting Serine/Threonine Kinase 1

RIPK3

Receptor Interacting Serine/Threonine Kinase 3

RMI

RecQ-mediated genome instability

RNF168

Ring finger protein 168

RTEL1

Regulator of telomere elongation helicase 1

SARS-CoV-2

Severe acute respiratory syndrome coronavirus 2

SASP

Senescence-associated secretory phenotype

SINEs

Short interspersed nuclear elements

SLE

Systemic lupus erythematosus

SLX4

Structure-specific endonuclease subunit

SMX complex

SLX1-SLX4, MUS81-EME1, and XPF-ERCC1

STING

Stimulator of interferon genes protein

SUV3

Suppressor of Var1, 3-Like 1

T-SCE

Telomere sister chromatid exchange

TBD

Telomere biology disorders

TBK1

TANK binding kinase 1

TCAB1

Telomerase cajal body protein 1

TERC

Telomerase RNA component

TERRA

Telomeric repeat-containing RNA

TERT

Catalytic subunit telomerase reverse transcriptase

TIF

Telomere dysfunction induced foci

TIN2

TERF1 interacting nuclear factor 2

TOP3A

DNA topoisomerase III alpha

TPP1

Tripeptidyl peptidase 1

TRAF

TNF receptor associated factor

TREX1

Three prime repair exonuclease 1

TRF1

Telomeric repeat binding factor 1

TRF2

Telomeric repeat binding factor 2

TZAP

Zinc finger and BTB domain containing 48

VACV

Vaccinia related kinase 2

VISA

Virus-induced signaling adaptor

WRAP53

WD repeat containing antisense to TP53

XRCC3

X-ray repair cross complementing 3

YAP1

Yes1 associated transcriptional regulator

ZBP1

Z-DNA binding protein 1