Effectiveness of transcranial direct current stimulation on balance and gait in patients with multiple sclerosis: systematic review and meta-analysis of randomized clinical trials

Lassmann H. Multiple sclerosis Pathology. Cold Spring Harb Perspect Med. 2018;8.

Kister I, Bacon TE, Chamot E, Salter AR, Cutter GR, Kalina JT, et al. Natural history of multiple sclerosis symptoms. Int J MS Care. 2013;15:146–58.

Article  PubMed  PubMed Central  Google Scholar 

Lublin FD, Reingold SC, Cohen JA, Cutter GR, Sørensen PS, Thompson AJ, et al. Defining the clinical course of multiple sclerosis: the 2013 revisions. Neurology. 2014;83:278–86.

Article  PubMed  PubMed Central  Google Scholar 

Cameron MH, Nilsagard Y. Balance, gait, and falls in multiple sclerosis. Handb Clin Neurol. 2018;159:237–50.

Article  PubMed  Google Scholar 

Mazumder R, Murchison C, Bourdette D, Cameron M. Falls in people with multiple sclerosis compared with falls in healthy controls. PLoS One. 2014; 25;9(9):e107620.

Kierkegaard M, Einarsson U, Gottberg K, Von Koch L, Holmqvist LW. The relationship between walking, manual dexterity, cognition and activity/participation in persons with multiple sclerosis. Mult Scler. 2012;18:639–46.

Article  PubMed  Google Scholar 

Beretta VS, Santos PCR, Orcioli-Silva D, Zampier VC, Vitório R, Gobbi LTB. Transcranial direct current stimulation for balance rehabilitation in neurological disorders: a systematic review and meta-analysis. Ageing Res Rev. 2022;81:101736.

Article  PubMed  Google Scholar 

Comber L, Galvin R, Coote S. Gait deficits in people with multiple sclerosis: a systematic review and meta-analysis. Gait Posture. 2017;51:25–35.

Article  PubMed  Google Scholar 

Rae-Grant A, Day GS, Marrie RA, Rabinstein A, Cree BAC, Gronseth GS, et al. Comprehensive systematic review summary: disease-modifying therapies for adults with multiple sclerosis. Neurology. 2018;90:789–800.

Article  PubMed  Google Scholar 

Beer S, Khan F, Kesselring J. Rehabilitation interventions in multiple sclerosis: an overview. J Neurol. 2012;259:1994–2008.

Article  PubMed  Google Scholar 

Baird JF, Sandroff BM, Motl RW. Therapies for mobility disability in persons with multiple sclerosis. Expert Rev Neurother. 2018;18:493–502.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iodice R, Manganelli F, Dubbioso R. The therapeutic use of non-invasive brain stimulation in multiple sclerosis - a review. Restor Neurol Neurosci. 2017;35:497–509.

PubMed  Google Scholar 

Corrini C, Gervasoni E, Perini G, Cosentino C, Putzolu M, Montesano A, et al. Mobility and balance rehabilitation in multiple sclerosis: a systematic review and dose-response meta-analysis. Mult Scler Relat Disord. 2023;69:104424.

Article  PubMed  Google Scholar 

Hiew S, Nguemeni C, Zeller D. Efficacy of transcranial direct current stimulation in people with multiple sclerosis: a review. Eur J Neurol. 2022;29:648–64.

Article  PubMed  Google Scholar 

Nitsche MA, Paulus W. Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans. Neurology. 2001;57:1899–901.

Article  CAS  PubMed  Google Scholar 

Lefaucheur JP, Antal A, Ayache SS, Benninger DH, Brunelin J, Cogiamanian F, et al. Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS). Clin Neurophysiol. 2017;128:56–92.

Article  PubMed  Google Scholar 

Fregni F, El-Hagrassy MM, Pacheco-Barrios K, Carvalho S, Leite J, Simis M, et al. Evidence-based guidelines and secondary Meta-analysis for the Use of Transcranial Direct Current Stimulation in Neurological and Psychiatric disorders. Int J Neuropsychopharmacol. 2021;24:256–313.

Article  PubMed  Google Scholar 

McLoughlin J, Barr C, Crotty M, Lord SR, Sturnieks DL. Association of Postural Sway with disability status and cerebellar dysfunction in people with multiple sclerosis: a preliminary study. Int J MS Care. 2015;17:146–51.

Article  PubMed  PubMed Central  Google Scholar 

Celnik P. Understanding and modulating motor learning with cerebellar stimulation. Cerebellum. 2015;14:171.

Article  PubMed  PubMed Central  Google Scholar 

Popa LS, Ebner TJ. Cerebellum, predictions and errors. Front Cell Neurosci. 2019;12:524.

Article  PubMed  PubMed Central  Google Scholar 

Sokolov AA, Miall RC, Ivry RB. The Cerebellum: adaptive prediction for Movement and Cognition. Trends Cogn Sci. 2017;21:313.

Article  PubMed  PubMed Central  Google Scholar 

Cochrane Handbook for Systematic Reviews of Interventions. Cochrane Training [Internet]. [cited 2023 Jun 29]. Available from: https://training.cochrane.org/handbook/current.

Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898.

Article  PubMed  Google Scholar 

Guyatt G, Oxman AD, Akl EA, Kunz R, Vist G, Brozek J, et al. GRADE guidelines: 1. Introduction—GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011;64:383–94.

Article  PubMed  Google Scholar 

Chapter 6. : Choosing effect measures and computing estimates of effect | Cochrane Training [Internet]. [cited 2023 Jun 29]. Available from: https://training.cochrane.org/handbook/current/chapter-06.

Scalzitti DA, Harwood KJ, Maring JR, Leach SJ, Ruckert EA, Costello E. Validation of the 2-Minute Walk Test with the 6-Minute Walk Test and other functional measures in persons with multiple sclerosis. Int J MS Care. 2018;20:158–63.

Article  PubMed  PubMed Central  Google Scholar 

Motl RW, Cohen JA, Benedict R, Phillips G, LaRocca N, Hudson LD, et al. Validity of the timed 25-foot walk as an ambulatory performance outcome measure for multiple sclerosis. Mult Scler. 2017;23:704.

Article  PubMed  PubMed Central  Google Scholar 

Sebastião E, Sandroff BM, Learmonth YC, Motl RW. Validity of the timed up and go test as a measure of functional mobility in persons with multiple sclerosis. Arch Phys Med Rehabil. 2016;97:1072–7.

Article  PubMed  Google Scholar 

Hobart JC, Riazi A, Lamping DL, Fitzpatrick R, Thompson AJ. Measuring the impact of MS on walking ability. Neurology. 2003;60:31–6.

Article  CAS  PubMed  Google Scholar 

Workman CD, Kamholz J, Rudroff T. Transcranial Direct Current Stimulation (tDCS) to Improve Gait in multiple sclerosis: a timing window comparison. Front Hum Neurosci. 2019;13:420.

Article  PubMed  PubMed Central  Google Scholar 

Oveisgharan S, Karimi Z, Abdi S, Sikaroodi H. Iranian Journal of Neurology © 2019 The use of brain stimulation in the rehabilitation of walking disability in patients with multiple sclerosis: A randomized double-blind clinical trial study Iranian Journal of Neurology Brain stimulation in multiple sclerosis [Internet]. Iran J Neurol. 2019. Available from: http://ijnl.tums.ac.ir.

Pilloni G, Choi C, Coghe G, Cocco E, Krupp LB, Pau M, et al. Gait and Functional mobility in multiple sclerosis: Immediate effects of Transcranial Direct Current Stimulation (tDCS) paired with Aerobic Exercise. Front Neurol. 2020;11:310.

Article  PubMed  PubMed Central  Google Scholar 

Pilloni G, Choi C, Shaw MT, Coghe G, Krupp L, Moffat M, et al. Walking in multiple sclerosis improves with tDCS: a randomized, double-blind, sham-controlled study. Ann Clin Transl Neurol. 2020;7:2310–9.

Article  PubMed  PubMed Central  Google Scholar 

Ehsani F, Ahmadi M, Masoudian N, Jaberzadeh S. Priming of postural training with cerebellar anodal transcranial direct current stimulation for its effects on postural balance and fear of falling in patients with multiple sclerosis: a randomized, double-blind, sham-controlled study. J Clin Neurosci. 2022;99:294–301.

Article  PubMed  Google Scholar 

Marotta N, De Sire A, Marinaro C, Moggio L, Inzitari MT, Russo I, et al. Efficacy of Transcranial Direct Current Stimulation (tDCS) on balance and gait in multiple sclerosis patients: a Machine Learning Approach. J Clin Med. 2022;11:3505.

Article  PubMed  PubMed Central  Google Scholar 

Rahimibarghani S, Azadvari M, Emami-Razavi SZ, Harirchian MH, Rahimi-Dehgolan S, Fateh HR. Effects of Nonconsecutive Sessions of Transcranial Direct Current Stimulation and Stationary Cycling on walking capacity in individuals with multiple sclerosis. Int J MS Care. 2022;24:202–8.

Article  PubMed  PubMed Central  Google Scholar 

Mohammadkhanbeigi S, Moghadas Tabrizi Y, Nabavi SM, Minoonejad H. The comparable effect of tDCS and core exercises on Balance and mobility in patients with multiple sclerosis. Iran Rehabilitation J. 2023;20:569–78.

Article  Google Scholar 

Baroni A, Magro G, Martinuzzi C, Brondi L, Masiero S, Milani G, et al. Combined effects of cerebellar tDCS and task-oriented circuit training in people with multiple sclerosis: a pilot randomized control trial. Restor Neurol Neurosci. 2022;40:85–95.

PubMed  Google Scholar 

Nguemeni C, Hiew S, Kögler S, Homola GA, Volkmann J, Zeller D. Split-Belt Training but not cerebellar Anodal tDCS improves Stability Control and reduces risk of fall in patients with multiple sclerosis. Brain Sci. 2021;12:63.

Article  PubMed  PubMed Central  Google Scholar 

Iodice R, Dubbioso R, Ruggiero L, Santoro L, Manganelli F. Anodal transcranial direct current stimulation of motor cortex does not ameliorate spasticity in multiple sclerosis. Restor Neurol Neurosci. 2015;33:487–92.

PubMed  Google Scholar 

Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol. 2018;17:162–73.

Article  PubMed  Google Scholar 

Meyer-Moock S, Feng YS, Maeurer M, Dippel FW, Kohlmann T. Systematic literature review and validity evaluation of the expanded disability status scale (EDSS) and the multiple sclerosis functional composite (MSFC) in patients with multiple sclerosis. BMC Neurol. 2014;14:58.

Article  PubMed  PubMed Central 

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