Andell P, Li X, Martinsson A, Andersson C, Stagmo M, Zoller B, et al. Epidemiology of valvular heart disease in a Swedish nationwide hospital-based register study. Heart. 2017;103(21):1696–703.

Article  PubMed  Google Scholar 

Goody PR, Hosen MR, Christmann D, Niepmann ST, Zietzer A, Adam M, et al. Aortic valve stenosis: from basic mechanisms to novel therapeutic targets. Arterioscler Thromb Vasc Biol. 2020;40(4):885–900.

Article  CAS  PubMed  Google Scholar 

Vahanian A, Beyersdorf F, Praz F, Milojevic M, Baldus S, Bauersachs J, et al. 2021 ESC/EACTS guidelines for the management of valvular heart disease. Eur Heart J. 2022;43(7):561–632.

Article  PubMed  Google Scholar 

Gendron N, Rosa M, Blandinieres A, Sottejeau Y, Rossi E, Van Belle E, et al. Human aortic valve interstitial cells display proangiogenic properties during calcific aortic valve disease. Arterioscler Thromb Vasc Biol. 2021;41(1):415–29.

CAS  PubMed  Google Scholar 

Maffeis C, Rossi A, Faggiano P. Aortic valve stenosis burden: where we are now? Int J Cardiol. 2021;339:128–9.

Article  PubMed  Google Scholar 

Bienjonetti-Boudreau D, Fleury MA, Voisine M, Paquin A, Chouinard I, Tailleur M, et al. Impact of sex on the management and outcome of aortic stenosis patients. Eur Heart J. 2021;42(27):2683–91.

Article  PubMed  Google Scholar 

DesJardin JT, Chikwe J, Hahn RT, Hung JW, Delling FN. Sex differences and similarities in valvular heart disease. Circ Res. 2022;130(4):455–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Matilla L, Garaikoetxea M, Arrieta V, Garcia-Pena A, Fernandez-Celis A, Navarro A, et al. Sex-differences in aortic stenosis: mechanistic insights and clinical implications. Front Cardiovasc Med. 2022;9:818371.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Simard L, Cote N, Dagenais F, Mathieu P, Couture C, Trahan S, et al. Sex-related discordance between aortic valve calcification and hemodynamic severity of aortic stenosis: is valvular fibrosis the explanation? Circ Res. 2017;120(4):681–91.

Article  CAS  PubMed  Google Scholar 

Matilla L, Martin-Nunez E, Garaikoetxea M, Navarro A, Vico JA, Arrieta V, et al. Characterization of the sex-specific pattern of angiogenesis and lymphangiogenesis in aortic stenosis. Front Cardiovasc Med. 2022;9:971802.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Calvier L, Miana M, Reboul P, Cachofeiro V, Martinez-Martinez E, de Boer RA, et al. Galectin-3 mediates aldosterone-induced vascular fibrosis. Arterioscler Thromb Vasc Biol. 2013;33(1):67–75.

Article  CAS  PubMed  Google Scholar 

Halimi H, Rigato A, Byrne D, Ferracci G, Sebban-Kreuzer C, ElAntak L, et al. Glycan dependence of Galectin-3 self-association properties. PLoS ONE. 2014;9(11):e111836.

Article  PubMed  PubMed Central  Google Scholar 

Iacobini C, Fantauzzi CB, Pugliese G, Menini S. Role of Galectin-3 in bone cell differentiation, bone pathophysiology and vascular osteogenesis. Int J Mol Sci. 2017;18(11):2481.

Article  PubMed  PubMed Central  Google Scholar 

Martinez-Martinez E, Brugnolaro C, Ibarrola J, Ravassa S, Buonafine M, Lopez B, et al. CT-1 (Cardiotrophin-1)-Gal-3 (Galectin-3) axis in cardiac fibrosis and inflammation. Hypertension. 2019;73(3):602–11.

Article  CAS  PubMed  Google Scholar 

Sadaba JR, Martinez-Martinez E, Arrieta V, Alvarez V, Fernandez-Celis A, Ibarrola J, et al. Role for Galectin-3 in calcific aortic valve stenosis. J Am Heart Assoc. 2016;5(11):e004360.

Article  PubMed  PubMed Central  Google Scholar 

Luo J, Wang S, Liu X, Zheng Q, Wang Z, Huang Y, et al. Galectin-3 promotes calcification of human aortic valve interstitial cells via the NF-kappa B signaling pathway. Cardiovasc Diagn Ther. 2022;12(2):196–207.

Article  PubMed  PubMed Central  Google Scholar 

Ho JE, Liu C, Lyass A, Courchesne P, Pencina MJ, Vasan RS, et al. Galectin-3, a marker of cardiac fibrosis, predicts incident heart failure in the community. J Am Coll Cardiol. 2012;60(14):1249–56.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jackson AS, Stanforth PR, Gagnon J, Rankinen T, Leon AS, Rao DC, et al. The effect of sex, age and race on estimating percentage body fat from body mass index: the heritage family study. Int J Obes Relat Metab Disord. 2002;26(6):789–96.

Article  CAS  PubMed  Google Scholar 

Yang H, Lei C, Cheng C, Feng Y, Zhang W, Petracco RG, et al. The antiapoptotic effect of galectin-3 in human endometrial cells under the regulation of estrogen and progesterone. Biol Reprod. 2012;87(2):39.

Article  PubMed  Google Scholar 

Yang H, Taylor HS, Lei C, Cheng C, Zhang W. Hormonal regulation of galectin 3 in trophoblasts and its effects on endometrium. Reprod Sci. 2011;18(11):1118–27.

Article  CAS  PubMed  Google Scholar 

Meyer S, van der Meer P, van Deursen VM, Jaarsma T, van Veldhuisen DJ, van der Wal MH, et al. Neurohormonal and clinical sex differences in heart failure. Eur Heart J. 2013;34(32):2538–47.

Article  CAS  PubMed  Google Scholar 

Schindler EI, Szymanski JJ, Hock KG, Geltman EM, Scott MG. Short- and long-term biologic variability of Galectin-3 and other cardiac biomarkers in patients with stable heart failure and healthy adults. Clin Chem. 2016;62(2):360–6.

Article  CAS  PubMed  Google Scholar 

Neumann FJ, Sousa-Uva M, Ahlsson A, Alfonso F, Banning AP, Benedetto U, et al. 2018 ESC/EACTS guidelines on myocardial revascularization. Eur Heart J. 2019;40(2):87–165.

Article  PubMed  Google Scholar 

Latif N, Quillon A, Sarathchandra P, McCormack A, Lozanoski A, Yacoub MH, et al. Modulation of human valve interstitial cell phenotype and function using a fibroblast growth factor 2 formulation. PLoS ONE. 2015;10(6):e0127844.

Article  PubMed  PubMed Central  Google Scholar 

Collins BC, Hunter CL, Liu Y, Schilling B, Rosenberger G, Bader SL, et al. Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry. Nat Commun. 2017;8(1):291.

Article  PubMed  PubMed Central  Google Scholar 

Ferrer I, Andres-Benito P, Ausin K, Pamplona R, Del Rio JA, Fernandez-Irigoyen J, et al. Dysregulated protein phosphorylation: a determining condition in the continuum of brain aging and Alzheimer’s disease. Brain Pathol. 2021;31(6):e12996.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shilov IV, Seymour SL, Patel AA, Loboda A, Tang WH, Keating SP, et al. The Paragon Algorithm, a next generation search engine that uses sequence temperature values and feature probabilities to identify peptides from tandem mass spectra. Mol Cell Proteomics. 2007;6(9):1638–55.

Article  CAS  PubMed  Google Scholar 

Tang WH, Shilov IV, Seymour SL. Nonlinear fitting method for determining local false discovery rates from decoy database searches. J Proteome Res. 2008;7(9):3661–7.

Article  CAS  PubMed  Google Scholar 

Gillet LC, Navarro P, Tate S, Rost H, Selevsek N, Reiter L, et al. Targeted data extraction of the MS/MS spectra generated by data-independent acquisition: a new concept for consistent and accurate proteome analysis. Mol Cell Proteomics. 2012;11(6):O111016717.

Article  Google Scholar 

Tyanova S, Temu T, Sinitcyn P, Carlson A, Hein MY, Geiger T, et al. The Perseus computational platform for comprehensive analysis of (prote)omics data. Nat Methods. 2016;13(9):731–40.

Article  CAS  PubMed  Google Scholar 

Jover E, Matilla L, Garaikoetxea M, Fernandez-Celis A, Muntendam P, Jaisser F, et al. Beneficial effects of mineralocorticoid receptor pathway blockade against endothelial inflammation induced by SARS-CoV-2 spike protein. Biomedicines. 2021;9(6):639.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Summerhill VI, Moschetta D, Orekhov AN, Poggio P, Myasoedova VA. Sex-specific features of calcific aortic valve disease. Int J Mol Sci. 2020;21(16):5620.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Voisine M, Hervault M, Shen M, Boilard AJ, Filion B, Rosa M, et al. Age, sex, and valve phenotype differences in fibro-calcific remodeling of calcified aortic valve. J Am Heart Assoc. 2020;9(10):e015610.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McCoy CM, Nicholas DQ, Masters KS. Sex-related differences in gene expression by porcine aortic valvular interstitial cells. PLoS ONE. 2012;7(7):e39980.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nelson V, Patil V, Simon LR, Schmidt K, McCoy CM, Masters KS. Angiogenic secretion profile of valvular interstitial cells varies with cellular sex and phenotype. Front Cardiovasc Med. 2021;8:736303.

Article  CAS  PubMed  PubMed Central