Obesity and its comorbidities, current treatment options and future perspectives: Challenging bariatric surgery?

AGB

adjustable gastric banding

AgRP

agouti-related peptide

ATM

adipose tissue macrophages

ATP

adenosine triphosphate

BAIBA

β-aminoisobutyric acid

BPD

bilio-pancreatic diversion

CVD

cardiovascular disease

DMH

dorso-medial hypothalamus

DPP-IV

dipeptidyl peptidase 4

FDA

Food and Drug Administration (U.S.)

FGF21

fibroblast growth factor 21

FGFR

fibroblast growth factor receptor

FNDC4

fibronectin type III domain-containing protein 4

GDF15

growth differentiation factor-15

GIP

glucose-dependent insulinotropic polypeptide

GIPR

gastric inhibitory polypeptide receptors

GLP-1

glucagon-like peptide 1

GLP1R

gastric inhibitory polypeptide 1 receptor

HCC

hepatocellular carcinoma

HFpEF

heart failure with preserved ejection fraction

HFrEF

heart failure with reduced ejection fraction

HPA

hypothalamic–pituitary–adrenal

IR-61

near-infrared fluorophore

MACE

major adverse cardiovascular events

MC4R

melanocortin-4 receptor

NAFLD

non alcoholic fatty liver disease

NASH

non-alcoholic steatohepatitis

nNOS

nitric oxide synthase

NPY2R

neuropeptide Y2 receptor

NYHA

New York Heart Association

POMC

pro-hormone proopiomelanocortin

PVN

paraventricular nucleus

RCT

randomized controlled trial

ROS

reactive oxygen species

RYGB

Roux-en-Y gastric bypass

SGLT

sodium-glucose co-transporter

SGLT2i

sodium-glucose co-transporter 2 inhibitors

T2DM

type 2 diabetes mellitus

TGF

transforming growth factor

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