Psilocybin for dementia prevention? The potential role of psilocybin to alter mechanisms associated with major depression and neurodegenerative diseases

5-HT2aR

5-Hydroxytryptamine (Serotonin) Receptor 2 A

AHN

Adult hippocampal neurogenesis

ALS

Amyotrophic Lateral Sclerosis

BDNF

Brain-Derived Neurotrophic Factor

CANTAB

Cambridge Neuropsychological Test Automated Battery

CCL2Chemokine (Csingle bondC Motif) Ligand 2CCR5

C-C chemokine receptor type 5

CD33

CD33 Molecule (a marker often found on certain immune cells)

CNS

Central Nervous System

DAMP

damage-associated molecular patterns

DLB

Dementia with Lewy Bodies

fAD

Familial Alzheimer's Disease

FKBP5

FK506 Binding Protein 5

FTD

Frontotemporal Dementia

GPCR

G-Protein Coupled Receptor

Gq

G-protein (stimulatory)

GR

Glucocorticoid Receptor

hAPP

Human Amyloid Precursor Protein

HPA

hypothalamic-pituitary-adrenal axis

HuC/HuD

Neuronal proteins (markers of mature neurons)

ICD

International Classification of Diseases

IDO

Indoleamine 2,3-dioxygenase

IL-1α

Interleukin-1 alpha

LSD

Lysergic acid diethylamide

MAOIs

Monoamine Oxidase Inhibitors

MAP2

Microtubule-Associated Protein 2

MAST

Depending on context, could be Mast Cell or an acronym for other terms.

MCI

Mild cognitive impairment

MDD

major depressive disorder

MIF

Macrophage Migration Inhibitory Factor

MMSE

Mini-Mental State Examination

MRI

Magnetic resonance imaging

MRS

Magnetic Resonance Spectroscopy

NAD-299

NAD-299 - A specific serotonin receptor antagonist

NFT

Neurofibrillary Tangles

NMDAR

N-methyl-d-aspartate (NMDA) receptor

PAL

Paired Associate Learning (often associated with CANTAB)

P2Y12

Purinergic receptor P2Y, G-protein coupled, 12 protein

PAMP

Pathogen associated molecular patterns

PDD

Parkinson's Disease Dementia

PET

Positron Emission Tomography

PSA-NCAM

Polysialic Acid-Neural Cell Adhesion Molecule

PTSD

Post-Traumatic Stress Disorder

RCT

Randomized Controlled Trial

SERT

serotonin transporter

SGK1

Serum/glucocorticoid Regulated Kinase 1

SOX2

SRY-Box Transcription Factor 2

SNRI

Serotonin and norepinephrine reuptake inhibitors

SSRI

Selective serotonin reuptake inhibitors

STAT1

Signal Transducer and Activator of Transcription 1

suPAR

Soluble Urokinase Plasminogen Activator Receptor

TCAs

Tricyclic Antidepressants

TCB-2

(4-Bromo-3,6-dimethoxybenzocyclobuten-1-yl)methylamine hydrobromide

TKP

Tryptophan-kynurenine pathway

TMEM119

Transmembrane protein 119

TNFα

tumor necrosis factor alpha

TRD

Treatment-resistant depression

TREM

Triggering Receptor Expressed on Myeloid Cells

TrkB

Tropomyosin receptor kinase B

TSPO

Translocator Protein 18 kDa

WHO

World Health Organisation

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