Afshar S, Shahidi S, Rohani AH, Komaki A, Asl SS (2018) The effect of NAD-299 and TCB-2 on learning and memory, hippocampal BDNF levels and amyloid plaques in streptozotocin-induced memory deficits in male rats. Psychopharmacology 235:2809–2822
Article CAS PubMed Google Scholar
Alper K, Cange J, Sah R, Schreiber-Gregory D, Sershen H, Vinod KY (2023) Psilocybin sex-dependently reduces alcohol consumption in C57BL/6J mice. Front Pharmacol 13:1074633
Article PubMed PubMed Central Google Scholar
Barrett FS, Krimmel SR, Griffiths RR, Seminowicz DA, Mathur BN (2020) Psilocybin acutely alters the functional connectivity of the claustrum with brain networks that support perception, memory, and attention. Neuroimage 218:116980
Article CAS PubMed Google Scholar
Bogenschutz MP, Forcehimes AA, Pommy JA, Wilcox CE, Barbosa PC, Strassman RJ (2015) Psilocybin-assisted treatment for alcohol dependence: a proof-of-concept study. J Psychopharmacol 29:289–299
Article CAS PubMed Google Scholar
Carhart-Harris RL, Bolstridge M, Day CM, Rucker J, Watts R, Erritzoe DE, Kaelen M, Giribaldi B, Bloomfield M, Pilling S (2018) Psilocybin with psychological support for treatment-resistant depression: six-month follow-up. Psychopharmacology 235:399–408
Article CAS PubMed Google Scholar
Carhart-Harris R, Giribaldi B, Watts R, Baker-Jones M, Murphy-Beiner A, Murphy R, Martell J, Blemings A, Erritzoe D, Nutt DJ (2021) Trial of psilocybin versus escitalopram for depression. N Engl J Med 384:1402–1411
Article CAS PubMed Google Scholar
Carter OL, Burr DC, Pettigrew JD, Wallis GM, Hasler F, Vollenweider FX (2005) Using psilocybin to investigate the relationship between attention, working memory, and the serotonin 1A and 2A receptors. J Cogn Neurosci 17:1497–1508
Catlow BJ, Song S, Paredes DA, Kirstein CL, Sanchez-Ramos J (2013) Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning. Exp Brain Res 228:481–491
Article CAS PubMed Google Scholar
Cavanna F, Muller S, de la Fuente LA, Zamberlan F, Palmucci M, Janeckova L, Kuchar M, Pallavicini C, Tagliazucchi E (2022) Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study. Transl Psychiatry 12:307
Article PubMed PubMed Central Google Scholar
Davis AK, Barrett FS, May DG, Cosimano MP, Sepeda ND, Johnson MW, Finan PH, Griffiths RR (2021) Effects of psilocybin-assisted therapy on major depressive disorder: a randomized clinical trial. JAMA Psychiat 78:481–489
Di Giovanni G, De Deurwaerdère P (2018) TCB-2 [(7R)-3-bromo-2, 5-dimethoxy-bicyclo [4.2. 0] octa-1, 3, 5-trien-7-yl] methanamine]: a hallucinogenic drug, a selective 5-HT2A receptor pharmacological tool, or none of the above? Neuropharmacology 142:20–29
Dinis-Oliveira RJ (2017) Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance. Drug Metab Rev 49:84–91
Article CAS PubMed Google Scholar
Fadiman J, Krob S (2017) Microdosing: the phenomenon, research results, and startling surprises Lecture presented at the Psychedelic Science 2017 conference, Oakland, CA
Fitzpatrick CM, Maric VS, Bate ST, Andreasen JT (2018) Influence of intertrial interval on basal and drug-induced impulsive action in the 5-choice serial reaction time task: effects of d-amphetamine and (±)-2, 5-dimethoxy-4-iodoamphetamine (DOI). Neurosci Lett 662:351–355
Article CAS PubMed Google Scholar
Fletcher PJ, Tampakeras M, Sinyard J, Higgins GA (2007) Opposing effects of 5-HT 2A and 5-HT 2C receptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test. Psychopharmacology 195:223–234
Article CAS PubMed Google Scholar
Fox MA, French HT, LaPorte JL, Blackler AR, Murphy DL (2010) The serotonin 5-HT 2A receptor agonist TCB-2: a behavioral and neurophysiological analysis. Psychopharmacology 212:13–23
Article CAS PubMed Google Scholar
Frey PW, Colliver JA (1973) Sensitivity and responsivity measures for discrimination learning. Learn Motiv 4:327–342
Grandjean J, Buehlmann D, Buerge M, Sigrist H, Seifritz E, Vollenweider FX, Pryce CR, Rudin M (2021) Psilocybin exerts distinct effects on resting state networks associated with serotonin and dopamine in mice. Neuroimage 225:117456
Article CAS PubMed Google Scholar
Green DM, Swets JA (1966) Signal detection theory and psychophysics. Wiley, New York
Griffiths RR, Johnson MW, Carducci MA, Umbricht A, Richards WA, Richards BD, Cosimano MP, Klinedinst MA (2016) Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: a randomized double-blind trial. J Psychopharmacol 30:1181–1197
Article CAS PubMed PubMed Central Google Scholar
Halberstadt AL, Powell SB, Geyer MA (2013) Role of the 5-HT2A receptor in the locomotor hyperactivity produced by phenylalkylamine hallucinogens in mice. Neuropharmacology 70:218–227
Article CAS PubMed PubMed Central Google Scholar
Halberstadt AL, Chatha M, Klein AK, Wallach J, Brandt SD (2020) Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. Neuropharmacology 167:107933
Article CAS PubMed PubMed Central Google Scholar
Hesselgrave N, Troppoli TA, Wulff AB, Cole AB, Thompson SM (2021) Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice. Proc Natl Acad Sci 118:e2022489118
Article CAS PubMed PubMed Central Google Scholar
Higgins GA, Enderlin M, Haman M, Fletcher PJ (2003) The 5-HT 2A receptor antagonist M100,907 attenuates motor and ‘impulsive-type’ behaviours produced by NMDA receptor antagonism. Psychopharmacology 170:309–319
Article CAS PubMed Google Scholar
Higgins GA, Carroll NK, Brown M, MacMillan C, Silenieks LB, Thevarkunnel S, Izhakova J, Magomedova L, DeLannoy I, Sellers EM (2021) Low doses of psilocybin and ketamine enhance motivation and attention in poor performing rats: evidence for an antidepressant property. Front Pharmacol 12:640241
Article CAS PubMed PubMed Central Google Scholar
Hvoslef-Eide M, Mar A, Nilsson S, Alsiö J, Heath C, Saksida L, Robbins T, Bussey T (2015) The NEWMEDS rodent touchscreen test battery for cognition relevant to schizophrenia. Psychopharmacology 232:3853–3872
Article CAS PubMed Google Scholar
Hvoslef-Eide M, Nilsson SR, Hailwood JM, Robbins TW, Saksida LM, Mar AC, Bussey TJ (2018) Effects of anterior cingulate cortex lesions on a continuous performance task for mice. Brain and Neuroscience Advances 2:2398212818772962
Article PubMed PubMed Central Google Scholar
Johnson MW, Garcia-Romeu A, Cosimano MP, Griffiths RR (2014) Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction. J Psychopharmacol 28:983–992
Article PubMed PubMed Central Google Scholar
Kehne JH, Baron BM, Carr AA, Chaney SF, Elands J, Feldman DJ, Frank RA, Van Giersbergen P, McCloskey TC, Johnson MP (1996) Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile. J Pharmacol Exp Ther 277:968–981
Kim CH, Hvoslef-Eide M, Nilsson SR, Johnson MR, Herbert BR, Robbins TW, Saksida LM, Bussey TJ, Mar AC (2015) The continuous performance test (rCPT) for mice: a novel operant touchscreen test of attentional function. Psychopharmacology 232:3947–3966
Article CAS PubMed PubMed Central Google Scholar
Koskinen T, Ruotsalainen S, Puumala T, Lappalainen R, Koivisto E, Männistö PT, Sirviö J (2000a) Activation of 5-HT2A receptors impairs response control of rats in a five-choice serial reaction time task. Neuropharmacology 39:471–481
Article CAS PubMed Google Scholar
Koskinen T, Ruotsalainen S, Sirviö J (2000b) The 5-HT2 receptor activation enhances impulsive responding without increasing motor activity in rats. Pharmacol Biochem Behav 66:729–738
Article CAS PubMed Google Scholar
Koskinen T, Haapalinna A, Sirvi J (2003) α-Adrenoceptor-mediated modulation of 5-HT2 receptor agonist induced impulsive responding in a 5-choice serial reaction time task. Pharmacol Toxicol 92:214–225
Article CAS PubMed Google Scholar
Kuypers KP, Ng L, Erritzoe D, Knudsen GM, Nichols CD, Nichols DE, Pani L, Soula A, Nutt D (2019) Microdosing psychedelics: more questions than answers? An overview and suggestions for future research. J Psychopharmacol 33:1039–1057
Article CAS PubMed PubMed Central Google Scholar
Leung K-K, Lee TM, Yip P, Li LS, Wong MM (2009) Selective attention biases of people with depression: positive and negative priming of depression-related information. Psychiatry Res 165:241–251
Lewis CR, Preller KH, Braden BB, Riecken C, Vollenweider FX (2020) Rostral anterior cingulate thickness predicts the emotional psilocybin experience. Biomedicines 8:34
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