Mechanism of RhoA regulating benign prostatic hyperplasia: RhoA-ROCK-β-catenin signaling axis and static & dynamic dual roles

Alonso-Magdalena P, Brossner C, Reiner A, Cheng G, Sugiyama N, Warner M, Gustafsson JA. A role for epithelial-mesenchymal transition in the etiology of benign prostatic hyperplasia. Proc Natl Acad Sci U S A. 2009;106:2859–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Basant A, Glotzer M. Spatiotemporal regulation of RhoA during cytokinesis. Curr Biol. 2018;28:R570–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bauman TM, Vezina CM, Huang W, Marker PC, Peterson RE, Ricke WA. Beta-catenin is elevated in human benign prostatic hyperplasia specimens compared to histologically normal prostate tissue. Am J Clin Exp Urol. 2014;2:313–22.

PubMed  PubMed Central  Google Scholar 

Berry SJ, Coffey DS, Walsh PC, Ewing LL. The development of human benign prostatic hyperplasia with age. J Urol. 1984;132:474–9.

Article  CAS  PubMed  Google Scholar 

Buchsbaum RJ. Rho activation at a glance. J Cell Sci. 2007;120:1149–52.

Article  CAS  PubMed  Google Scholar 

Buttyan R, Sawczuk IS, Benson MC, Siegal JD, Olsson CA. Enhanced expression of the c-myc protooncogene in high-grade human prostate cancers. Prostate. 1987;11:327–37.

Article  CAS  PubMed  Google Scholar 

Cai Q, Chen F, Xu F, Wang K, Zhang K, Li G, Chen J, Deng H, He Q. Epigenetic silencing of microRNA-125b-5p promotes liver fibrosis in nonalcoholic fatty liver disease via integrin alpha8-mediated activation of RhoA signaling pathway. Metab Clin Exp. 2020;104: 154140.

Article  CAS  PubMed  Google Scholar 

Chen SY, Du Y, Song J. MicroRNA-340 inhibits epithelial-mesenchymal transition by impairing ROCK-1-dependent Wnt/beta-catenin signaling pathway in epithelial cells from human benign prostatic hyperplasia. Chin Med J (engl). 2018;131:2008–12.

Article  CAS  PubMed  Google Scholar 

Chughtai B, Forde JC, Thomas DD, Laor L, Hossack T, Woo HH, Te AE, Kaplan SA. Benign prostatic hyperplasia. Nat Rev Dis Primers. 2016;2:16031.

Article  PubMed  Google Scholar 

Doble BW, Woodgett JR. GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci. 2003;116:1175–86.

Article  CAS  PubMed  Google Scholar 

Fanto M, Weber U, Strutt DI, Mlodzik M. Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye. Curr Biol. 2000;10:979–88.

Article  CAS  PubMed  Google Scholar 

Gacci M, Eardley I, Giuliano F, Hatzichristou D, Kaplan SA, Maggi M, McVary KT, Mirone V, Porst H, Roehrborn CG. Critical analysis of the relationship between sexual dysfunctions and lower urinary tract symptoms due to benign prostatic hyperplasia. Eur Urol. 2011;60:809–25.

Article  PubMed  Google Scholar 

Gajate C, Mollinedo F. Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy. J Biol Chem. 2005;280:11641–7.

Article  CAS  PubMed  Google Scholar 

Habas R, Kato Y, He X. Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. Cell. 2001;107:843–54.

Article  CAS  PubMed  Google Scholar 

He W, Wang X, Zhan D, Li M, Wang Q, Liu J, Liu D, Fu X, Qian Q, Li Y, Chen P, Zeng G, Wang X, DiSanto ME, Zhang X. Changes in the expression and functional activities of Myosin II isoforms in human hyperplastic prostate. Clin Sci (lond). 2021;135:167–83.

Article  PubMed  Google Scholar 

Howe GA, Addison CL. RhoB controls endothelial cell morphogenesis in part via negative regulation of RhoA. Vasc Cell. 2012;4:1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang ZX, Mao XM, Wu RF, Huang SM, Ding XY, Chen QH, Chen QX. RhoA/ROCK pathway mediates the effect of oestrogen on regulating epithelial-mesenchymal transition and proliferation in endometriosis. J Cell Mol Med. 2020;24:10693–704.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jaffe AB, Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol. 2005;21:247–69.

Article  CAS  PubMed  Google Scholar 

Kim EH, Larson JA, Andriole GL. Management of benign prostatic hyperplasia. Annu Rev Med. 2016;67:137–51.

Article  CAS  PubMed  Google Scholar 

Kim JG, Kim MJ, Choi WJ, Moon MY, Kim HJ, Lee JY, Kim J, Kim SC, Kang SG, Seo GY, Kim PH, Park JB. Wnt3A induces GSK-3beta phosphorylation and beta-catenin accumulation through RhoA/ROCK. J Cell Physiol. 2017a;232:1104–13.

Article  CAS  PubMed  Google Scholar 

Kim JG, Kwon HJ, Wu G, Park Y, Lee JY, Kim J, Kim SC, Choe M, Kang SG, Seo GY, Kim PH, Park JB. RhoA GTPase oxidation stimulates cell proliferation via nuclear factor-kappaB activation. Free Radic Biol Med. 2017b;103:57–68.

Article  CAS  PubMed  Google Scholar 

Kim Y, Lee D, Jo H, Go C, Yang J, Kang D, Kang JS. GV1001 interacts with androgen receptor to inhibit prostate cell proliferation in benign prostatic hyperplasia by regulating expression of molecules related to epithelial-mesenchymal transition. Aging (albany NY). 2021;13:3202–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Knipe RS, Probst CK, Lagares D, Franklin A, Spinney JJ, Brazee PL, Grasberger P, Zhang L, Black KE, Sakai N, Shea BS, Liao JK, Medoff BD, Tager AM. The rho kinase isoforms ROCK1 and ROCK2 each contribute to the development of experimental pulmonary fibrosis. Am J Respir Cell Mol Biol. 2018;58:471–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lam M, Kerr KP, Exintaris B. Involvement of Rho-kinase signaling pathways in nerve evoked and spontaneous contractions of the Guinea pig prostate. J Urol. 2013;189:1147–54.

Article  CAS  PubMed  Google Scholar 

Leung T, Chen XQ, Manser E, Lim L. The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol Cell Bio. 1996;16:5313–27.

Article  CAS  Google Scholar 

Li S, Li C, Zhang Y, He X, Chen X, Zeng X, Liu F, Chen Y, Chen J. Targeting mechanics-induced fibroblast activation through cd44-rhoa-yap pathway ameliorates crystalline silica-induced silicosis. Theranostics. 2019;9:4993–5008.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu D, Mei X, Wang L, Yang X. RhoA inhibits apoptosis and increases proliferation of cultured SPCA1 lung cancer cells. Mol Med Rep. 2017;15:3963–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu J, Liu D, Zhang J, He W, Guo Y, Li Y, Chen P, DiSanto ME, Zhang X. Expression and functional activity of myosin II in hyperplastic prostates of varying volumes. Cell Signal. 2023;106: 110658.

Article  CAS  PubMed  Google Scholar 

Madaule P, Axel R. A novel ras-related gene family. Cell. 1985;41:31–40.

Article  CAS  PubMed  Google Scholar 

Madersbacher S, Sampson N, Culig Z. Pathophysiology of benign prostatic hyperplasia and benign prostatic enlargement: a mini-review. Gerontology. 2019;65:458–64.

Article  CAS  PubMed  Google Scholar 

Matsui T, Amano M, Yamamoto T, Chihara K, Nakafuku M, Ito M, Nakano T, Okawa K, Iwamatsu A, Kaibuchi K. Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO J. 1996;15:2208–16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Murillo-Garzon V, Kypta R. WNT signalling in prostate cancer. Nat Rev Urol. 2017;14:683–96.

Article  CAS  PubMed  Google Scholar 

Nagy B, Szendroi A, Romics I. Overexpression of CD24, c-myc and phospholipase 2A in prostate cancer tissue samples obtained by needle biopsy. Pathol Oncol Res. 2009;15:279–83.

Article  CAS  PubMed  Google Scholar 

Ohgushi M, Matsumura M, Eiraku M, Murakami K, Aramaki T, Nishiyama A, Muguruma K, Nakano T, Suga H, Ueno M, Ishizaki T, Suemori H, Narumiya S, Niwa H, Sasai Y. Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells. Cell Stem Cell. 2010;7:225–39.

Article  CAS  PubMed  Google Scholar 

Papadopoulou N, Charalampopoulos I, Alevizopoulos K, Gravanis A, Stournaras C. Rho/ROCK/actin signaling regulates membrane androgen receptor induced apoptosis in prostate cancer cells. Exp Cell Res. 2008;314:3162–74.

Article  CAS  PubMed  Google Scholar 

留言 (0)

沒有登入
gif