The mortality risk factors in B. cereus bacteremia in hematologic disorders are still unknown. In this study, patients with B. cereus bacteremia in hematologic disorders were selected in St. lukes international hospital and from electronic databases. A total of 176 patients [median age, 41 years (3–88 years); 99 (56%) males] were included. Of these patients, 141 (80%) had acute leukemia, and 93 (53%) died. Univariate analysis showed that neutropenia, CNS, gastrointestinal, and respiratory infections/symptoms were significantly associated with infection-related death. Meanwhile, glycopeptide use and management with source control were protective factors. Multivariate logistic regression analysis showed that infection-related death was significantly associated with CNS [odds ratio (OR): 3.49, 95% confidence interval (CI) 1.25–9.80], gastrointestinal (OR: 5.22, 95% CI 1.82–8.99), and respiratory infections/symptoms (OR: 8.98, 95% CI 1.62–49.9), as well as glycopeptide use (OR: 0.10, 95% CI 0.03–0.31) and source control (OR: 0.11, 95% CI 0.03–0.37). In conclusion, early glycopeptide administration and source control should be performed upon detection of infections suspicious for B. cereus.