American Psychiatric Association (APA). Diagnostic and statistical manual of mental disorders (DSM-5®). 2013.

Ecker C, Bookheimer SY, Murphy DGM. Neuroimaging in autism spectrum disorder: brain structure and function across the lifespan. Lancet Neurol. 2015;14(11):1121–34.

Article  PubMed  Google Scholar 

van Rooij D, Anagnostou E, Arango C, Auzias G, Behrmann M, Busatto GF, et al. Cortical and subcortical brain morphometry differences between patients with autism spectrum disorder and healthy individuals across the lifespan: results from the ENIGMA ASD working group. Am J Psychiatry. 2018;175(4):359–69.

Article  PubMed  Google Scholar 

Ecker C. The neuroanatomy of autism spectrum disorder: an overview of structural neuroimaging findings and their translatability to the clinical setting. Autism. 2017;21:18–28.

Article  PubMed  Google Scholar 

Leyfer OT, Folstein SE, Bacalman S, Davis NO, Dinh E, Morgan J, et al. Comorbid psychiatric disorders in children with autism: interview development and rates of disorders. J Autism Dev Disord. 2006;36(7):849–61.

Article  PubMed  Google Scholar 

Hanson E, Cerban BM, Slater CM, Caccamo LM, Bacic J, Chan E. Brief report: prevalence of attention deficit/hyperactivity disorder among individuals with an autism spectrum disorder. J Autism Dev Disord. 2013;43(6):1459–64.

Article  PubMed  Google Scholar 

Baker BL, Blacher J. Disruptive behavior disorders in adolescents with ASD: comparisons to youth with intellectual disability or typical cognitive development. J Ment Health Res Intellect Disabil. 2015;8(2):98–116.

Article  Google Scholar 

de Bruin EI, Ferdinand RF, Meester S, de Nijs PFA, Verheij F. High rates of psychiatric co-morbidity in PDD-NOS. J Autism Dev Disord. 2007;37(5):877–86.

Article  PubMed  Google Scholar 

Blakemore SJ. The social brain in adolescence. Nat Rev Neurosci. 2008;9(4):267–77.

Article  CAS  PubMed  Google Scholar 

Hoogman M, Bralten J, Hibar DP, Mennes M, Zwiers MP, Schweren LSJ, et al. Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis. Lancet Psychiatry. 2017;4(4):310–9.

Article  PubMed  PubMed Central  Google Scholar 

Faraone SV, Asherson P, Banaschewski T, Biederman J, Buitelaar JK, Ramos-Quiroga JA, et al. Attention-deficit/hyperactivity disorder. Nat Rev Dis Primers. 2015;1.

Hoogman M, Muetzel R, Guimaraes JP, Shumskaya E, Mennes M, Zwiers MP, et al. Brain imaging of the cortex in ADHD: a coordinated analysis of large-scale clinical and population-based samples. Am J Psychiatry. 2019;176(7):531–42.

Article  PubMed  PubMed Central  Google Scholar 

Brieber S, Neufang S, Bruning N, Kamp-Becker I, Remschmidt H, Herpertz-Dahlmann B, et al. Structural brain abnormalities in adolescents with autism spectrum disorder and patients with attention deficit/hyperactivity disorder. J Child Psychol Psychiatry. 2007;48(12):1251–8.

Article  PubMed  Google Scholar 

Park MTM, Raznahan A, Shaw P, Gogtay N, Lerch JP, Chakravarty MM. Neuroanatomical phenotypes in mental illness: identifying convergent and divergent cortical phenotypes across autism, ADHD and schizophrenia. J Psychiatry Neurosci. 2018;43(3):201–12.

Article  PubMed  PubMed Central  Google Scholar 

Mizuno Y, Kagitani-Shimono K, Jung M, Makita K, Takiguchi S, Fujisawa TX, et al. Structural brain abnormalities in children and adolescents with comorbid autism spectrum disorder and attention-deficit/hyperactivity disorder. Transl Psychiatry. 2019;9(1):332.

Article  PubMed  PubMed Central  Google Scholar 

Mahajan R, Dirlikov B, Crocetti D, Mostofsky SH. Motor circuit anatomy in children with autism spectrum disorder with or without attention deficit hyperactivity disorder. Autism Res. 2016;9(1):67–81.

Article  PubMed  Google Scholar 

Nickel K, Tebartz van Elst L, Manko J, Unterrainer J, Rauh R, Klein C, et al. Inferior frontal gyrus volume loss distinguishes between autism and (comorbid) attention-deficit/hyperactivity disorder—a FreeSurfer analysis in children. Front Psychiatry. 2018;9(October):1–11.

Google Scholar 

Ecker C, Murphy DGM. Neuroimaging in autism—from basic science to translational research. Nat Rev Neurol. 2014;10(2):82–91.

Article  PubMed  Google Scholar 

Huttenlocher PR. Synaptic density in human frontal cortex—developmental changes and effects of aging. Brain Res. 1979;163(2):195–205.

Article  CAS  PubMed  Google Scholar 

Nemani JK, Kostovi I, Nemani O. Prenatal and perinatal development of radial cell columns in the human auditory cortex. Acta Otolaryngol. 1984;97(5–6):489–95. https://doi.org/10.3109/00016488409132926.

Article  Google Scholar 

Rakic P. Neuronal migration and contact guidance in the primate telencephalon. Postgrad Med J. 1978;54(Suppl 1):25–40.

PubMed  Google Scholar 

Pretzsch CM, Floris DL, Schäfer T, Bletsch A, Gurr C, Lombardo MV, et al. Cross-sectional and longitudinal neuroanatomical profiles of distinct clinical (adaptive) outcomes in autism. Mol Psychiatry. 2023. https://www.nature.com/articles/s41380-023-02016-z.

Charman T, Loth E, Tillmann J, Crawley D, Wooldridge C, Goyard D, et al. The EU-AIMS Longitudinal European Autism Project (LEAP): clinical characterisation. Mol Autism. 2017;8(1):1–21.

Article  Google Scholar 

Wozniak RH, Leezenbaum NB, Northrup JB, West KL, Iverson JM. The development of autism spectrum disorders: variability and causal complexity. Wiley Interdiscip Rev Cogn Sci. 2017;8(1–2): e1426.

Article  Google Scholar 

Joon P, Kumar A, Parle M. What is autism? Pharmacol Rep. 2021;73(5):1255–64.

Article  PubMed  Google Scholar 

Luo Y, Weibman D, Halperin JM, Li X. A review of heterogeneity in attention deficit/hyperactivity disorder (ADHD). Front Hum Neurosci. 2019;11:13.

Google Scholar 

Hawrylycz MJ, Lein ES, Guillozet-Bongaarts AL, Shen EH, Ng L, Miller JA, et al. An anatomically comprehensive atlas of the adult human brain transcriptome. Nature. 2012;489(7416):391–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sandin S, Lichtenstein P, Kuja-Halkola R, Hultman CM, Larsson H, Reichenberg A. The heritability of autism spectrum disorder. JAMA. 2017;318(12):1182.

Article  PubMed  PubMed Central  Google Scholar 

Cross-Disorder Group of the Psychiatric Genomics Consortium. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet. 2013;45(9):984–94.

Article  PubMed Central  Google Scholar 

Geschwind DH. Genetics of autism spectrum disorders. Trends Cogn Sci. 2011;15(9):409–16.

Article  PubMed  PubMed Central  Google Scholar 

Gilman SR, Iossifov I, Levy D, Ronemus M, Wigler M, Vitkup D. Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses. Neuron. 2011;70(5):898–907.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huguet G, Benabou M, Bourgeron T. The genetics of autism spectrum disorders. In: Sassone-Corsi P, Christen Y, editors. A time for metabolism and hormones. Springer; 2016. p. 101–29.

Chapter  Google Scholar 

Demontis D, Walters GB, Athanasiadis G, Walters R, Therrien K, Farajzadeh L, et al. Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains. medRxiv. 2022;15:2022.02.14.22270780.

Cross-Disorder Group of the Psychiatric Genomics Consortium. Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders. Cell. 2019;179(7):1469-1482.e11.

Article  PubMed Central  Google Scholar 

Rommelse NNJ, Franke B, Geurts HM, Hartman CA, Buitelaar JK. Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder. Eur Child Adolesc Psychiatry. 2010;19(3):281–95.

Article  PubMed  PubMed Central  Google Scholar 

American Psychiatric Association (APA). Diagnostic and statistical manual of mental disorders. 1994.

Association AP. Diagnostic and statistical manual of mental disorders. 2000.

WH. O. The ICD-10 Classification of mental and behavioural disorders: diagnostic criteria for research. 1993;2013.

Dale AM, Fischl B, Sereno MI. Cortical surface-based analysis. Neuroimage. 1999;9(2):179–94.

Article  CAS  PubMed  Google Scholar 

Fischl B, Sereno MI, Dale AM. Cortical surface-based analysis. Neuroimage. 1999;9(2):195–207.

Article  CAS  PubMed  Google Scholar 

Ségonne F, Dale AM, Busa E, Glessner M, Salat D, Hahn HK, et al. A hybrid approach to the skull stripping problem in MRI. Neuroimage. 2004;22(3):1060–75.

Article  PubMed  Google Scholar 

Jovicich J, Czanner S, Greve D, Haley E, van der Kouwe A, Gollub R, et al. Reliability in multi-site structural MRI studies: effects of gradient non-linearity correction on phantom and human data. Neuroimage. 2006;30(2):436–43.

Article  PubMed  Google Scholar 

Fischl B, Dale AM. Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci. 2000;97(20):11050–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ecker C, Pretzsch CM, Bletsch A, Mann C, Schaefer T, Ambrosino S, et al. Interindividual differences in cortical thickness and their genomic underpinnings in autism spectrum disorder. Am J Psychiatry. 2021;(7):appi.ajp.2021.2.

Winkler AM, Sabuncu MR, Yeo BTT, Fischl B, Greve DN, Kochunov P, et al. Measuring and comparing brain cortical surface area and other areal quantities. Neuroimage. 2012;61(4):1428–43.

Article  PubMed  Google Scholar 

Gorgolewski1 KJ, Fox AS, Chang L et al. Tight fitting genes: finding relations between statistical maps and gene expression patterns [Internet]Hamburg. In: 2014. https://f1000research.com/posters/1097120.

Satterstrom FK, Kosmicki JA, Wang J, Breen MS, De Rubeis S, An JY, et al. Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism. Cell. 2020;180(3):568-584.e23.

Article  CAS  PubMed  PubMed Central