Network pharmacology-based anti-colorectal cancer activity of piperlonguminine in the ethanolic root extract of Piper longum L

Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. Cancer J Clinicians. 2018;68(1):7–30.

Article  Google Scholar 

Gupta R, Bhatt LK, Johnston TP, Prabhavalkar KS. Colon cancer stem cells: potential target for the treatment of colorectal cancer. Cancer Biol Ther. 2019;20(8):1068–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yaghoubi A, Khazaei M, Avan A, Hasanian SM, Soleimanpour S. The bacterial instrument as a promising therapy for colon cancer. Int J Colorectal Dis. 2020;35:595–606.

Article  PubMed  Google Scholar 

Gelibter AJ, Caponnetto S, Urbano F, Emiliani A, Scagnoli S, Sirgiovanni G, Napoli VM, Cortesi E. Adjuvant chemotherapy in resected colon cancer: when, how and how long? Surg Oncol. 2019;1(30):100–7.

Article  Google Scholar 

Singh I, Krishna R, Israr J, Kumar A. Determination of piperine in ethyl acetate extract of Piper longum root and evaluation of antioxidant, antibacterial activity. Biochem Cell Arch. 2023;23(1):189–94.

Article  Google Scholar 

Manoj P, Soniya EV, Banerjee NS, Ravichandran P. Recent studies on well-known spice, Piper longum Linn. Nat. Prod. Radiance 2004;3(4):222–27.

Google Scholar 

Singh I, Mishra HP, Kumar P, Kumar A. In-silico based identification of novel phytomolecules from Piper Longum for drug discovery against cox-2. J Drug Alcohol Res. 2023;12:11.

Google Scholar 

Salehi B, Zakaria ZA, Gyawali R, Ibrahim SA, Rajkovic J, Shinwari ZK, Khan T, Sharifi-Rad J, Ozleyen A, Turkdonmez E, Valussi M. Piper species: a comprehensive review on their phytochemistry, biological activities and applications. Molecules. 2019;24(7):1364.

Article  PubMed  PubMed Central  Google Scholar 

Kumar S, Kamboj J, Sharma S. Overview for various aspects of the health benefits of Piper longum linn fruit. J Acupuncture Meridian Studies. 2011;4(2):134–40.

Article  Google Scholar 

Chatterjee A, Dutta CP. Alkaloids of Piper longum Linn—I: structure and synthesis of piperlongumine and piperlonguminine. Tetrahedron. 1967;23(4):1769–81.

Article  CAS  PubMed  Google Scholar 

Zhu P, Qian J, Xu Z, Meng C, Liu J, Shan W, Zhu W, Wang Y, Yang Y, Zhang W, Zhang Y. Piperlonguminine and piperine analogues as TrxR inhibitors that promote ROS and autophagy and regulate p38 and Akt/mTOR signaling. J Nat Prod. 2020;83(10):3041–9.

Article  CAS  PubMed  Google Scholar 

Chandran U, Mehendale N, Tillu G, Patwardhan B. Network pharmacology of ayurveda formulation Triphala with special reference to anti-cancer property. Comb Chem High Throughput Screening. 2015;18(9):846–54.

Article  CAS  Google Scholar 

Bi YH, Zhang LH, Chen SJ, Ling QZ. Antitumor mechanisms of curcumae rhizoma based on network pharmacology. Evid-Based Complement Altern Med. 2018;2018:1–9.

Article  Google Scholar 

Hossain R, Quispe C, Herrera-Bravo J, Islam MS, Sarkar C, Islam MT, Martorell M, Cruz-Martins N, Al-Harrasi A, Al-Rawahi A, Sharifi-Rad J. Lasia spinosa chemical composition and therapeutic potential: a literature-based review. Oxid Med Cell Longev. 2021;28:2021.

Google Scholar 

Astani A, Reichling J, Schnitzler P. Melissa officinalis extract inhibits attachment of herpes simplex virus in vitro. Chemotherapy. 2012;58(1):70–7.

Article  CAS  PubMed  Google Scholar 

Sharifi-Rad J, Quispe C, Bouyahya A, El-Menyiy N, El-Omari N, Shahinozzaman M, Ara HaqueOvey M, Koirala N, Panthi M, Ertani A, Nicola S. Ethnobotany, phytochemistry, biological activities, and health-promoting effects of the genus Bulbophyllum. Evid-Based Complement Altern Med. 2022;2022:1–15.

Article  Google Scholar 

Dhyani P, Quispe C, Sharma E, Bahukhandi A, Sati P, Attri DC, Szopa A, Sharifi-Rad J, Docea AO, Mardare I, Calina D. Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine. Cancer Cell Int. 2022;22(1):1–20.

Article  Google Scholar 

Singh I, Krishna R, Ahmad K, Kumar A. Phytochemical characterization, antioxidant and antibacterial activity evaluation of ethanolic extract of Piper longum root. Biol Forum. 2023;15(2):94–101.

Google Scholar 

Ain QU, Khan H, Mubarak MS, Pervaiz A. Plant alkaloids as antiplatelet agent: drugs of the future in the light of recent developments. Front Pharmacol. 2016;22(7):292.

Google Scholar 

Das R, Agrawal S, Kumar P, Singh AK, Shukla PK, Bhattacharya I, Tiwari KN, Mishra SK, Tripathi AK. Network pharmacology of apigeniflavan: a novel bioactive compound of Trema orientalis Linn. in the treatment of pancreatic cancer through bioinformatics approaches. 3 Biotech. 2023;13(5):160.

Article  PubMed  Google Scholar 

Agrawal S, Das R, Singh AK, Kumar P, Shukla PK, Bhattacharya I, Tripathi AK, Mishra SK, Tiwari KN. Network pharmacology-based anti-pancreatic cancer potential of kaempferol and catechin of Trema orientalis L. through computational approach. Med Oncol. 2023;40(5):133.

Article  CAS  PubMed  Google Scholar 

Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev. 2012;1(64):4–17.

Article  Google Scholar 

Lipinski CA. Lead-and drug-like compounds: the rule-of-five revolution. Drug Discov Today Technol. 2004;1(4):337–41.

Article  CAS  PubMed  Google Scholar 

National Center for Biotechnology Information. PubChem Compound Summary for CID 5320621, Piperlonguminine, 2023. https://pubchem.ncbi.nlm.nih.gov/compound/Piperlonguminine. Accessed 29 June 2023.

Bird CW, Katritzky AR, editors. Comprehensive heterocyclic chemistry: the structure, reactions, synthesis and uses of heterocyclic compounds [in 8 volumes], vol. 4. Pergamon Press; 1984.

Google Scholar 

Arbyn M, Weiderpass E, Bruni L, de Sanjosé S, Saraiya M, Ferlay J, Bray F. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis. Lancet Glob Health. 2020;8(2):e191-203.

Article  PubMed  Google Scholar 

Hayes-Jordan AA, Sandler G, Malakorn S, Xiao LC, Kopetz S, Rodriquez-Bigas M. Colon cancer in patients under 25 years old: a different disease? J Am Coll Surg. 2020;230(4):648–56.

Article  PubMed  Google Scholar 

O’Keefe SJ, Li JV, Lahti L, Ou J, Carbonero F, Mohammed K, Posma JM, Kinross J, Wahl E, Ruder E, Vipperla K. Fat, fibre and cancer risk in African Americans and rural Africans. Nat Commun. 2015;6(1):1–4.

Article  Google Scholar 

Winawer SJ. The history of colorectal cancer screening: a personal perspective. Dig Dis Sci. 2015;60:596–608.

Article  PubMed  Google Scholar 

Ma Y, Yang W, Song M, Smith-Warner SA, Yang J, Li Y, Ma W, Hu Y, Ogino S, Hu FB, Wen D. Type 2 diabetes and risk of colorectal cancer in two large US prospective cohorts. Br J Cancer. 2018;119(11):1436–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kyu HH, Bachman VF, Alexander LT, Mumford JE, Afshin A, Estep K, Veerman JL, Delwiche K, Iannarone ML, Moyer ML, Cercy K. Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta-analysis for the global burden of disease study 2013. BMJ. 2016 Aug 9;354.

Gavrilas LI, Cruceriu D, Mocan A, Loghin F, Miere D, Balacescu O. Plant-derived bioactive compounds in colorectal cancer: insights from combined regimens with conventional chemotherapy to overcome drug-resistance. Biomedicines. 2022;10(8):1948.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ayez N, van der Stok EP, de Wilt H, Radema SA, van Hillegersberg R, Roumen RM, Vreugdenhil G, Tanis PJ, Punt CJ, Dejong CH, Jansen RL. Neo-adjuvant ch emotherapy followed by surgery versus surgery a lone in high-ris k patients with resectable colorectal liver m et a stases: the CHARISMA randomized multicenter clinical trial. BMC Cancer. 2015;15:1–7.

Article  CAS  Google Scholar 

Skarkova V, Kralova V, Vitovcova B, Rudolf E. Selected aspects of chemoresistance mechanisms in colorectal carcinoma—a focus on epithelial-to-mesenchymal transition, autophagy, and apoptosis. Cells. 2019;8(3):234.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gundogdu G, Dodurga Y, Elmas L, Tasci SY, Karaoglan ES. Investigation of the anticancer mechanism of isoorientin isolated from Eremurus spectabilis leaves via cell cycle pathways in HT-29 human colorectal adenocarcinoma cells. Eurasian J Med. 2018;50(3):168.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yoo E, Lee J, Lertpatipanpong P, Ryu J, Kim CT, Park EY, Baek SJ. Anti-proliferative activity of A. Oxyphylla and its bioactive constituent nootkatone in colorectal cancer cells. BMC Cancer. 2020;20(1):1–2.

Article  Google Scholar 

Li X, Chen M, Yao Z, Du H, Zhang T, Wang H, Xie Y, Li Z. Jujuboside B induces mitochondrial-dependent apoptosis in colorectal cancer through ROS-mediated PI3K/Akt pathway in vitro and in vivo. J Funct Foods. 2021;1(87):104796.

Article  Google Scholar 

Bartnik M, Sławińska-Brych A, Żurek A, Kandefer-Szerszeń M, Zdzisińska B. 8-methoxypsoralen reduces AKT phosphorylation, induces intrinsic and extrinsic apoptotic pathways, and suppresses cell growth of SK-N-AS neuroblastoma and SW620 metastatic colon cancer cells. J Ethnopharmacol. 2017;31(207):19–29.

Article  Google Scholar 

Mohamed GA, Al-Abd AM, El-Halawany AM, Abdallah HM, Ibrahim SR. New xanthones and cytotoxic constituents from Garcinia mangostana fruit hulls against human hepatocellular, breast, and colorectal cancer cell lines. J Ethnopharmacol. 2017;23(198):302–12.

Article  Google Scholar 

Windham TC, Parikh NU, Siwak DR, Summy JM, McConkey DJ, Kraker AJ, Gallick GE. Src activation regulates anoikis in human colon tumor cell lines. Oncogene. 2002;21(51):7797–807.

Article  CAS  PubMed  Google Scholar 

Chen J, Elfiky A, Han M, Chen C, Saif MW. The role of Src in colon cancer and its therapeutic implications. Clin Colorectal Cancer. 2014;13(1):5–13.

Article  PubMed  Google Scholar 

Vojtěchová M, Turečková J, Kučerová D, Šloncová E, Vachtenheim J, Tuháčková Z. Regulation of mTORC1 signaling by Src kinase activity is Akt1-independent in RSV-transformed cells. Neoplasia. 2008;10(2):99–107.

Article  PubMed  PubMed Central  Google Scholar 

Zou Z, Tao T, Li H, Zhu X. mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges. Cell Biosci. 2020;10(1):1–1.

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