Ge Y, Zhao R, Li B, et al. Aerobic glycolysis and tumor progression of hepatocellular carcinoma are mediated by ubiquitin of P53 K48-linked regulated by TRIM37. Exp Cell Res. 2022;421: 113377.
Cramer T. Impact of dietary carbohydrate restriction on the pathobiology of hepatocellular carcinoma: the gut-liver axis and beyond. Semin Immunol. 2023;101736.
Tilekar K, Upadhyay N, Iancu CV et al. Power of two: combination of therapeutic approaches involving glucose transporter (GLUT) inhibitors to combat cancer. Biochim Biophys Acta (BBA) Rev Cancer. 2020;1874:188457
Feng J, Li J, Wu L, et al. Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma. J Exp Clin Cancer Res. 2020;39:1–19.
Xia H, Chen J, Gao H, et al. Hypoxia-induced modulation of glucose transporter expression impacts 18 F-fluorodeoxyglucose PET-CT imaging in hepatocellular carcinoma. Eur J Nucl Med Mol Imaging. 2020;47:787–97.
Abbaszadeh Z, Çeşmeli S, Avcı ÇB. Crucial players in glycolysis: cancer progress. Gene. 2020;726: 144158.
Liang B, Jiang Y, Song S, et al. ASPP2 suppresses tumour growth and stemness characteristics in HCC by inhibiting Warburg effect via WNT/β-catenin/HK2 axis. J Cell Mol Med. 2023;27:659–71.
Cossu V, Bonanomi M, Bauckneht M, et al. Two high-rate pentose-phosphate pathways in cancer cells. Sci Rep. 2020;10:22111.
Mukherjee S, Bhatti GK, Chhabra R, et al. Targeting mitochondria as a potential therapeutic strategy against chemoresistance in cancer. Biomed Pharmacother. 2023;160: 114398.
Zaidi S, Gandhi J, Joshi G, et al. The anticancer potential of metformin on prostate cancer. Prostate Cancer Prostatic Dis. 2019;22:351–61.
Wu W, Dang S, Feng Q, et al. MicroRNA-542-3p inhibits the growth of hepatocellular carcinoma cells by targeting FZD7/Wnt signaling pathway. Biochem Biophys Res Commun. 2017;482:100–5.
Chadt A, Al-Hasani H. Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease. Pflügers Arch J Physiol. 2020;472:1273–98.
Choi BY. Biochemical basis of anti-cancer-effects of phloretin—a natural dihydrochalcone. Molecules. 2019;24:278.
Shiratori R, Furuichi K, Yamaguchi M, et al. Glycolytic suppression dramatically changes the intracellular metabolic profile of multiple cancer cell lines in a mitochondrial metabolism-dependent manner. Sci Rep. 2019;9:1–15.
Grasmann G, Smolle E, Olschewski H, Leithner K. Gluconeogenesis in cancer cells–repurposing of a starvation-induced metabolic pathway? Biochim Biophys Acta (BBA)-Rev Cancer. 2019;1872:24–36
Montal ED, Dewi R, Bhalla K, et al. PEPCK coordinates the regulation of central carbon metabolism to promote cancer cell growth. Mol Cell. 2015;60:571–83.
Lee Y-S, Lee E-K, Oh H-H et al. Sodium meta-arsenite ameliorates hyperglycemia in obese diabetic db/db mice by inhibition of hepatic gluconeogenesis. J Diabetes Res. 2014.
Wang XL, Herzog B, Waltner-Law M, et al. The synergistic effect of dexamethasone and all-trans-retinoic acid on hepatic phosphoenolpyruvate carboxykinase gene expression involves the coactivator p300. J Biol Chem. 2004;279:34191–200.
Pathak S, Kumar Das J, Jyoti Biswas S, Khuda-Bukhsh AR. Protective potentials of a potentized homeopathic drug, Lycopodium-30, in ameliorating azo dye induced hepatocarcinogenesis in mice. Mol Cell Biochem. 2006;285:121–31.
Mariadoss AVA, Vinyagam R, Rajamanickam V, et al. Pharmacological aspects and potential use of phloretin: a systemic review. Mini Rev Med Chem. 2019;19:1060–7.
Shang F, Liu M, Li B, et al. The anti-angiogenic effect of dexamethasone in a murine hepatocellular carcinoma model by augmentation of gluconeogenesis pathway in malignant cells. Cancer Chemother Pharmacol. 2016;77:1087–96.
Elmetwalli A, Hashish SM, Hassan MG et al. Modulation of the oxidative damage, inflammation, and apoptosis-related genes by dicinnamoyl-L-tartaric acid in liver cancer. Naunyn Schmiedebergs Arch Pharmacol. 2023b;1–13.
Elmetwalli A, Diab T, Albalawi AN et al. Diarylheptanoids/sorafenib as a potential anticancer combination against hepatocellular carcinoma: the p53/MMP9 axis of action. Naunyn Schmiedebergs Arch Pharmacol. 2023a;1–17.
Attia AA, Salama AF, Eldiasty JG, et al. Amygdalin potentiates the anti-cancer effect of Sorafenib on Ehrlich ascites carcinoma and ameliorates the associated liver damage. Sci Rep. 2022;12:1–9.
Bancroft JD, Layton C. The hematoxylins and eosin. Bancroft’s Theory Pract Histol Tech. 2012;7:173–86.
El-Shehawy AA, Elmetwalli A, El-Far AH, et al. Thymoquinone, piperine, and sorafenib combinations attenuate liver and breast cancers progression: epigenetic and molecular docking approaches. BMC Complement Med Ther. 2023;23:1–21.
Nasser HM, El-Naggar SA, El-Sayed Rizk ME-SR, et al. Effect of sorafenib on liver biochemistry prior to vitamin B17 coadministration in ehrlich ascites carcinoma mice model: preliminary phase study. Biochem Lett. 2021;17:40–9.
Liu D, Song T. Changes in and challenges regarding the surgical treatment of hepatocellular carcinoma in China. Biosci Trends. 2021;15:142–7.
He Z, Chen Q, He W, et al. Hepatocellular carcinoma subtypes based on metabolic pathways reveals potential therapeutic targets. Front Oncol. 2023;13:1086604.
Bian X, Chen H, Yang P, et al. Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation. Nat Commun. 2017;8:14420.
Tian H, Zhu X, Lv Y, et al. Glucometabolic reprogramming in the hepatocellular carcinoma microenvironment: cause and effect. Cancer Manag Res. 2020;12:5957.
Wang Z, Dong C. Gluconeogenesis in cancer: function and regulation of PEPCK, FBPase, and G6Pase. Trends Cancer. 2019;5:30–45.
Biswas SJ, Gorain S, Patra M et al. Evaluating the chemopreventive properties of aqueous seed extract of trigonella foenum graecum against p-dimethylaminoazobenzene (p-DAB) induced carcinogenesis in mice. Fenugreek. 2021;6:481–502.
Un H, Ugan RA, Gurbuz MA, et al. Phloretin and phloridzin guard against cisplatin-induced nephrotoxicity in mice through inhibiting oxidative stress and inflammation. Life Sci. 2021;266: 118869.
Klueh U, Liu Z, Cho B, et al. Continuous glucose monitoring in normal mice and mice with prediabetes and diabetes. Diabetes Technol Ther. 2006;8:402–12.
Bai Q, Liu Y, Wang C-M et al. Hepatic but not intestinal FBP1 is required for fructose metabolism and tolerance. Endocrinology. 2023;164:bqad054.
Wu S, Zhang K, Liang Y, et al. Nano-enabled tumor Systematic energy exhaustion via zinc (II) interference mediated glycolysis inhibition and specific GLUT1 depletion. Adv Sci. 2022;9:2103534.
Saraei P, Asadi I, Kakar MA, Moradi-Kor N. The beneficial effects of metformin on cancer prevention and therapy: a comprehensive review of recent advances. Cancer Manag Res. 2019;11:3295.
Sheng H, Niu B, Sun H. Metabolic targeting of cancers: from molecular mechanisms to therapeutic strategies. Curr Med Chem. 2009;16:1561–87.
George Thompson AM, Ursu O, Babkin P, et al. Discovery of a specific inhibitor of human GLUT5 by virtual screening and in vitro transport evaluation. Sci Rep. 2016;6:1–9.
Leone RD, Powell JD. Metabolism of immune cells in cancer. Nat Rev Cancer. 2020;20:516–31.
Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (80-). 2009;324:1029–33.
Park D-B. Metformin promotes apoptosis but suppresses autophagy in glucose-deprived H4IIE hepatocellular carcinoma cells. Diabetes Metab J. 2015;39:518–27.
Wei R, Mao L, Xu P, et al. Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models. Food Funct. 2018;9:5682–96.
Li H, Li X, Liu S, et al. Programmed cell death-1 (PD-1) checkpoint blockade in combination with a mammalian target of rapamycin inhibitor restrains hepatocellular carcinoma growth induced by hepatoma cell–intrinsic PD-1. Hepatology. 2017;66:1920–33.
Kang K, Wang X, Chen X, et al. Beclin 1 and nuclear factor-κBp65 are upregulated in hepatocellular carcinoma. Oncol Lett. 2013;5:1813–8.
Pierotti MA, Berrino F, Gariboldi M, et al. Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects. Oncogene. 2013;32:1475–87.
Nardone V, Barbarino M, Angrisani A, et al. CDK4, CDK6/cyclin-D1 complex inhibition and radiotherapy for cancer control: a role for autophagy. Int J Mol Sci. 2021;22:8391.
Costa RH, Kalinichenko VV, Holterman A-XL, Wang X. Transcription factors in liver development, differentiation, and regeneration. Hepatology. 2003;38:1331–47.
Karra AG, Tziortziou M, Kylindri P, et al. Boswellic acids and their derivatives as potent regulators of glucocorticoid receptor actions. Arch Biochem Biophys. 2020;695: 108656.
De Bosscher K, Vanden Berghe W, Haegeman G. The interplay between the glucocorticoid receptor and nuclear factor-κB or activator protein-1: molecular mechanisms for gene repression. Endocr Rev. 2003;24:488–522.
Sarkar D, Dutta D, Mandal SC, Bose S. Role of tea polyphenols in diabetes. Pharma Rev Sept. 2018;109–117.
Lin S-C, Chen M-C, Liu S, et al. Phloretin inhibits Zika virus infection by interfering with cellular glucose utilisation. Int J Antimicrob Agents. 2019;54:80–4.
Comments (0)