Alappat S, Zhang ZY, Chen YP (2003) Msx homeobox gene family and craniofacial development. Cell Res 13:429–442

Article  CAS  PubMed  Google Scholar 

Byers MR (1980) Development of sensory innervation in dentin. J Comp Neurol 191:413–427

Article  CAS  PubMed  Google Scholar 

Chen Z, Gao B, Zhou X (2012) Expression patterns of histone acetyltransferases p300 and CBP during murine tooth development. In Vitro Cell Dev Biol Anim 48:61–68

Article  PubMed  Google Scholar 

Chen AN, Luo Y, Yang YH, Fu JT, Geng XM, Shi JP, Yang J (2021) Lactylation, a Novel Metabolic Reprogramming Code: current status and prospects. Front Immunol 12:688910

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi H, Jin H, Kim JY, Lim KT, Choung HW, Park JY, Chung JH, Choung PH (2014) Hypoxia promotes CEMP1 expression and induces cementoblastic differentiation of human dental stem cells in an HIF-1-dependent manner. Tissue Eng Part A 20:410–423

Article  CAS  PubMed  Google Scholar 

Dai SK, Liu PP, Li X, Jiao LF, Teng ZQ, Liu CM (2022) Dynamic profiling and functional interpretation of histone lysine crotonylation and lactylation during neural development. Development 149

Guven G, Gunhan O, Akbulut E, Cehreli ZC (2007) Investigation of proliferative activity in the developing human tooth using Ki-67 immunostaining. Med Princ Pract 16:454–459

Article  PubMed  Google Scholar 

Hildebrand C, Fried K, Tuisku F, Johansson CS (1995) Teeth and tooth nerves. Prog Neurobiol 45:165–222

Article  CAS  PubMed  Google Scholar 

Jernvall J, Thesleff I (2000) Reiterative signaling and patterning during mammalian tooth morphogenesis. Mech Dev 92:19–29

Article  CAS  PubMed  Google Scholar 

Jernvall J, Kettunen P, Karavanova I, Martin LB, Thesleff I (1994) Evidence for the role of the enamel knot as a control center in mammalian tooth cusp formation: non-dividing cells express growth stimulating Fgf-4 gene. Int J Dev Biol 38:463–469

CAS  PubMed  Google Scholar 

Jernvall J, Aberg T, Kettunen P, Keränen S, Thesleff I (1998) The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot. Development 125:161–169

Article  CAS  PubMed  Google Scholar 

Jin H, Park JY, Choi H, Choung PH (2013) HDAC inhibitor trichostatin A promotes proliferation and odontoblast differentiation of human dental pulp stem cells. Tissue Eng Part A 19:613–624

Article  CAS  PubMed  Google Scholar 

Kettunen P, Løes S, Furmanek T, Fjeld K, Kvinnsland IH, Behar O, Yagi T, Fujisawa H, Vainio S, Taniguchi M, Luukko K (2005) Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfbeta1 regulate semaphorin 3a expression in the dental mesenchyme. Development 132:323–334

Article  CAS  PubMed  Google Scholar 

Kettunen P, Spencer-Dene B, Furmanek T, Kvinnsland IH, Dickson C, Thesleff I, Luukko K (2007) Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning. Mech Dev 124:868–883

Article  CAS  PubMed  Google Scholar 

Kim JJ, Kim SJ, Kim YS, Kim SY, Park SH, Kim EC (2012) The role of SIRT1 on angiogenic and odontogenic potential in human dental pulp cells. J Endod 38:899–906

Article  PubMed  Google Scholar 

Kimura S, Takeshita N, Oyanagi T, Seki D, Jiang W, Hidaka K, Fukumoto S, Takahashi I, Takano-Yamamoto T (2022) HIF-2α inhibits ameloblast differentiation via Hey2 in tooth development. J Dent Res 101:1637–1644

Article  CAS  PubMed  Google Scholar 

Kondo S, Tamura Y, Bawden JW, Tanase S (2001) The immunohistochemical localization of bax and Bcl-2 and their relation to apoptosis during amelogenesis in developing rat molars. Arch Oral Biol 46:557–568

Article  CAS  PubMed  Google Scholar 

Kouzarides T (2007) Chromatin modifications and their function. Cell 128:693–705

Article  CAS  PubMed  Google Scholar 

Lesot H, Brook AH (2009) Epithelial histogenesis during tooth development. Arch Oral Biol 54(Suppl 1):S25–33

Article  CAS  PubMed  Google Scholar 

Lumsden AG (1988) Spatial organization of the epithelium and the role of neural crest cells in the initiation of the mammalian tooth germ. Development 103:155–169

Article  PubMed  Google Scholar 

Mishina Y (2021a) Augmented BMP signaling commits cranial neural crest cells to a chondrogenic fate by suppressing autophagic β-catenin degradation. Sci Signal 14

Mohamed SS, Atkinson ME (1983) A histological study of the innervation of developing mouse teeth. J Anat 136:735–749

CAS  PubMed  PubMed Central  Google Scholar 

Moreno-Yruela C, Bæk M, Monda F, Olsen CA (2022a) Chiral posttranslational modification to lysine ε-Amino groups. Acc Chem Res 55:1456–1466

Article  CAS  PubMed  Google Scholar 

Moreno-Yruela C, Zhang D, Wei W, Bæk M, Liu W, Gao J, Danková D, Nielsen AL, Bolding JE, Yang L, Jameson ST, Wong J, Olsen CA, Zhao Y (2022b) Class I histone deacetylases (HDAC1-3) are histone lysine delactylases. Sci Adv 8:eabi6696

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mustonen T, Tümmers M, Mikami T, Itoh N, Zhang N, Gridley T, Thesleff I (2002) Lunatic fringe, FGF, and BMP regulate the notch pathway during epithelial morphogenesis of teeth. Dev Biol 248:281–293

Article  CAS  PubMed  Google Scholar 

Nian F, Qian Y, Xu F, Yang M, Wang H, Zhang Z (2022) LDHA promotes osteoblast differentiation through histone lactylation. Biochem Biophys Res Commun 615:31–35

Article  CAS  PubMed  Google Scholar 

Pagella P, Jiménez-Rojo L, Mitsiadis TA (2014) Roles of innervation in developing and regenerating orofacial tissues. Cell Mol Life Sci 71:2241–2251

Article  CAS  PubMed  Google Scholar 

Paino F, La Noce M, Tirino V, Naddeo P, Desiderio V, Pirozzi G, De Rosa A, Laino L, Altucci L, Papaccio G (2014) Histone deacetylase inhibition with valproic acid downregulates osteocalcin gene expression in human dental pulp stem cells and osteoblasts: evidence for HDAC2 involvement. Stem Cells 32:279–289

Article  CAS  PubMed  Google Scholar 

Pan L, Feng F, Wu J, Fan S, Han J, Wang S, Yang L, Liu W, Wang C, Xu K (2022) Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells. Pharmacol Res 181:106270

Article  CAS  PubMed  Google Scholar 

Sabari BR, Zhang D, Allis CD, Zhao Y (2017) Metabolic regulation of gene expression through histone acylations. Nat Rev Mol Cell Biol 18:90–101

Article  CAS  PubMed  Google Scholar 

Thesleff I, Keränen S, Jernvall J (2001) Enamel knots as signaling centers linking tooth morphogenesis and odontoblast differentiation. Adv Dent Res 15:14–18

Article  CAS  PubMed  Google Scholar 

Viriot L, Peterková R, Vonesch JL, Peterka M, Ruch JV, Lesot H (1997) Mouse molar morphogenesis revisited by three-dimensional reconstruction. III. Spatial distribution of mitoses and apoptoses up to bell-staged first lower molar teeth. Int J Dev Biol 41:679–690

CAS  PubMed  Google Scholar 

Yang J, Wan C, Nie S, Jian S, Sun Z, Zhang L, Chen Z (2013a) Localization of Beclin1 in mouse developing tooth germs: possible implication of the interrelation between autophagy and apoptosis. J Mol Histol 44:619–627

Article  CAS  PubMed  Google Scholar 

Yang JW, Zhu LX, Yuan GH, Chen YX, Zhang L, Zhang L, Chen Z (2013b) Autophagy appears during the development of the mouse lower first molar. Histochem Cell Biol 139:109–118

Article  CAS  PubMed  Google Scholar 

Yang J, Toda Nakamura M, Hallett SA, Ueharu H, Zhang H, Kelley K, Fukuda T, Komatsu Y, Mishina Y (2021b) Generation of a new mouse line with conditionally activated signaling through the BMP receptor, ACVR1: a tool to characterize pleiotropic roles of BMP functions. Genesis 59:e23419

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang W, Wang P, Cao P, Wang S, Yang Y, Su H, Nashun B (2021c) Hypoxic in vitro culture reduces histone lactylation and impairs pre-implantation embryonic development in mice. Epigenetics Chromatin 14:57

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang Z, Yan C, Ma J, Peng P, Ren X, Cai S, Shen X, Wu Y, Zhang S, Wang X, Qiu S, Zhou J, Fan J, Huang H, Gao Q (2023) Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma. Nat Metab 5:61–79

Article  CAS  PubMed  Google Scholar 

Yang J, Kitami M, Pan H, Nakamura MT, Zhang H, Liu F, Zhu L Komatsu Y, and

Zhang D, Tang Z, Huang H, Zhou G, Cui C, Weng Y, Liu W, Kim S, Lee S, Perez-Neut M, Ding J, Czyz D, Hu R, Ye Z, He M, Zheng YG, Shuman HA, Dai L, Ren B, Roeder RG, Becker L, Zhao Y (2019) Metabolic regulation of gene expression by histone lactylation. Nature 574:575–580

Article  CAS