Silenced-C5ar1 improved multiple organ injury in sepsis rats via inhibiting neutrophil extracellular trap

Bhan C, Dipankar P, Chakraborty P, Sarangi PP (2016) Role of cellular events in the pathophysiology of sepsis. Inflamm Res 65(11):853–868. https://doi.org/10.1007/s00011-016-0970-x

Article  CAS  PubMed  Google Scholar 

Brinkmann V, Zychlinsky A (2007) Beneficial suicide: why neutrophils die to make NETs. Nat Rev Microbiol 5(8):577–582. https://doi.org/10.1038/nrmicro1710

Article  CAS  PubMed  Google Scholar 

Bukong TN, Cho Y, Iracheta-Vellve A, Saha B, Lowe P, Adejumo A, Furi I, Ambade A, Gyongyosi B, Catalano D, Kodys K, Szabo G (2018) Abnormal neutrophil traps and impaired efferocytosis contribute to liver injury and sepsis severity after binge alcohol use. J Hepatol 69(5):1145–1154. https://doi.org/10.1016/j.jhep.2018.07.005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chakraborty S, Winkelmann VE, Braumüller S, Palmer A, Schultze A, Klohs B, Ignatius A, Vater A, Fauler M, Frick M, Huber-Lang M (2021) Role of the C5a–C5a receptor axis in the inflammatory responses of the lungs after experimental polytrauma and hemorrhagic shock. Sci Rep 11(1):2158. https://doi.org/10.1038/s41598-020-79607-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Colón DF, Wanderley CW, Franchin M, Silva CM, Hiroki CH, Castanheira FVS, Donate PB, Lopes AH, Volpon LC, Kavaguti SK, Borges VF, Speck-Hernandez CA, Ramalho F, Carlotti AP, Carmona F, Alves-Filho JC, Liew FY, Cunha FQ (2019) Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis. Crit Care 23(1):113. https://doi.org/10.1186/s13054-019-2407-8

Article  PubMed  PubMed Central  Google Scholar 

Czaikoski PG, Mota JM, Nascimento DC, Sônego F, Castanheira FV, Melo PH, Scortegagna GT, Silva RL, Barroso-Sousa R, Souto FO, Pazin-Filho A, Figueiredo F, Alves-Filho JC, Cunha FQ (2016) Neutrophil extracellular traps induce organ damage during experimental and clinical sepsis. PLoS ONE 11(2):e0148142. https://doi.org/10.1371/journal.pone.0148142

Article  CAS  PubMed  PubMed Central  Google Scholar 

Delano MJ, Ward PA (2016) The immune system’s role in sepsis progression, resolution, and long-term outcome. Immunol Rev 274(1):330–353. https://doi.org/10.1111/imr.12499

Article  CAS  PubMed  PubMed Central  Google Scholar 

Denk S, Taylor RP, Wiegner R, Cook EM, Lindorfer MA, Pfeiffer K, Paschke S, Eiseler T, Weiss M, Barth E, Lambris JD, Kalbitz M, Martin T, Barth H, Messerer DAC, Gebhard F, Huber-Lang MS (2017) Complement C5a-induced changes in neutrophil morphology during inflammation. Scand J Immunol 86(3):143–155. https://doi.org/10.1111/sji.12580

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ding Z, Du F, Averitt VR, Jakobsson G, Rönnow CF, Rahman M, Schiopu A, Thorlacius H (2021) Targeting S100A9 reduces neutrophil recruitment, inflammation and lung damage in abdominal sepsis. Int J Mol Sci 22:23. https://doi.org/10.3390/ijms222312923

Article  CAS  Google Scholar 

Du X, Zhang M, Zhou H, Wang W, Zhang C, Zhang L, Qu Y, Li W, Liu X, Zhao M, Tu K, Li YQ (2022) Decoy nanozymes enable multitarget blockade of proinflammatory cascades for the treatment of multi-drug-resistant bacterial sepsis. Research. https://doi.org/10.34133/2022/9767643

Article  PubMed  PubMed Central  Google Scholar 

Hawez A, Taha D, Algaber A, Madhi R, Rahman M, Thorlacius H (2022) MiR-155 regulates neutrophil extracellular trap formation and lung injury in abdominal sepsis. J Leukoc Biol 111(2):391–400. https://doi.org/10.1002/jlb.3a1220-789rr

Article  CAS  PubMed  Google Scholar 

Herrmann JB, Muenstermann M, Strobel L, Schubert-Unkmeir A, Woodruff TM, Gray-Owen SD, Klos A, Johswich KO (2018) Complement C5a receptor 1 exacerbates the pathophysiology of N meningitidis sepsis and is a potential target for disease treatment. mBio. https://doi.org/10.1128/mBio.01755-17

Article  PubMed  PubMed Central  Google Scholar 

Janicova A, Relja B (2021) Neutrophil phenotypes and functions in trauma and trauma-related sepsis. Shock 56(1):16–29. https://doi.org/10.1097/shk.0000000000001695

Article  CAS  PubMed  Google Scholar 

Kalbitz M, Fattahi F, Herron TJ, Grailer JJ, Jajou L, Lu H, Huber-Lang M, Zetoune FS, Sarma JV, Day SM, Russell MW, Jalife J, Ward PA (2016) Complement destabilizes cardiomyocyte function in vivo after polymicrobial sepsis and in vitro. J Immunol 197(6):2353–2361. https://doi.org/10.4049/jimmunol.1600091

Article  CAS  PubMed  Google Scholar 

Kovach MA, Standiford TJ (2012) The function of neutrophils in sepsis. Curr Opin Infect Dis 25(3):321–327. https://doi.org/10.1097/QCO.0b013e3283528c9b

Article  CAS  PubMed  Google Scholar 

Liao YL, Zhou XY, Ji MH, Qiu LC, Chen XH, Gong CS, Lin Y, Guo YH, Yang JJ (2021) S100A9 Upregulation contributes to learning and memory impairments by promoting microglia M1 polarization in sepsis survivor mice. Inflammation 44(1):307–320. https://doi.org/10.1007/s10753-020-01334-6

Article  CAS  PubMed  Google Scholar 

Liu S, Wang X, She F, Zhang W, Liu H, Zhao X (2021) Effects of neutrophil-to-lymphocyte ratio combined with interleukin-6 in predicting 28-day mortality in patients with sepsis. Front Immunol 12:639735

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mai SH, Khan M, Dwivedi DJ, Ross CA, Zhou J, Gould TJ, Gross PL, Weitz JI, Fox-Robichaud AE, Liaw PC (2015) Delayed but not early treatment with DNase reduces organ damage and improves outcome in a murine model of sepsis. Shock 44(2):166–172. https://doi.org/10.1097/shk.0000000000000396

Article  CAS  PubMed  Google Scholar 

Mastellos DC, Pires da Silva BGP, Fonseca BAL, Fonseca NP, Auxiliadora-Martins M, Mastaglio S, Ruggeri A, Sironi M, Radermacher P, Chrysanthopoulou A, Skendros P, Ritis K, Manfra I, Iacobelli S, Huber-Lang M, Nilsson B, Yancopoulou D, Connolly ES, Garlanda C, Ciceri F, Risitano AM, Calado RT, Lambris JD (2020) Complement C3 vs C5 inhibition in severe COVID-19: early clinical findings reveal differential biological efficacy. Clin Immunol 220:108598. https://doi.org/10.1016/j.clim.2020.108598

Article  CAS  PubMed  PubMed Central  Google Scholar 

Middleton EA, Rowley JW, Campbell RA, Grissom CK, Brown SM, Beesley SJ, Schwertz H, Kosaka Y, Manne BK, Krauel K, Tolley ND, Eustes AS, Guo L, Paine R 3, Harris ES, Zimmerman GA, Weyrich AS, Rondina MT (2019) Sepsis alters the transcriptional and translational landscape of human and murine platelets. Blood 134(12):911–923. https://doi.org/10.1182/blood.2019000067

Article  CAS  PubMed  PubMed Central  Google Scholar 

Monneret G, Finck ME, Venet F, Debard AL, Bohé J, Bienvenu J, Lepape A (2004) The anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentration. Immunol Lett 95(2):193–198. https://doi.org/10.1016/j.imlet.2004.07.009

Article  CAS  PubMed  Google Scholar 

Muenstermann M, Strobel L, Klos A, Wetsel RA, Woodruff TM, Köhl J, Johswich KO (2019) Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections. Virulence 10(1):677–694. https://doi.org/10.1080/21505594.2019.1640035

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ortiz-Espinosa S, Morales X, Senent Y, Alignani D, Tavira B, Macaya I, Ruiz B, Moreno H, Remírez A, Sainz C, Rodriguez-Pena A, Oyarbide A, Ariz M, Andueza MP, Valencia K, Teijeira A, Hoehlig K, Vater A, Rolfe B, Woodruff TM, Lopez-Picazo JM, Vicent S, Kochan G, Escors D, Gil-Bazo I, Perez-Gracia JL, Montuenga LM, Lambris JD, Ortiz de Solorzano C, Lecanda F, Ajona D, Pio R (2022) Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis. Cancer Lett 529:70–84. https://doi.org/10.1016/j.canlet.2021.12.027

Article  CAS  PubMed  Google Scholar 

Panacek EA, Marshall JC, Albertson TE, Johnson DH, Johnson S, MacArthur RD, Miller M, Barchuk WT, Fischkoff S, Kaul M, Teoh L, Van Meter L, Daum L, Lemeshow S, Hicklin G, Doig C (2004) Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab’)2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels. Crit Care Med 32(11):2173–2182. https://doi.org/10.1097/01.ccm.0000145229.59014.6c

Article  CAS  PubMed  Google Scholar 

Platt CD, Zaman F, Bainter W, Stafstrom K, Almutairi A, Reigle M, Weeks S, Geha RS, Chou J (2021) Efficacy and economics of targeted panel versus whole-exome sequencing in 878 patients with suspected primary immunodeficiency. J Allergy Clin Immunol 147(2):723–726. https://doi.org/10.1016/j.jaci.2020.08.022

Article  CAS  PubMed  Google Scholar 

Prokop JW, May T, Strong K, Bilinovich SM, Bupp C, Rajasekaran S, Worthey EA, Lazar J (2018) Genome sequencing in the clinic: the past, present, and future of genomic medicine. Physiol Genomics 50(8):563–579. https://doi.org/10.1152/physiolgenomics.00046.2018

Article  CAS  PubMed  PubMed Central  Google Scholar 

Riazuddin S, Hussain M, Razzaq A, Iqbal Z, Shahzad M, Polla DL, Song Y, van Beusekom E, Khan AA, Tomas-Roca L, Rashid M, Zahoor MY, Wissink-Lindhout WM, Basra MAR, Ansar M, Agha Z, van Heeswijk K, Rasheed F, Van de Vorst M, Veltman JA, Gilissen C, Akram J, Kleefstra T, Assir MZ, Grozeva D, Carss K, Raymond FL, O’Connor TD, Riazuddin SA, Khan SN, Ahmed ZM, de Brouwer APM, van Bokhoven H, Riazuddin S (2017) Exome sequencing of Pakistani consanguineous families identifies 30 novel candidate genes for recessive intellectual disability. Mol Psychiatry 22(11):1604–1614. https://doi.org/10.1038/mp.2016.109

Article  CAS  PubMed  Google Scholar 

Riedemann NC, Neff TA, Guo RF, Bernacki KD, Laudes IJ, Sarma JV, Lambris JD, Ward PA (2003) Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression. J Immunol 170(1):503–507. https://doi.org/10.4049/jimmunol.170.1.503

Article  CAS  PubMed  Google Scholar 

Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, Colombara DV, Ik

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