Sexual differences in locus coeruleus neurons and related behavior in C57BL/6J mice

Bangasser DA, Valentino RJ. Sex differences in stress-related psychiatric disorders: neurobiological perspectives. Front Neuroendocrinol. 2014;35(3):303–19.

Article  PubMed  PubMed Central  Google Scholar 

Bartley EJ, Fillingim RB. Sex differences in pain: a brief review of clinical and experimental findings. Br J Anaesth. 2013;111(1):52–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hamson DK, Roes MM, Galea LA. Sex hormones and cognition: neuroendocrine influences on memory and learning. Compr Physiol. 2016;6(3):1295–337.

Article  PubMed  Google Scholar 

Angst J, Gamma A, Gastpar M, Lépine JP, Mendlewicz J, Tylee A, et al. Gender differences in depression. Epidemiological findings from the European DEPRES I and II studies. Eur Arch Psychiatry Clin Neurosci. 2002;252(5):201–9.

Article  CAS  PubMed  Google Scholar 

Bekker MH, van Mens-Verhulst J. Anxiety disorders: sex differences in prevalence, degree, and background, but gender-neutral treatment. Gend Med. 2007;4:S178-93.

Article  PubMed  Google Scholar 

Dahlhamer J, Lucas J, Zelaya C, Nahin R, Mackey S, DeBar L, et al. Prevalence of chronic pain and high-impact chronic pain among adults—United States, 2016. MMWR Morb Mortal Wkly Rep. 2018;67(36):1001–6.

Article  PubMed  PubMed Central  Google Scholar 

Fillingim RB. Sex, gender, and pain: women and men really are different. Curr Rev Pain. 2000;4(1):24–30.

Article  CAS  PubMed  Google Scholar 

Gogos A, Ney LJ, Seymour N, Van Rheenen TE, Felmingham KL. Sex differences in schizophrenia, bipolar disorder, and post-traumatic stress disorder: are gonadal hormones the link? Br J Pharmacol. 2019;176(21):4119–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kendler KS, Kessler RC, Walters EE, MacLean C, Neale MC, Heath AC, et al. Stressful life events, genetic liability, and onset of an episode of major depression in women. Am J Psychiatry. 1995;152(6):833–42.

Article  CAS  PubMed  Google Scholar 

Baron-Cohen S, Knickmeyer RC, Belmonte MK. Sex differences in the brain: implications for explaining autism. Science. 2005;310(5749):819–23.

Article  CAS  PubMed  Google Scholar 

Mandy W, Chilvers R, Chowdhury U, Salter G, Seigal A, Skuse D. Sex differences in autism spectrum disorder: evidence from a large sample of children and adolescents. J Autism Dev Disord. 2012;42(7):1304–13.

Article  PubMed  Google Scholar 

Rucklidge JJ. Gender differences in attention-deficit/hyperactivity disorder. Psychiatr Clin North Am. 2010;33(2):357–73.

Article  PubMed  Google Scholar 

Bangasser DA, Wiersielis KR, Khantsis S. Sex differences in the locus coeruleus-norepinephrine system and its regulation by stress. Brain Res. 2016;1641(Pt B):177–88.

Article  CAS  PubMed  Google Scholar 

De Vries GJ, Simerly RB. Anatomy, development, and function of sexually dimorphic neural circuits in the mammalian brain. In: Pfaff DW, Arnold AP, Rubin RT, editors. Hormones, brain and behaviour. Amsterdam: Elsevier; 2002. p. 137– XXIX.

Chapter  Google Scholar 

Hutton LA, Gu G, Simerly RB. Development of a sexually dimorphic projection from the bed nuclei of the stria terminalis to the anteroventral periventricular nucleus in the rat. J Neurosci. 1998;18(8):3003–13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shah NM, Pisapia DJ, Maniatis S, Mendelsohn MM, Nemes A, Axel R. Visualizing sexual dimorphism in the brain. Neuron. 2004;43(3):313–9.

Article  CAS  PubMed  Google Scholar 

Yagi S, Galea LAM. Sex differences in hippocampal cognition and neurogenesis. Neuropsychopharmacology. 2019;44(1):200–13.

Article  PubMed  Google Scholar 

Schwarz LA, Luo L. Organization of the locus coeruleus-norepinephrine system. Curr Biol. 2015;25(21):R1051–6.

Article  CAS  PubMed  Google Scholar 

Aston-Jones G, Cohen JD. An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Annu Rev Neurosci. 2005;28:403–50.

Article  CAS  PubMed  Google Scholar 

Carter ME, Yizhar O, Chikahisa S, Nguyen H, Adamantidis A, Nishino S, et al. Tuning arousal with optogenetic modulation of locus coeruleus neurons. Nat Neurosci. 2010;13(12):1526–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li L, Feng X, Zhou Z, Zhang H, Shi Q, Lei Z, et al. Stress accelerates defensive responses to looming in mice and involves a locus coeruleus-superior colliculus projection. Curr Biol. 2018;28(6):859-71.e5.

Article  CAS  PubMed  Google Scholar 

McCall JG, Siuda ER, Bhatti DL, Lawson LA, McElligott ZA, Stuber GD, et al. Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior. Elife. 2017;6: e18247.

Article  PubMed  PubMed Central  Google Scholar 

Sara SJ. The locus coeruleus and noradrenergic modulation of cognition. Nat Rev Neurosci. 2009;10(3):211–23.

Article  CAS  PubMed  Google Scholar 

Waterhouse BD, Navarra RL. The locus coeruleus-norepinephrine system and sensory signal processing: a historical review and current perspectives. Brain Res. 2019;1709:1–15.

Article  CAS  PubMed  Google Scholar 

Bangasser DA, Zhang X, Garachh V, Hanhauser E, Valentino RJ. Sexual dimorphism in locus coeruleus dendritic morphology: a structural basis for sex differences in emotional arousal. Physiol Behav. 2011;103(3–4):342–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Van Bockstaele EJ, Bajic D, Proudfit H, Valentino RJ. Topographic architecture of stress-related pathways targeting the noradrenergic locus coeruleus. Physiol Behav. 2001;73(3):273–83.

Article  PubMed  Google Scholar 

Mulvey B, Bhatti DL, Gyawali S, Lake AM, Kriaucionis S, Ford CP, et al. Molecular and functional sex differences of noradrenergic neurons in the mouse locus coeruleus. Cell Rep. 2018;23(8):2225–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McLean AC, Valenzuela N, Fai S, Bennett SA. Performing vaginal lavage, crystal violet staining, and vaginal cytological evaluation for mouse estrous cycle staging identification. J Vis Exp. 2012;67: e4389.

Google Scholar 

Busquets-Garcia A, Puighermanal E, Pastor A, de la Torre R, Maldonado R, Ozaita A. Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses. Biol Psychiatry. 2011;70(5):479–86.

Article  CAS  PubMed  Google Scholar 

Hascoët M, Bourin M. A new approach to the light/dark test procedure in mice. Pharmacol Biochem Behav. 1998;60(3):645–53.

Article  PubMed  Google Scholar 

Suárez-Pereira I, García-Domínguez I, Bravo L, Santiago M, García-Revilla J, Espinosa-Oliva AM, et al. The absence of caspase-8 in the dopaminergic system leads to mild autism-like behavior. Front Cell Dev Biol. 2022;10: 839715.

Article  PubMed  PubMed Central  Google Scholar 

Deacon RM. Burrowing in rodents: a sensitive method for detecting behavioral dysfunction. Nat Protoc. 2006;1(1):118–21.

Article  CAS  PubMed  Google Scholar 

Humo M, Ayazgök B, Becker LJ, Waltisperger E, Rantamäki T, Yalcin I. Ketamine induces rapid and sustained antidepressant-like effects in chronic pain induced depression: role of MAPK signaling pathway. Prog Neuropsychopharmacol Biol Psychiatry. 2020;100: 109898.

Article  CAS  PubMed  Google Scholar 

Berrocoso E, Ikeda K, Sora I, Uhl GR, Sánchez-Blázquez P, Mico JA. Active behaviours produced by antidepressants and opioids in the mouse tail suspension test. Int J Neuropsychopharmacol. 2013;16(1):151–62.

Article  CAS  PubMed  Google Scholar 

Berrocoso E, Rojas-Corrales MO, Mico JA. Differential role of 5-HT1A and 5-HT1B receptors on the antinociceptive and antidepressant effect of tramadol in mice. Psychopharmacology. 2006;188(1):111–8.

Article  CAS  PubMed  Google Scholar 

Porsolt RD, Bertin A, Jalfre M. Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther. 1977;229(2):327–36.

CAS  PubMed  Google Scholar 

Suárez-Pereira I, Canals S, Carrión AM. Adult newborn neurons are involved in learning acquisition and long-term memory formation: the distinct demands on temporal neurogenesis of different cognitive tasks. Hippocampus. 2015;25(1):51–61.

Article  PubMed  Google Scholar 

Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat

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