Alarcon-Martinez L, Yilmaz-Ozcan S, Yemisci M, Schallek J, Kılıç K, Can A, Di Polo A, Dalkara T (2018) Capillary pericytes express α-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection. Elife 7. https://doi.org/10.7554/eLife.34861

Baluk P, McDonald DM (2018) Imaging lymphatics in mouse lungs. Methods Mol Biol 1846:161–180. https://doi.org/10.1007/978-1-4939-8712-2_11

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baluk P, Fuxe J, Hashizume H, Romano T, Lashnits E, Butz S, Vestweber D, Corada M, Molendini C, Dejana E, McDonald DM (2007) Functionally specialized junctions between endothelial cells of lymphatic vessels. J Exp Med 204:2349–2362. https://doi.org/10.1084/jem.20062596

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baluk P, Naikawadi RP, Kim S, Rodriguez F, Choi D, Hong YK, Wolters PJ, McDonald DM (2020) Lymphatic proliferation ameliorates Pulmonary Fibrosis after Lung Injury. Am J Pathol 190:2355–2375. https://doi.org/10.1016/j.ajpath.2020.08.018

Article  CAS  PubMed  PubMed Central  Google Scholar 

Banerji S, Ni J, Wang SX, Clasper S, Su J, Tammi R, Jones M, Jackson DG (1999) LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. J Cell Biol 144:789–801. https://doi.org/10.1083/jcb.144.4.789

Article  CAS  PubMed  PubMed Central  Google Scholar 

Belvisi MG (2002) Overview of the innervation of the lung. Curr Opin Pharmacol 2:211–215. https://doi.org/10.1016/s1471-4892(02)00145-5

Article  CAS  PubMed  Google Scholar 

Breslin JW, Yang Y, Scallan JP, Sweat RS, Adderley SP, Murfee WL (2018) Lymphatic Vessel Network structure and physiology. Compr Physiol 9:207–299. https://doi.org/10.1002/cphy.c180015

Article  PubMed  PubMed Central  Google Scholar 

Ebina M (2017) Pathognomonic remodeling of blood and lymphatic capillaries in idiopathic pulmonary fibrosis. Respir Investig 55:2–9. https://doi.org/10.1016/j.resinv.2016.08.005

Article  PubMed  Google Scholar 

Ebina M, Shibata N, Ohta H, Hisata S, Tamada T, Ono M, Okaya K, Kondo T, Nukiwa T (2010) The disappearance of subpleural and interlobular lymphatics in idiopathic pulmonary fibrosis. Lymphat Res Biol 8:199–207. https://doi.org/10.1089/lrb.2010.0008

Article  CAS  PubMed  Google Scholar 

El-Chemaly S, Malide D, Zudaire E, Ikeda Y, Weinberg BA, Pacheco-Rodriguez G, Rosas IO, Aparicio M, Ren P, MacDonald SD, Wu HP, Nathan SD, Cuttitta F, McCoy JP, Gochuico BR, Moss J (2009) Abnormal lymphangiogenesis in idiopathic pulmonary fibrosis with insights into cellular and molecular mechanisms. Proc Natl Acad Sci U S A 106:3958–3963. https://doi.org/10.1073/pnas.0813368106

Article  PubMed  PubMed Central  Google Scholar 

Folan-Curran J, Hickey K, Monkhouse WS (1994) Innervation of the rat external auditory meatus: a retrograde tracing study. Somatosens Mot Res 11:65–68. https://doi.org/10.3109/08990229409028858

Article  CAS  PubMed  Google Scholar 

Iijima T, Tagawa T (1976) Adrenergic and cholinergic innervation of the arteriovenous anastomosis in the rabbit’s ear. Anat Rec 185:373–380. https://doi.org/10.1002/ar.1091850309

Article  CAS  PubMed  Google Scholar 

Jurisic G, Detmar M (2009) Lymphatic endothelium in health and disease. Cell Tissue Res 335:97–108. https://doi.org/10.1007/s00441-008-0644-2

Article  CAS  PubMed  Google Scholar 

Kambouchner M, Bernaudin JF (2009) Intralobular pulmonary lymphatic distribution in normal human lung using D2-40 antipodoplanin immunostaining. J Histochem Cytochem 57:643–648. https://doi.org/10.1369/jhc.2009.953067

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim SH, Patil MJ, Hadley SH, Bahia PK, Butler SG, Madaram M, Taylor-Clark TE (2022) Mapping of the sensory innervation of the mouse lung by specific vagal and dorsal Root Ganglion neuronal subsets. eNeuro 9. https://doi.org/10.1523/eneuro.0026-22.2022

Lara AR, Cosgrove GP, Janssen WJ, Huie TJ, Burnham EL, Heinz DE, Curran-Everett D, Sahin H, Schwarz MI, Cool CD, Groshong SD, Geraci MW, Tuder RM, Hyde DM, Henson PM (2012) Increased lymphatic vessel length is associated with the fibroblast reticulum and disease severity in usual interstitial pneumonia and nonspecific interstitial pneumonia. Chest 142:1569–1576. https://doi.org/10.1378/chest.12-0029

Article  CAS  PubMed  PubMed Central  Google Scholar 

Le Cras TD, Goines J, Lakes N, Pastura P, Hammill AM, Adams DM, Boscolo E (2020) Constitutively active PIK3CA mutations are expressed by lymphatic and vascular endothelial cells in capillary lymphatic venous malformation. Angiogenesis 23:425–442. https://doi.org/10.1007/s10456-020-09722-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leak LV (1980) Lymphatic removal of fluids and particles in the mammalian lung. Environ Health Perspect 35:55–75. https://doi.org/10.1289/ehp.803555

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maby-El Hajjami H, Petrova TV (2008) Developmental and pathological lymphangiogenesis: from models to human disease. Histochem Cell Biol 130:1063–1078. https://doi.org/10.1007/s00418-008-0525-5

Article  CAS  PubMed  Google Scholar 

Mazzone SB, Undem BJ (2016) Vagal afferent innervation of the Airways in Health and Disease. Physiol Rev 96:975–1024. https://doi.org/10.1152/physrev.00039.2015

Article  CAS  PubMed  PubMed Central  Google Scholar 

McHale NG (1990) Lymphatic innervation. Blood Vessels 27:127–136. https://doi.org/10.1159/000158803

Article  CAS  PubMed  Google Scholar 

Mercante B, Ginatempo F, Manca A, Melis F, Enrico P, Deriu F (2018) Anatomo-physiologic basis for Auricular Stimulation. Med Acupunct 30:141–150. https://doi.org/10.1089/acu.2017.1254

Article  PubMed  PubMed Central  Google Scholar 

Ohtani O, Ohtani Y (2008) Organization and developmental aspects of lymphatic vessels. Arch Histol Cytol 71:1–22. https://doi.org/10.1679/aohc.71.1

Article  PubMed  Google Scholar 

Oliver G (2022) Lymphatic endothelial cell fate specification in the mammalian embryo: an historical perspective. Dev Biol 482:44–54. https://doi.org/10.1016/j.ydbio.2021.12.005

Article  CAS  PubMed  Google Scholar 

Pacheco-Rodriguez G, Glasgow CG, Ikeda Y, Steagall WK, Yu ZX, Tsukada K, Beasley BW, Gochuico BR, Erdag G, Lurain K, Sampaio De Melo M, Ramaswami R, Darling TN, Filie A, Moss J (2022) A mixed blood-lymphatic endothelial cell phenotype in lymphangioleiomyomatosis and idiopathic pulmonary fibrosis but not in Kaposi’s Sarcoma or Tuberous Sclerosis Complex. Am J Respir Cell Mol Biol 66:337–340. https://doi.org/10.1165/rcmb.2021-0293LE

Article  CAS  PubMed  Google Scholar 

Parra ER, Araujo CA, Lombardi JG, Ab’Saber AM, Carvalho CR, Kairalla RA, Capelozzi VL (2012) Lymphatic fluctuation in the parenchymal remodeling stage of acute interstitial pneumonia, organizing pneumonia, nonspecific interstitial pneumonia and idiopathic pulmonary fibrosis. Braz J Med Biol Res 45:466–472. https://doi.org/10.1590/s0100-879x2012007500055

Article  CAS  PubMed  PubMed Central  Google Scholar 

Randolph GJ, Angeli V, Swartz MA (2005) Dendritic-cell trafficking to lymph nodes through lymphatic vessels. Nat Rev Immunol 5:617–628. https://doi.org/10.1038/nri1670

Article  CAS  PubMed  Google Scholar 

Reed HO, Wang L, Sonett J, Chen M, Yang J, Li L, Aradi P, Jakus Z, D’Armiento J, Hancock WW, Kahn ML (2019) Lymphatic impairment leads to pulmonary tertiary lymphoid organ formation and alveolar damage. J Clin Invest 129:2514–2526. https://doi.org/10.1172/jci125044

Article  PubMed  PubMed Central  Google Scholar 

Scallan JP, Zawieja SD, Castorena-Gonzalez JA, Davis MJ (2016) Lymphatic pumping: mechanics, mechanisms and malfunction. J Physiol 594:5749–5768. https://doi.org/10.1113/jp272088

Article  CAS  PubMed  PubMed Central  Google Scholar 

Scavelli C, Weber E, Aglianò M, Cirulli T, Nico B, Vacca A, Ribatti D (2004) Lymphatics at the crossroads of angiogenesis and lymphangiogenesis. J Anat 204:433–449. https://doi.org/10.1111/j.0021-8782.2004.00293.x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Secker GA, Harvey NL (2015) VEGFR signaling during lymphatic vascular development: from progenitor cells to functional vessels. Dev Dyn 244:323–331. https://doi.org/10.1002/dvdy.24227

Article  CAS  PubMed  Google Scholar 

Secker GA, Harvey NL (2021) Regulation of VEGFR Signalling in Lymphatic Vascular Development and Disease: an update. Int J Mol Sci 22. https://doi.org/10.3390/ijms22147760

Srinivasan RS, Dillard ME, Lagutin OV, Lin FJ, Tsai S, Tsai MJ, Samokhvalov IM, Oliver G (2007) Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature. Genes Dev 21:2422–2432. https://doi.org/10.1101/gad.1588407

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stump B, Cui Y, Kidambi P, Lamattina AM, El-Chemaly S (2017) Lymphatic changes in respiratory Diseases: more than just remodeling of the lung? Am J Respir Cell Mol Biol 57:272–279. https://doi.org/10.1165/rcmb.2016-0290TR

Article  CAS