Use of Circulating Tumor DNA (ctDNA) for Early Molecular Detection of Breast Cancer Relapse in Patients with Triple-Negative Breast Cancer (TNBC)

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Stecklein SR, Kimler BF, Yoder R, et al. ctDNA and residual cancer burden are prognostic in triple-negative breast cancer patients with residual disease. npj Breast Cancer 2023:9(10). Doi:https://doi.org/10.1038/s41523-023-00512-7. This study shows that ctDNA predicts RCB class in patients with residual TNBC.

Magbanua MJ, Swigart LB, Ahmed Z, et al. Clinical significance and biology of circulating tumor DNA in high-risk early-stage HER2-negative breast cancer receiving neoadjuvant chemotherapy. Cancer Cell. 2023;4:1–12. https://doi.org/10.1016/j.ccell.2023.04.008. This article shows that ctDNA dynamics during NAC predicts clinical outcomes and ctDNA clearance and/or negativity despite residual disease is associated with improved survival.

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