Breast Cancer Clinical Trials in East Africa

Herremans KM, Riner AN, Charles AM, Balch JA, Vudatha V, Freudenberger DC, et al. From bench to bedside: pursuing equity in precision medicine approaches to pancreatic cancer care. Front Oncol. 2022;8:12. Available from: https://www.frontiersin.org/articles/10.3389/fonc.2022.1086779/full

Google Scholar 

Granholm A, Alhazzani W, Derde LPG, Angus DC, Zampieri FG, Hammond NE, et al. Randomised clinical trials in critical care: past, present and future. Intensive Care Med. 2022;48(2):164. cited 2023 Feb 22; Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636283/

Article  CAS  PubMed  Google Scholar 

Sharma R, Aashima NM, Fronterre C, Sewagudde P, Ssentongo AE, et al. Mapping cancer in Africa: a comprehensive and comparable characterization of 34 cancer types using estimates from GLOBOCAN 2020. Front Public Health. 2022;10:744. cited 2022 Sep 4, Available from: https://www.frontiersin.org/articles/10.3389/fpubh.2022.839835/full

Article  Google Scholar 

Lynch-Kelly K, Singer M, Williams NR. The landscape of randomised controlled trials of therapies in breast cancer in low and middle income countries. Int J Breast Cancer. 2017;2017:1–6. cited 2023 Feb 26, Available from. https://doi.org/10.1155/2017/4259704.

Article  Google Scholar 

Toto N, Douglas E, Gmeiner M, Barrett LK, Lindblad R, Makhaza L, et al. Conducting clinical trials in sub-Saharan Africa: challenges and lessons learned from the Malawi Cryptosporidium study. Trials. 2020;21(1):680. cited 2022 Feb 15; Available from: https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04620-8

Article  PubMed  PubMed Central  Google Scholar 

Menon MP, Niyonzima N, Gralow J, Orem J. Breast cancer clinical trials: the landscape at the Uganda Cancer Institute and lessons learned. JCO Glob Oncol. 2021;7(7):127–32. cited 2023 Feb 26; Available from. https://doi.org/10.1200/GO.20.00185.

Article  PubMed  Google Scholar 

Clark LT, Watkins L, Piña IL, Elmer M, Akinboboye O, Gorham M, et al. Increasing diversity in clinical trials: overcoming critical barriers. Curr Probl Cardiol. 2019;44(5):148–72. cited 2022 Sep 3; Available from: https://www.sciencedirect.com/science/article/pii/S0146280618301889

Article  PubMed  Google Scholar 

Hwenda L, Sidibe M, Makanga M. The African medicines agency: the key to unlocking clinical research in Africa. Lancet Glob Health. 2022;10(8):e1088–9. cited 2023 Feb 22; Available from: http://www.ncbi.nlm.nih.gov/pubmed/35716676

Article  CAS  PubMed  Google Scholar 

•• Saleh M, Chandrashekar DS, Shahin S, Agarwal S, Kim H-G, Behring M, et al. Comparative analysis of triple-negative breast cancer transcriptomics of Kenyan, African American and Caucasian Women. Transl Oncol. 2021;14(7):101086. cited 2022 Feb 15; Available from: http://www.ncbi.nlm.nih.gov/pubmed/33839593. Findings from this study suggest discrete differences in the up and downregulated genes in patients with TNBC who belong to the African ancesty compared to African American and Caucasian women.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49. cited 2023 Apr 3; Available from: http://www.ncbi.nlm.nih.gov/pubmed/33538338

Article  PubMed  Google Scholar 

Tanne JH. Young black women have more aggressive breast cancers than white women. BMJ Br Med J. 2004;329(7456):13. cited 2023 Apr 5; Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC443477/

Article  Google Scholar 

Receptor-defined breast cancer in five East African countries and its implications for treatment: systematic review and meta-analysis Pallvi Popli, - Google Search, Internet, cited 2023 Apr 3. Available from: https://www.google.com/search?client=safari&rls=en&q=(8)+Receptor-Defined+Breast+Cancer+in+Five+East+African+Countries+and+Its+Implications+for+Treatment:+Systematic+Review+and+Meta-Analysis+Pallvi+Popli,&ie=UTF-8&oe=UTF-8

TANZANIA BREAST HEALTH CARE ASSESSMENT 2017 An assessment of breast cancer early detection, diagnosis and treatment in Tanzania. Internet, cited 2023 Apr 3, Available from: https://www.komen.org/wp-content/uploads/Full_Tanzania_Assessment_report.pdf

Rweyemamu LP, Gültaşlar BK, Akan G, Dharsee N, Namkinga LA, Lyantagaye SL, et al. Breast cancer in East Africa: prevalence and spectrum of germline SNV/indel and CNVs in BRCA1 and BRCA2 genes among breast cancer patients in Tanzania. Cancer Med. 2023;12(3):3395–409. cited 2023 Apr 3; Available from: http://www.ncbi.nlm.nih.gov/pubmed/35908255

Article  CAS  PubMed  Google Scholar 

• Twahir M, Oyesegun R, Yarney J, Gachii A, Edusa C, Nwogu C, et al. Real-world challenges for patients with breast cancer in sub-Saharan Africa: a retrospective observational study of access to care in Ghana, Kenya and Nigeria. BMJ Open. 2021;11(3):e041900. Internet, cited 2023 Apr 3; Available from: http://www.ncbi.nlm.nih.gov/pubmed/33653746. Lack of standardised management pathways and uneven distribution of healthcare resources and financial constraints on side of the patient are major barriers to optimal care in patients with Breast Cancer in SSA.

Article  PubMed  PubMed Central  Google Scholar 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359–86. cited 2023 Apr 3; Available from: http://www.ncbi.nlm.nih.gov/pubmed/25220842

Article  CAS  PubMed  Google Scholar 

Total # cancer cases (2018). cited 2023 Apr 5; Available from: https://cdn.who.int/media/docs/default-source/country-profiles/cancer/ken-2020.pdf?sfvrsn=fffdb0e3_2&download=TRUE

Anyigba CA, Awandare GA, Paemka L. Breast cancer in sub-Saharan Africa: the current state and uncertain future. Exp Biol Med. 2021;246(12):1377–87. Internet, cited 2023 Apr 3; Available from: http://www.ncbi.nlm.nih.gov/pubmed/33926257

Article  CAS  Google Scholar 

Sayed S, Moloo Z, Wasike R, Bird P, Oigara R, Govender D, et al. Is breast cancer from Sub Saharan Africa truly receptor poor? Prevalence of ER/PR/HER2 in breast cancer from Kenya. Breast. 2014;23(5):591–6. Internet, cited 2023 Apr 3; Available from: http://www.ncbi.nlm.nih.gov/pubmed/25012047

Article  PubMed  Google Scholar 

Giaquinto AN, Sung H, Miller KD, Kramer JL, Newman LA, Minihan A, et al. Breast cancer statistics, 2022. CA Cancer J Clin. 2022;72(6):524–41. Internet, cited 2023 Apr 3; Available from: https://onlinelibrary.wiley.com/doi/10.3322/caac.21754

Article  PubMed  Google Scholar 

Sayed S, Moloo Z, Wasike R, Bird P, Oigara R, Njoroge FW, et al. Ethnicity and breast cancer characteristics in Kenya. Breast Cancer Res Treat. 2018;167(2):425–37. Internet, cited 2023 Apr 3; Available from: http://www.ncbi.nlm.nih.gov/pubmed/28951987

Article  PubMed  Google Scholar 

Ekpe E, Shaikh AJ, Shah J, Jacobson JS, Sayed S. Metastatic breast cancer in Kenya: presentation, pathologic characteristics, and patterns-findings from a tertiary cancer center. J Glob Oncol. 2019;5:1–11. Internet, cited 2023 Apr 3; Available from: http://www.ncbi.nlm.nih.gov/pubmed/31291138

PubMed  Google Scholar 

Wata DE, Osanjo GO, Oluka M, Guantai AN. Predictors of breast cancer treatment outcomes in Kenyan women. African J Pharmacol Ther. 2013;2(4) Internet, cited 2023 Apr 3; Available from: http://journals.uonbi.ac.ke/ajpt/article/view/1174

Jedy-Agba E, McCormack V, Adebamowo C, Dos-Santos-Silva I. Stage at diagnosis of breast cancer in sub-Saharan Africa: a systematic review and meta-analysis. Lancet Glob Health. 2016;4(12):e923–35. Internet, cited 2023 Apr 3; Available from: http://www.ncbi.nlm.nih.gov/pubmed/27855871

Article  PubMed  PubMed Central  Google Scholar 

Sayed S, Moloo Z, Ngugi A, Allidina A, Ndumia R, Mutuiri A, et al. Breast camps for awareness and early diagnosis of breast cancer in countries with limited resources: a multidisciplinary model from Kenya. Oncologist. 2016;21(9):1138–48. Internet, cited 2023 Apr 3; Available from: http://www.ncbi.nlm.nih.gov/pubmed/27401898

Article  PubMed  PubMed Central  Google Scholar 

National Bureau of Statistics Nairobi K. Kenya demographic and health survey 2022 key indicators report. 2023, Internet, cited 2023 Apr 3. Available from: http://www.DHSprogram.com

Antabe R, Kansanga M, Sano Y, Kyeremeh E, Galaa Y. Utilization of breast cancer screening in Kenya: what are the determinants? BMC Health Serv Res. 2020;20(1):228. Internet, cited 2023 Apr 3; Available from: http://www.ncbi.nlm.nih.gov/pubmed/32183801

Article  PubMed  PubMed Central  Google Scholar 

Sayed S, Ngugi AK, Mahoney MR, Kurji J, Talib ZM, Macfarlane SB, et al. Breast cancer knowledge, perceptions and practices in a rural community in coastal Kenya. BMC Public Health. 2019;19(1):180. Internet, cited 2023 Apr 3; Available from: https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-019-6464-3

Article  PubMed  PubMed Central  Google Scholar 

Chuma J, Okungu V. Viewing the Kenyan health system through an equity lens: implications for universal coverage. Int J Equity Health. 2011;10(1):22. Internet, cited 2023 Apr 3; Available from: http://equityhealthj.biomedcentral.com/articles/10.1186/1475-9276-10-22

Article  PubMed  PubMed Central  Google Scholar 

The National Cancer Institute of Kenya - NCI Kenya, Internet. cited 2023 Apr 3. Available from: https://www.ncikenya.or.ke/

Kizub DA, Naik S, Abogan AA, Pain D, Sammut S, Shulman LN, et al. Access to and affordability of World Health Organization essential medicines for cancer in Sub-Saharan Africa: examples from Kenya, Rwanda, and Uganda. Oncologist. 2022;27(11):958–70. cited 2023 Apr 3; Available from: http://www.ncbi.nlm.nih.gov/pubmed/36094141

Article  PubMed  PubMed Central  Google Scholar 

Pramesh CS, Badwe RA, Bhoo-Pathy N, Booth CM, Chinnaswamy G, Dare AJ, et al. Priorities for cancer research in low- and middle-income countries: a global perspective. Nat Med. 2022;28(4):649–57. cited 2023 Apr 3; Available from: https://www.nature.com/articles/s41591-022-01738-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

•• Home - ClinicalTrials.gov. Internet, cited 2023 Apr 3. Available from: https://clinicaltrials.gov/Data from ClinicalTrials.gov suggests that there are a currently only 2 breast cancer trials that are active in Kenya.

Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Aromatase inhibitors versus tamoxifen in premenopausal women with oestrogen receptor-positive early-stage breast cancer treated with ovarian suppression: a patient-level meta-analysis of 7030 women from four randomised trials. Lancet Oncol. 2022;23(3):382–92. Internet, cited 2023 Apr 3; Available from: http://www.ncbi.nlm.nih.gov/pubmed/35123662

Article  Google Scholar 

Angus L, Beije N, Jager A, Martens JWM, Sleijfer S. ESR1 mutations: moving towards guiding treatment decision-making in metastatic breast cancer patients. Cancer Treat Rev. 2017;52:33–40. Internet, cited 2023 Apr 3; Available from: http://www.ncbi.nlm.nih.gov/pubmed/27886589

Article  CAS  PubMed  Google Scholar 

Home - ClinicalTrials.gov. Internet, cited 2022 Mar 27. Available from: https://www.clinicaltrials.gov/

Wolff AC, Hammond MEH, Schwartz JN, Hagerty KL, Allred DC, Cote RJ, et al. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. Arch Pathol Lab Med. 2007;131(1):18–43. Internet, cited 2023 Apr 4; Available from: http://www.ncbi.nlm.nih.gov/pubmed/19548375

Article  CAS  PubMed  Google Scholar 

Ortmann O, Blohmer J-U, Sibert NT, Brucker S, Janni W, Wöckel A, et al. Current clinical practice and outcome of neoadjuvant chemotherapy for early breast cancer: analysis of individual data from 94,638 patients treated in 55 breast cancer centers. J Cancer Res Clin Oncol. 2023;149(3):1195–209. Internet, cited 2023 Apr 5; Available from: https://link.springer.com/10.1007/s00432-022-03938-x

Article  CAS  PubMed 

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