Agarwal V, Bell GW, Nam JW, Bartel DP (2015) Predicting effective microRNA target sites in mammalian mRNAs. Elife 4. https://doi.org/10.7554/eLife.05005

An S, Hu H, Li Y, Hu Y (2020) Pyroptosis plays a role in Osteoarthritis. Aging Dis 11:1146–1157. https://doi.org/10.14336/AD.2019.1127

Article  PubMed  PubMed Central  Google Scholar 

Casadei L, Calore F, Creighton CJ, Guescini M, Batte K, Iwenofu OH, Zewdu A, Braggio DA, Bill KL, Fadda P, Lovat F, Lopez G, Gasparini P, Chen JL, Kladney RD, Leone G, Lev D, Croce CM, Pollock RE (2017) Exosome-derived mir-25-3p and miR-92a-3p stimulate Liposarcoma Progression. Cancer Res 77:3846–3856. https://doi.org/10.1158/0008-5472.CAN-16-2984

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen L, Li Q, Wang J, Jin S, Zheng H, Lin J, He F, Zhang H, Ma S, Mei J, Yu J (2017) MiR-29b-3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN. J Cell Mol Med 21:3347–3359. https://doi.org/10.1111/jcmm.13237

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen J, Liu M, Luo X, Peng L, Zhao Z, He C, He Y (2020a) Exosomal miRNA-486-5p derived from rheumatoid arthritis fibroblast-like synoviocytes induces osteoblast differentiation through the Tob1/BMP/Smad pathway. Biomater Sci 8:3430–3442. https://doi.org/10.1039/c9bm01761e

Article  CAS  PubMed  Google Scholar 

Chen R, Ye B, Xie H, Huang Y, Wu Z, Wu H, Wang X, Miao H, Liang W (2020b) Mir-129-3p alleviates chondrocyte apoptosis in knee joint fracture-induced osteoarthritis through CPEB1. J Orthop Surg Res 15:552. https://doi.org/10.1186/s13018-020-02070-1

Article  PubMed  PubMed Central  Google Scholar 

Correia de Sousa M, Gjorgjieva M, Dolicka D, Sobolewski C, Foti M (2019) Deciphering miRNAs’ action through miRNA editing. Int J Mol Sci 20. https://doi.org/10.3390/ijms20246249

Ding Y, Wang L, Zhao Q, Wu Z, Kong L (2019) MicroRNA93 inhibits chondrocyte apoptosis and inflammation in osteoarthritis by targeting the TLR4/NFkappaB signaling pathway. Int J Mol Med 43:779–790. https://doi.org/10.3892/ijmm.2018.4033

Article  CAS  PubMed  Google Scholar 

Duan A, Shen K, Li B, Li C, Zhou H, Kong R, Shao Y, Qin J, Yuan T, Ji J, Guo W, Wang X, Xue T, Li L, Huang X, Sun Y, Cai Z, Liu W, Liu F (2021) Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model. Stem Cell Res Ther 12:427. https://doi.org/10.1186/s13287-021-02507-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fang Y, Tian S, Pan Y, Li W, Wang Q, Tang Y, Yu T, Wu X, Shi Y, Ma P, Shu Y (2020) Pyroptosis: a new frontier in cancer. Biomed Pharmacother 121:109595. https://doi.org/10.1016/j.biopha.2019.109595

Article  CAS  PubMed  Google Scholar 

Fuehrer J, Pichler KM, Fischer A, Giurea A, Weinmann D, Altmann F, Windhager R, Gabius HJ, Toegel S (2021) N-Glycan profiling of chondrocytes and fibroblast-like synoviocytes: towards functional glycomics in osteoarthritis. Proteom Clin Appl 15:e2000057. https://doi.org/10.1002/prca.202000057

Article  CAS  Google Scholar 

Glasson SS, Chambers MG, Van Den Berg WB, Little CB (2010) The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthr Cartil 18 Suppl 3S17–23. https://doi.org/10.1016/j.joca.2010.05.025

He X, Deng L (2021) Potential of mir-25-3p in protection of chondrocytes: emphasis on osteoarthritis. Folia Histochem Cytobiol 59:30–39. https://doi.org/10.5603/FHC.a2021.0004

Article  CAS  PubMed  Google Scholar 

Holyoak DT, Chlebek C, Kim MJ, Wright TM, Otero M, van der Meulen MCH (2019) Low-level cyclic tibial compression attenuates early osteoarthritis progression after joint injury in mice. Osteoarthritis Cartilage 27:1526–1536. https://doi.org/10.1016/j.joca.2019.06.005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu J, Zhou J, Wu J, Chen Q, Du W, Fu F, Yu H, Yao S, Jin H, Tong P, Chen D, Wu C, Ruan H (2020) Loganin ameliorates cartilage degeneration and osteoarthritis development in an osteoarthritis mouse model through inhibition of NF-kappaB activity and pyroptosis in chondrocytes. J Ethnopharmacol 247:112261. https://doi.org/10.1016/j.jep.2019.112261

Article  CAS  PubMed  Google Scholar 

Hui X, Zhang S, Wang Y (2018) miR4543p suppresses cell migration and invasion by targeting CPEB1 in human glioblastoma. Mol Med Rep 18:3965–3972. https://doi.org/10.3892/mmr.2018.9386

Article  CAS  PubMed  Google Scholar 

Hwang HS, Kim HA (2015) Chondrocyte apoptosis in the pathogenesis of Osteoarthritis. Int J Mol Sci 16:26035–26054. https://doi.org/10.3390/ijms161125943

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang S, Liu Y, Xu B, Zhang Y, Yang M (2020) Noncoding RNAs: New regulatory code in chondrocyte apoptosis and autophagy. Wiley Interdiscip Rev RNA 11:e1584. https://doi.org/10.1002/wrna.1584

Article  CAS  PubMed  Google Scholar 

Jin F, Liao L, Zhu Y (2021) MiR-467b alleviates lipopolysaccharide-induced inflammation through targeting STAT1 in chondrogenic ATDC5 cells. Int J Immunogenet 48:435–442. https://doi.org/10.1111/iji.12534

Article  CAS  PubMed  Google Scholar 

Jones-Bolin S (2012) Guidelines for the care and use of laboratory animals in biomedical research. Curr Protoc Pharmacol Appendix 4. https://doi.org/10.1002/0471141755.pha04bs59. Appendix 4B

Lespasio MJ, Piuzzi NS, Husni ME, Muschler GF, Guarino A, Mont MA (2017) Knee osteoarthritis: a primer. Perm J 21:16–183. https://doi.org/10.7812/TPP/16-183

Article  PubMed  PubMed Central  Google Scholar 

Li JH, Liu S, Zhou H, Qu LH, Yang JH (2014) starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res 42:D92–D97. https://doi.org/10.1093/nar/gkt1248

Article  CAS  PubMed  Google Scholar 

Li L, Lan J, Ye Y, Yang B, Yang X, Cai Z (2019) CPEB1 expression correlates with severity of posttraumatic ankle osteoarthritis and aggravates Catabolic Effect of IL-1beta on Chondrocytes. Inflammation 42:628–636. https://doi.org/10.1007/s10753-018-0920-6

Article  CAS  PubMed  Google Scholar 

Li X, Mei W, Huang Z, Zhang L, Zhang L, Xu B, Shi X, Xiao Y, Ma Z, Liao T, Zhang H, Wang P (2020) Casticin suppresses monoiodoacetic acid-induced knee osteoarthritis through inhibiting HIF-1alpha/NLRP3 inflammasome signaling. Int Immunopharmacol 86:106745. https://doi.org/10.1016/j.intimp.2020.106745

Article  CAS  PubMed  Google Scholar 

Lin JJ, Tao K, Gao N, Zeng H, Wang DL, Yang J, Weng J (2021) Triptolide inhibits expression of inflammatory cytokines and proliferation of fibroblast-like Synoviocytes Induced by IL-6/sIL-6R-Mediated JAK2/STAT3 signaling pathway. Curr Med Sci 41:133–139. https://doi.org/10.1007/s11596-020-2302-1

Article  CAS  PubMed  Google Scholar 

Liu Q, Wu Z, Hu D, Zhang L, Wang L, Liu G (2019) Low dose of indomethacin and hedgehog signaling inhibitor administration synergistically attenuates cartilage damage in osteoarthritis by controlling chondrocytes pyroptosis. Gene 712:143959. https://doi.org/10.1016/j.gene.2019.143959

Article  CAS  PubMed  Google Scholar 

Miao C, Zhou W, Wang X, Fang J (2021) The Research Progress of Exosomes in Osteoarthritis, with Particular emphasis on the mediating roles of miRNAs and lncRNAs. Front Pharmacol 12:685623. https://doi.org/10.3389/fphar.2021.685623

Article  CAS  PubMed  PubMed Central  Google Scholar 

Michael JW, Schluter-Brust KU, Eysel P (2010) The epidemiology, etiology, diagnosis, and treatment of osteoarthritis of the knee. Dtsch Arztebl Int 107:152–162. https://doi.org/10.3238/arztebl.2010.0152

Article  PubMed  PubMed Central  Google Scholar 

Miyaki S (2018) [Cartilage/chondrocyte research and osteoarthritis. The role of microRNAs and extracellular vesicles in osteoarthritis pathogenesis.]. Clin Calcium 28:783-8. https://doi.org/CliCa1806783788

Munir J, Yoon JK, Ryu S (2020) Therapeutic miRNA-Enriched extracellular vesicles: current approaches and future prospects. Cells 9. https://doi.org/10.3390/cells9102271

Nagaoka K, Fujii K, Zhang H, Usuda K, Watanabe G, Ivshina M, Richter JD (2016) CPEB1 mediates epithelial-to-mesenchyme transition and breast cancer metastasis. Oncogene 35:2893–2901. https://doi.org/10.1038/onc.2015.350

Article  CAS  PubMed  Google Scholar 

Nygaard G, Firestein GS (2020) Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes. Nat Rev Rheumatol 16:316–33 https://doi.org/10.1038/s41584-020-0413-5

Ouyang Y, Tang Y, Fu L, Peng S, Wu W, Tan D, Fu X (2020) Exosomes secreted by chronic hepatitis B patients with PNALT and liver inflammation grade >/= A2 promoted the progression of liver cancer by transferring mir-25-3p to inhibit the co-expression of TCF21 and HHIP. Cell Prolif 53:e12833. https://doi.org/10.1111/cpr.12833

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng Y, Zhao JL, Peng ZY, Xu WF, Yu GL (2020) Exosomal mir-25-3p from mesenchymal stem cells alleviates myocardial infarction by targeting pro-apoptotic proteins and EZH2. Cell Death Dis 11:317. https://doi.org/10.1038/s41419-020-2545-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rezus E, Burlui A, Cardoneanu A, Macovei LA, Tamba BI, Rezus C (2021) From pathogenesis to therapy in knee osteoarthritis: bench-to-Bedside. Int J Mol Sci 22. https://doi.org/10.3390/ijms22052697

Rigden DJ, Fernandez XM (2020) The 27th annual nucleic acids Research database issue and molecular biology database collection. Nucleic Acids Res 48:D1–D8. https://doi.org/10.1093/nar/gkz1161

Article  CAS  PubMed  Google Scholar 

Rose BJ, Kooyman DL (2016) A tale of two joints: the role of Matrix Metalloproteases in Cartilage Biology. Dis Markers 2016:4895050. https://doi.org/10.1155/2016/4895050

Article  CAS  PubMed  PubMed Central