Pereira MP, Steinke S, Zeidler C, Forner C, Riepe C, Augustin M, et al. European academy of dermatology and venereology European prurigo project: expert consensus on the definition, classification and terminology of chronic prurigo. J Eur Acad Dermatol Venereol. 2018;32:1059–65. https://doi.org/10.1111/jdv.14570.

Article  CAS  PubMed  Google Scholar 

Ständer S. How to define chronic pruritus: symptom or disease? Exp Dermatol. 2019;28:1461–5. https://doi.org/10.1111/exd.13953.

Article  PubMed  Google Scholar 

Schürmann CM, Schedel F, Plewig G, Löser C, Ständer H, Ständer S. Nihil certum: Historische Entwicklung des Begriffs Prurigo [Nihil certum: historical development of the term prurigo]. Hautarzt. 2014;65(8):674–83. https://doi.org/10.1007/s00105-014-2752-0.

Article  PubMed  Google Scholar 

Misery L. Chronic prurigo. Br J Dermatol. 2022;187:464–71. https://doi.org/10.1111/bjd.21698.

Article  PubMed  Google Scholar 

Gründel S, Pereira MP, Storck M, Osada N, Schneider G, Ständer S, Zeidler C. Analysis of 325 patients with chronic nodular prurigo: clinics, burden of disease and course of treatment. Acta Derm Venereol. 2020;100:adv00269. https://doi.org/10.2340/00015555-3571.

Pereira MP, Hoffmann V, Weisshaar E, Wallengren J, Halvorsen JA, Garcovich S, et al. Chronic nodular prurigo: clinical profile and burden. A European cross-sectional study. J Eur Acad Dermatol Venereol. 2020;34:2373–83. https://doi.org/10.1111/jdv.16309.

Augustin M, Garbe C, Hagenström K, Petersen J, Pereira MP, Ständer S. Prevalence, incidence and presence of comorbidities in patients with prurigo and pruritus in Germany: a population-based claims data analysis. J Eur Acad Dermatol Venereol. 2021;35:2270–6. https://doi.org/10.1111/jdv.17485.

Article  CAS  PubMed  Google Scholar 

Huang AH, Canner JK, Khanna R, Kang S, Kwatra SG. Real-world prevalence of prurigo nodularis and burden of associated diseases. J Invest Dermatol. 2020;140:480-483.e4. https://doi.org/10.1016/j.jid.2019.07.697.

Article  CAS  PubMed  Google Scholar 

Boozalis E, Tang O, Patel S, Semenov YR, Pereira MP, Stander S, et al. Ethnic differences and comorbidities of 909 prurigo nodularis patients. J Am Acad Dermatol. 2018;79:714-719.e3. https://doi.org/10.1016/j.jaad.2018.04.047.

Article  PubMed  PubMed Central  Google Scholar 

Alkon N, Assen FP, Arnoldner T, Bauer WM, Medjimorec MA, Shaw LE, et al. Single-cell RNA sequencing defines disease-specific differences between chronic nodular prurigo and atopic dermatitis. J Allergy Clin Immunol. 2023. https://doi.org/10.1016/j.jaci.2023.04.019.

Article  PubMed  Google Scholar 

Deng J, Parthasarathy V, Marani M, Bordeaux Z, Lee K, Trinh C, et al. Extracellular matrix and dermal nerve growth factor dysregulation in prurigo nodularis compared to atopic dermatitis. Front Med (Lausanne). 2022;9:1022889. https://doi.org/10.3389/fmed.2022.1022889.

Article  PubMed  PubMed Central  Google Scholar 

Storck M, Sandmann S, Bruland P, Pereira MP, Steinke S, Riepe C, et al. Pruritus Intensity Scales across Europe: a prospective validation study. J Eur Acad Dermatol Venereol. 2021;35:1176–85. https://doi.org/10.1111/jdv.17111.

Article  CAS  PubMed  Google Scholar 

Pereira MP, Zeidler C, Nau T, Bobko S, Evers AWM, Garcovich S, et al. Position Statement: Linear prurigo is a subtype of chronic prurigo. J Eur Acad Dermatol Venereol. 2019;33:263–6. https://doi.org/10.1111/jdv.15275.

Article  CAS  PubMed  Google Scholar 

Zeidler C, Pereira MP, Ständer S. Chronic prurigo: similar clinical profile and burden across clinical phenotypes. Front Med (Lausanne). 2021;8: 649332. https://doi.org/10.3389/fmed.2021.649332.

Article  PubMed  PubMed Central  Google Scholar 

Brenaut E, Halvorsen JA, Dalgard FJ, Lien L, Balieva F, Sampogna F, et al. The self-assessed psychological comorbidities of prurigo in European patients: a multicentre study in 13 countries. J Eur Acad Dermatol Venereol. 2019;33:157–62. https://doi.org/10.1111/jdv.15145.

Article  CAS  PubMed  Google Scholar 

Zeidler C, Pereira MP, Dugas M, Augustin M, Storck M, Weyer-Elberich V, et al. The burden in chronic prurigo: patients with chronic prurigo suffer more than patients with chronic pruritus on non-lesional skin: a comparative, retrospective, explorative statistical analysis of 4,484 patients in a real-world cohort. J Eur Acad Dermatol Venereol. 2021;35:738–43. https://doi.org/10.1111/jdv.16929.

Article  CAS  PubMed  Google Scholar 

Pereira MP, Zeidler C, Wallengren J, Halvorsen JA, Weisshaar E, Garcovich S, et al. Chronic nodular prurigo: a European cross-sectional study of patient perspectives on therapeutic goals and satisfaction. Acta Derm Venereol. 2021;101:adv00403. https://doi.org/10.2340/00015555-3726.

Schneider G, Driesch G, Heuft G, Evers S, Luger TA, Ständer S. Psychosomatic cofactors and psychiatric comorbidity in patients with chronic itch. Clin Exp Dermatol. 2006;31:762–7. https://doi.org/10.1111/j.1365-2230.2006.02211.x.

Article  CAS  PubMed  Google Scholar 

Jørgensen KM, Egeberg A, Gislason GH, Skov L, Thyssen JP. Anxiety, depression and suicide in patients with prurigo nodularis. J Eur Acad Dermatol Venereol. 2017;31:e106–7. https://doi.org/10.1111/jdv.13827.

Article  PubMed  Google Scholar 

Schneider G, Zeidler C, Pereira MP, Ständer S. One third of chronic prurigo patients scratch automatically and in the absence of itch - a naturalistic study of 1142 patients. J Eur Acad Dermatol Venereol. 2022;36:e297–300. https://doi.org/10.1111/jdv.17777.

Article  CAS  PubMed  Google Scholar 

Oexle N, Rüsch N. Stigma—risikofaktor und Konsequenz suizidalen Verhaltens: implikationen für die Suizidprävention. [Stigma—risk factor and consequence of suicidal behavior: implications for suicide prevention]. Nervenarzt. 2018;89:779–83. https://doi.org/10.1007/s00115-017-0450-8.

Stumpf A, Ständer S, Warlich B, Fritz F, Bruland P, Pfleiderer B, et al. Relations between the characteristics and psychological comorbidities of chronic pruritus differ between men and women: women are more anxious than men. Br J Dermatol. 2015;172:1323–8. https://doi.org/10.1111/bjd.13492.

Article  CAS  PubMed  Google Scholar 

Shao Y, Zhu Y, Xiao Z, Shen Y, Dai B, Tang H, Wang D. RNA sequencing reveals the transcriptome profile of the atopic prurigo nodularis with severe itching. Exp Dermatol. 2023;32:30–40. https://doi.org/10.1111/exd.14678.

Article  CAS  PubMed  Google Scholar 

Calugareanu A, Specque F, Demouche S, Grolleau C, Dobos G, Merandet M, et al. Transcriptomic landscape of prurigo nodularis lesional skin CD3+ T cells using single-cell RNA-sequencing. J Invest Dermatol. 2023. https://doi.org/10.1016/j.jid.2023.05.011.

Article  PubMed  Google Scholar 

Sutaria N, Alphonse MP, Roh YS, Choi J, Parthasarathy V, Deng J, et al. Cutaneous transcriptomics identifies fibroproliferative and neurovascular gene dysregulation in prurigo nodularis compared with psoriasis and atopic dermatitis. J Invest Dermatol. 2022;142:2537–40. https://doi.org/10.1016/j.jid.2022.02.010.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsoi LC, Hacini-Rachinel F, Fogel P, Rousseau F, Xing X, Patrick MT, et al. Transcriptomic characterization of prurigo nodularis and the therapeutic response to nemolizumab. J Allergy Clin Immunol. 2022;149:1329–39. https://doi.org/10.1016/j.jaci.2021.10.004.

Article  CAS  PubMed  Google Scholar 

Agelopoulos K, Renkhold L, Wiegmann H, Dugas M, Süer A, Zeidler C, et al. Transcriptomic, epigenomic, and neuroanatomic signatures differ in chronic prurigo, atopic dermatitis, and brachioradial pruritus. J Invest Dermatol. 2023;143:264-272.e3. https://doi.org/10.1016/j.jid.2022.08.042.

Article  CAS  PubMed  Google Scholar 

Hashimoto T, Nattkemper LA, Kim HS, Kursewicz CD, Fowler E, Shah SM, et al. Dermal periostin: a new player in itch of prurigo nodularis. Acta Derm Venereol. 2021;101:adv00375. https://doi.org/10.2340/00015555-3702.

Patel JR, Joel MZ, Lee KK, Kambala A, Cornman H, Oladipo O, et al. Single-cell RNA sequencing reveals dysregulated fibroblast subclusters in prurigo nodularis. bioRxiv 2023. https://doi.org/10.1101/2023.01.29.526050.

Hashimoto T, Okuno S, Okuzawa M, Satoh T. Increased sensitivity to touch-evoked itch (punctate hyperknesis) in prurigo nodularis and type 2 inflammation: a cross-sectional pilot study. J Eur Acad Dermatol Venereol. 2023;37:e789–91. https://doi.org/10.1111/jdv.18942.

Article  PubMed  Google Scholar 

Liu T, Chu Y, Li S, Wang Y, Zhong X, Fang H, Qiao J. Myeloid dendritic cells are increased in the lesional skin and associated with pruritus in patients with prurigo nodularis. MedComm. 2020;2023(4): e204. https://doi.org/10.1002/mco2.204.

Article  Google Scholar 

Hashimoto T, Nattkemper LA, Kim HS, Kursewicz CD, Fowler E, Shah SM, et al. Itch intensity in prurigo nodularis is closely related to dermal interleukin-31, oncostatin M, IL-31 receptor alpha and oncostatin M receptor beta. Exp Dermatol. 2021;30:804–10. https://doi.org/10.1111/exd.14279.

Article  CAS  PubMed  Google Scholar 

Parthasarathy V, Cravero K, Deng J, Sun Z, Engle SM, Auxier AN, et al. Circulating plasma IL-13 and periostin are dysregulated type 2 inflammatory biomarkers in prurigo nodularis: a cluster analysis. Front Med (Lausanne). 2022;9:1011142. https://doi.org/10.3389/fmed.2022.1011142.

Article  PubMed  PubMed Central  Google Scholar 

Parthasarathy V, Cravero K, Xu L, Deng J, Sun Z, Engle SM, et al. The blood proteomic signature of prurigo nodularis reveals distinct inflammatory and neuropathic endotypes: a cluster analysis. J Am Acad Dermatol. 2023;88:1101–9. https://doi.org/10.1016/j.jaad.2023.01.042.

Article  PubMed  Google Scholar 

Ju T, Labib A, Nattkemper L, Engle S, Auxier A, Hahn N, et al. Serum interleukin-13 and caspase 8 are elevated in prurigo nodularis. Acta Derm Venereol. 2023;103:adv00861. https://doi.org/10.2340/actadv.v103.4804.

Chaowattanapanit S, Wongjirattikarn R, Chaisuriya N, Ungarreevittaya P, Poosekeaw P, Winaikosol K, et al. Increased IL-31 expression in serum and tissue protein in prurigo nodularis. Ther Adv Chronic Dis. 2022;13:20406223221112560. https://doi.org/10.1177/20406223221112561.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sutaria N, Alphonse MP, Marani M, Parthasarathy V, Deng J, Wongvibulsin S, et al. Cluster analysis of circulating plasma biomarkers in prurigo nodularis reveals a distinct systemic inflammatory signature in African Americans. J Invest Dermatol. 2022;142:1300-1308.e3. https://doi.org/10.1016/j.jid.2021.10.011.

Article  CAS  PubMed  Google Scholar 

Pereira MP, Pogatzki-Zahn E, Snels C, Vu T-H, Üçeyler N, Loser K, et al. There is no functional small-fibre neuropathy in prurigo nodularis despite neuroanatomical alterations. Exp Dermatol. 2017;26:969–71. https://doi.org/10.1111/exd.13343.