Gallo RL. Human skin is the largest epithelial surface for interaction with microbes. J Investig Dermatol. 2017;137:1213–4.

Article  CAS  PubMed  Google Scholar 

Borkowski AW, Gallo RL. The coordinated response of the physical and antimicrobial peptide barriers of the skin. J Investig Dermatol. 2011;131:285–7.

Article  CAS  PubMed  Google Scholar 

Lai Y, Di Nardo A, Nakatsuji T, Leichtle A, Yang Y, Cogen AL, et al. Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury. Nat Med. 2009;15:1377–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grice EA, Segre JA. The human microbiome: our second genome. Annu Rev Genomics Hum Genet. 2012;13:151–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Byrd AL, Belkaid Y, Segre JA. The human skin microbiome. Nat Rev Microbiol. 2018;16:143–55.

Article  CAS  PubMed  Google Scholar 

Marchesi JR, Ravel J. The vocabulary of microbiome research: a proposal. Microbiome. 2015;3:31.

Article  PubMed  PubMed Central  Google Scholar 

Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11:506–14.

Article  PubMed  Google Scholar 

Gibson GR, Hutkins R, Sanders ME, Prescott SL, Reimer RA, Salminen SJ, et al. Expert consensus document: the International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol. 2017;14:491–502.

Article  PubMed  Google Scholar 

Salminen S, Collado MC, Endo A, Hill C, Lebeer S, Quigley EMM, et al. The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nat Rev Gastroenterol Hepatol. 2021;18:649–67.

Article  PubMed  PubMed Central  Google Scholar 

Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012;486:207–14.

Article  ADS  Google Scholar 

Proctor L. Priorities for the next 10 years of human microbiome research. Nature. 2019;569:623–5.

Article  CAS  PubMed  ADS  Google Scholar 

Oh J, Byrd AL, Deming C, Conlan S, NISC Comparative Sequencing Program, Kong HH, et al. Biogeography and individuality shape function in the human skin metagenome. Nature. 2014;514:59–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grice EA, Segre JA. The skin microbiome. Nat Rev Microbiol. 2011;9:244–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao Z, Perez-Perez GI, Chen Y, Blaser MJ. Quantitation of major human cutaneous bacterial and fungal populations. J Clin Microbiol. 2010;48:3575–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Costello EK, Lauber CL, Hamady M, Fierer N, Gordon JI, Knight R. Bacterial community variation in human body habitats across space and time. Science. 2009;326:1694–7.

Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

Gao Z, Tseng C, Pei Z, Blaser MJ. Molecular analysis of human forearm superficial skin bacterial biota. Proc Natl Acad Sci USA. 2007;104:2927–32.

Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

Grice EA, Kong HH, Conlan S, Deming CB, Davis J, Young AC, et al. Topographical and temporal diversity of the human skin microbiome. Science. 2009;324:1190–2.

Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

Findley K, Oh J, Yang J, Conlan S, Deming C, Meyer JA, et al. Topographic diversity of fungal and bacterial communities in human skin. Nature. 2013;498:367–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Capone KA, Dowd SE, Stamatas GN, Nikolovski J. Diversity of the human skin microbiome early in life. J Investig Dermatol. 2011;131:2026–32.

Article  CAS  PubMed  Google Scholar 

Dominguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G, Fierer N, et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci USA. 2010;107:11971–5.

Article  PubMed  PubMed Central  ADS  Google Scholar 

Stamatas GN, Roux P-F, Boireau-Adamezyk E, Lboukili I, Oddos T. Skin maturation from birth to 10 years of age: structure, function, composition and microbiome. Exp Dermatol. 2023;32:1420–9.

Article  PubMed  Google Scholar 

Perez Perez GI, Gao Z, Jourdain R, Ramirez J, Gany F, Clavaud C, et al. Body site is a more determinant factor than human population diversity in the healthy skin microbiome. PLoS One. 2016;11: e0151990.

Article  PubMed  PubMed Central  Google Scholar 

Oh J, Byrd AL, Park M, NISC Comparative Sequencing Program, Kong HH, Segre JA. Temporal stability of the human skin microbiome. Cell. 2016;165:854–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grice EA, Kong HH, Renaud G, Young AC, NISC Comparative Sequencing Program, Bouffard GG, et al. A diversity profile of the human skin microbiota. Genome Res. 2008;18:1043–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lehtimäki J, Karkman A, Laatikainen T, Paalanen L, von Hertzen L, Haahtela T, et al. Patterns in the skin microbiota differ in children and teenagers between rural and urban environments. Sci Rep. 2017;7: 45651.

Article  PubMed  PubMed Central  ADS  Google Scholar 

Zhu T, Liu X, Kong F-Q, Duan Y-Y, Yee AL, Kim M, et al. Age and mothers: potent influences of children’s skin microbiota. J Investig Dermatol. 2019;139:2497-505.e6.

Article  CAS  PubMed  Google Scholar 

Blaser MJ, Dominguez-Bello MG, Contreras M, Magris M, Hidalgo G, Estrada I, et al. Distinct cutaneous bacterial assemblages in a sampling of South American Amerindians and US residents. ISME J. 2013;7:85–95.

Article  CAS  PubMed  Google Scholar 

Gonzalez ME, Schaffer JV, Orlow SJ, Gao Z, Li H, Alekseyenko AV, et al. Cutaneous microbiome effects of fluticasone propionate cream and adjunctive bleach baths in childhood atopic dermatitis. J Am Acad Dermatol. 2016;75:481-93.e8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chien AL, Tsai J, Leung S, Mongodin EF, Nelson AM, Kang S, et al. Association of systemic antibiotic treatment of acne with skin microbiota characteristics. JAMA Dermatol. 2019;155:425–34.

Article  PubMed  PubMed Central  Google Scholar 

Wongtada C, Prombutara P, Asawanonda P, Noppakun N, Kumtornrut C, Chatsuwan T. Distinct skin microbiome modulation following different topical acne treatments in mild acne vulgaris patients: a randomized, investigator-blinded exploratory study. Exp Dermatol. 2023;32:906–14.

Article  CAS  PubMed  Google Scholar 

Nolan ZT, Banerjee K, Cong Z, Gettle SL, Longenecker AL, Kawasawa YI, et al. Treatment response to isotretinoin correlates with specific shifts in Cutibacterium acnes strain composition within the follicular microbiome. Exp Dermatol. 2023;32:955–64.

Article  CAS  PubMed  Google Scholar 

McCoy WH, Otchere E, Rosa BA, Martin J, Mann CM, Mitreva M. Skin ecology during sebaceous drought: how skin microbes respond to isotretinoin. J Investig Dermatol. 2019;139:732–5.

Article  CAS  PubMed  Google Scholar 

Rocha LA, Ferreira de Almeida E Borges L, Gontijo Filho PP. Changes in hands microbiota associated with skin damage because of hand hygiene procedures on the health care workers. Am J Infect Control. 2009;37:155–9.

Article  PubMed  Google Scholar 

Baldwin HE, Bhatia ND, Friedman A, Eng RM, Seite S. The role of cutaneous microbiota harmony in maintaining a functional skin barrier. J Drugs Dermatol. 2017;16:12–8.

CAS  PubMed  Google Scholar 

Liu Q, Ranallo R, Rios C, Grice EA, Moon K, Gallo RL. Crosstalk between skin microbiota and immune system in health and disease. Nat Immunol. 2023;24:895–8.

Article  CAS  PubMed