Sex-biased gene and microRNA expression in the developing mouse brain is associated with neurodevelopmental functions and neurological phenotypes

Beery AK, Zucker I. Sex bias in neuroscience and biomedical research. Neurosci Biobehav Rev. 2011;35(3):565–72.

Article  PubMed  Google Scholar 

McCarthy MM, Arnold AP, Ball GF, Blaustein JD, De Vries GJ. Sex differences in the brain: the not so inconvenient truth. J Neurosci. 2012;2(7):2241–7.

Article  Google Scholar 

Shansky RM. Are hormones a “female problem” for animal research? Outdated gender stereotypes are influencing experimental design in laboratory animals. Science. 2019;364(6443):825–6.

Article  CAS  PubMed  Google Scholar 

Middeldorp CM, Hammerschlag AR, Ouwens KG, Groen-Blokhuis MM, St. Pourcain B, Greven CU, Pappa I, Tiesler CMT, Ang W, Nolte IM, et al. A genome-wide association meta-analysis of attention-deficit/hyperactivity disorder symptoms in population-based pediatric cohorts. J Am Acad Child Adolesc Psychiatry. 2016;55(10):896-905.e896.

Article  PubMed  Google Scholar 

Henriksen MG, Nordgaard J, Jansson LB. Genetics of schizophrenia: overview of methods, findings and limitations. Front Hum Neurosci. 2017;11:322.

Article  PubMed  Google Scholar 

Courchesne E, Mouton PR, Calhoun ME, Semendeferi K, Ahrens-Barbeau C, Hallet MJ, Barnes CC, Pierce K. Neuron number and size in prefrontal cortex of children with autism. JAMA. 2011;306(18):2001–10.

Article  CAS  PubMed  Google Scholar 

Lynch A, Davison K. Gendered expectations on the recognition of ADHD in young women and educational implications. Irish Educ Stud. 2022. https://doi.org/10.1080/03323315.2022.2032264.

Article  Google Scholar 

Santos S, Ferreira H, Martins J, Gonçalves J, Castelo-Branco M. Male sex bias in early and late onset neurodevelopmental disorders: shared aspects and differences in autism spectrum disorder, attention deficit/hyperactivity disorder, and schizophrenia. Neurosci Biobehav Rev. 2022;135: 104577.

Article  CAS  PubMed  Google Scholar 

Moore I, Morgan G, Welham A, Russell G. The intersection of autism and gender in the negotiation of identity: a systematic review and metasynthesis. Fem Psychol. 2022;32(4):421–42.

Article  Google Scholar 

Arnold AP. A general theory of sexual differentiation. J Neurosci Res. 2017;95(1–2):291–300.

Article  CAS  PubMed  Google Scholar 

Chini M, Hanganu-Opatz IL. Prefrontal cortex development in health and disease: lessons from rodents and humans. Trends Neurosci. 2021;44(3):227–40.

Article  CAS  PubMed  Google Scholar 

Qureshi IA, Mehler MF. Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease. Nat Rev Neurosci. 2012;13(8):528–41.

Article  CAS  PubMed  Google Scholar 

Bartel DP. Metazoan microRNAs. Cell. 2018;173(1):20–51.

Article  CAS  PubMed  Google Scholar 

Ohtsuka M, Ling H, Doki Y, Mori M, Calin GA. MicroRNA processing and human cancer. J Clin Med. 2015;4(8):1651–67.

Article  CAS  PubMed  Google Scholar 

Friedman RC, Farh KKH, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 2009;19(1):92–105.

Article  CAS  PubMed  Google Scholar 

Sun E, Shi Y. MicroRNAs: small molecules with big roles in neurodevelopment and diseases. Exp Neurol. 2014;268:46–53.

Article  PubMed  Google Scholar 

Geaghan M, Cairns MJ. MicroRNA and posttranscriptional dysregulation in psychiatry. Biol Psychiatry. 2015;78(4):231–9.

Article  CAS  PubMed  Google Scholar 

McCarthy MM, Pickett LA, VanRyzin JW, Kight KE. Surprising origins of sex differences in the brain. Horm Behav. 2015;76:3–10.

Article  PubMed  Google Scholar 

Ingleby FC, Flis I, Morrow EH. Sex-biased gene expression and sexual conflict throughout development. Cold Spring Harb Perspect Biol. 2015;7(1): a017632.

Article  Google Scholar 

Koturbash I, Zemp F, Kolb B, Kovalchuk O. Sex-specific radiation-induced microRNAome responses in the hippocampus, cerebellum and frontal cortex in a mouse model. Mutat Res Genetic Toxicol Environ Mutagenes. 2011;722(2):114–8.

Article  CAS  Google Scholar 

Cui C, Yang W, Shi J, Zhou Y, Yang J, Cui Q, Zhou Y. Identification and analysis of human sex-biased microRNAs. Genom Proteom Bioinform. 2018;16(3):200–11.

Article  CAS  Google Scholar 

Hirsch MM, Brusco J, Vaccaro T, Margis R, Moreira JE, Gottfried C, Rasia-Filho AA. Sex differences and estrous cycle changes in synaptic plasticity-related microRNA in the rat medial amygdala. Neuroscience. 2018;379:405–14.

Article  CAS  PubMed  Google Scholar 

Kodama L, Guzman E, Etchegaray JI, Li Y, Sayed FA, Zhou L, Zhou Y, Zhan L, Le D, Udeochu JC, et al. Microglial microRNAs mediate sex-specific responses to tau pathology. Nat Neurosci. 2020;23:167–71.

Article  CAS  PubMed  Google Scholar 

Corrales WA, Silva JP, Parra CS, Olave FA, Aguayo FI, Román-Albasini L, Aliaga E, Venegas-Zamora L, Avalos AM, Rojas PS, et al. Sex-dependent changes of miRNA levels in the hippocampus of adrenalectomized rats following acute corticosterone administration. ACS Chem Neurosci. 2021;12(16):2981–3001.

Article  CAS  PubMed  Google Scholar 

Luo PX, Manning CE, Fass JN, Williams VA, Hao R, Campi KL, Trainor BC. Sex-specific effects of social defeat stress on miRNA expression in the anterior BNST. Behav Brain Res. 2021;401: 113084.

Article  CAS  PubMed  Google Scholar 

Mavrikaki M, Pantano L, Potter D, Rogers-Grazado MA, Anastasiadou E, Slack FJ, Amr SS, Ressler KJ, Daskalakis NP, Chartoff E. Sex-dependent changes in miRNA expression in the bed nucleus of the stria terminalis following stress. Front Mol Neurosci. 2019;12:236.

Article  CAS  PubMed  Google Scholar 

McKibben LA, Dwivedi Y. Early-life stress induces genome-wide sex-dependent miRNA expression and correlation across limbic brain areas in rats. Epigenomics. 2021;13(13):1031–56.

Article  CAS  PubMed  Google Scholar 

Ziats MN, Rennert OM. Identification of differentially expressed microRNAs across the developing human brain. Mol Psychiatry. 2014;19(7):848–52.

Article  CAS  PubMed  Google Scholar 

Kim CK, Pak TR. miRNA degradation in the mammalian brain. Am J Phys Cell Physiol. 2020;319(4):C624–9.

Article  CAS  Google Scholar 

Morgan CP, Bale TL. Early prenatal stress epigenetically programs dysmasculinization in second-generation offspring via the paternal lineage. J Neurosci. 2011;31(33):11748–55.

Article  CAS  PubMed  Google Scholar 

Morgan CP, Bale TL. Sex differences in microRNA-mRNA networks: examination of novel epigenetic programming mechanisms in the sexually dimorphic neonatal hypothalamus. Biol Sex Differ. 2017;8(1):27.

Article  PubMed  Google Scholar 

Murphy SJ, Lusardi TA, Phillips JI, Saugstad JA. Sex differences in microRNA expression during development in rat cortex. Neurochem Int. 2014;77:24–32.

Article  CAS  PubMed  Google Scholar 

Arnold AP, Chen X. What does the “four core genotypes” mouse model tell us about sex differences in the brain and other tissues? Front Neuroendocrinol. 2009;30(1):1–9.

Article  PubMed  Google Scholar 

McCarthy MM. A new view of sexual differentiation of mammalian brain. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2020;206(3):369–78.

Article  PubMed  Google Scholar 

Afgan E, Sloggett C, Goonasekera N, Makunin I, Benson D, Crowe M, Gladman S, Kowsar Y, Pheasant M, Horst R, et al. Genomics virtual laboratory: a practical bioinformatics workbench for the cloud. PLoS ONE. 2015;10(10): e0140829.

Article  PubMed  Google Scholar 

Bolger AM, Lohse M, Usadel B. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics. 2014;30(15):2114–20.

Article  CAS  PubMed  Google Scholar 

Andrews S. FastQC—a quality control tool for high throughput sequence data. In: Babraham bioinformatics. 2010.

Kim D, Pertea G, Trapnell C, Pimentel H, Kelley R, Salzberg SL. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol. 2013;14(4):1–13.

Article  Google Scholar 

Trapnell C, Williams BA, Pertea G, Mortazavi A, Kwan G, Van Baren MJ, Salzberg SL, Wold BJ, Pachter L. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol. 2010;28(5):511–5.

Article  CAS  PubMed  Google Scholar 

Liao Y, Smyth GK, Shi W. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics. 2014;30(7):923–30.

Article  CAS  PubMed 

留言 (0)

沒有登入
gif