The effect of conjugated linoleic acids on inflammation, oxidative stress, body composition and physical performance: a comprehensive review of putative molecular mechanisms

Peyman N, Rezai-Rad M, Tehrani H, Gholian-Aval M, Vahedian-Shahroodi M, Miri HH. Digital media-based health intervention on the promotion of women’s physical activity: a quasi-experimental study. BMC Public Health. 2018;18(1):1–7.

Article  Google Scholar 

Molinero O, Márquez S. Use of nutritional supplements in sports: risks, knowledge, and behavioural-related factors. Nutr Hosp. 2009;24(2):128–34.

CAS  PubMed  Google Scholar 

McDowall JA. Supplement use by young athletes. J Sports Sci Med. 2007;6(3):337.

PubMed  PubMed Central  Google Scholar 

Gahche J. Dietary supplement use among US adults has increased since NHANES III (1988–1994): US Department of Health and Human Services, Centers for Disease Control and …; 2011.

Braun H, Koehler K, Geyer H, Kleinert J, Mester J, Schänzer W. Dietary supplement use among elite young German athletes. Int J Sport Nutr Exerc Metab. 2009;19(1):97–109.

Article  PubMed  Google Scholar 

Askari G, Ghiasvand R, Feizi A, Ghanadian SM, Karimian J. The effect of quercetin supplementation on selected markers of inflammation and oxidative stress. J Res Med Sci. 2012;17(7):637.

PubMed  PubMed Central  Google Scholar 

Pingitore A, Lima GPP, Mastorci F, Quinones A, Iervasi G, Vassalle C. Exercise and oxidative stress: potential effects of antioxidant dietary strategies in sports. Nutrition. 2015;31(7–8):916–22.

Article  CAS  PubMed  Google Scholar 

Nieman D, Dumke C, Henson D, McAnulty S, McAnulty L, Lind R, et al. Immune and oxidative changes during and following the Western States Endurance Run. Int J Sports Med. 2003;24(07):541–7.

Article  CAS  PubMed  Google Scholar 

Nieman DC, Dumke CL, Henson DA, McAnulty SR, Gross SJ, Lind RH. Muscle damage is linked to cytokine changes following a 160-km race. Brain Behav Immun. 2005;19(5):398–403.

Article  CAS  PubMed  Google Scholar 

Thom E, Wadstein J, Gudmundsen O. Conjugated linoleic acid reduces body fat in healthy exercising humans. J Int Med Res. 2001;29(5):392–6.

Article  CAS  PubMed  Google Scholar 

Mendes RR, Pires I, Oliveira A, Tirapegui J. Effects of creatine supplementation on the performance and body composition of competitive swimmers. J Nutr Biochem. 2004;15(8):473–8.

Article  CAS  PubMed  Google Scholar 

Bhattacharya A, Banu J, Rahman M, Causey J, Fernandes G. Biological effects of conjugated linoleic acids in health and disease. J Nutr Biochem. 2006;17(12):789–810.

Article  CAS  PubMed  Google Scholar 

den Hartigh LJ. Conjugated linoleic acid effects on cancer, obesity, and atherosclerosis: a review of pre-clinical and human trials with current perspectives. Nutrients. 2019;11(2):370.

Article  Google Scholar 

Griinari J, Corl B, Lacy S, Chouinard P, Nurmela K, Bauman D. Conjugated linoleic acid is synthesized endogenously in lactating dairy cows by Δ9-desaturase. J Nutr. 2000;130(9):2285–91.

Article  CAS  PubMed  Google Scholar 

Khan SA, Vanden Heuvel JP. Role of nuclear receptors in the regulation of gene expression by dietary fatty acids (review). J Nutr Biochem. 2003;14(10):554–67.

Article  CAS  PubMed  Google Scholar 

Wang T, Chen Y, Dong T, Ma X, Wang L, Yu D, et al. Supercritical electrocatalytic catalyst activation and its application in safflower seed oil isomerisation to prepare conjugated linoleic acid. Int J Food Sci Technol. 2021;56:3885–92.

Article  CAS  Google Scholar 

Dilzer A, Park Y. Implication of conjugated linoleic acid (CLA) in human health. Crit Rev Food Sci Nutr. 2012;52(6):488–513.

Article  CAS  PubMed  Google Scholar 

Nunes JC, Torres AG. Fatty acid and CLA composition of Brazilian dairy products, and contribution to daily intake of CLA. J Food Compos Anal. 2010;23(8):782–9.

Article  CAS  Google Scholar 

Fritsche J, Steinhart H. Amounts of conjugated linoleic acid (CLA) in German foods and evaluation of daily intake. Z Lebensm Forsch A. 1998;206(2):77–82.

Article  CAS  Google Scholar 

Raff M, Tholstrup T, Basu S, Nonboe P, Sørensen MT, Straarup EM. A diet rich in conjugated linoleic acid and butter increases lipid peroxidation but does not affect atherosclerotic, inflammatory, or diabetic risk markers in healthy young men. J Nutr. 2008;138(3):509–14.

Article  CAS  PubMed  Google Scholar 

Lehnen TE, da Silva MR, Camacho A, Marcadenti A, Lehnen AM. A review on effects of conjugated linoleic fatty acid (CLA) upon body composition and energetic metabolism. J Int Soc Sports Nutr. 2015;12(1):1–11.

Article  CAS  Google Scholar 

Kim Y, Kim J, Whang K-Y, Park Y. Impact of conjugated linoleic acid (CLA) on skeletal muscle metabolism. Lipids. 2016;51(2):159–78.

Article  PubMed  Google Scholar 

Steck SE, Chalecki AM, Miller P, Conway J, Austin GL, Hardin JW, et al. Conjugated linoleic acid supplementation for twelve weeks increases lean body mass in obese humans. J Nutr. 2007;137(5):1188–93.

Article  CAS  PubMed  Google Scholar 

Banni S, Petroni A, Blasevich M, Carta G, Angioni E, Murru E, et al. Detection of conjugated C16 PUFAs in rat tissues as possible partial beta-oxidation products of naturally occurring conjugated linoleic acid and its metabolites. Biochim Biophys Acta BBA Mol Cell Biol Lipids. 2004;1682(1–3):120–7.

CAS  Google Scholar 

Kreider RB, Ferreira MP, Greenwood M, Wilson M, Almada AL. Effects of conjugated linoleic acid supplementation during resistance training on body composition, bone density, strength, and selected hematological markers. J Strength Cond Res. 2002;16(3):325–34.

PubMed  Google Scholar 

Eftekhari MH, Aliasghari F, Babaei-Beigi MA, Hasanzadeh J. Effect of conjugated linoleic acid and omega-3 fatty acid supplementation on inflammatory and oxidative stress markers in atherosclerotic patients. ARYA Atheroscler. 2013;9(6):311.

Google Scholar 

Matin S, Nemati A, Ghobadi H, Alipanah-Moghadam R, Rezagholizadeh L. The effect of conjugated linoleic acid on oxidative stress and matrix metalloproteinases 2 and 9 in patients with COPD. Int J Chron Obstruct Pulmon Dis. 2018;13:1449.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park N-Y, Valacchi G, Lim Y. Effect of dietary conjugated linoleic acid supplementation on early inflammatory responses during cutaneous wound healing. Mediat Inflamm. 2010;2010:1–8.

Article  Google Scholar 

Basiricò L, Morera P, Dipasquale D, Tröscher A, Bernabucci U. Comparison between conjugated linoleic acid and essential fatty acids in preventing oxidative stress in bovine mammary epithelial cells. J Dairy Sci. 2017;100(3):2299–309.

Article  PubMed  Google Scholar 

Preiser JC. Oxidative stress. J Parenter Enter Nutr. 2012;36(2):147–54.

Article  CAS  Google Scholar 

Hadi V, Pahlavani N, Malekahmadi M, Nattagh-Eshtivani E, Navashenaq JG, Hadi S, et al. Nigella sativa in controlling Type 2 diabetes, cardiovascular, and rheumatoid arthritis diseases: molecular aspects. J Res Med Sci. 2021;26:20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferrero-Miliani L, Nielsen O, Andersen P, Girardin S. Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1β generation. Clin Exp Immunol. 2007;147(2):227–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Spittle M, Hoenich NA, Handelman G, Adhikarla R, Homel P, Levin NW. Oxidative stress and inflammation in hemodialysis patients. In: Improving prognosis for kidney disorders. Springer; 2002. p. 45–52.

Chatzinikolaou A, Fatouros IG, Gourgoulis V, Avloniti A, Jamurtas AZ, Nikolaidis MG, et al. Time course of changes in performance and inflammatory responses after acute plyometric exercise. J Strength Cond Res. 2010;24(5):1389–98.

Article  PubMed  Google Scholar 

Bedi A, Lynch EB, Sibilsky Enselman ER, Davis ME, DeWolf PD, Makki TA, et al. Elevation in circulating biomarkers of cartilage damage and inflammation in athletes with femoroacetabular impingement. Am J Sports Med. 2013;41(11):2585–90.

Article  PubMed  PubMed Central  Google Scholar 

Viladomiu M, Hontecillas R, Bassaganya-Riera J. Modulation of inflammation and immunity by dietary conjugated linoleic acid. Eur J Pharmacol. 2016;785:87–95.

Article  CAS  PubMed  Google Scholar 

Powers SK, Jackson MJ. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev. 2008;88(4):1243–76.

Article  CAS  PubMed  Google Scholar 

Bassaganya-Riera J, Hontecillas R, Beitz D. Colonic anti-inflammatory mechanisms of conjugated linoleic acid. Clin Nutr. 2002;21(6):451–9.

Article  CAS  PubMed  Google Scholar 

Bassaganya-Riera J, Hontecillas R. Dietary CLA and n-3 PUFA in inflammatory bowel disease. Curr Opin Clin Nutr Metab Care. 2010;13(5):569.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu Y, Correll P, Heuvel JV. Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPARγ-dependent mechanism. Biochim Biophys Acta (BBA)-Mol Cell Biol Lipids. 2002;1581(3):89–99.

CAS  Google Scholar 

Goedecke JH, Rae DE, Smuts CM, Lambert EV, O’Shea M. Conjugated linoleic acid isomers, t10c12 and c9t11, are differentially incorporated into adipose tissue and skeletal muscle in humans. Lipids. 2009;44(11):983.

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