Brown TD, Johnston RC, Saltzman CL, Marsh JL, Buckwalter JA. Posttraumatic osteoarthritis: a first estimate of incidence, prevalence, and burden of disease. J Orthop Trauma. 2006;20:739–44.

Article  PubMed  Google Scholar 

Thomas AC, Hubbard-Turner T, Wikstrom EA, Palmieri-Smith RM. Epidemiology of posttraumatic osteoarthritis. J Athl Train. 2017;52:491–6.

Article  PubMed  PubMed Central  Google Scholar 

Øiestad BE, Engebretsen L, Storheim K, Risberg MA. Knee osteoarthritis after anterior cruciate ligament injury: a systematic review. Am J Sports Med. 2009;37:1434–43.

Article  PubMed  Google Scholar 

Lattermann C, Jacobs CA, Proffitt Bunnell M, Huston LJ, Gammon LG, Johnson DL, et al. A multicenter study of early anti-inflammatory treatment in patients with acute anterior cruciate ligament tear. Am J Sports Med. 2017;45:325–33.

Article  PubMed  Google Scholar 

Friel NA, Chu CR. The role of ACL injury in the development of posttraumatic knee osteoarthritis. Clin Sports Med. 2013;32:1–12.

Article  PubMed  PubMed Central  Google Scholar 

Riordan EA, Little C, Hunter D. Pathogenesis of post-traumatic OA with a view to intervention. Best Pract Res Clin Rheumatol. Elsevier BV. 2014;28:17–30.

Google Scholar 

Lattermann C, Proffitt M, Huston LJ, Gammon L, Johnson DL, Kraus VB, et al. Multicenter orthopaedic outcome network early anti-inflammatory treatment in patients with acute ACL tear (MOON-AAA) clinical trial. Orthop J Sports Med. SAGE Publications. 2016;4:2325967116S0018.

Article  Google Scholar 

Nathan C, Ding A. Nonresolving inflammation. Cell. 2010;140:871–82.

Article  CAS  PubMed  Google Scholar 

Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, et al. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2018;9:7204–18.

Article  PubMed  Google Scholar 

Tsuchida AI, Beekhuizen M, Rutgers M, van Osch GJVM, Bekkers JEJ, Bot AGJ, et al. Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in vitro regeneration model. Arthritis Res Ther. 2012;14:R262.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lubberts E, Joosten LA, van de Loo FA, van den Gersselaar LA, van den Berg WB. Reduction of interleukin-17-induced inhibition of chondrocyte proteoglycan synthesis in intact murine articular cartilage by interleukin-4. Arthritis Rheum. 2000;43:1300–6.

Article  CAS  PubMed  Google Scholar 

Lattermann C, Conley CE-W, Johnson DL, Reinke EK, Huston LJ, Huebner JL, et al. Select biomarkers on the day of anterior cruciate ligament reconstruction predict poor patient-reported outcomes at 2-year follow-up: a pilot study. Biomed Res Int. 2018;2018:9387809.

Article  PubMed  PubMed Central  Google Scholar 

King JD, Rowland G, Villasante Tezanos AG, Warwick J, Kraus VB, Lattermann C, et al. Joint fluid proteome after anterior cruciate ligament rupture reflects an acute posttraumatic inflammatory and chondrodegenerative state. Cartilage. 2018:1947603518790009.

Amano K, Huebner JL, Stabler TV, Tanaka M, McCulloch CE, Lobach I, et al. Synovial fluid profile at the time of anterior cruciate ligament reconstruction and its association with cartilage matrix composition 3 years after surgery. Am J Sports Med. 2018;46:890–9.

Article  PubMed  PubMed Central  Google Scholar 

•• Irie K, Uchiyama E, Iwaso H. Intraarticular inflammatory cytokines in acute anterior cruciate ligament injured knee. Knee. 2003;10:93–6. An interesting study investigating the acute inflammatory response and pro-inflammatory cytokine release in the synovial fluid after anterior cruciate ligament injury.

Waly NE, Refaiy A, Aborehab NM. IL-10 and TGF-β: roles in chondroprotective effects of glucosamine in experimental osteoarthritis? Pathophysiol. 2017;24:45–9.

Article  CAS  Google Scholar 

Deligne C, Casulli S, Pigenet A, Bougault C, Campillo-Gimenez L, Nourissat G, et al. Differential expression of interleukin-17 and interleukin-22 in inflamed and non-inflamed synovium from osteoarthritis patients. Osteoarthritis Cartilage. 2015;23:1843–52.

Article  CAS  PubMed  Google Scholar 

Lu J, Feng X, Zhang H, Wei Y, Yang Y, Tian Y, et al. Maresin-1 suppresses IL-1β-induced MMP-13 secretion by activating the PI3K/AKT pathway and inhibiting the NF-κB pathway in synovioblasts of an osteoarthritis rat model with treadmill exercise. Connect Tissue Res. Informa UK Limited. 2021;62:508–18.

Article  CAS  PubMed  Google Scholar 

Perretti M, Cooper D, Dalli J, Norling LV. Immune resolution mechanisms in inflammatory arthritis. Nat Rev Rheumatol. 2017;13:87–99.

Article  CAS  PubMed  Google Scholar 

Yang YH, Morand EF, Getting SJ, Paul-Clark M, Liu DL, Yona S, et al. Modulation of inflammation and response to dexamethasone by annexin 1 in antigen-induced arthritis. Arthritis Rheum. 2004;50:976–84.

Article  CAS  PubMed  Google Scholar 

•• Serhan CN, Chiang N, Dalli J, Levy BD. Lipid mediators in the resolution of inflammation. Cold Spring Harb Perspect Biol. 2014;7:a016311. An important study showing the structure and functional roles of these novel lipid mediators (specialized pro-resolving mediators) of resolution.

Serhan CN. Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways. Annu Rev Immunol Ann Rev. 2007;25:101–37.

Article  CAS  Google Scholar 

Bannenberg G, Serhan CN. Specialized pro-resolving lipid mediators in the inflammatory response: an update. Biochim Biophys Acta. Elsevier BV. 2010;1801:1260–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perretti M, Norling LV. Actions of SPM in regulating host responses in arthritis. Mol Aspects Med. Elsevier BV. 2017;58:57–64.

Article  CAS  PubMed  Google Scholar 

Gronert K, Maheshwari N, Khan N, Hassan IR, Dunn M, Laniado Schwartzman M. A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense. J Biol Chem. Elsevier BV; 2005;280:15267–15278.

Hsiao H-M, Thatcher TH, Colas RA, Serhan CN, Phipps RP, Sime PJ. Resolvin D1 reduces emphysema and chronic inflammation. Am J Pathol. 2015;185:3189–201.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Benabdoun HA, Kulbay M, Rondon E-P, Vallières F, Shi Q, Fernandes J, et al. In vitro and in vivo assessment of the proresolutive and antiresorptive actions of resolvin D1: relevance to arthritis. Arthritis Res Ther. Springer Science and Business Media LLC. 2019;21:72.

Article  PubMed  PubMed Central  Google Scholar 

Benabdoune H, Rondon E-P, Shi Q, Fernandes J, Ranger P, Fahmi H, et al. The role of resolvin D1 in the regulation of inflammatory and catabolic mediators in osteoarthritis. Inflamm Res Springer Sci Bus. Media LLC. 2016;65:635–45.

CAS  Google Scholar 

Conte FP, Menezes-de-Lima O Jr, Verri WA Jr, Cunha FQ, Penido C, Henriques MG. Lipoxin A(4) attenuates zymosan-induced arthritis by modulating endothelin-1 and its effects. Br J Pharmacol. Wiley. 2010;161:911–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lima-Garcia JF, Dutra RC, da Silva K, Motta EM, Campos MM, Calixto JB. The precursor of resolvin D series and aspirin-triggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats. Br J Pharmacol. Wiley. 2011;164:278–93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin S, Chen H, Li Y, Zhong H, Sun W, Wang J, et al. Maresin 1 improves the Treg/Th17 imbalance in rheumatoid arthritis through miR-21. Ann Rheum Dis. 2018;77:1644–52.

Article  CAS  PubMed  Google Scholar 

Allen BL, Montague-Cardoso K, Simeoli R, Colas RA, Oggero S, Vilar B. Imbalance of pro-resolving lipid mediators in persistent allodynia dissociated from signs of clinical arthritis. Pain. 2020;161:2155–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arnardottir HH, Dalli J, Norling LV, Colas RA, Perretti M, Serhan CN. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation. J Immunol. 2016;197:2362–8.

Article  CAS  PubMed  Google Scholar 

Sano Y, Toyoshima S, Miki Y, Taketomi Y, Ito M, Lee H, et al. Activation of inflammation and resolution pathways of lipid mediators in synovial fluid from patients with severe rheumatoid arthritis compared with severe osteoarthritis. Asia Pac Allergy Asia Pac Assoc Allergy, Asthma, Clin Immunol. 2020;10:e21.

Google Scholar 

Hashimoto A, Hayashi I, Murakami Y, Sato Y, Kitasato H, Matsushita R, et al. Antiinflammatory mediator lipoxin A4 and its receptor in synovitis of patients with rheumatoid arthritis. J Rheumatol. 2007;34:2144–53.

CAS  PubMed  Google Scholar 

Khella CM, Horvath JM, Asgarian R, Rolauffs B, Hart ML. Anti-inflammatory therapeutic approaches to prevent or delay post-traumatic osteoarthritis (PTOA) of the knee joint with a focus on sustained delivery approaches. Int J Mol Sci. MDPI AG. 2021;22:8005.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jacobs CA, Conley CEW, Kraus VB, Lansdown DA, Lau BC, Li X, et al. MOntelukast as a potential CHondroprotective treatment following Anterior cruciate ligament reconstruction (MOCHA trial): study protocol for a double-blind, randomized, placebo-controlled clinical trial. Trials. Springer Sci Bus. Media LLC; 2022;23:98.

Chaudhari AMW, Briant PL, Bevill SL, Koo S, Andriacchi TP. Knee kinematics, cartilage morphology, and osteoarthritis after ACL injury. Med Sci Sports Exerc. Ovid Technologies (Wolters Kluwer Health); 2008;40:215–222.

Swärd P, Frobell R, Englund M, Roos H, Struglics A. Cartilage and bone markers and inflammatory cytokines are increased in synovial fluid in the acute phase of knee injury (hemarthrosis)--a cross-sectional analysis. Osteoarthritis Cartilage. Elsevier BV. 2012;20:1302–8.

Article  PubMed  Google Scholar 

Cameron M, Buchgraber A, Passler H, Vogt M, Thonar E, Fu F, et al. The natural history of the anterior cruciate ligament-deficient knee. Changes in synovial fluid cytokine and keratan sulfate concentrations. Am J Sports Med. 1997;25:751–4.

Article  CAS  PubMed  Google Scholar 

Harkey MS, Luc BA, Golightly YM, Thomas AC, Driban JB, Hackney AC, et al. Osteoarthritis-related biomarkers following anterior cruciate ligament injury and reconstruction: a systematic review. Osteoarthritis Cartilage. Elsevier BV. 2015;23:1–12.

Article  CAS  PubMed