Salari N, Darvishi N, Bartina Y, Larti M, Kiaei A, Hemmati M, Shohaimi S, Mohammadi M. Global prevalence of osteoporosis among the world older adults: a comprehensive systematic review and meta-analysis. J Orthop Surg Res. 2021;16:669.

Article  PubMed  PubMed Central  Google Scholar 

Li R, Boer CG, Oei L, Medina-Gomez C. The gut microbiome: a new frontier in musculoskeletal research. Current Osteoporosis Rep. 2021;19:347–57.

Article  CAS  Google Scholar 

Pacifici R. Bone remodeling and the microbiome. Cold Spring Harb Perspect Med. 2018;8:a031203. https://doi.org/10.1101/cshperspect.a031203.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Byrd DA, Carson TL, Williams F, Vogtmann E. Elucidating the role of the gastrointestinal microbiota in racial and ethnic health disparities. Genome Biology. 2020;21:192.

Article  PubMed  PubMed Central  Google Scholar 

Kaplan RC, Wang Z, Usyk M, et al. Gut microbiome composition in the Hispanic Community Health Study/Study of Latinos is shaped by geographic relocation, environmental factors, and obesity. Genome Biology. 2019;20:219.

Article  PubMed  PubMed Central  Google Scholar 

•• Dwiyanto J, Hussain MH, Reidpath D, Ong KS, Qasim A, Lee SWH, Lee SM, Foo SC, Chong CW, Rahman S. Ethnicity influences the gut microbiota of individuals sharing a geographical location: a cross-sectional study from a middle-income country. Scientific Reports. 2021;11:2618. This multi-ethnic study conducted in Malaysia shows the more relevant impact of ethnicity, compared to geography, on gut microbioal composition.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brooks AW, Priya S, Blekhman R, Bordenstein SR. Gut microbiota diversity across ethnicities in the United States. PLoS Biol. 2018;16:e2006842.

Article  PubMed  PubMed Central  Google Scholar 

Deschasaux M, Bouter KE, Prodan A, et al. Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography. Nat Med. 2018;24:1526–31.

Article  CAS  PubMed  Google Scholar 

• Ang QY, Alba DL, Upadhyay V, et al. The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health. eLife. 2021;10:e70349. This interesting study highlights an important distinction between race ethnicity and geography in relation to gut microbial composition of individuals living in the U.S.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ruiz-Esteves KN, Teysir J, Schatoff D, Yu EW, Burnett-Bowie S-AM. Disparities in osteoporosis care among postmenopausal women in the United States. Maturitas. 2022;156:25–9.

Article  PubMed  Google Scholar 

•• Noel SE, Santos MP, Wright NC. Racial and ethnic disparities in bone health and outcomes in the United States. J Bone Miner Res. 2021;36:1881–905. This important study is a comprehensive review of the existing health disparities in bone in the U.S., highlighting the critical need for studies comprised of diverse populations.

Article  PubMed  Google Scholar 

Wade SW, Strader C, Fitzpatrick LA, Anthony MS, O'Malley CD. Estimating prevalence of osteoporosis: examples from industrialized countries. Arch Osteoporos. 2014;9:182.

Article  CAS  PubMed  Google Scholar 

Di Stefano M, Veneto G, Malservisi S, Corazza GR. Small intestine bacterial overgrowth and metabolic bone disease. Dig Dis Sci. 2001;46:1077–82.

Article  PubMed  Google Scholar 

•• Huang R, Liu P, Bai Y, et al. Changes in the gut microbiota of osteoporosis patients based on 16S rRNA gene sequencing: a systematic review and meta-analysis. J Zhejiang Univ Sci B. 2022;23:1002–13. This comprehensive review of the current global epidemiological knowledge about the relation between gut microbiota and bone health includes consideration of racial and ethnic differences.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Gao X, Lv J, Zeng Y, Li Q, Wang L, Zhang Y, Gao W, Wang J. Gut microbiome signature are correlated with bone mineral density alterations in the Chinese elders. Front Cell Infect Microbiol. 2022;12:827575.

Article  CAS  PubMed  PubMed Central  Google Scholar 

• Greenbaum J, Lin X, Su KJ, Gong R, Shen H, Shen J, Xiao HM, Deng HW. Integration of the human gut microbiome and serum metabolome reveals novel biological factors involved in the regulation of bone mineral density. Front Cell Infect Microbiol. 2022;12:853499. This multi-omics study included network analysis that identified several gut microbial-serum metabolite relations that may regulate BMD.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wei M, Li C, Dai Y, Zhou H, Cui Y, Zeng Y, Huang Q, Wang Q. High-throughput absolute quantification sequencing revealed osteoporosis-related gut microbiota alterations in Han Chinese elderly. Frontiers in Cellular and Infection. Microbiology. 2021;11

• Rettedal EA, Ilesanmi-Oyelere BL, Roy NC, Coad J, Kruger MC. The gut microbiome is altered in postmenopausal women with osteoporosis and osteopenia. JBMR Plus. 2021;5:e10452. This study is noteworth for its extensive examination of the gut-microbiome-bone relation using shotgun metagenomic sequencing in a Western cohort of women.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu Z, Xie Z, Sun J, et al. Gut microbiome reveals specific dysbiosis in primary osteoporosis. Front Cell Infect Microbiol. 2020;10:160.

Article  PubMed  PubMed Central  Google Scholar 

• Ling CW, Miao Z, Xiao ML, et al. The association of gut microbiota with osteoporosis is mediated by amino acid metabolism: multiomics in a large cohort. J Clin Endocrinol Metab. 2021;106:e3852–64. This study is important for its inclusion of men, its large size (n = 1776), and its finding that amina acid metabolism plays a key role in the gut microbiota-bone relation.

Article  PubMed  Google Scholar 

Das M, Cronin O, Keohane DM, et al. Gut microbiota alterations associated with reduced bone mineral density in older adults. Rheumatology. 2019;58:2295–304.

Article  PubMed  PubMed Central  Google Scholar 

Li C, Huang Q, Yang R, Dai Y, Zeng Y, Tao L, Li X, Zeng J, Wang Q. Gut microbiota composition and bone mineral loss-epidemiologic evidence from individuals in Wuhan, China. Osteoporos Int. 2019;30:1003–13.

Article  CAS  PubMed  Google Scholar 

Chen L, Yan S, Yang M, et al. The gut microbiome is associated with bone turnover markers in postmenopausal women. Am J Transl Res. 2021;13:12601–13.

CAS  PubMed  PubMed Central  Google Scholar 

•• Wang Z, Chen K, Wu C, et al. An emerging role of Prevotella histicola on estrogen deficiency-induced bone loss through the gut microbiota-bone axis in postmenopausal women and in ovariectomized mice. Am J Clin Nutr. 2021;114:1304–13. This elegant study identified a decreased abundance of the gut microbe genus Prevotella in postmenopausal women with low BMD and then supplemented ovariectomized mice with Prevotella histicola, finding positive changes in bone volume of treated mice compared to controls.

Article  PubMed  Google Scholar 

He J, Xu S, Zhang B, et al. Gut microbiota and metabolite alterations associated with reduced bone mineral density or bone metabolic indexes in postmenopausal osteoporosis. Aging (Albany NY). 2020;12:8583–604.

Article  CAS  PubMed  Google Scholar 

. Palacios-González B, Ramírez-Salazar EG, Rivera-Paredez B, et al. (2020) A multi-omic analysis for low bone mineral density in postmenopausal women suggests a relationship between diet, metabolites, and microbiota. Microorganisms 8(11):1630. The is the sole study examining the gut microbiome-bone health relation in a Latin American population.

• Orwoll ES, Parimi N, Wiedrick J, Lapidus J, Napoli N, Wilkinson JE, Huttenhower C, Langsetmo L, Kiel DP. Analysis of the associations between the human fecal microbiome and bone density, structure, and strength: the Osteoporotic Fractures in Men (MrOS) cohort. J Bone Miner Res. 2022;37:597–607. This is the sole study examining the gut-microbiome-bone relation in males only.

Article  CAS  PubMed  Google Scholar 

• Morato-Martínez M, López-Plaza B, Santurino C, Palma-Milla S, Gómez-Candela C. A dairy product to reconstitute enriched with bioactive nutrients stops bone loss in high-risk menopausal women without pharmacological treatment. Nutrients. 2020;12:2203. This is an encouraging study in women showing the significant protective effect on BMD of a nutritional intervention.

Article  PubMed  PubMed Central  Google Scholar 

Takimoto T, Hatanaka M, Hoshino T, Takara T, Tanaka K, Shimizu A, Morita H, Nakamura T. Effect of Bacillus subtilis C-3102 on bone mineral density in healthy postmenopausal Japanese women: a randomized, placebo-controlled, double-blind clinical trial. Bioscience of Microbiota, Food and Health. 2018;37:87–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jansson P-A, Curiac D, Lazou Ahrén I, Hansson F, Martinsson Niskanen T, Sjögren K, Ohlsson C. Probiotic treatment using a mix of three Lactobacillus strains for lumbar spine bone loss in postmenopausal women: a randomised, double-blind, placebo-controlled, multicentre trial. The Lancet Rheumatology. 2019;1:e154–62.

Article  Google Scholar 

Nilsson AG, Sundh D, Bäckhed F, Lorentzon M. Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo-controlled, double-blind, clinical trial. J Int Med. 2018;284:307–17.

Article  CAS  Google Scholar 

Yan J, Charles JF. Gut microbiota and IGF-1. Calcif Tissue Int. 2018;102:406–14.

Article  PubMed  PubMed Central  Google Scholar 

Yan J, Takakura A, Zandi-Nejad K, Charles JF. Mechanisms of gut microbiota-mediated bone remodeling. Gut Microbes. 2018;9:84–92.

Article  CAS  PubMed  Google Scholar 

Locatelli V, Bianchi VE. Effect of GH/IGF-1 on bone metabolism and osteoporsosis. Int J Endocrinol. 2014;2014:235060.

Article  PubMed  PubMed Central  Google Scholar 

Wallimann A, Magrath W, Thompson K, Moriarty T, Richards RG, Akdis CA, O’Mahony L, Hernandez CJ. Gut microbial-derived short-chain fatty acids and bone: a potential role in fracture healing. Eur Cell Mater. 2021;41:454–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li J-Y, Yu M, Pal S, Tyagi AM, Dar H, Adams J, Weitzmann MN, Jones RM, Pacifici R. Parathyroid hormone-dependent bone formation requires butyrate production by intestinal microbiota. J Clin Investig. 2020;130:1767–81.

Article  CAS  PubMed  PubMed Central