Loss of Pkd1 limits susceptibility to colitis and colorectal cancer

American_Cancer_Society. Colorectal cancer facts and figures 2014–2016. Atlanta: American Cancer Society I; 2014.

Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 1990;61:759–67.

Article  CAS  PubMed  Google Scholar 

Jones S, Chen WD, Parmigiani G, Diehl F, Beerenwinkel N, Antal T, et al. Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci USA. 2008;105:4283–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Glaire MA, Brown M, Church DN, Tomlinson I. Cancer predisposition syndromes: lessons for truly precision medicine. J Pathol. 2017;241:226–35.

Article  PubMed  Google Scholar 

Scarpa A, Chang DK, Nones K, Corbo V, Patch AM, Bailey P, et al. Whole-genome landscape of pancreatic neuroendocrine tumours. Nature. 2017;543:65–71.

Article  CAS  PubMed  Google Scholar 

Ma H, Brosens LAA, Offerhaus GJA, Giardiello FM, de Leng WWJ, Montgomery EA. Pathology and genetics of hereditary colorectal cancer. Pathology. 2018;50:49–59.

Article  CAS  PubMed  Google Scholar 

Huyghe JR, Bien SA, Harrison TA, Kang HM, Chen S, Schmit SL, et al. Discovery of common and rare genetic risk variants for colorectal cancer. Nat Genet. 2019;51:76–87.

Article  CAS  PubMed  Google Scholar 

Wetmore JB, Calvet JP, Yu AS, Lynch CF, Wang CJ, Kasiske BL, et al. Polycystic kidney disease and cancer after renal transplantation. J Am Soc Nephrol. 2014;25:2335–41.

Article  PubMed  PubMed Central  Google Scholar 

Cornec-Le Gall E, Torres VE, Harris PC. Genetic complexity of autosomal dominant polycystic kidney and liver diseases. J Am Soc Nephrol. 2018;29:13–23.

Article  PubMed  Google Scholar 

Heyer CM, Sundsbak JL, Abebe KZ, Chapman AB, Torres VE, Grantham JJ, et al. Predicted mutation strength of nontruncating PKD1 mutations aids genotype-phenotype correlations in autosomal dominant polycystic kidney disease. J Am Soc Nephrol. 2016;27:2872–84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ward CJ, Wu Y, Johnson RA, Woollard JR, Bergstralh EJ, Cicek MS, et al. Germline PKHD1 mutations are protective against colorectal cancer. Hum Genet. 2011;129:345–9.

Article  PubMed  PubMed Central  Google Scholar 

Cornec-Le Gall E, Alam A, Perrone RD. Autosomal dominant polycystic kidney disease. Lancet. 2019;393:919–35.

Article  PubMed  Google Scholar 

Geng L, Segal Y, Pavlova A, Barros EJ, Lohning C, Lu W, et al. Distribution and developmentally regulated expression of murine polycystin. Am J Physiol. 1997;272:F451–459.

CAS  PubMed  Google Scholar 

Conduit SE, Hakim S, Feeney SJ, Ooms LM, Dyson JM, Abud HE, et al. Beta-catenin ablation exacerbates polycystic kidney disease progression. Hum Mol Genet. 2019;28:230–44.

CAS  PubMed  Google Scholar 

Wuebken A, Schmidt-Ott KM. WNT/beta-catenin signaling in polycystic kidney disease. Kidney Int. 2011;80:135–8.

Article  CAS  PubMed  Google Scholar 

Gargalionis AN, Korkolopoulou P, Farmaki E, Piperi C, Dalagiorgou G, Adamopoulos C, et al. Polycystin-1 and polycystin-2 are involved in the acquisition of aggressive phenotypes in colorectal cancer. Int J Cancer. 2015;136:1515–27.

Article  CAS  PubMed  Google Scholar 

Outeda P, Huso DL, Fisher SA, Halushka MK, Kim H, Qian F, et al. Polycystin signaling is required for directed endothelial cell migration and lymphatic development. Cell reports. 2014;7:634–44.

Article  CAS  PubMed  Google Scholar 

Piontek K, Menezes LF, Garcia-Gonzalez MA, Huso DL, Germino GG. A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1. Nat Med. 2007;13:1490–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Piontek KB, Huso DL, Grinberg A, Liu L, Bedja D, Zhao H, et al. A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo. J Am Soc Nephrol. 2004;15:3035–43.

Article  PubMed  Google Scholar 

Nikonova AS, Plotnikova OV, Serzhanova V, Efimov A, Bogush I, Cai KQ, et al. Nedd9 restrains renal cystogenesis in Pkd1-/- mice. Proc Natl Acad Sci USA. 2014;111:12859–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nikonova AS, Deneka AY, Kiseleva AA, Korobeynikov V, Gaponova A, Serebriiskii IG, et al. Ganetespib limits ciliation and cystogenesis in autosomal-dominant polycystic kidney disease (ADPKD). FASEB J. 2018;32:2735–46.

Article  PubMed  PubMed Central  Google Scholar 

Seeger-Nukpezah T, Proia DA, Egleston BL, Nikonova AS, Kent T, Cai KQ, et al. Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease. Proc Natl Acad Sci USA. 2013;110:12786–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, et al. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature. 2012;491:254–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hinoi T, Loda M, Fearon ER. Silencing of CDX2 expression in colon cancer via a dominant repression pathway. J Biol Chem. 2003;278:44608–16.

Article  CAS  PubMed  Google Scholar 

Hinoi T, Akyol A, Theisen BK, Ferguson DO, Greenson JK, Williams BO, et al. Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation. Cancer Res. 2007;67:9721–30.

Article  CAS  PubMed  Google Scholar 

Billips LG, Petitte D, Landreth KS. Bone marrow stromal cell regulation of B lymphopoiesis: interleukin-1 (IL-1) and IL-4 regulate stromal cell support of pre-B cell production in vitro. Blood. 1990;75:611–9.

Article  CAS  PubMed  Google Scholar 

Boj SF, Hwang CI, Baker LA, Chio II, Engle DD, Corbo V, et al. Organoid models of human and mouse ductal pancreatic cancer. Cell. 2015;160:324–38.

Article  CAS  PubMed  Google Scholar 

Deneka AY, Kopp MC, Nikonova AS, Gaponova AV, Kiseleva AA, Hensley HH, et al. Nedd9 restrains autophagy to limit growth of early stage non-small cell lung cancer. Cancer Res. 2021;81:3717–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Debnath J, Muthuswamy SK, Brugge JS. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods. 2003;30:256–68.

Article  CAS  PubMed  Google Scholar 

Trapnell C, Pachter L, Salzberg SL. TopHat: discovering splice junctions with RNA-Seq. Bioinformatics. 2009;25:1105–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Trapnell C, Williams BA, Pertea G, Mortazavi A, Kwan G, van Baren MJ, et al. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol. 2010;28:511–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Trapnell C, Hendrickson DG, Sauvageau M, Goff L, Rinn JL, Pachter L. Differential analysis of gene regulation at transcript resolution with RNA-seq. Nat Biotechnol. 2013;31:46–53.

Article  CAS  PubMed  Google Scholar 

Fragiadaki M, Macleod FM, Ong ACM. The controversial role of fibrosis in autosomal dominant polycystic kidney disease. Int J Mol Sci. 2020;21:8936.

Article  PubMed  PubMed Central  Google Scholar 

van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, Hurlstone A, et al. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell. 2002;111:241–50.

Article  PubMed  Google Scholar 

Zhu G, Wang Y, Huang B, Liang J, Ding Y, Xu A, et al. A Rac1/PAK1 cascade controls beta-catenin activation in colon cancer cells. Oncogene. 2012;31:1001–12.

Article  CAS  PubMed  Google Scholar 

Grantham JJ. Polycystic kidney disease: neoplasia in disguise. Am J Kidney Dis. 1990;15:110–6.

Article  CAS  PubMed  Google Scholar 

Grantham JJ, Nair V, Winklhoffer F. Cystic diseases of the kidney. In: Brenner BM, editors. Brenner & rector’s the kidney. Philadelphia: WB Saunders Company; 2000. p. 1699–730.

Choi CR, Bakir IA, Hart AL, Graham TA. Clonal evolution of colorectal cancer in IBD. Nat Rev Gastroenterol Hepatol. 2017;14:218–29.

Article  PubMed  Google Scholar 

留言 (0)

沒有登入
gif