Mannstadt M, Bilezikian JP, Thakker RV, Hannan FM, Clarke BL, Reijnmark L, et al. Hypoparathyroidism. Nat Rev Dis Prim. 2017;3:17055. https://doi.org/10.1038/nrdp.2017.55.

Article  PubMed  Google Scholar 

Kim J-M, Lin C, Stavre Z, Greenblatt MB, Shim J-H. Osteoblast-osteoclast communication and bone homeostasis. Cells. 2020. https://doi.org/10.3390/cells9092073.

Silva BC, Bilezikian JP. Skeletal abnormalities in hypoparathyroidism and in primary hyperparathyroidism. Rev Endocr Metab Disord. 2021;22:789–802. https://doi.org/10.1007/S11154-020-09614-0.

Hepp N, Frederiksen AL, Dunø M, Jørgensen NR, Langdahl B, Vedtofte P, et al. Multiple fractures and impaired bone fracture healing in a patient with pycnodysostosis and hypophosphatasia. Calcif Tissue Int. 2019;105:681–6. https://doi.org/10.1007/s00223-019-00605-1.

Article  CAS  PubMed  Google Scholar 

Xue J-Y, Ikegawa S, Guo L. Genetic disorders associated with the RANKL/OPG/RANK pathway. J Bone Miner Metab. 2021;39:45–53. https://doi.org/10.1007/s00774-020-01148-4.

Article  CAS  PubMed  Google Scholar 

Underbjerg L, Sikjaer T, Mosekilde L, Rejnmark L. Postsurgical hypoparathyroidism-risk of fractures, psychiatric diseases, cancer, cataract, and infections. J Bone Miner Res. 2014;29:2504–10. https://doi.org/10.1002/jbmr.2273.

Vadiveloo T, Donnan PT, Leese CJ, Abraham KJ, Leese GP. Increased mortality and morbidity in patients with chronic hypoparathyroidism: a population-based study. Clin Endocrinol (Oxf). 2019;90:285–92. https://doi.org/10.1111/cen.13895.

Fujiyama K, Kiriyama T, Ito M, Nakata K, Yamashita S, Yokoyama N, et al. Attenuation of postmenopausal high turnover bone loss in patients with hypoparathyroidism. J Clin Endocrinol Metab. 1995;80:2135–8. https://doi.org/10.1210/jcem.80.7.7608266.

Article  CAS  PubMed  Google Scholar 

Mendonça ML, Pereira FA, Nogueira-Barbosa MH, Monsignore LM, Teixeira SR, Watanabe PCA, et al. Increased vertebral morphometric fracture in patients with postsurgical hypoparathyroidism despite normal bone mineral density. BMC Endocr Disord. 2013;13:1. https://doi.org/10.1186/1472-6823-13-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cipriani C, Minisola S, Bilezikian JP, Diacinti DD, Colangelo L, Piazzolla V, et al. Vertebral fracture assessment in postmenopausal women with postsurgical hypoparathyroidism. J Clin Endocrinol Metab. 2021;106:1303–11. https://doi.org/10.1210/clinem/dgab076.

Article  PubMed  PubMed Central  Google Scholar 

Underbjerg L, Sikjaer T, Mosekilde L, Rejnmark L. The epidemiology of nonsurgical hypoparathyroidism in Denmark: a nationwide case finding study. J Bone Miner Res. 2015;30:1738–44. https://doi.org/10.1002/jbmr.2501.

Chawla H, Saha S, Kandasamy D, Sharma R, Sreenivas V, Goswami R. Vertebral fractures and bone mineral density in patients with idiopathic hypoparathyroidism on long-term follow-up. J Clin Endocrinol Metab. 2017;102:251–8. https://doi.org/10.1210/jc.2016-3292.

• Saha S, Mannar V, Kandasamy D, Sreenivas V, Goswami R. Vertebral fractures, trabecular bone score and their determinants in chronic hypoparathyroidism. J Endocrinol Invest. 2022;45:1777–86. https://doi.org/10.1007/s40618-022-01818-2. Reports findings of an increased risk of vertebral fractures in non-surgical HypoPT.

Article  CAS  PubMed  Google Scholar 

Kim SH, Rhee Y, Kim YM, Won YJ, Noh J, Moon H, et al. Prevalence and complications of nonsurgical hypoparathyroidism in Korea: a nationwide cohort study. PLoS One. 2020;15:e0232842. https://doi.org/10.1371/journal.pone.0232842.

Abugassa S, Nordenström J, Eriksson S, Sjödén G. Bone mineral density in patients with chronic hypoparathyroidism. J Clin Endocrinol Metab. 1993;76:1617–21. https://doi.org/10.1210/jcem.76.6.8501170.

Article  CAS  PubMed  Google Scholar 

Laway BA, Goswami R, Singh N, Gupta N, Seith A. Pattern of bone mineral density in patients with sporadic idiopathic hypoparathyroidism. Clin Endocrinol (Oxf). 2006;64:405–9. https://doi.org/10.1111/j.1365-2265.2006.02479.x.

Chan FKW, Tiu S-C, Choi K-L, Choi C-H, Kong APS, Shek C-C. Increased bone mineral density in patients with chronic hypoparathyroidism. J Clin Endocrinol Metab. 2003;88:3155–9. https://doi.org/10.1210/jc.2002-021388.

Article  CAS  PubMed  Google Scholar 

Ye J, Li Q, Nie J. Prevalence, characteristics, and associated risk factors of wrist fractures in americans above 50: the crosssectional NHANES study. Front Endocrinol (Lausanne). 2022. https://doi.org/10.3389/fendo.2022.800129.

Meier RPH, Perneger TV, Stern R, Rizzoli R, Peter RE. Increasing occurrence of atypical femoral fractures associated with bisphosphonate use. Arch Intern Med. 2012;172:930–6. https://doi.org/10.1001/archinternmed.2012.1796.

Article  PubMed  Google Scholar 

Liu J, Chen S, Quan T, Wang Y, Wang O, Nie M, et al. Bone microstructure of adult patients with non-surgical hypoparathyroidism assessed by high-resolution peripheral quantitative computed tomography. Osteoporos Int. 2020;31:2219–30. https://doi.org/10.1007/s00198-020-05506-w.

Starr JR, Tabacco G, Majeed R, Omeragic B, Bandeira L, Rubin MR. PTH and bone material strength in hypoparathyroidism as measured by impact microindentation. Osteoporos Int. 2020;31:327–33. https://doi.org/10.1007/s00198-019-05177-2.

Article  CAS  PubMed  Google Scholar 

Sakane EN, Vieira MCC, Lazaretti-Castro M, Maeda SS. Predictors of poor bone microarchitecture assessed by trabecular bone score in postsurgical hypoparathyroidism. J Clin Endocrinol Metab. 2019;104:5795–803. https://doi.org/10.1210/jc.2019-00698.

Article  PubMed  Google Scholar 

McCloskey EV, Odén A, Harvey NC, Leslie WD, Hans D, Johansson H, et al. A meta-analysis of trabecular bone score in fracture risk prediction and its relationship to FRAX. J Bone Miner Res. 2016;31:940–8. https://doi.org/10.1002/jbmr.2734.

Iglesias SG, Dominguez MLDM, Herrero EF, Martinez-Pueyo JI, Arroba CM-A, Diaz-Guerra GM, et al. Trabecular bone score and bone mineral density in patients with postsurgical hypoparathyroidism after total thyroidectomy for differentiated thyroid carcinoma. Surgery. 2019;165:814–9. https://doi.org/10.1016/j.surg.2018.10.034.

Cusano NE, Nishiyama KK, Zhang C, Rubin MR, Boutroy S, McMahon DJ, et al. Noninvasive assessment of skeletal microstructure and estimated bone strength in hypoparathyroidism. J Bone Miner Res. 2016;31:308–16. https://doi.org/10.1002/jbmr.2609.

Chen Q, Kaji H, Iu M-F, Nomura R, Sowa H, Yamauchi M, et al. Effects of an excess and a deficiency of endogenous parathyroid hormone on volumetric bone mineral density and bone geometry determined by peripheral quantitative computed tomography in female subjects. J Clin Endocrinol Metab. 2003;88:4655–8. https://doi.org/10.1210/jc.2003-030470.

Article  CAS  PubMed  Google Scholar 

Mannstadt M, Clarke BL, Vokes T, Brandi ML, Ranganath L, Fraser WD, et al. Efficacy and safety of recombinant human parathyroid hormone (1–84) in hypoparathyroidism (REPLACE): a double-blind, placebo-controlled, randomised, phase 3 study. Lancet Diabetes Endocrinol. 2013;1:275–83. https://doi.org/10.1016/S2213-8587(13)70106-2.

Sikjaer T, Rejnmark L, Thomsen JS, Tietze A, Brüel A, Andersen G, et al. Changes in 3-dimensional bone structure indices in hypoparathyroid patients treated with PTH(1–84): a randomized controlled study. J Bone Miner Res. 2012;27:781–8. https://doi.org/10.1002/jbmr.1493.

Article  CAS  PubMed  Google Scholar 

Rubin MR, Zhou H, Cusano NE, Majeed R, Omeragic B, Gomez M, et al. The effects of long-term administration of rhPTH(1–84) in hypoparathyroidism by bone histomorphometry. J Bone Miner Res. 2018;33:1931–9. https://doi.org/10.1002/jbmr.3543.

Article  CAS  PubMed  Google Scholar 

Sikjaer T, Moser E, Rolighed L, Underbjerg L, Bislev LS, Mosekilde L, et al. Concurrent hypoparathyroidism is associated with impaired physical function and quality of life in hypothyroidism. J Bone Miner Res. 2016;31:1440–8. https://doi.org/10.1002/jbmr.2812.

•• Khan AA, Rejnmark L, Rubin M, Schwarz P, Vokes T, Clarke B, et al. PaTH Forward: a randomized, double-blind, placebo-controlled phase 2 trial of TransCon PTH in adult hypoparathyroidism. J Clin Endocrinol Metab. 2021;102:e372–85. https://doi.org/10.1210/clinem/dgab577. Reports finding from a RCT on treatment with a new long-acting PTH analog.