1. Hurford, R, Wolters, FJ, Li, L, et al. Prevalence, predictors, and prognosis of symptomatic intracranial stenosis in patients with transient ischaemic attack or minor stroke: a population-based cohort study. Lancet Neurol 2020; 19: 413–421.
Google Scholar | Crossref | Medline2. Man, S, Xian, Y, Holmes, DN, et al. Association between thrombolytic door-to-needle time and 1-year mortality and readmission in patients with acute ischemic stroke. Jama 2020; 323: 2170–2184.
Google Scholar | Crossref | Medline3. Park, YJ, Borlongan, CV. Recent advances in cell therapy for stroke. J Cereb Blood Flow Metab 2021; 41: 2797–2799.
Google Scholar | SAGE Journals | ISI4. An, C, Shi, Y, Li, P, et al. Molecular dialogs between the ischemic brain and the peripheral immune system: dualistic roles in injury and repair. Prog Neurobiol 2014; 115: 6–24.
Google Scholar | Crossref | Medline | ISI5. Na, SY, Mracsko, E, Liesz, A, et al. Amplification of regulatory T cells using a CD28 superagonist reduces brain damage after ischemic stroke in mice. Stroke 2015; 46: 212–220.
Google Scholar | Crossref | Medline | ISI6. Heindl, S, Ricci, A, Carofiglio, O, et al. Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies. J Exp Med 2021; 218: e20202411.
Google Scholar | Crossref | Medline7. Li, S, Huang, Y, Liu, Y, et al. Change and predictive ability of circulating immunoregulatory lymphocytes in long-term outcomes of acute ischemic stroke. J Cereb Blood Flow Metab 2021; 41: 2280–2294.
Google Scholar | SAGE Journals | ISI8. Huang, X, Hussain, B, Chang, J. Peripheral inflammation and blood-brain barrier disruption: effects and mechanisms. CNS Neurosci Ther 2021; 27: 36–47.
Google Scholar | Crossref | Medline9. Liesz, A, Suri-Payer, E, Veltkamp, C, et al. Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat Med 2009; 15: 192–199.
Google Scholar | Crossref | Medline | ISI10. Li, P, Gan, Y, Sun, BL, et al. Adoptive regulatory T-cell therapy protects against cerebral ischemia. Ann Neurol 2013; 74: 458–471.
Google Scholar | Crossref | Medline | ISI11. Li, P, Mao, L, Zhou, G, et al. Adoptive regulatory T-cell therapy preserves systemic immune homeostasis after cerebral ischemia. Stroke 2013; 44: 3509–3515.
Google Scholar | Crossref | Medline12. Wang, HY, Ye, JR, Cui, LY, et al. Regulatory T cells in ischemic stroke. Acta Pharmacol Sin 2021. DOI: 10.1038/s41401-021-00641-4.
Google Scholar13. Wang, H, Wang, Z, Wu, Q, et al. Regulatory T cells in ischemic stroke. CNS Neurosci Ther 2021; 27: 643–651. 2021/01/21. DOI: 10.1111/cns.13611.
Google Scholar | Crossref | Medline14. Shi L, Sun Z, Su W, et al. Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke. Immunity 2021; 54: 1527–1542.e8.
Google Scholar | Crossref15. Yang, K, Blanco, DB, Neale, G, et al. Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling. Nature 2017; 548: 602–606.
Google Scholar | Crossref | Medline16. Berod, L, Friedrich, C, Nandan, A, et al. De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat Med 2014; 20: 1327–1333.
Google Scholar | Crossref | Medline17. Wang, X, Zhou, Y, Tang, D, et al. ACC1 (acetyl coenzyme a carboxylase 1) is a potential immune modulatory target of cerebral ischemic stroke. Stroke 2019; 50: 1869–1878.
Google Scholar | Crossref | Medline18. Roth, S, Singh, V, Tiedt, S, et al. Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke. Sci Transl Med 2018; 10: 03–16. 2018//DOI: 10.1126/scitranslmed.aao1313.
Google Scholar | Crossref19. Liesz, A, Dalpke, A, Mracsko, E, et al. DAMP signaling is a key pathway inducing immune modulation after brain injury. J Neurosci 2015; 35: 583–598.
Google Scholar | Crossref | Medline | ISI20. Xie, J, Mendez, JD, Mendez-Valenzuela, V, et al. Cellular signalling of the receptor for advanced glycation end products (RAGE). Cell Signal 2013; 25: 2185–2197.
Google Scholar | Crossref | Medline | ISI21. Li, P, Wang, L, Zhou, Y, et al. C-C chemokine receptor type 5 (CCR5)-mediated docking of transferred tregs protects against early blood-brain barrier disruption after stroke. Jaha 2017; 6: e006387.
Google Scholar | Crossref22. Muhammad, S, Barakat, W, Stoyanov, S, et al. The HMGB1 receptor RAGE mediates ischemic brain damage. J Neurosci 2008; 28: 12023–12031.
Google Scholar | Crossref | Medline | ISI23. Percie Du Sert, N, Hurst, V, Ahluwalia, A, et al. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. J Cereb Blood Flow Metab 2020; 40: 1769–1777.
Google Scholar | SAGE Journals | ISI24. Cekanaviciute, E, Fathali, N, Doyle, KP, et al. Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice. Glia 2014; 62: 1227–1240.
Google Scholar | Crossref | Medline | ISI25. Rogers, DC, Campbell, CA, Stretton, JL, et al. Correlation between motor impairment and infarct volume after permanent and transient Middle cerebral artery occlusion in the rat. Stroke 1997; 28: 2060–2066.
Google Scholar | Crossref | Medline | ISI26. Bouet, V, Boulouard, M, Toutain, J, et al. The adhesive removal test: a sensitive method to assess sensorimotor deficits in mice. Nat Protoc 2009; 4: 1560–1564.
Google Scholar | Crossref | Medline | ISI27. Varanasi, SK, Kumar, SV, Rouse, BT. Determinants of tissue-specific metabolic adaptation of T cells. Cell Metab 2020; 32: 908–919.
Google Scholar | Crossref | Medline28. Chamorro, A, Meisel, A, Planas, AM, et al. The immunology of acute stroke. Nat Rev Neurol 2012; 8: 401–410.
Google Scholar | Crossref | Medline | ISI29. Wood, TR, Vu, PT, Comstock, BA, et al. Cytokine and chemokine responses to injury and treatment in a nonhuman primate model of hypoxic-ischemic encephalopathy treated with hypothermia and erythropoietin. J Cereb Blood Flow Metab 2021; 41: 2054–2066.
Google Scholar | SAGE Journals30. Li, Y, Zhu, ZY, Huang, TT, et al. The peripheral immune response after stroke-A double edge sword for blood-brain barrier integrity. CNS Neurosci Ther 2018; 24: 1115–1128.
Google Scholar | Crossref | Medline31. Brown, J, Kingsbury, C, Lee, JY, et al. Spleen participation in partial MHC class II construct neuroprotection in stroke. CNS Neurosci Ther 2020; 26: 663–669.
Google Scholar | Crossref | Medline32. Wong, CH, Jenne, CN, Lee, WY, et al. Functional innervation of hepatic iNKT cells is immunosuppressive following stroke. Science 2011; 334: 101–105.
Google Scholar | Crossref | Medline | ISI33. Li, J, Zeng, Q, Su, W, et al. FBXO10 prevents chronic unpredictable stress-induced behavioral despair and cognitive impairment through promoting RAGE degradation. CNS Neurosci Ther 2021; 27: 1504–1517.
Google Scholar | Crossref | Medline34. Vincent, AM, Perrone, L, Sullivan, KA, et al. Receptor for advanced glycation end products activation injures primary sensory neurons via oxidative stress. Endocrinology 2007; 148: 548–558.
Google Scholar | Crossref | Medline | ISI35. Orlova, VV, Choi, EY, Xie, C, et al. A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires mac-1-integrin. Embo J 2007; 26: 1129–1139.
Google Scholar | Crossref | Medline | ISI36. Mao, L, Li, P, Zhu, W, et al. Regulatory T cells ameliorate tissue plasminogen activator-induced brain haemorrhage after stroke. Brain 2017; 140: 1914–1931.
Google Scholar | Crossref | Medline37. Zhang, H, Xia, Y, Ye, Q, et al. In vivo expansion of regulatory T cells with IL-2/IL-2 antibody complex protects against transient ischemic stroke. J Neurosci 2018; 38: 10168–10179.
Google Scholar | Crossref | Medline38. Ito, M, Komai, K, Mise-Omata, S, et al. Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery. Nature 2019; 565: 246–250.
Google Scholar | Crossref | Medline