No conflicts of interest exist and no writing assistance was obtained for this study.

Guarantor of the article: CPG. Author roles: CPG: study concept and design, data collection and analysis, manuscript preparation and critical review; RT, FZ, SR, ES: data collection and analysis, critical manuscript review; BDR: data analysis and manuscript preparation and critical review; MF, NdB, MV: data collection and critical manuscript review; DS: study concept and design, data collection and analysis, manuscript preparation and critical review

Disclosures: CPG: consultant for Medtronic, Diversatek, Ironwood, Isothrive, Takeda, and Quintiles RT; BDR, MF: no disclosures; NdB: speaker for Malesci; FZ: consultant/speaker for Takeda, Allergan, Biocodex, Vifor Pharma, Mayoli Spindler, Ipsen, Abbott, Reckitt Benckiser, Alfasigma; SR: consulting Medtronic, research support Diversatek Healthcare, Medtronic; ES: Lecture Fee: Medtronic, Takeda, Janssen, MSD, Abbvie, Malesci; Consulting: Medtronic, Takeda, Janssen, MSD, Reckitt Bencikser, Sofar, Unifarco, SILA, Oftagest; MFV: consultant for Medtronic, research support from Diversatek; DS: research grants: Reckitt Benckiser UK, Jinshan Technology China, Alfa Sigma Italy