Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229–63.

PubMed  Google Scholar 

van der Schee L, Verbeeck A, Deckers IAG, Kuijpers C, Offerhaus GJA, Seerden TCJ, Vleggaar FP, Brosens LAA, Moons LMG, Snaebjornsson P, et al. Variation in the detection of lymphovascular invasion in T1 colorectal cancer and its impact on treatment: A nationwide Dutch study. United Eur Gastroenterol J. 2024;12(10):1429–39.

Article  Google Scholar 

Lee H, Yoo SY, Park IJ, Hong SM, Lim SB, Yu CS, Kim JC. The Prognostic Reliability of Lymphovascular Invasion for Patients with T3N0 Colorectal Cancer in Adjuvant Chemotherapy Decision Making. Cancers (Basel). 2022;14(12).

Knijn N, van Exsel UEM, de Noo ME, Nagtegaal ID. The value of intramural vascular invasion in colorectal cancer - a systematic review and meta-analysis. Histopathology. 2018;72(5):721–8.

Article  PubMed  Google Scholar 

Huh JW, Lee JH, Kim HR, Kim YJ. Prognostic significance of lymphovascular or perineural invasion in patients with locally advanced colorectal cancer. Am J Surg. 2013;206(5):758–63.

Article  PubMed  Google Scholar 

Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK, Meyer L, Gress DM, Byrd DR, Winchester DP. The eighth edition AJCC cancer staging manual: continuing to build a Bridge from a population-based to a more personalized approach to cancer staging. CA Cancer J Clin. 2017;67(2):93–9.

PubMed  Google Scholar 

Yuan Z, Weng S, Ye C, Hu H, Zhang S, Yuan Y. CSCO guidelines for colorectal cancer version 2022: updates and discussions. Chin J Cancer Res. 2022;34(2):67–70.

Article  PubMed  PubMed Central  Google Scholar 

Benson AB, Venook AP, Al-Hawary MM, Azad N, Chen YJ, Ciombor KK, Cohen S, Cooper HS, Deming D, Garrido-Laguna I, et al. Rectal Cancer, version 2.2022, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2022;20(10):1139–67.

Article  CAS  PubMed  Google Scholar 

Watanabe T, Itabashi M, Shimada Y, Tanaka S, Ito Y, Ajioka Y, Hamaguchi T, Hyodo I, Igarashi M, Ishida H, et al. Japanese society for cancer of the colon and rectum (JSCCR) guidelines 2014 for treatment of colorectal cancer. Int J Clin Oncol. 2015;20(2):207–39.

Article  PubMed  PubMed Central  Google Scholar 

Chandramohan A, Mittal R, Dsouza R, Yezzaji H, Eapen A, Simon B, John R, Singh A, Ram TS, Jesudason MR, et al. Prognostic significance of MR identified EMVI, tumour deposits, mesorectal nodes and pelvic side wall disease in locally advanced rectal cancer. Colorectal Dis. 2022;24(4):428–38.

Article  PubMed  Google Scholar 

Gardin I, Grégoire V, Gibon D, Kirisli H, Pasquier D, Thariat J, Vera P. Radiomics: principles and radiotherapy applications. Crit Rev Oncol Hematol. 2019;138:44–50.

Article  CAS  PubMed  Google Scholar 

Ma Y, Lin C, Liu S, Wei Y, Ji C, Shi F, Lin F, Zhou Z. Radiomics features based on internal and marginal areas of the tumor for the preoperative prediction of microsatellite instability status in colorectal cancer. Front Oncol. 2022;12:1020349.

Article  PubMed  PubMed Central  Google Scholar 

Jiang W, Meng R, Cheng Y, Wang H, Han T, Qu N, Yu T, Hou Y, Xu S. Intra- and peritumoral based radiomics for assessment of lymphovascular invasion in invasive breast cancer. J Magn Reson Imaging. 2024;59(2):613–25.

Article  PubMed  Google Scholar 

Li M, Jin Y, Rui J, Zhang Y, Zhao Y, Huang C, Liu S, Song B. Computed tomography-based radiomics for predicting lymphovascular invasion in rectal cancer. Eur J Radiol. 2022;146:110065.

Article  PubMed  Google Scholar 

Tong P, Sun D, Chen G, Ni J, Li Y. Biparametric magnetic resonance imaging-based radiomics features for prediction of lymphovascular invasion in rectal cancer. BMC Cancer. 2023;23(1):61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ge YX, Xu WB, Wang Z, Zhang JQ, Zhou XY, Duan SF, Hu SD, Fei BJ. Prognostic value of CT radiomics in evaluating lymphovascular invasion in rectal cancer: diagnostic performance based on different volumes of interest. J Xray Sci Technol. 2021;29(4):663–74.

CAS  PubMed  Google Scholar 

Greten FR, Grivennikov SI. Inflammation and cancer: Triggers, Mechanisms, and consequences. Immunity. 2019;51(1):27–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tong G, Shen Y, Li H, Qian H, Tan Z. NLRC4, inflammation and colorectal cancer (Review). Int J Oncol 2024, 65(4).

Cao X, Wang X, Song J, Su Y, Wang L, Yin Y. Pretreatment multiparametric MRI radiomics-integrated clinical hematological biomarkers can predict early rapid metastasis in patients with nasopharyngeal carcinoma. BMC Cancer. 2024;24(1):435.

Article  PubMed  PubMed Central  Google Scholar 

Zhong Y, Chen L, Ding F, Ou W, Zhang X, Weng S. Assessing microvascular invasion in HBV-related hepatocellular carcinoma: an online interactive nomogram integrating inflammatory markers, radiomics, and convolutional neural networks. Front Oncol. 2024;14:1401095.

Article  PubMed  PubMed Central  Google Scholar 

Tustison NJ, Avants BB, Cook PA, Zheng Y, Egan A, Yushkevich PA, Gee JC. N4ITK: improved N3 bias correction. IEEE Trans Med Imaging. 2010;29(6):1310–20.

Article  PubMed  PubMed Central  Google Scholar 

Nyúl LG, Udupa JK, Zhang X. New variants of a method of MRI scale standardization. IEEE Trans Med Imaging. 2000;19(2):143–50.

Article  PubMed  Google Scholar 

Benchoufi M, Matzner-Lober E, Molinari N, Jannot AS, Soyer P. Interobserver agreement issues in radiology. Diagn Interv Imaging. 2020;101(10):639–41.

Article  CAS  PubMed  Google Scholar 

Liu Z, Luo C, Chen X, Feng Y, Feng J, Zhang R, Ouyang F, Li X, Tan Z, Deng L, et al. Noninvasive prediction of perineural invasion in intrahepatic cholangiocarcinoma by clinicoradiological features and computed tomography radiomics based on interpretable machine learning: a multicenter cohort study. Int J Surg. 2024;110(2):1039–51.

Article  PubMed  Google Scholar 

Lim SB, Yu CS, Jang SJ, Kim TW, Kim JH, Kim JC. Prognostic significance of lymphovascular invasion in sporadic colorectal cancer. Dis Colon Rectum. 2010;53(4):377–84.

Article  PubMed  Google Scholar 

Ale Ali H, Kirsch R, Razaz S, Jhaveri A, Thipphavong S, Kennedy ED, Jhaveri KS. Extramural venous invasion in rectal cancer: overview of imaging, histopathology, and clinical implications. Abdom Radiol (NY). 2019;44(1):1–10.

Article  PubMed  Google Scholar 

Sun Q, Liu T, Liu P, Luo J, Zhang N, Lu K, Ju H, Zhu Y, Wu W, Zhang L, et al. Perineural and lymphovascular invasion predicts for poor prognosis in locally advanced rectal cancer after neoadjuvant chemoradiotherapy and surgery. J Cancer. 2019;10(10):2243–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang F, Chen G, Zhang Z, Yuan Y, Wang Y, Gao YH, Sheng W, Wang Z, Li X, Yuan X et al. The Chinese society of clinical oncology (CSCO): clinical guidelines for the diagnosis and treatment of colorectal cancer, 2024 update. Cancer Commun (Lond) 2024.

Glynne-Jones R, Wyrwicz L, Tiret E, Brown G, Rödel C, Cervantes A, Arnold D. Rectal cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2017;28(suppl4):iv22–40.

Article  CAS  PubMed  Google Scholar 

Wong C, Liu T, Zhang C, Li M, Zhang H, Wang Q, Fu Y. Preoperative detection of lymphovascular invasion in rectal cancer using intravoxel incoherent motion imaging based on radiomics. Med Phys. 2024;51(1):179–91.

Article  PubMed  Google Scholar 

Cai C, Hu T, Gong J, Huang D, Liu F, Fu C, Tong T. Multiparametric MRI-based radiomics signature for preoperative Estimation of tumor-stroma ratio in rectal cancer. Eur Radiol. 2021;31(5):3326–35.

Article  PubMed  Google Scholar 

Kudou M, Nakanishi M, Kuriu Y, Murayama Y, Arita T, Kishimoto M, Konishi E, Goto M, Yamada K, Otsuji E. Value of intra-tumor heterogeneity evaluated by diffusion-weighted MRI for predicting pathological stages and therapeutic responses to chemoradiotherapy in lower rectal cancer. J Cancer. 2020;11(1):168–76.

Article  PubMed  PubMed Central  Google Scholar 

Mc Entee PD, Shokuhi P, Rogers AC, Mehigan BJ, McCormick PH, Gillham CM, Kennedy MJ, Gallagher DJ, Ryan CE, Muldoon CB, et al. Extramural venous invasion (EMVI) in colorectal cancer is associated with increased cancer recurrence and cancer-related death. Eur J Surg Oncol. 2022;48(7):1638–42.

Article  PubMed  Google Scholar 

Altinmakas E, Dogan H, Taskin OC, Ozoran E, Bugra D, Adsay V, Balik E, Gurses B. Extramural venous invasion (EMVI) revisited: a detailed analysis of various characteristics of EMVI and their role as a predictive imaging biomarker in the neoadjuvant treatment response in rectal cancer. Abdom Radiol (NY). 2022;47(6):1975–87.

Article