Association of impaired awareness of hypoglycemia and real-time continuous glucose monitoring with the occurrence and frequency of severe hypoglycemia in adults with type 1 diabetes mellitus: a real-world panel data analysis from the PR-IAH study

Morales J, Schneider D. Hypoglycemia. Am J Med. 2014;127(10 Suppl):S17-24. https://doi.org/10.1016/j.amjmed.2014.07.004.

Article  PubMed  CAS  Google Scholar 

Freeman NLB, Muthukkumar R, Weinstock RS, Wickerhauser MV, Kahkoska AR. Use of machine learning to identify characteristics associated with severe hypoglycemia in older adults with type 1 diabetes: a post-hoc analysis of a case-control study. BMJ Open Diabetes Res Care. 2024;12(1): e003748. https://doi.org/10.1136/bmjdrc-2023-003748.

Article  PubMed  PubMed Central  Google Scholar 

Urakami T. Severe hypoglycemia: is it still a threat for children and adolescents with type 1 diabetes? Front Endocrinol (Lausanne). 2020;11: 609.

PubMed  Google Scholar 

Liu J, Wang R, Ganz ML, Paprocki Y, Schneider D, Weatherall J. The burden of severe hypoglycemia in type 1 diabetes. Curr Med Res Opin. 2018;34(1):171–7. https://doi.org/10.1080/03007995.2017.1391079.

Article  PubMed  CAS  Google Scholar 

Chen YX, Liu ZR, Yu Y, Yao ES, Liu XH, Liu L. Effect of recurrent severe hypoglycemia on cognitive performance in adult patients with diabetes: a meta-analysis. J Huazhong Univ Sci Technol Med Sci. 2017;37(5):642–8.

Google Scholar 

Cook AJ, DuBose SN, Foster N, Smith EL, Wu M, Margiotta G, Rickels MR, Speight J, de Zoysa N, Amiel SA. Cognitions associated with hypoglycemia awareness status and severe hypoglycemia experience in adults with type 1 diabetes. Diabetes Care. 2019;42(10):1854–64.

PubMed  CAS  Google Scholar 

Mesa A, Giménez M, Perea V, Serés-Noriega T, Boswell L, Blanco J, Milad C, Pané A, Esmatjes E, Vinagre I, Conget I, Viñals C, Amor AJ. Severe hypoglycemia and hypoglycemia awareness are associated with preclinical atherosclerosis in patients with type 1 diabetes without an estimated high cardiovascular risk. Diabetes Metab Res Rev. 2024;40(3): e3785. https://doi.org/10.1002/dmrr.3785.

Article  PubMed  CAS  Google Scholar 

Weinstock RS, Xing D, Maahs DM, Michels A, Rickels MR, Peters AL, Bergenstal RM, Harris B, Dubose SN, Miller KM, Beck RW, T1D Exchange Clinic Network. Severe hypoglycemia and diabetic ketoacidosis in adults with type 1 diabetes: results from the T1D exchange clinic registry. J Clin Endocrinol Metab. 2013;98(8):3411–9. https://doi.org/10.1210/jc.2013-1589.

Article  PubMed  CAS  Google Scholar 

Hernar I, Strandberg RB, Nilsen RM, Cooper JG, Skinner TC, Iversen MM, Richards DA, Lie SS, Løvaas KF, Madsen TV, Ueland GÅ, Haugstvedt A. Prevalence and risk factors for impaired awareness of hypoglycaemia: a registry-based study of 10,202 adults with type 1 diabetes in Norway. Diabet Med. 2024. https://doi.org/10.1111/dme.15480.

Article  PubMed  PubMed Central  Google Scholar 

Farrell CM, McCrimmon RJ. Clinical approaches to treat impaired awareness of hypoglycaemia. Ther Adv Endocrinol Metab. 2021;12:20420188211000250. https://doi.org/10.1177/20420188211000248.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Henriksen M, Due-Andersen R, Thorsteinsson B, et al. Recurrent severe hypoglycemia in type 1 diabetes: potential for prevention? Diabetes Manag. 2014;4(6):479–87.

CAS  Google Scholar 

Little SA, Speight J, Leelarathna L, Walkinshaw E, Tan HK, Bowes A, Lubina-Solomon A, Chadwick TJ, Stocken DD, Brennand C, Marshall SM, Wood R, Kerr D, Flanagan D, Heller SR, Evans ML, Shaw JAM. Sustained reduction in severe hypoglycemia in adults with type 1 diabetes complicated by impaired awareness of hypoglycemia: two-year follow-up in the HypoCOMPaSS randomized clinical trial. Diabetes Care. 2018;41(8):1600–7. https://doi.org/10.2337/dc17-2682.

Article  PubMed  CAS  Google Scholar 

Song JW, Chung KC. Observational studies: cohort and case-control studies. Plast Reconstr Surg. 2010;126(6):2234–42. https://doi.org/10.1097/PRS.0b013e3181f44abc.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Colditz GA. Overview of the epidemiology methods and applications: strengths and limitations of observational study designs. Crit Rev Food Sci Nutr. 2010;50(Suppl 1(s1)):10–2. https://doi.org/10.1080/10408398.2010.526838.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Pérez-Guerrero EE, Guillén-Medina MR, Márquez-Sandoval F, Vera-Cruz JM, Gallegos-Arreola MP, Rico-Méndez MA, Aguilar-Velázquez JA, Gutiérrez-Hurtado IA. Methodological and statistical considerations for cross-sectional, case-control, and cohort studies. J Clin Med. 2024;13(14):4005. https://doi.org/10.3390/jcm13144005.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hsiao C. Benefits and limitations of panel data. Econometr Rev. 1985;4(1):121–74. https://doi.org/10.1080/07474938508800078.

Article  Google Scholar 

Pinto de Costa M, Stewart R. Investigating time-dependent COVID-19 pandemic mental health data: Challenges and opportunities of using panel data analysis. PLoS Med. 2023;20(4): e1004219. https://doi.org/10.1371/journal.pmed.1004219.

Article  Google Scholar 

Yasuda H, Sanada M, Kitada K, Terashima T, Kim H, Sakaue Y, Fujitani M, Kawai H, Maeda K, Kashiwagi A. Rationale and usefulness of newly devised abbreviated diagnostic criteria and staging for diabetic polyneuropathy. Diabetes Res Clin Pract. 2007;77(Suppl 1):S178–83.

PubMed  CAS  Google Scholar 

Seaquist ER, Anderson J, Childs B, Cryer P, Dagogo-Jack S, Fish L, Heller SR, Rodriguez H, Rosenzweig J, Vigersky R. Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society. Diabetes Care. 2013;36(5):1384–95. https://doi.org/10.2337/dc12-2480.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gold AE, MacLeod KM, Frier BM. Frequency of severe hypoglycemia in patients with type I diabetes with impaired awareness of hypoglycemia. Diabetes Care. 1994;17(7):697–703. https://doi.org/10.2337/diacare.17.7.697.

Article  PubMed  CAS  Google Scholar 

Mizokami-Stout KR, Li Z, Foster NC, Shah V, Aleppo G, McGill JB, Pratley R, Toschi E, Ang L, Pop-Busui R, for T1D Exchange Clinic Network, T1D Exchange Clinic Networ k. The contemporary prevalence of diabetic neuropathy in type 1 diabetes: findings from the T1D exchange. Diabetes Care. 2020;43(4):806–12. https://doi.org/10.2337/dc19-1583.

Article  PubMed  PubMed Central  Google Scholar 

Giorda CB, Ozzello A, Gentile S, Aglialoro A, Chiambretti A, Baccetti F, Gentile FM, Lucisano G, Nicolucci A, Rossi MC, HYPOS-1 Study Group of AMD. Incidence and risk factors for severe and symptomatic hypoglycemia in type 1 diabetes. Results of the HYPOS-1 study. Acta Diabetol. 2015;52(5):845–53. https://doi.org/10.1007/s00592-015-0713-4.

Article  PubMed  CAS  Google Scholar 

Pedersen-Bjergaard U, Pramming S, Heller SR, Wallace TM, Rasmussen AK, Jørgensen HV, Matthews DR, Hougaard P, Thorsteinsson B. Severe hypoglycaemia in 1076 adult patients with type 1 diabetes: influence of risk markers and selection. Diabetes Metab Res Rev. 2004;20(6):479–86. https://doi.org/10.1002/dmrr.482.

Article  PubMed  Google Scholar 

Flatt AJS, Little SA, Speight J, Leelarathna L, Walkinshaw E, Tan HK, Bowes A, Lubina-Solomon A, Holmes-Truscott E, Chadwick TJ, Wood R, McDonald TJ, Kerr D, Flanagan D, Brooks A, Heller SR, Evans ML, Shaw JAM. Predictors of recurrent severe hypoglycemia in adults with type 1 diabetes and impaired awareness of hypoglycemia during the HypoCOMPaSS study. Diabetes Care. 2020;43(1):44–52. https://doi.org/10.2337/dc19-0630.

Article  PubMed  Google Scholar 

Ding X, Fang C, Li X, Cao YJ, Zhang QL, Huang Y, Pan J, Zhang X. Type 1 diabetes-associated cognitive impairment and diabetic peripheral neuropathy in Chinese adults: results from a prospective cross-sectional study. BMC Endocr Disord. 2019;19(1):34. https://doi.org/10.1186/s12902-019-0359-2.

Article  PubMed  PubMed Central  Google Scholar 

Sakane N, Kato K, Hata S, Nishimura E, Araki R, Kouyama K, Hatao M, Matoba Y, Matsushita Y, Domichi M, Suganuma A, Sakane S, Murata T, Wu FL. Protective and risk factors of impaired awareness of hypoglycemia in patients with type 1 diabetes: a cross-sectional analysis of baseline data from the PR-IAH study. Diabetol Metab Syndr. 2023;15(1):79. https://doi.org/10.1186/s13098-023-01024-x.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ohshima J, Nukada H. Hypoglycaemic neuropathy: microvascular changes due to recurrent hypoglycaemic episodes in rat sciatic nerve. Brain Res. 2002;947(1):84–9. https://doi.org/10.1016/s0006-8993(02)02910-4.

Article  PubMed  CAS  Google Scholar 

Sherr JL, Laffel LM, Liu J, Wolf W, Bispham J, Chapman KS, Finan D, Titievsky L, Liu T, Hagan K, Gaglia J, Chandarana K, Bergenstal R, Pettus J. Severe hypoglycemia and impaired awareness of hypoglycemia persist in people with type 1 diabetes despite use of diabetes technology: results from a cross-sectional survey. Diabetes Care. 2024;47(6):941–7. https://doi.org/10.2337/dc23-1765.

Article  PubMed 

Comments (0)

No login
gif