Effects of Sarcopenia on Patient Outcomes in Gastrointestinal Cancer: An Umbrella Review of Published Meta-Analyses

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229–63.

PubMed  Google Scholar 

Zhu Y, Guo X, Zhang Q, Yang Y. Prognostic value of sarcopenia in patients with rectal cancer: a meta-analysis. PLoS One [Internet]. 2022;17(6 June):1–11. https://doi.org/10.1371/journal.pone.0270332.

CAS  Google Scholar 

Thormann M, Omari J, Pech M, Damm R, Croner R, Perrakis A, et al. Low skeletal muscle mass and post-operative complications after surgery for liver malignancies: a meta-analysis. Langenbeck’s Arch Surg [Internet]. 2022;407(4):1369–79. https://doi.org/10.1007/s00423-022-02541-5.

Google Scholar 

Shachar SS, Williams GR, Muss HB, Nishijima TF. Prognostic value of sarcopenia in adults with solid tumours: a meta-analysis and systematic review. Eur J Cancer [Internet]. 2016;57:58–67. https://doi.org/10.1016/j.ejca.2015.12.030.

PubMed  Google Scholar 

Pamoukdjian F, Bouillet T, Lévy V, Soussan M, Zelek L, Paillaud E. Prevalence and predictive value of pre-therapeutic sarcopenia in cancer patients: a systematic review. Clin Nutr. 2018;37(4):1101–13.

PubMed  Google Scholar 

Kirk B, Cawthon PM, Arai H, Ávila-Funes JA, Barazzoni R, Bhasin S, et al. The conceptual definition of sarcopenia: Delphi consensus from the global leadership initiative in sarcopenia (GLIS). Age Ageing. 2024;53(afae052):1–10.

Google Scholar 

Levolger S, Van Vugt JLA, De Bruin RWF, IJzermans JNM. Systematic review of sarcopenia in patients operated on for gastrointestinal and hepatopancreatobiliary malignancies. Br J Surg. 2015;102(12):1448–58.

CAS  PubMed  Google Scholar 

Reisinger KW, Van Vugt JLA, Tegels JJW, Snijders C, Hulsewé KWE, Hoofwijk AGM, et al. Functional compromise reflected by sarcopenia, frailty, and nutritional depletion predicts adverse postoperative outcome after colorectal cancer surgery. Ann Surg. 2015;261(2):345–52.

PubMed  Google Scholar 

Luo L, Fan Y, Wang Y, Wang Z, Zhou J. Prevalence and clinical outcomes of sarcopenia in patients with esophageal, gastric or colorectal cancers receiving preoperative neoadjuvant therapy: a meta-analysis. Asia-Pacific J Oncol Nurs [Internet]. 2024;11(4):100436. https://doi.org/10.1016/j.apjon.2024.100436.

Google Scholar 

Yoshimura Y, Wakabayashi H. Interventions for treating sarcopenia: a systematic review and meta-analysis of randomized controlled studies. J Am Med Dir Assoc [Internet]. 2017;18(6):553.e1–553.e16. https://doi.org/10.1016/j.jamda.2017.03.019.

PubMed  Google Scholar 

Pesce A, Fabbri N, Colombari S, Uccellatori L, Grazzi G, Lordi R, et al. A randomized controlled clinical trial on multimodal prehabilitation in colorectal cancer patients to improve functional capacity: preliminary results. Surg Endosc [Internet]. 2024;38(12):7440–50. https://doi.org/10.1007/s00464-024-11198-8.

PubMed  Google Scholar 

Belbasis L, Bellou V, Ioannidis JPA. Conducting umbrella reviews. BMJ Med. 2022;1(1):e000071.

PubMed  PubMed Central  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021. https://doi.org/10.1136/bmj.n71

Muka T, Glisic M, Milic J, Verhoog S, Bohlius J, Bramer W, et al. A 24-step guide on how to design, conduct, and successfully publish a systematic review and meta-analysis in medical research. Eur J Epidemiol [Internet]. 2020;35(1):49–60. https://doi.org/10.1007/s10654-019-00576-5.

PubMed  Google Scholar 

Teperikidis L, Boulmpou A, Papadoloulos C, Biondi-Zoccai G. Using ChatGPT to perform a systematic review: a tutorial. Minerva Cardiol Angiol. 2024;6:547–67.

Google Scholar 

Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Syst Rev [Internet]. 2016;5(1):1–10. https://doi.org/10.1186/s13643-016-0384-4.

Google Scholar 

Siontis KC, Hernandez-Boussard T, Ioannidis JPA. Overlapping meta-analyses on the same topic: survey of published studies. BMJ. 2013;347(7921):1–11.

Google Scholar 

Shea BJ, Reeves BC, Wells G, Thuku M, Hamel C, Moran J, et al. AMSTAR 2: A critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ. 2017;358:1–9.

Google Scholar 

Harrison S, Jones HE, Martin RM, Lewis SJ, Higgins JPT. The albatross plot: a novel graphical tool for presenting results of diversely reported studies in a systematic review. Res Synth Methods. 2017;8(3):281–9.

PubMed  PubMed Central  Google Scholar 

Fusar-Poli P, Radua J. Ten simple rules for conducting umbrella reviews. Evid Based Ment Health. 2018;21(3):95–100.

PubMed  PubMed Central  Google Scholar 

Gosling CJ, Solanes A, Fusar-Poli P, Radua J. Metaumbrella: the first comprehensive suite to perform data analysis in umbrella reviews with stratification of the evidence. BMJ Ment Heal. 2023;26(1):1–8.

Google Scholar 

Zhang G, Meng S, Li R, Ye J, Zhao L. Clinical significance of sarcopenia in the treatment of patients with primary hepatic malignancies, a systematic review and meta-analysis. Oncotarget. 2017;8(60):102474–85.

PubMed  PubMed Central  Google Scholar 

Boshier PR, Heneghan R, Markar SR, Baracos VE, Low DE. Assessment of body composition and sarcopenia in patients with esophageal cancer: a systematic review and meta-analysis. Dis Esophagus. 2018;31(8):1–11.

Google Scholar 

Simonsen C, De Heer P, Bjerre ED, Suetta C, Hojman P, Pedersen BK, et al. Sarcopenia and postoperative complication risk in gastrointestinal surgical oncology. Ann Surg. 2018;268(1):58–69.

PubMed  Google Scholar 

Mintziras I, Miligkos M, Wächter S, Manoharan J, Maurer E, Bartsch DK. Sarcopenia and sarcopenic obesity are significantly associated with poorer overall survival in patients with pancreatic cancer: systematic review and meta-analysis. Int J Surg [Internet]. 2018;59(June):19–26. https://doi.org/10.1016/j.ijsu.2018.09.014.

PubMed  Google Scholar 

Chang KV, De CJ, Wu WT, Huang KC, Hsu CT, Han DS. Association between loss of skeletal muscle mass and mortality and tumor recurrence in hepatocellular carcinoma: a systematic review and meta-analysis. Liver Cancer. 2018;7(1):90–103.

PubMed  Google Scholar 

Sun G, Li Y, Peng Y, Lu D, Zhang F, Cui X, et al. Can sarcopenia be a predictor of prognosis for patients with non-metastatic colorectal cancer? A systematic review and meta-analysis. Int J Colorectal Dis. 2018;33(10):1419–27.

PubMed  Google Scholar 

Yang Z, Zhou X, Ma B, Xing Y, Jiang X, Wang Z. Predictive value of preoperative sarcopenia in patients with gastric cancer: a meta-analysis and systematic review. J Gastrointest Surg. 2018;22(11):1890–902.

PubMed  Google Scholar 

Deng HY, Zha P, Peng L, Hou L, Huang KL, Li XY. Preoperative sarcopenia is a predictor of poor prognosis of esophageal cancer after esophagectomy: a comprehensive systematic review and meta-analysis. Dis Esophagus. 2019;32(3):1–10.

Google Scholar 

Hua H, Xu X, Tang Y, Ren Z, Xu Q, Chen L. Effect of sarcopenia on clinical outcomes following digestive carcinoma surgery: a meta-analysis. Support Care Cancer. 2019;27(7):2385–94.

PubMed  Google Scholar 

Bundred J, Kamarajah SK, Roberts KJ. Body composition assessment and sarcopenia in patients with pancreatic cancer: a systematic review and meta-analysis. Hpb [Internet]. 2019;21(12):1603–12. https://doi.org/10.1016/j.hpb.2019.05.018.

PubMed  Google Scholar 

Rinninella E, Cintoni M, Raoul P, Pozzo C, Strippoli A, Bria E, et al. Muscle mass, assessed at diagnosis by L3-CT scan as a prognostic marker of clinical outcomes in patients with gastric cancer: a systematic review and meta-analysis. Clin Nutr [Internet]. 2020;39(7):2045–54. https://doi.org/10.1016/j.clnu.2019.10.021.

PubMed  Google Scholar 

Cao Q, Xiong Y, Zhong Z, Ye Q. Computed tomography-assessed sarcopenia indexes predict major complications following surgery for hepatopancreatobiliary malignancy: a meta-analysis. Ann Nutr Metab. 2019;74(1):24–34.

CAS  PubMed  Google Scholar 

Su H, Ruan J, Chen T, Lin E, Shi L. CT-assessed sarcopenia is a predictive factor for both long-term and short-term outcomes in gastrointestinal oncology patients: a systematic review and meta-analysis. Cancer Imaging. 2019;19(1):1–15.

Google Scholar 

Kamarajah SK, Bundred J, Tan BHL. Body composition assessment and sarcopenia in patients with gastric cancer: a systematic review and meta-analysis. Gastric Cancer. 2019;22:10–22.

PubMed  Google Scholar 

Xu L, Jing Y, Zhao C, Zhang Q, Zhao X, Yang J, et al. Preoperative computed tomography-assessed skeletal muscle index is a novel prognostic factor in patients with hepatocellular carcinoma following hepatectomy: a meta-analysis. J Gastrointest Oncol. 2020;11(5):1040–53.

PubMed  PubMed Central  Google Scholar 

Lee CM, Kang J. Prognostic impact of myosteatosis in patients with colorectal cancer: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle. 2020;11(5):1270–82.

PubMed  PubMed Central  Google Scholar 

Wang PY, Xu LD, Chen XK, Xu L, Yu YK, Zhang RX, et al. Sarcopenia and short-term outcomes after esophagectomy: a meta-analysis. Ann Surg Oncol. 2020;27(8):3041–51.

PubMed  Google Scholar 

Borggreve AS, den Boer RB, van Boxel GI, de Jong PA, Veldhuis WB, Steenhagen E, van Hillegersberg R, Ruurda JP. The predictive value of low muscle mass as measured on CT scans for postoperative complications and mortality in gastric cancer patients: a systematic review and meta-analysis. J Clin Med. 2020;9(1):199. https://doi.org/10.3390/jcm9010199.

PubMed  PubMed Central  Google Scholar 

Schizas D, Frountzas M, Lidoriki I, Spartalis E, Toutouzas K, Dimitroulis D, et al. Sarcopenia does not affect postoperative complication rates in oesophageal cancer surgery : a systematic review and meta-analysis. Ann R Coll Surg Engl. 2020;102:120–32.

CAS  PubMed  Google Scholar 

Guan J, Yang Q, Chen C, Wang G, Zhu H. Prognostic value of low skeletal muscle mass in hepatocellular carcinoma patients treated with sorafenib or lenvatinib: a meta-analysis. EXCLI J. 2021;20:1–16.

PubMed  PubMed Central  Google Scholar 

Xie H, Wei L, Liu M, Yuan G, Tang S, Gan J. Preoperative computed tomography-assessed sarcopenia as a predictor of complications and long-term prognosis in patients with colorectal cancer: a systematic review and meta-analysis. Langenbeck’s Arch Surg. 2021;406(6):1775–88.

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