Buchberger, A. R., DeLaney, K., Johnson, J. & Li, L. Mass spectrometry imaging: a review of emerging advancements and future insights. Anal. Chem. 90, 240–265 (2018).

Article  CAS  PubMed  Google Scholar 

Norris, J. L. & Caprioli, R. M. Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research. Chem. Rev. 113, 2309–2342 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chughtai, K. & Heeren, R. M. A. Mass spectrometric imaging for biomedical tissue analysis. Chem. Rev. 110, 3237–3277 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu, C., Dill, A. L., Eberlin, L. S., Cooks, R. G. & Ifa, D. R. Mass spectrometry imaging under ambient conditions. Mass Spectrom. Rev. 32, 218–243 (2013).

Article  CAS  PubMed  Google Scholar 

Lanni, E. J., Rubakhin, S. S. & Sweedler, J. V. Mass spectrometry imaging and profiling of single cells. J. Proteom. 75, 5036–5051 (2012).

Article  CAS  Google Scholar 

Boxer, S. G., Kraft, M. L. & Weber, P. K. Advances in imaging secondary ion mass spectrometry for biological samples. Annu. Rev. Biophys. 38, 53–74 (2009).

Article  CAS  PubMed  Google Scholar 

Römpp, A. & Spengler, B. Mass spectrometry imaging with high resolution in mass and space. Histochem. Cell Biol. 139, 759–783 (2013).

Article  PubMed  PubMed Central  Google Scholar 

Prideaux, B. & Stoeckli, M. Mass spectrometry imaging for drug distribution studies. J. Proteom. 75, 4999–5013 (2012).

Article  CAS  Google Scholar 

Watrous, J. D. & Dorrestein, P. C. Imaging mass spectrometry in microbiology. Nat. Rev. Microbiol. 9, 683–694 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vaysse, P. M., Heeren, R. M. A., Porta, T. & Balluff, B. Mass spectrometry imaging for clinical research—latest developments, applications, and current limitations. Analyst 142, 2690–2712 (2017).

Article  CAS  PubMed  Google Scholar 

Chung, H., Huang, P., Chen, C., Lee, C. & Hsu, C. Next‐generation pathology practices with mass spectrometry imaging. Mass Spectrom. Rev. 42, 2446–2465 (2023).

Article  CAS  PubMed  Google Scholar 

Holbrook, J. H., Kemper, G. E. & Hummon, A. B. Quantitative mass spectrometry imaging: therapeutics & biomolecules. Chem. Commun. (Camb.) 60, 2137–2151 (2024).

Article  CAS  PubMed  Google Scholar 

de Rond, T., Danielewicz, M. & Northen, T. High throughput screening of enzyme activity with mass spectrometry imaging. Curr. Opin. Biotechnol. 31, 1–9 (2015).

Article  PubMed  Google Scholar 

Taira, S., Uematsu, K., Kaneko, D. & Katano, H. Mass spectrometry imaging: applications to food science. Anal. Sci. 30, 197–203 (2014).

Article  CAS  PubMed  Google Scholar 

Caprioli, R. M., Farmer, T. B. & Gile, J. Molecular imaging of biological samples: localization of peptides and proteins using MALDI-TOF MS. Anal. Chem. 69, 4751–4760 (1997).

Article  CAS  PubMed  Google Scholar 

Wiseman, J. M., Ifa, D. R., Song, Q. & Cooks, R. G. Tissue imaging at atmospheric pressure using desorption electrospray ionization (DESI) mass spectrometry. Angew. Chem. Int. Ed. 45, 7188–7192 (2006).

Article  CAS  Google Scholar 

Giesen, C. et al. Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry. Nat. Methods 11, 417–422 (2014).

Article  CAS  PubMed  Google Scholar 

Laskin, J., Heath, B. S., Roach, P. J., Cazares, L. & Semmes, O. J. Tissue imaging using nanospray desorption electrospray ionization sass Spectrometry. Anal. Chem. 84, 141–148 (2012).

Article  CAS  PubMed  Google Scholar 

Sampson, J. S., Hawkridge, A. M. & Muddiman, D. C. Generation and detection of multiply-charged peptides and proteins by matrix-assisted laser desorption electrospray ionization (MALDESI) Fourier transform ion cyclotron resonance mass spectrometry. J. Am. Soc. Mass Spectrom. 17, 1712–1716 (2006).

Article  CAS  PubMed  Google Scholar 

Nemes, P. & Vertes, A. Laser ablation electrospray ionization for atmospheric pressure, in vivo, and imaging mass spectrometry. Anal. Chem. 79, 8098–8106 (2007).

Article  CAS  PubMed  Google Scholar 

Liu, Q., Guo, Z. & He, L. Mass spectrometry imaging of small molecules using desorption/ionization on silicon. Anal. Chem. 79, 3535–3541 (2007).

Article  CAS  PubMed  Google Scholar 

Roach, P. J., Laskin, J. & Laskin, A. Nanospray desorption electrospray ionization: an ambient method for liquid-extraction surface sampling in mass spectrometry. Analyst 135, 2233–2236 (2010).

Article  CAS  PubMed  Google Scholar 

Yang, M. et al. Nano-DESI mass spectrometry imaging of proteoforms in biological tissues with high spatial resolution. Anal. Chem. 95, 5214–5222 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Unsihuay, D. et al. High-resolution imaging and identification of biomolecules using Nano-DESI coupled to ion mobility spectrometry. Anal. Chim. Acta 1186, 339085 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li, X. et al. High-throughput Nano-DESI mass spectrometry imaging of biological tissues using an integrated microfluidic probe. Anal. Chem. 94, 9690–9696 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huffstutler, C. D. et al. Multiple selected ion monitoring mode for sensitive imaging of eicosanoids in tissues using nanospray desorption electrospray ionization (nano-DESI) mass spectrometry. Int. J. Mass Spectrom. 491, 117101 (2023).

Article  CAS  Google Scholar 

Unsihuay, D. et al. Imaging and analysis of isomeric unsaturated lipids through online photochemical derivatization of carbon-carbon double bonds. Angew. Chem. Int. Ed. 60, 7559–7563 (2021).

Article  CAS  Google Scholar 

Hale, O. J. & Cooper, H. J. Native mass spectrometry imaging of proteins and protein complexes by Nano-DESI. Anal. Chem. 93, 4619–4627 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lillja, J. & Lanekoff, I. Quantitative determination of sn-positional phospholipid isomers in MSn using silver cationization. Anal. Bioanal. Chem. 414, 7473–7482 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iqfath, M., Wali, S. N., Amer, S., Hernly, E. & Laskin, J. Nanospray desorption electrospray ionization mass spectrometry imaging (nano-DESI MSI): a tutorial review. ACS Meas. Sci. Au 4, 475–487 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yin, R., Burnum-Johnson, K. E., Sun, X., Dey, S. K. & Laskin, J. High spatial resolution imaging of biological tissues using nanospray desorption electrospray ionization mass spectrometry. Nat. Protoc. 14, 3445–3470 (2019).

Article  CAS  PubMed  PubMed Central