Leask MP, Crișan TO, Ji A, Matsuo H, Köttgen A, Merriman TR (2024) The pathogenesis of gout: molecular insights from genetic, epigenomic and transcriptomic studies. Nat Rev Rheumatol 20:510–523. https://doi.org/10.1038/s41584-024-01137-1

Article  PubMed  Google Scholar 

Kimura Y, Yanagida T, Onda A, Tsukui D, Hosoyamada M, Kono H (2020) Soluble uric acid promotes atherosclerosis via AMPK (AMP-Activated protein Kinase)-Mediated inflammation. Arterioscler Thromb Vasc Biol 40:570–582. https://doi.org/10.1161/ATVBAHA.119.313224

Article  CAS  PubMed  Google Scholar 

Kong P, Cui ZY, Huang XF, Zhang DD, Guo RJ, Han M (2022) Inflammation and atherosclerosis: signaling pathways and therapeutic intervention. Signal Transduct Target Ther 7:131. https://doi.org/10.1038/s41392-022-00955-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saito Y, Tanaka A, Node K, Kobayashi Y (2021) Uric acid and cardiovascular disease: A clinical review. J Cardiol 78:51–57. https://doi.org/10.1016/j.jjcc.2020.12.013

Article  PubMed  Google Scholar 

Ferguson LD, Molenberghs G, Verbeke G, Rahimi K, Rao S, McInnes IB et al (2024) Gout and incidence of 12 cardiovascular diseases: a case-control study including 152 663 individuals with gout and 709 981 matched controls. Lancet Rheumatol 6:e156–e167. https://doi.org/10.1016/S2665-9913(23)00338-7

Article  CAS  PubMed  Google Scholar 

Lee TS, Lu TM, Chen CH, Guo BC, Hsu CP (2021) Hyperuricemia induces endothelial dysfunction and accelerates atherosclerosis by disturbing the asymmetric dimethylarginine/dimethylarginine dimethylaminotransferase 2 pathway. Redox Biol. 2021; 46:102108. https://doi.org/10.1016/j.redox.2021.102108

Strandberg TE, Kovanen PT Coronary artery disease: ‘gout’ in the artery? Eur Heart J 42:2761–2764. https://doi.org/10.1093/eurheartj/ehab276

Nardi V, Franchi F, Prasad M, Fatica EM, Alexander MP, Bois MC et al (2022) Uric acid expression in carotid atherosclerotic plaque and serum uric acid are associated with cerebrovascular events. Hypertension 79:1814–1823. https://doi.org/10.1161/HYPERTENSIONAHA.122.19247

Article  CAS  PubMed  Google Scholar 

Si K, Chi J, Xu L, Dong B, Huang Y, Zhang H et al (2024) Tophi and carotid atherosclerosis in gout patients: role of insulin resistance. Nutr Metab Cardiovasc Dis 34:1134–1141. https://doi.org/10.1016/j.numecd.2023.11.019

Article  CAS  PubMed  Google Scholar 

O’Neil LJ, Alpízar-Rodríguez D, Deane KD (2024) Rheumatoid arthritis: the continuum of disease and strategies for prediction, early intervention, and prevention. J Rheumatol 51:337–349. https://doi.org/10.3899/jrheum.2023-0334

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nikiphorou E, de Lusignan S, Mallen CD, Khavandi K, Bedarida G, Buckley CD et al (2020) Cardiovascular risk factors and outcomes in early rheumatoid arthritis: a population-based study. Heart 106:1566–1572. https://doi.org/10.1136/heartjnl-2019-316193

Article  CAS  PubMed  Google Scholar 

Mathieu S, Lambert C, Fayet F, Couderc M, Beauger M, Malochet S et al (2023) Comparison of the cardiovascular risk profile of rheumatoid arthritis versus hand osteoarthritis patients. Rheumatol Int 43:2065–2072. https://doi.org/10.1007/s00296-023-05405-3

Article  CAS  PubMed  Google Scholar 

Hansildaar R, Vedder D, Baniaamam M, Tausche AK, Gerritsen M, Nurmohamed MT (2021) Cardiovascular risk in inflammatory arthritis: rheumatoid arthritis and gout. Lancet Rheumatol 3:e58–e70. https://doi.org/10.1016/S2665-9913(20)30221-6

Article  CAS  PubMed  Google Scholar 

Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3rd et al (2010) 2010 Rheumatoid arthritis classification criteria: an American college of rheumatology/european league against rheumatism collaborative initiative. Ann Rheum Dis 69:1580–1588. https://doi.org/10.1136/ard.2010.138461

Article  PubMed  Google Scholar 

Neogi T, Jansen TL, Dalbeth N, Fransen J, Schumacher HR, Berendsen D et al (2015) 2015 Gout classification criteria: an American college of rheumatology/european league against rheumatism collaborative initiative. Arthritis Rheumatol 67:2557–2568. https://doi.org/10.1002/art.39254

Article  PubMed  PubMed Central  Google Scholar 

Wigerblad G, Kaplan MJ (2023) Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases. Nat Rev Immunol 2023 23:274–288. https://doi.org/10.1038/s41577-022-00787-0

Zhu Y, Wang T, Yang Y, Wang Z, Chen X, Wang L et al (2024) Low shear stress exacerbates atherosclerosis by inducing the generation of neutrophil extracellular traps via Piezo1-mediated mechanosensation. Atherosclerosis 391:117473. https://doi.org/10.1016/j.atherosclerosis.2024.117473

Article  CAS  PubMed  Google Scholar 

Chatfield SM, Grebe K, Whitehead LW, Rogers KL, Nebl T, Murphy JM, Wicks IP (2018) Monosodium urate crystals generate Nuclease-Resistant neutrophil extracellular traps via a distinct molecular pathway. J Immunol 200:1802–1816. https://doi.org/10.4049/jimmunol.1701382

Article  CAS  PubMed  Google Scholar 

Kim SK (2022) The mechanism of the NLRP3 inflammasome activation and pathogenic implication in the pathogenesis of gout. J Rheum Dis 29:140–153. https://doi.org/10.4078/jrd.2022.29.3.140

Article  PubMed  PubMed Central  Google Scholar 

Karasawa T, Takahashi M (2017) Role of NLRP3 inflammasomes in atherosclerosis. J Atheroscler Thromb 24:443–451. https://doi.org/10.5551/jat.RV17001

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yin H, Liu N, Sigdel KR, Duan L (2022) Role of NLRP3 inflammasome in rheumatoid arthritis. Front Immunol 13:931690. https://doi.org/10.3389/fimmu.2022.931690

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mihaylova V, Kazakova M, Batalov Z, Karalilova R, Batalov A, Sarafian V (2024) JAK inhibitors improve ATP production and mitochondrial function in rheumatoid arthritis: a pilot study. Rheumatol Int 44:57–65. https://doi.org/10.1007/s00296-023-05501-4

Article  CAS  PubMed  Google Scholar 

Zamudio-Cuevas Y, Martínez-Flores K, Fernández-Torres J, Loissell-Baltazar YA, Medina-Luna D, López-Macay A et al (2016) Monosodium urate crystals induce oxidative stress in human synoviocytes. Arthritis Res Ther 18:117. https://doi.org/10.1186/s13075-016-1012-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Q, Wang Q, Zhu J, Xiao Q, Zhang L (2018) Reactive oxygen species: key regulators in vascular health and diseases. Br J Pharmacol 175:1279–1292. https://doi.org/10.1111/bph.13828

Article  CAS  PubMed  Google Scholar 

Matsuzawa Y, Kwon TG, Lennon RJ, Lerman LO, Lerman A (2015) Prognostic value of Flow-Mediated vasodilation in brachial artery and fingertip artery for cardiovascular events: A systematic review and Meta-Analysis. J Am Heart Assoc 4:e002270. https://doi.org/10.1161/JAHA.115.002270

Article  CAS  PubMed  PubMed Central  Google Scholar 

Willeit P, Tschiderer L, Allara E, Reuber K, Seekircher L, Gao L et al (2020) Carotid Intima-Media thickness progression as surrogate marker for cardiovascular risk: Meta-Analysis of 119 clinical trials involving 100 667 patients. Circulation 142:621–642. https://doi.org/10.1161/CIRCULATIONAHA.120.046361

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kelshiker MA, Seligman H, Howard JP, Rahman H, Foley M, Nowbar AN et al (2022) Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis. Eur Heart J 43:1582–1593. https://doi.org/10.1093/eurheartj/ehab775

Article  PubMed  Google Scholar 

Janssens HJ, Arts PG, Schalk BW, Biermans MC (2017) Gout and rheumatoid arthritis, both to keep in Mind in cardiovascular risk management: A primary care retrospective cohort study. Joint Bone Spine 84:59–64. https://doi.org/10.1016/j.jbspin.2015.12.003

Article  PubMed  Google Scholar 

Disveld IJM, Fransen J, Rongen GA, Kienhorst LBE, Zoakman S, Janssens HJEM, Janssen M (2018) Crystal-proven gout and characteristic gout severity factors are associated with cardiovascular disease. J Rheumatol 45:858–863. https://doi.org/10.3899/jrheum.170555

Article  CAS  PubMed