Clinical features and diagnostic challenges in crowned dens syndrome: a systematic review and meta-analysis

Bouvet J, Parc JL, Michalski B et al (1985) Acute neck pain due to calcifications surrounding the odontoid process: the crowned dens syndrome. Arthr Rhuem 28:1417–1420. https://doi.org/10.1002/art.1780281215

Article  CAS  Google Scholar 

Abhishek A, Tedeschi SK, Pascart T et al (2023) The 2023 ACR/EULAR classification criteria for calcium pyrophosphate deposition disease. Ann Rheum Dis 82:1248–1257. https://doi.org/10.1136/ard-2023-224575

Article  PubMed  Google Scholar 

Pascart T, Robinet P, Ottaviani S et al (2023) Evaluating the safety and short-term equivalence of Colchicine versus prednisone in older patients with acute calcium pyrophosphate crystal arthritis (COLCHICORT): an open-label, multicentre, randomised trial. Lancet Rheumatol 5:e523–e531. https://doi.org/10.1016/S2665-9913(23)00165-0

Article  CAS  PubMed  Google Scholar 

Pascart T, Filippou G, Lioté F et al (2024) Calcium pyrophosphate deposition disease. Lancet Rheumatol 6:e791–e804. https://doi.org/10.1016/S2665-9913(24)00122-X

Article  CAS  PubMed  Google Scholar 

Oka A, Okazaki K, Takeno A et al (2015) Crowned dens syndrome: report of three cases and a review of the literature. J Emerg Med 49:e9–e13. https://doi.org/10.1016/j.jemermed.2015.02.005

Article  PubMed  Google Scholar 

Aouba A, Vuillemin-Bodaghi V, Mutschler C, De Bandt M (2004) Crowned dens syndrome misdiagnosed as polymyalgia rheumatica, giant cell arteritis, meningitis or spondylitis: an analysis of eight cases. Rheumatology 43:1508–1512. https://doi.org/10.1093/rheumatology/keh370

Article  CAS  PubMed  Google Scholar 

Michel J, Bedel J-B, Pinson C, Joly L-M (2023) Crowned dens syndrome: an uncommon mimic of meningitis in the emergency department. Am J Emerg Med 63. https://doi.org/10.1016/j.ajem.2022.09.045.:180.e1-180.e3

Conticini E, Di Martino V, De Stefano R et al (2020) Crowned dens syndrome presenting as hemiplegia and hypoesthesia. J Clin Rheumatol 26:e312–e313. https://doi.org/10.1097/RHU.0000000000001165

Article  PubMed  Google Scholar 

Bansal A, Gupta M (2019) Crowned dens syndrome presenting as pyrexia of unknown origin (PUO). Rom J Intern Med 57:266–269. https://doi.org/10.2478/rjim-2019-0011

Article  PubMed  Google Scholar 

Heck A, Nolan N, Rojas-Moreno C (2018) Crowned dens syndrome: calcium pyrophosphate deposition disease masquerading as osteomyelitis. J Rheumatol 45:1422–1423. https://doi.org/10.3899/jrheum.170921

Article  PubMed  Google Scholar 

Koyfman A, Yaffe D (2014) Crowned dens syndrome. A case report. Neuroradiol J 27:495–497. https://doi.org/10.15274/NRJ-2014-10056

Article  PubMed  PubMed Central  Google Scholar 

Goto S, Umehara J, Aizawa T, Kokubun S (2007) Crowned dens syndrome: the journal of bone and joint. Surgery-American Volume 89:2732–2736. https://doi.org/10.2106/JBJS.F.01322

Article  Google Scholar 

Tang J, Li J, Wu C et al (2020) Report of four cases of crowned dens syndrome: clinical presentation, CT findings and treatment. Exp Ther Med. https://doi.org/10.3892/etm.2020.9128

Article  PubMed  PubMed Central  Google Scholar 

Gasparyan AY, Ayvazyan L, Blackmore H, Kitas GD (2011) Writing a narrative biomedical review: considerations for authors, peer reviewers, and editors. Rheumatol Int 31:1409–1417. https://doi.org/10.1007/s00296-011-1999-3

Article  PubMed  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https://doi.org/10.1136/bmj.n71

Article  PubMed  PubMed Central  Google Scholar 

Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A (2016) Rayyan—a web and mobile app for systematic reviews. Syst Rev 5:210. https://doi.org/10.1186/s13643-016-0384-4

Article  PubMed  PubMed Central  Google Scholar 

Sangha O (2000) Epidemiology of rheumatic diseases. Rheumatology 39:3–12. https://doi.org/10.1093/rheumatology/39.suppl_2.3

Article  PubMed  Google Scholar 

Schulz N, Lange U, Klemm P (2024) Crowned dens syndrome: die Krone der Kristallarthropathien. Osteologie 33:196–200. https://doi.org/10.1055/a-2343-5944

Article  Google Scholar 

Palmowski A, Riedel J, Kamieniarz P et al (2025) Crowned dens syndrome: a rare differential diagnosis of meningitis. Can J Emerg Med 27:233–234. https://doi.org/10.1007/s43678-024-00850-w

Article  Google Scholar 

Kermani TA, Warrington KJ (2013) Polymyalgia rheumatica. Lancet 381:63–72. https://doi.org/10.1016/S0140-6736(12)60680-1

Article  PubMed  Google Scholar 

Kermani TA, Schäfer VS, Crowson CS et al (2010) Increase in age at onset of giant cell arteritis: a population-based study. Ann Rheum Dis 69:780–781. https://doi.org/10.1136/ard.2009.111005

Article  PubMed  Google Scholar 

Delerme S, Castro S, Viallon A et al (2009) Meningitis in elderly patients. Eur J Emerg Med 16:273. https://doi.org/10.1097/MEJ.0b013e3283101866

Article  PubMed  Google Scholar 

Brown R, Hussain M, McHugh K et al (2001) Discitis in young children. J Bone Joint Surg Br Volume 83–B:106–111. https://doi.org/10.1302/0301-620X.83B1.0830106

Article  Google Scholar 

Fernandez-Lozano D, Dominguez-Alvaro M, Narváez J et al (2024) AB1292 SEX DIFFERENCES IN GIANT CELL ARTERITIS: DATA FROM THE ARTESER REGISTRY. Ann Rheum Dis 83:1991–1992. https://doi.org/10.1136/annrheumdis-2024-eular.4843

Article  Google Scholar 

Giovanna Colombo M, Wetzel A-J, Haumann H et al (2022) Polymyalgia rheumatica. Dtsch Arztebl Int 119:411–417. https://doi.org/10.3238/arztebl.m2022.0218

Article  PubMed Central  Google Scholar 

Alsuwaidan S (2021) Prevalence of comorbidity among elderly. https://doi.org/10.33552/GJAGR.2021.01.000518. GJAGR 1:

Uh M, Dewar C, Spouge D, Blocka K (2013) Crowned dens syndrome: a rare cause of acute neck pain. Clin Rheumatol 32:711–714. https://doi.org/10.1007/s10067-013-2179-5

Article  PubMed  Google Scholar 

van de Beek D, de Gans J, Spanjaard L et al (2004) Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med 351:1849–1859. https://doi.org/10.1056/NEJMoa040845

Article  PubMed  Google Scholar 

Thomas KE, Hasbun R, Jekel J, Quagliarello VJ (2002) The diagnostic accuracy of Kernig’s sign, Brudzinski’s sign, and nuchal rigidity in adults with suspected meningitis. CLIN INFECT DIS 35:46–52. https://doi.org/10.1086/340979

Article  PubMed  Google Scholar 

Siau K, Lee M, Laversuch CJ (2011) Acute pseudogout of the neck–the crowned dens syndrome: 2 case reports and review of the literature. Rheumatol Int 31:85–88. https://doi.org/10.1007/s00296-009-1145-7

Article  PubMed  Google Scholar 

Williams CJ, Rosenthal AK (2021) Pathogenesis of calcium pyrophosphate deposition disease. Best Pract Res Clin Rheumatol 35:101718. https://doi.org/10.1016/j.berh.2021.101718

Article  PubMed  Google Scholar 

Chang D-G, Park J-B, Jung H-Y, Seo KJ (2020) Cervical myelopathy due to subaxial calcium pyrophosphate dihydrate (CPPD) deposition with simultaneous asymptomatic crowned dens syndrome: two case reports. BMC Musculoskelet Disord 21:713. https://doi.org/10.1186/s12891-020-03736-x

Article  PubMed  PubMed Central  Google Scholar 

Dankert Eggum EN, Hevesi SA, Sandefur BJ (2024) A diagnosis fit for a queen: crowned dens syndrome. Clin Pract Cases Emerg Med 8:381–383. https://doi.org/10.5811/cpcem.19473

Article  PubMed  PubMed Central  Google Scholar 

Griffiths MJ, McGill F, Solomon T (2018) Management of acute meningitis. Clin Med (Lond) 18:164–169. https://doi.org/10.7861/clinmedicine.18-2-164

Article  PubMed 

Comments (0)

No login
gif