Afman LA, Blom HJ, Drittij MJ, Brouns MR, van Straaten HWM (2005) Inhibition of transmethylation disturbs neurulation in chick embryos. Brain Res Dev Brain Res 158(1–2):59–65

Article  PubMed  CAS  Google Scholar 

Bai B, Zhang Q, Liu X, Miao C, Shangguan S, Bao Y, Guo J, Wang L, Zhang T, Li H (2014) Different epigenetic alterations are associated with abnormal IGF2/Igf2 upregulation in neural tube defects. PLoS ONE 9(11):e113308

Article  PubMed  PubMed Central  Google Scholar 

Balla T (2013) Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev 93:1019–1137

Article  PubMed  PubMed Central  CAS  Google Scholar 

Battaglia FC, Meschia G, Blechner JN, Barron DH (1961) The free myo-inositol concentration of adult and fetal tissues of several species. Q J Exp Physiol Cogn Med Sci 46:188–193

PubMed  CAS  Google Scholar 

Beacher F, Simmons A, Daly E, Prasher V, Adams C, Margallo-Lana ML, Morris R, Lovestone S, Murphy K, Murphy DG (2005) Hippocampal myo-inositol and cognitive ability in adults with down syndrome. An in vivo proton magnetic resonance spectroscopy study. Arch Gen Psychiatry 62:1360–1365

Article  PubMed  Google Scholar 

Breton-Larrivee M, Elizabeth Elder E, McGraw S (2019) DNA methylation, environmental exposures and early embryo development. Anim Reprod 16(3):465–474

Article  PubMed  PubMed Central  Google Scholar 

Brown LD, Cheung A, Harwood JEF, Battaglia FC (2009) Inositol and mannose utilization rates in term and late-preterm infants exceed nutritional intakes. J Nutr 139(9):1648–1652

Article  PubMed  PubMed Central  CAS  Google Scholar 

Burdge GC, Lillycrop KA (2010) Nutrition, epigenetics and developmental plasticity: implications for Understanding human disease. Annu Rev Nutr 30:315–339

Article  PubMed  CAS  Google Scholar 

Cavalli P, Tedoldi S, Riboli B (2008) Inositol supplementation in pregnancies at risk of apparently folate-resistant NTDs. Birth Defects Res Clin Mol Teratol 82:540–542

Article  CAS  Google Scholar 

Cavalli P, Tonni G, Grosso E, Poggiani C (2011) Effects of inositol supplementation in a cohort of mothers at risk of producing an NTD pregnancy. Birth Defects Res Clin Mol Teratol 91:962–965

Article  CAS  Google Scholar 

Chen SQ, Wang PJ, Ten GJ, Zhan W, Li MH, Zang FC (2009) Role of myo-inositol by magnetic resonance spectroscopy in early diagnosis of Alzheimer’âs disease in APP/PS1 Transgenic mice. Dement Geriatr Cogn Disord 28:558–566

Article  PubMed  Google Scholar 

Chen X, Guo J, Lei Y, Zou J, Lu X, Bao Y, Wu L, Wu J, Zheng X, Shen Y, Wu BL, Zhang T (2010) Global DNA hypomethylation is associated with NTD-affected pregnancy: a case-control study. Birth Defects Res Clin Mol Teratol 88(7):575–581

Article  CAS  Google Scholar 

Cindrova-Davies T, Jauniaux E, Elliot MG, Gong S, Burton GJ, Charnock-Jones DS (2017) RNA-seq reveals conservation of function among the yolk sacs of human, mouse, and chicken. ProcNatlAcad Sci USA 114:E4753–E4761

CAS  Google Scholar 

Cockroft DL (1979) Nutrient requirements of rat embryos undergoing organogenesis in vitro. J Reprod Fertil 57:505–510

Article  PubMed  CAS  Google Scholar 

Cockroft DL (1988) Changes with gestational age in the nutritional requirements of postimplantation rat embryos in culture. Teratology 38:281–290

Article  PubMed  CAS  Google Scholar 

Cockroft DL, Brook FA, Copp AJ (1992) Inositol deficiency increases the susceptibility to neural tube defects of genetically predisposed (curly tail) mouse embryos in vitro. Teratology 45:223–232

Article  PubMed  CAS  Google Scholar 

Colazingari S, Fiorenza MT, Carlomagno G, Najjar R, Bevilacqua A (2014) Improvement of mouse embryo quality by myo-inositol supplementation of IVF media. J Assist Reprod Genet 31:463–469

Article  PubMed  PubMed Central  Google Scholar 

Copp AJ, Greene ND (2010) Genetics and development of neural tube defects. J Pathol 220:217–230

Article  PubMed  PubMed Central  CAS  Google Scholar 

Copp AJ, Greene NDE, Murdoch JN (2003) The genetic basis of mammalian neurulation. Nat Rev Genet 4:784–793

Article  PubMed  Google Scholar 

Dean W, Lucifero D, Santos F (2005) DNA methylation in mammalian development and disease. Birth Defects Res C Embryo Today 75(2):98–111

Article  PubMed  CAS  Google Scholar 

Dhar GA, Saha S, Mitra P, Chaudhuri RN (2021) DNA methylation and regulation of gene expression: guardian of our health. Nucleus (Calcutta) 64(3):259–270

Article  PubMed  CAS  Google Scholar 

Dunlevy LPE, Burren KA, Chitty LS, Copp AJ, Greene NDE (2006a) Excess methionine suppresses the methylation cycle and inhibits neural tube closure in mouse embryos. FEBS Lett 580(11):2803–2807

Article  PubMed  CAS  Google Scholar 

Dunlevy LPE, Burren KA, Mills K, Chitty LS, Copp AJ, Greene NDE (2006b) Integrity of the methylation cycle is essential for mammalian neural tube closure. Birth Defects Res Clin Mol Teratol 76(7):544–552

Article  CAS  Google Scholar 

Ehlers K, Sturje H, Merker HJ, Nau H (1992) Valproic acid-induced spina bifida: a mouse model. Teratology 45(2):145–154

Article  PubMed  CAS  Google Scholar 

Facchinetti F, Cavalli P, Copp AJ, D’Anna R, Kandaraki E, Greene NDE, Unfer V (2020) An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs). Expert Opin Drug Metab Toxicol 12:1187–1198

Article  Google Scholar 

Fleming IN, Batty IH, Prescott AR, Gray A, Kular GS, Stewart H, Downes CP (2004) Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1. Biochem J 382:857–865

Article  PubMed  PubMed Central  CAS  Google Scholar 

Friedman SD, Shaw DW, Artru AA, Dawson G, Petropoulos H, Dager SR (2006) Gray and white matter brain chemistry in young children with autism. Arch Gen Psychiatry 63:786–794

Article  PubMed  CAS  Google Scholar 

Friso S, Choi SW, Girelli D, Mason JB, Dolnikowski GG, Bagley PJ, Olivieri O, Jacques PF, Rosenberg IH, Corrocher R, Selhub J (2002) A common mutation in the 5, 10 methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci USA 99(8):5606–5611

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gambioli R, Forte G, Aragona C, Bevilacqua A, Bizzarri M, Unfer V (2021) The use of D-chiro-Inositol in clinical practice. Eur Rev Med Pharm Sci 25:438–446

CAS  Google Scholar 

Gelineau-van Waes J, Starr L, Maddox J, Aleman F, Voss KA, Wilberding J, Riley RT (2005) Maternal Fumonisin exposure and risk for neural tube defects: mechanisms in an in vivo mouse model. Birth Defects Res Clin Mol Teratol 73(7):487–497

Article  CAS  Google Scholar 

Greene ND, Copp AJ (1997) Inositol prevents folate-resistant neural tube defects in the mouse. Nat Med 3:60–66

Article  PubMed  CAS  Google Scholar 

Greene NDE, Stainer P, Moore GE (2011) The emerging role of epigenetic mechanisms in the etiology of neural tube defects. Epigenetics 6(7):875–883

Article  PubMed  PubMed Central  CAS  Google Scholar 

Greene ND, Leung KY, Gay V, Burren K, Mills K, Chitty LS, Copp AJ (2016) Inositol for the prevention of neural tube defects: a pilot randomised controlled trial. Br J Nutr 115:974–983