Metformin Protects Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons from Oxidative Damage Through Antioxidant Mechanisms

Ababneh NA, Al-Kurdi B, Ali D, Abuarqoub D, Barham R, Salah B, Awidi A (2020a) Establishment of a human induced pluripotent stem cell (iPSC) line (JUCTCi010-A) from a healthy Jordanian female skin dermal fibroblast. Stem Cell Res 47(June):101891. https://doi.org/10.1016/j.scr.2020.101891

Article  PubMed  CAS  Google Scholar 

Ababneh NA, Al-Kurdi B, Ali D, Barham R, Sharar N, Mrahleh MM, Salah B, Awidi A (2020b) Generation of a human induced pluripotent stem cell (iPSC) line (JUCTCi011-A) from skin fibroblasts of a healthy Jordanian male subject. Stem Cell Res 48:101923. https://doi.org/10.1016/j.scr.2020.101923

Article  PubMed  CAS  Google Scholar 

Ahn MJ, Cho GW (2017) Metformin promotes neuronal differentiation and neurite outgrowth through AMPK activation in human bone marrow-mesenchymal stem cells. Biotechnol Appl Chem 64(6):836–842. https://doi.org/10.1002/bab.1584

Article  CAS  Google Scholar 

Akter KA, Sharma S, Sifat AE, Zhang Y, Patel DK, Cucullo L, Abbruscato TJ (2024) Metformin ameliorates neuroinflammatory environment for neurons and astrocytes during in vitro and in vivo stroke and tobacco smoke chemical exposure: role of Nrf2 activation. Redox Biol 75:103266. https://doi.org/10.1016/j.redox.2024.103266

Article  PubMed  PubMed Central  CAS  Google Scholar 

Alsalem M, Ellaithy A, Bloukh S, Haddad M, Saleh T (2024) Targeting therapy-induced senescence as a novel strategy to combat chemotherapy-induced peripheral neuropathy. Supportive Care Cancer: Official J Multinational Association Supportive Care Cancer 32(1):85. https://doi.org/10.1007/s00520-023-08287-0

Article  Google Scholar 

Areti A, Yerra VG, Naidu V, Kumar A (2014) Oxidative stress and nerve damage: role in chemotherapy induced peripheral neuropathy. Redox Biol 2:289–295. https://doi.org/10.1016/j.redox.2014.01.006

Article  PubMed  PubMed Central  CAS  Google Scholar 

Barber SC, Shaw PJ (2010) Oxidative stress in ALS: key role in motor neuron injury and therapeutic target. Free Radic Biol Med 48(5):629–641. https://doi.org/10.1016/j.freeradbiomed.2009.11.018

Article  PubMed  CAS  Google Scholar 

Bax M, McKenna J, Do-Ha D, Stevens CH, Higginbottom S, Balez R, Cabral-da-Silva MEC, Farrawell NE, Engel M, Poronnik P, Yerbury JJ, Saunders DN, Ooi L (2019) The ubiquitin proteasome system is a key regulator of pluripotent stem cell survival and motor neuron differentiation. Cells 8(6):581. https://doi.org/10.3390/cells8060581

Article  PubMed  PubMed Central  CAS  Google Scholar 

Binlateh T, Tanasawet S, Rattanaporn O, Sukketsiri W, Hutamekalin P (2019) Metformin promotes neuronal differentiation via crosstalk between Cdk5 and Sox6 in neuroblastoma cells. Evidence-based Complement Altern Medicine: eCAM 2019:1765182. https://doi.org/10.1155/2019/1765182

Article  Google Scholar 

Binlateh T, Reudhabibadh R, Prommeenate P, Hutamekalin P (2022) Investigation of mechanisms underlying the inhibitory effects of Metformin against proliferation and growth of neuroblastoma SH-SY5Y cells. Toxicology in vitro: an international journal published in association with BIBRA. 83:105410. https://doi.org/10.1016/j.tiv.2022.105410

Brown C, McKee C, Bakshi S, Walker K, Hakman E, Halassy S, Svinarich D, Dodds R, Govind CK, Chaudhry GR (2019) Mesenchymal stem cells: cell therapy and regeneration potential. J Tissue Eng Regen Med 13(9):1738–1755. https://doi.org/10.1002/term.2914

Article  PubMed  CAS  Google Scholar 

Burroughs SL, Duncan RS, Rayudu P, Kandula P, Payne AJ, Clark JL, Koulen P, Kaja S (2012) Plate reader-based assays for measuring cell viability, neuroprotection and calcium in primary neuronal cultures. J Neurosci Methods 203(1):141–145. https://doi.org/10.1016/j.jneumeth.2011.09.007

Article  PubMed  CAS  Google Scholar 

Butterfield DA (2002) Amyloid beta-peptide (1–42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer’s disease brain. A review. Free Radic Res 36(12):1307–1313. https://doi.org/10.1080/1071576021000049890

Article  PubMed  CAS  Google Scholar 

Chang X, Zhang T, Zhang W, Zhao Z, Sun J (2020) Natural drugs as a treatment strategy for cardiovascular disease through the regulation of oxidative stress. Oxidative Med Cell Longev 2020:5430407. https://doi.org/10.1155/2020/5430407

Article  CAS  Google Scholar 

Chen X, Guo C, Kong J (2012) Oxidative stress in neurodegenerative diseases. Neural Regeneration Res 7(5):376–385. https://doi.org/10.3969/j.issn.1673-5374.2012.05.009

Article  CAS  Google Scholar 

Chen Z, Tao S, Li X, Yao Q (2018) Resistin destroys mitochondrial biogenesis by inhibiting the PGC-1α/ NRF1/TFAM signaling pathway. Biochem Biophys Res Commun 504(1):13–18. https://doi.org/10.1016/j.bbrc.2018.08.027

Article  PubMed  CAS  Google Scholar 

Chen A, Kristiansen CK, Hong Y, Kianian A, Fang EF, Sullivan GJ, Wang J, Li X, Bindoff LA, Liang KX (2021) Nicotinamide riboside and Metformin ameliorate mitophagy defect in induced pluripotent stem Cell-Derived astrocytes with POLG mutations. Front Cell Dev Biology 9:737304. https://doi.org/10.3389/fcell.2021.737304

Article  Google Scholar 

Dadwal P, Mahmud N, Sinai L, Azimi A, Fatt M, Wondisford FE, Miller FD, Morshead CM (2015) Activating endogenous neural precursor cells using Metformin leads to neural repair and functional recovery in a model of childhood brain injury. Stem Cell Rep 5(2):166–173. https://doi.org/10.1016/j.stemcr.2015.06.011

Article  CAS  Google Scholar 

Dröge W (2002) Free radicals in the physiological control of cell function. Physiol Rev 82(1):47–95. https://doi.org/10.1152/physrev.00018.2001

Article  PubMed  Google Scholar 

Du ZW, Chen H, Liu H, Lu J, Qian K, Huang CL, Zhong X, Fan F, Zhang SC (2015) Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nat Commun 6:6626. https://doi.org/10.1038/ncomms7626

Article  PubMed  CAS  Google Scholar 

Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ (2011) Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy, vol 331. Science, New York, N.Y.), pp 456–461. 6016https://doi.org/10.1126/science.1196371

Book  Google Scholar 

El-Mir MY, Detaille D, R-Villanueva G, Delgado-Esteban M, Guigas B, Attia S, Fontaine E, Almeida A, Leverve X (2008) Neuroprotective role of antidiabetic drug Metformin against apoptotic cell death in primary cortical neurons. J Mol Neuroscience: MN 34(1):77–87. https://doi.org/10.1007/s12031-007-9002-1

Article  CAS  Google Scholar 

Elefantova K, Lakatos B, Kubickova J, Sulova Z, Breier A (2018) Detection of the mitochondrial membrane potential by the cationic dye JC-1 in L1210 cells with massive overexpression of the plasma membrane ABCB1 drug transporter. Int J Mol Sci 19(7):1985. https://doi.org/10.3390/ijms19071985

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ericson J, Thor S, Edlund T, Jessell TM, Yamada T (1992) Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1. Sci (New York N Y) 256(5063):1555–1560. https://doi.org/10.1126/science.1350865

Article  CAS  Google Scholar 

Figueroa D, Asaduzzaman M, Young F (2018) Real time monitoring and quantification of reactive oxygen species in breast cancer cell line MCF-7 by 2’,7’-dichlorofluorescin diacetate (DCFDA) assay. J Pharmacol Toxicol Methods 94(Pt 1):26–33. https://doi.org/10.1016/j.vascn.2018.03.007

Article  PubMed  CAS  Google Scholar 

Goulding MD, Lumsden A, Gruss P (1993) Signals from the notochord and floor plate regulate the region-specific expression of two pax genes in the developing spinal cord. Development 117(3):1001–1016. https://doi.org/10.1242/dev.117.3.1001

Article  PubMed  CAS  Google Scholar 

Greer EL, Oskoui PR, Banko MR, Maniar JM, Gygi MP, Gygi SP, Brunet A (2007) The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J Biol Chem 282(41):30107–30119. https://doi.org/10.1074/jbc.M705325200

Article  PubMed  CAS  Google Scholar 

Guo H, Ouyang Y, Yin H, Cui H, Deng H, Liu H, Jian Z, Fang J, Zuo Z, Wang X, Zhao L, Zhu Y, Geng Y, Ouyang P (2022) Induction of autophagy via the ROS-dependent AMPK-mTOR pathway protects copper-induced spermatogenesis disorder. Redox Biol 49:102227. https://doi.org/10.1016/j.redox.2021.102227

Article  PubMed  CAS  Google Scholar 

Han YH, Yang YM, Kim SZ, Park WH (2010) Attenuation of MG132-induced HeLa cell death by N-acetyl cysteine via reducing reactive oxygen species and preventing glutathione depletion. Anticancer Res 30(6):2107–2112

PubMed  CAS 

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