de Martel C, Plummer M, Vignat J, Franceschi S (2017) Worldwide burden of cancer attributable to HPV by site, country and HPV type. Int J Cancer 141(4):664–670. https://doi.org/10.1002/ijc.30716

Article  CAS  PubMed  PubMed Central  Google Scholar 

CDC. Cancers linked with hpv each year. Cancer. Published April 25, 2024. Accessed July 4, 2024. https://www.cdc.gov/cancer/hpv/cases.html

Chaturvedi AK, Engels EA, Pfeiffer RM et al (2011) Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol 29(32):4294–4301. https://doi.org/10.1200/JCO.2011.36.4596

Article  PubMed  PubMed Central  Google Scholar 

Zhang Y, Fakhry C, D’Souza G (2021) Projected association of human papillomavirus vaccination with oropharynx cancer incidence in the US, 2020–2045. JAMA Oncol 7(10):e212907. https://doi.org/10.1001/jamaoncol.2021.2907

Article  PubMed  PubMed Central  Google Scholar 

Green JA, Kirwan JM, Tierney JF et al (2001) Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis. Lancet 358(9284):781–786. https://doi.org/10.1016/S0140-6736(01)05965-7

Article  CAS  PubMed  Google Scholar 

Lacas B, Carmel A, Landais C et al (2021) Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group. Radiother Oncol 156:281–293. https://doi.org/10.1016/j.radonc.2021.01.013

Article  PubMed  PubMed Central  Google Scholar 

Northover J, Glynne-Jones R, Sebag-Montefiore D et al (2010) Chemoradiation for the treatment of epidermoid anal cancer: 13-year follow-up of the first randomised UKCCCR Anal Cancer Trial (ACT I). Br J Cancer 102(7):1123–1128. https://doi.org/10.1038/sj.bjc.6605605

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gillison ML, Trotti AM, Harris J et al (2019) Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non-inferiority trial. Lancet. https://doi.org/10.1016/S0140-6736(18)32779-X

Article  PubMed  Google Scholar 

Schwarz JK, Siegel BA, Dehdashti F, Grigsby PW (2012) Metabolic response on post-therapy FDG-PET predicts patterns of failure after radiotherapy for cervical cancer. Int J Radiat Oncol Biol Phys 83(1):185–190. https://doi.org/10.1016/j.ijrobp.2011.05.053

Article  PubMed  Google Scholar 

Sebag-Montefiore D, James R, Meadows H, Begum R, Cunningham D, Northover J et al (2012) The pattern and timing of disease recurrence in squamous cancer of the anus: mature results from the NCRI ACT II trial. JCO 30:4029–4029. https://doi.org/10.1200/jco.2012.30.15_suppl.4029

Article  Google Scholar 

Masroor F, Corpman D, Carpenter DM, Ritterman Weintraub M, Cheung KHN, Wang KH (2019) Association of NCCN-recommended posttreatment surveillance with outcomes in patients with HPV-associated oropharyngeal squamous cell carcinoma. JAMA Otolaryngol Head Neck Surg 145(10):903–908. https://doi.org/10.1001/jamaoto.2019.1934

Article  PubMed  PubMed Central  Google Scholar 

Wan JCM, Massie C, Garcia-Corbacho J et al (2017) Liquid biopsies come of age: towards implementation of circulating tumour DNA. Nat Rev Cancer 17(4):223–238. https://doi.org/10.1038/nrc.2017.7

Article  CAS  PubMed  Google Scholar 

Crowley E, Di Nicolantonio F, Loupakis F, Bardelli A (2013) Liquid biopsy: monitoring cancer-genetics in the blood. Nat Rev Clin Oncol 10(8):472–484. https://doi.org/10.1038/nrclinonc.2013.110

Article  CAS  PubMed  Google Scholar 

Kustanovich A, Schwartz R, Peretz T, Grinshpun A (2019) Life and death of circulating cell-free DNA. Cancer Biol Ther 20(8):1057–1067. https://doi.org/10.1080/15384047.2019.1598759

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chan KCA, Woo JKS, King A et al (2017) Analysis of plasma epstein-barr virus dna to screen for nasopharyngeal cancer. N Engl J Med. https://doi.org/10.1056/NEJMoa1701717

Article  PubMed  PubMed Central  Google Scholar 

Lin JC, Wang WY, Chen KY et al (2004) Quantification of plasma Epstein-Barr virus DNA in patients with advanced nasopharyngeal carcinoma. N Engl J Med 350(24):2461–2470. https://doi.org/10.1056/NEJMoa032260

Article  CAS  PubMed  Google Scholar 

Burd EM, Dean CL (2016) Human papillomavirus. Microbiol Spectr. https://doi.org/10.1128/microbiolspec.DMIH2-0001-2015

Article  PubMed  Google Scholar 

McBride AA, Warburton A (2017) The role of integration in oncogenic progression of HPV-associated cancers. PLoS Pathog. https://doi.org/10.1371/journal.ppat.1006211

Article  PubMed  PubMed Central  Google Scholar 

Lin G, Li J (2023) Circulating HPV DNA in HPV-associated cancers. Clin Chim Acta 542:117269. https://doi.org/10.1016/j.cca.2023.117269

Article  CAS  PubMed  Google Scholar 

Damerla RR, Lee NY, You D et al (2019) Detection of early human papillomavirus-associated cancers by liquid biopsy. JCO Precis Oncol. https://doi.org/10.1200/PO.18.00276

Article  PubMed  PubMed Central  Google Scholar 

Sivars L, Palsdottir K, Crona Guterstam Y, Falconer H, Hellman K, Tham E (2023) The current status of cell-free human papillomavirus DNA as a biomarker in cervical cancer and other HPV-associated tumors: a review. Int J Cancer 152(11):2232–2242. https://doi.org/10.1002/ijc.34333

Article  CAS  PubMed  Google Scholar 

Chatfield-Reed K, Roche VP, Pan Q (2021) cfDNA detection for HPV+ squamous cell carcinomas. Oral Oncol 115:104958. https://doi.org/10.1016/j.oraloncology.2020.104958

Article  CAS  PubMed  PubMed Central  Google Scholar 

Routman DM, Kumar S, Chera BS et al (2022) Detectable postoperative circulating tumor human papillomavirus DNA and association with recurrence in patients with HPV-associated oropharyngeal squamous cell carcinoma. Int J Radiat Oncol Biol Phys 113(3):530–538. https://doi.org/10.1016/j.ijrobp.2022.02.012

Article  PubMed  Google Scholar 

Han K, Zou J, Zhao Z, Baskurt Z, Zheng Y, Barnes E, Croke J, Ferguson SE, Fyles A, Gien L, Gladwish A, Lecavalier-Barsoum M, Lheureux S, Lukovic J, Mackay H, Marchand EL, Metser U, Milosevic M, Taggar AS, Bratman SV, Leung E (2024) Clinical validation of human papilloma virus circulating tumor DNA for early detection of residual disease after chemoradiation in cervical cancer. J Clin Oncol. https://doi.org/10.1200/JCO.23.00954

Article  PubMed  Google Scholar 

de Sanjosé S, Serrano B, Tous S, Alejo M, Lloveras B, Quirós B, Clavero O, Vidal A, Ferrándiz-Pulido C, Pavón MÁ, Holzinger D, Halec G, Tommasino M, Quint W, Pawlita M, Muñoz N, Bosch FX, Alemany L; RIS HPV TT, VVAP and Head and Neck study groups. Burden of Human Papillomavirus (HPV)-Related Cancers Attributable to HPVs 6/11/16/18/31/33/45/52 and 58. JNCI Cancer Spectr. 2019 Jan 7;2(4):pky045. https://doi.org/10.1093/jncics/pky045. PMID: 31360870; PMCID: PMC6649711.

Van Doorslaer K (2013) Evolution of the papillomaviridae. Virology 445(1–2):11–20. https://doi.org/10.1016/j.virol.2013.05.012

Article  CAS  PubMed  Google Scholar 

Kojabad AA, Farzanehpour M, Galeh HEG et al (2021) Droplet digital PCR of viral DNA/RNA, current progress, challenges, and future perspectives. J Med Virol. https://doi.org/10.1002/jmv.26846

Article  PubMed  PubMed Central  Google Scholar 

Gillison ML, Akagi K, Xiao W, Jiang B, Pickard RKL, Li J, Swanson BJ, Agrawal AD, Zucker M, Stache-Crain B, Emde AK, Geiger HM, Robine N, Coombes KR, Symer DE (2019) Human papillomavirus and the landscape of secondary genetic alterations in oral cancers. Genome Res. https://doi.org/10.1101/gr.241141.118

Article  PubMed  PubMed Central  Google Scholar 

Lingen MW, Xiao W, Schmitt A et al (2013) Low etiologic fraction for high-risk human papillomavirus in oral cavity squamous cell carcinomas. Oral Oncol 49(1):1–8. https://doi.org/10.1016/j.oraloncology.2012.07.002

Article  PubMed  Google Scholar 

Jordan RC, Lingen MW, Perez-Ordonez B et al (2012) Validation of methods for oropharyngeal cancer HPV status determination in US cooperative group trials. Am J Surg Pathol 36(7):945–954.