Timmis A, Townsend N, Gale C, Grobbee R, Maniadakis N, Flather M, et al. European Society of Cardiology: cardiovascular disease statistics 2017. Eur Heart J. 2018;39(7):508–79.

Article  PubMed  Google Scholar 

Erlinge D, Maehara A, Ben-Yehuda O, Bøtker HE, Maeng M, Kjøller-Hansen L, et al. Identification of vulnerable plaques and patients by intracoronary near-infrared spectroscopy and ultrasound (PROSPECT II): a prospective natural history study. Lancet. 2021;397(10278):985–95.

Article  CAS  PubMed  Google Scholar 

Cerrato E, Mejía-Rentería H, Dehbi HM, Ahn JM, Cook C, Dupouy P, et al. Revascularization deferral of nonculprit stenoses on the basis of fractional flow reserve: 1-year outcomes of 8,579 patients. JACC Cardiovasc Interv. 2020;13(16):1894–903.

Article  PubMed  Google Scholar 

van der Schaaf RJ, Timmer JR, Ottervanger JP, Hoorntje JC, de Boer MJ, Suryapranata H, et al. Long-term impact of multivessel disease on cause-specific mortality after ST elevation myocardial infarction treated with reperfusion therapy. Heart. 2006;92(12):1760–3.

Article  PubMed  PubMed Central  Google Scholar 

Bianchini E, Basile M, Bianchini F, Zito A, Romagnoli E, Aurigemma C, et al. Multivessel revascularization in non-ST segment elevation acute coronary syndromes: a systematic review and meta-analysis of 182,798 patients. Int J Cardiol. 2024;413: 132392.

Article  PubMed  Google Scholar 

Achim A, Péter O, Cocoi M, Serban A, Mot S, Dadarlat-Pop A, et al. Correlation between coronary artery disease with other arterial systems: similar, albeit separate, underlying pathophysiologic mechanisms. J Cardiovasc Dev Dis. 2023;10:5.

Google Scholar 

Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20(5):1262–75.

Article  CAS  PubMed  Google Scholar 

Waksman R, Di Mario C, Torguson R, Ali ZA, Singh V, Skinner WH, et al. Identification of patients and plaques vulnerable to future coronary events with near-infrared spectroscopy intravascular ultrasound imaging: a prospective, cohort study. Lancet. 2019;394(10209):1629–37.

Article  CAS  PubMed  Google Scholar 

Motoyama S, Sarai M, Harigaya H, Anno H, Inoue K, Hara T, et al. Computed tomographic angiography characteristics of atherosclerotic plaques subsequently resulting in acute coronary syndrome. J Am Coll Cardiol. 2009;54(1):49–57.

Article  PubMed  Google Scholar 

van Rosendael AR, Shaw LJ, Xie JX, Dimitriu-Leen AC, Smit JM, Scholte AJ, et al. Superior risk stratification with coronary computed tomography angiography using a comprehensive atherosclerotic risk score. JACC Cardiovasc Imaging. 2019;12(10):1987–97.

Article  PubMed  PubMed Central  Google Scholar 

Lee JM, Choi G, Koo BK, Hwang D, Park J, Zhang J, et al. Identification of high-risk plaques destined to cause acute coronary syndrome using coronary computed tomographic angiography and computational fluid dynamics. JACC Cardiovasc Imaging. 2019;12(6):1032–43.

Article  PubMed  Google Scholar 

Westra J, Andersen BK, Campo G, Matsuo H, Koltowski L, Eftekhari A, et al. Diagnostic performance of in-procedure angiography-derived quantitative flow reserve compared to pressure-derived fractional flow reserve: the FAVOR II Europe-Japan study. J Am Heart Assoc. 2018;7:14.

Article  Google Scholar 

Tanigaki T, Emori H, Kawase Y, Kubo T, Omori H, Shiono Y, et al. QFR versus FFR derived from computed tomography for functional assessment of coronary artery stenosis. JACC Cardiovasc Interv. 2019;12(20):2050–9.

Article  PubMed  Google Scholar 

Case BC, Torguson R, Mintz GS, Di Mario C, Medranda GA, Zhang C, et al. Additive effect of multiple high-risk coronary artery segments on patient outcomes: LRP study sub-analysis. Cardiovasc Revasc Med. 2023;46:38–43.

Article  PubMed  Google Scholar 

Calvert PA, Obaid DR, O’Sullivan M, Shapiro LM, McNab D, Densem CG, et al. Association between IVUS findings and adverse outcomes in patients with coronary artery disease: the VIVA (VH-IVUS in Vulnerable Atherosclerosis) Study. JACC Cardiovasc Imaging. 2011;4(8):894–901.

Article  PubMed  Google Scholar 

Akutsu Y, Hamazaki Y, Sekimoto T, Kaneko K, Kodama Y, Li HL, et al. Dataset of calcified plaque condition in the stenotic coronary artery lesion obtained using multidetector computed tomography to indicate the addition of rotational atherectomy during percutaneous coronary intervention. Data Brief. 2016;7:376–80.

Article  PubMed  PubMed Central  Google Scholar 

Koo BK, Erglis A, Doh JH, Daniels DV, Jegere S, Kim HS, et al. Diagnosis of ischemia-causing coronary stenoses by noninvasive fractional flow reserve computed from coronary computed tomographic angiograms. Results from the prospective multicenter DISCOVER-FLOW (Diagnosis of Ischemia-Causing Stenoses Obtained Via Noninvasive Fractional Flow Reserve) study. J Am Coll Cardiol. 2011;58(19):1989–97.

Article  PubMed  Google Scholar 

Tu S, Westra J, Yang J, von Birgelen C, Ferrara A, Pellicano M, et al. Diagnostic accuracy of fast computational approaches to derive fractional flow reserve from diagnostic coronary angiography: the international multicenter FAVOR pilot study. JACC Cardiovasc Interv. 2016;9(19):2024–35.

Article  PubMed  Google Scholar 

Puri R, Nicholls SJ, Brennan DM, Andrews J, Liew GY, Carbone A, et al. Coronary atheroma composition and its association with segmental endothelial dysfunction in non-ST segment elevation myocardial infarction: novel insights with radiofrequency (iMAP) intravascular ultrasonography. Int J Cardiovasc Imaging. 2015;31(2):247–57.

Article  PubMed  Google Scholar 

Bonetti PO, Lerman LO, Lerman A. Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol. 2003;23(2):168–75.

Article  CAS  PubMed  Google Scholar 

Lerman A, Burnett JC Jr. Intact and altered endothelium in regulation of vasomotion. Circulation. 1992;86(6):2–9.

Google Scholar 

Cheng C, Tempel D, van Haperen R, van der Baan A, Grosveld F, Daemen MJ, et al. Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress. Circulation. 2006;113(23):2744–53.

Article  PubMed  Google Scholar 

Waksman R, Legutko J, Singh J, Orlando Q, Marso S, Schloss T, et al. FIRST: fractional flow reserve and intravascular ultrasound relationship study. J Am Coll Cardiol. 2013;61(9):917–23.

Article  PubMed  Google Scholar 

Usui E, Yonetsu T, Kanaji Y, Hoshino M, Yamaguchi M, Hada M, et al. Relationship between optical coherence tomography-derived morphological criteria and functional relevance as determined by fractional flow reserve. J Cardiol. 2018;71(4):359–66.

Article  PubMed  Google Scholar 

Lee SY, Shin DH, Shehata I, Kim JS, Kim BK, Ko YG, et al. Association between fractional flow reserve and coronary plaque characteristics assessed by optical coherence tomography. J Cardiol. 2016;68(4):342–5.

Article  PubMed  Google Scholar 

Zuo W, Sun R, Zhang X, Qu Y, Ji Z, Su Y, et al. The association between quantitative flow ratio and intravascular imaging-defined vulnerable plaque characteristics in patients with stable angina and non-ST-segment elevation acute coronary syndrome. Front Cardiovasc Med. 2021;8: 690262.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kanno Y, Sugiyama T, Hoshino M, Usui E, Hamaya R, Kanaji Y, et al. Optical coherence tomography-defined plaque vulnerability in relation to functional stenosis severity stratified by fractional flow reserve and quantitative flow ratio. Catheter Cardiovasc Interv. 2020;96(3):E238–47.

Article  PubMed  Google Scholar 

Lee SH, Hong D, Dai N, Shin D, Choi KH, Kim SM, et al. Anatomic and hemodynamic plaque characteristics for subsequent coronary events. Front Cardiovasc Med. 2022;9: 871450.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Min JK, Leipsic J, Pencina MJ, Berman DS, Koo BK, van Mieghem C, et al. Diagnostic accuracy of fractional flow reserve from anatomic CT angiography. JAMA. 2012;308(12):1237–45.

Article  CAS  PubMed  PubMed Central  Google Scholar