Azalim P, do Monte FM, Rendeiro MM, Liu X, O’Doherty GA, Fontes CF, Leitão SG, Quintas LEM, Noël F (2020) Conformational states of the pig kidney Na+/K+-ATPase differently affect bufadienolides and cardenolides: a directed structure-activity and structure-kinetics study. Biochem Pharmacol 171:113679
Article CAS PubMed Google Scholar
Buege JA, Aust SD (1978) Microsomal lipid peroxidation. Methods Enzymol 52:302–310
Article CAS PubMed Google Scholar
Chaudhary S, Parvez S (2012) An in vitro approach to assess the neurotoxicity of valproic acid-induced oxidative stress in cerebellum and cerebral cortex of young rats. Neuroscience 225:258–268
Article CAS PubMed Google Scholar
Clausen MV, Hilbers F, Poulsen H (2017) The structure and function of the Na, K-ATPase isoforms in health and disease. Front Physiol 8:371
Article PubMed PubMed Central Google Scholar
Concato-Lopes VM, Gonçalves-Lens MD, Tomiotto-Pellissier F, Detoni MB, Cruz EMS, Bortoleti BTdS, Carloto ACM, Rodrigues ACJ, Silva TF, Siqueira EdS, de Matos RLN, Alves Cardoso IL, Conchon-Costa I, Lazarin-Bidóia D, Arakawa NS, Dekker RFH, Mantovani MS, Pavanelli WR (2024) Trilobolide-6-O-isobutyrate from Sphagneticola trilobata acts by inducing oxidative stress, metabolic changes and apoptosis-like processes by caspase 3/7 activation of human lung cancer cell lines. Phytomedicine 128:155536
Article CAS PubMed Google Scholar
Cui X, Xie Z (2017) Protein interaction and Na/K-ATPase-mediated signal transduction. Molecules 22:990
Article PubMed PubMed Central Google Scholar
Denton RM, McCormack JG (1990) Ca2+ as a second messenger within mitochondria of the heart and other tissues. Annu Rev Physiol 52(1):451–466. https://doi.org/10.1146/annurev.ph.52.030190.002315
Elbaz HA, Stueckle TA, Tse W, Rojanasakul Y, Dinu CZ (2012) Digitoxin and its analogs as novel cancer therapeutics. Exp Hematol Oncol 1:4
Article CAS PubMed PubMed Central Google Scholar
Emam H, Zhao Q-L, Furusawa Y, Refaat A, Ahmed K, Kadowaki M, Kondo T (2012) Apoptotic cell death by the novel natural compound, cinobufotalin. Chem Biol Interact 199:154–160
Article CAS PubMed Google Scholar
Fiske CH, Subbarow YJ (1925) The colorimetric determination of phosphorus. Biol Chem 66:375–400
Hajnóczky G, Csordás G, Das S, Garcia-Perez C, Saotome M, Sinha Roy S, Yi M (2006) Mitochondrial calcium signalling and cell death: approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis. Cell Calcium 40:553–560
Article PubMed PubMed Central Google Scholar
Jiang Z-Y, Woollard ACS, Wolff SP (1990) Hydrogen peroxide production during experimental protein glycation. FEBS Lett 268:69–71
Article CAS PubMed Google Scholar
Jollow DJ, Mitchell JR, Zampaglione N, Gillette JR (1974) Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology 11:151–169
Article CAS PubMed Google Scholar
Jomova K, Raptova R, Alomar SY, Alwasel SH, Nepovimova E, Kuca K, Valko M (2023) Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging. Arch Toxicol 97:2499–2574
Article CAS PubMed PubMed Central Google Scholar
Kanai R, Cornelius F, Ogawa H, Motoyama K, Vilsen B, Toyoshima C (2020) Binding of cardiotonic steroids to Na+, K+-ATPase in the E2P state. PNAS 118:e2020438118
Article PubMed Central Google Scholar
Katz A, Lifshitz Y, Bab-Dinitz E, Kapri-Pardes E, Goldshleger R, Tal DM, Karlish SJD (2010) Selectivity of digitalis glycosides for isoforms of human Na, K-ATPase. J Biol Chem 285:19582–19592
Article CAS PubMed PubMed Central Google Scholar
Kerkhofs M, Bittremieux M, Morciano G, Giorgi C, Pinton P, Parys JB, Bultynck G (2018) Emerging molecular mechanisms in chemotherapy: Ca2+ signaling at the mitochondria-associated endoplasmic reticulum membranes. Cell Death Dis 9:334
Article PubMed PubMed Central Google Scholar
Klodos I, Esmann M, Post RL (2002) Large-scale preparation of sodium-potassium ATPase from kidney outer medulla. Kidney Int 62:2097–2100
Article CAS PubMed Google Scholar
Kowalczyk P, Sulejczak D, Kleczkowska P, Bukowska-Ośko I, Kucia M, Popiel M, Wietrak E, Kramkowski K, Wrzosek K, Kaczyńska K (2021) Mitochondrial oxidative stress—a causative factor and therapeutic target in many diseases. Int J Mol Sci 22:13384
Article CAS PubMed PubMed Central Google Scholar
Krenn L, Kopp B (1998) Bufadienolides from animal and plant sources. Phytochemistry 48:1–29
Article CAS PubMed Google Scholar
Laursen M, Yatime L, Nissen P, Fedosova NU (2013) Crystal structure of the high-affinity Na+, K+-ATPase- ouabain complex with Mg2+ bound in the cation binding site. PNAS 110:10958–10963
Article CAS PubMed PubMed Central Google Scholar
Lefranc F, Mijatovic T, Kondo Y, Sauvage SC, Roland IC, Debeir O, Krstic D, Vasic V, Gailly P, Kondo S, Blanco G, Kiss R (2008) Targeting the α1 subunit of the sodium pump to combat glioblastoma cells. Neurosurgery 62:211
Maehly AC (1954) The assay of catalases and peroxidases. Methods Biochem Anal 1:357–424
Marrocco I, Altieri F, Peluso I (2017) Measurement and clinical significance of biomarkers of oxidative stress in humans. Oxid Med Cell Longev 2017:1–32
Martindale JL, Holbrook NJ (2002) Cellular response to oxidative stress: Signaling for suicide and survival*. J Cell Physiol 192:1–15
Article CAS PubMed Google Scholar
Mijatovic T, Roland I, Van Quaquebeke E, Nilsson B, Mathieu A, Van Vynckt F, Darro F, Blanco G, Facchini V, Kiss R (2007) The α1 subunit of the sodium pump could represent a novel target to combat non-small cell lung cancers. Journal of Pathology 212:170–179
Article CAS PubMed Google Scholar
Misra HP, Fridovich I (1972) The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 247:3170–3175
Article CAS PubMed Google Scholar
Newman RA, Yang P, Hittelman WN, Tao Lu, Ho DH, Ni D, Chan D, Vijjeswarapu M, Cartwright C, Dixon S, Felix E, Addington C (2006) Oleandrin-mediated oxidative stress in human melanoma cells. J Exp Ther Oncol 5:167–181
O’Doherty G, Zhou M (2008) The de novo synthesis of oligosaccharides: application to the medicinal chemistry SAR-study of digitoxin. Curr Top Med Chem 8:114–125
Post RL, Hegyvary C, Kume S (1972) Activation by adenosine triphosphate in the phosphorylation kinetics of sodium and potassium ion transport adenosine triphosphatase. J Biol Chem 247:6530–6540
Article CAS PubMed Google Scholar
Sakai H, Suzuki T, Maeda M, Takahashi Y, Horikawa N, Minamimura T, Tsukada K, Takeguchi N (2004) Up-regulation of Na+, K+-ATPase α3-isoform and down-regulation of the α1-isoform in human colorectal cancer. FEBS Lett 563:151–154
Article CAS PubMed Google Scholar
Silva LND, Pessoa MTC, Alves SLG, Venugopal J, Cortes VF, Santos HL, Villar JAFP, Barbosa LA (2017) Differences of lipid membrane modulation and oxidative stress by digoxin and 21-benzylidene digoxin. Exp Cell Res 359:291–298
Article CAS PubMed Google Scholar
Taniguchi K, Post RL (1975) Synthesis of adenosine triphosphate and exchange between inorganic phosphate and adenosine triphosphate in sodium and potassium ion transport adenosine triphosphatase. J Biol Chem 250:3010–3018
Comments (0)